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Gene: IL8 |
Gene summary for IL8 |
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Gene information | Species | Human | Gene symbol | IL8 | Gene ID | 3576 |
Gene name | C-X-C motif chemokine ligand 8 | |
Gene Alias | GCP-1 | |
Cytomap | 4q13.3 | |
Gene Type | protein-coding | GO ID | GO:0001525 | UniProtAcc | A0A024RDA5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
3576 | IL8 | Pt13.a | Human | Liver | HCC | 8.72e-28 | 8.15e-01 | 0.021 |
3576 | IL8 | Pt13.b | Human | Liver | HCC | 6.11e-48 | 1.19e+00 | 0.0251 |
3576 | IL8 | Pt13.c | Human | Liver | HCC | 6.11e-10 | 5.72e-01 | 0.0076 |
3576 | IL8 | Pt14.d | Human | Liver | HCC | 1.05e-09 | 3.67e-01 | 0.0143 |
3576 | IL8 | P1_S1_AK | Human | Skin | AK | 4.80e-27 | -8.45e-01 | -0.3399 |
3576 | IL8 | P2_S3_AK | Human | Skin | AK | 3.30e-28 | -8.45e-01 | -0.3287 |
3576 | IL8 | P2_S4_SCCIS | Human | Skin | SCCIS | 2.83e-26 | -8.45e-01 | -0.3043 |
3576 | IL8 | P3_S6_AK | Human | Skin | AK | 3.30e-28 | -8.45e-01 | -0.3256 |
3576 | IL8 | P4_S8_cSCC | Human | Skin | cSCC | 2.90e-18 | -8.45e-01 | -0.3095 |
3576 | IL8 | P5_S10_cSCC | Human | Skin | cSCC | 3.30e-28 | -8.45e-01 | -0.299 |
3576 | IL8 | P1_cSCC | Human | Skin | cSCC | 1.05e-12 | -5.84e-01 | 0.0292 |
3576 | IL8 | P2_cSCC | Human | Skin | cSCC | 2.36e-14 | -6.43e-01 | -0.024 |
3576 | IL8 | P4_cSCC | Human | Skin | cSCC | 1.02e-06 | -6.85e-01 | -0.00290000000000005 |
3576 | IL8 | cSCC_p1 | Human | Skin | cSCC | 3.30e-28 | -8.45e-01 | -0.1916 |
3576 | IL8 | cSCC_p10 | Human | Skin | cSCC | 3.30e-28 | -8.45e-01 | -0.2095 |
3576 | IL8 | cSCC_p11 | Human | Skin | cSCC | 1.97e-27 | -8.45e-01 | -0.2102 |
3576 | IL8 | cSCC_p3 | Human | Skin | cSCC | 3.30e-28 | -8.45e-01 | -0.2085 |
3576 | IL8 | cSCC_p4 | Human | Skin | cSCC | 2.26e-24 | -8.45e-01 | -0.2022 |
3576 | IL8 | cSCC_p6 | Human | Skin | cSCC | 1.17e-26 | -8.45e-01 | -0.1989 |
3576 | IL8 | cSCC_p7 | Human | Skin | cSCC | 2.26e-24 | -8.45e-01 | -0.2332 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0516419 | Oral cavity | OSCC | Influenza A | 116/3704 | 171/8465 | 1.23e-10 | 1.78e-09 | 9.08e-10 | 116 |
hsa05130114 | Oral cavity | OSCC | Pathogenic Escherichia coli infection | 129/3704 | 197/8465 | 4.32e-10 | 5.17e-09 | 2.63e-09 | 129 |
hsa05135110 | Oral cavity | OSCC | Yersinia infection | 94/3704 | 137/8465 | 2.85e-09 | 3.08e-08 | 1.57e-08 | 94 |
hsa05167113 | Oral cavity | OSCC | Kaposi sarcoma-associated herpesvirus infection | 125/3704 | 194/8465 | 3.67e-09 | 3.84e-08 | 1.96e-08 | 125 |
hsa05163112 | Oral cavity | OSCC | Human cytomegalovirus infection | 139/3704 | 225/8465 | 2.77e-08 | 2.38e-07 | 1.21e-07 | 139 |
hsa05131113 | Oral cavity | OSCC | Shigellosis | 150/3704 | 247/8465 | 3.96e-08 | 3.12e-07 | 1.59e-07 | 150 |
hsa05417113 | Oral cavity | OSCC | Lipid and atherosclerosis | 131/3704 | 215/8465 | 2.20e-07 | 1.45e-06 | 7.37e-07 | 131 |
hsa0516113 | Oral cavity | OSCC | Hepatitis B | 103/3704 | 162/8465 | 2.34e-07 | 1.51e-06 | 7.69e-07 | 103 |
hsa0493316 | Oral cavity | OSCC | AGE-RAGE signaling pathway in diabetic complications | 69/3704 | 100/8465 | 2.61e-07 | 1.65e-06 | 8.41e-07 | 69 |
hsa04657112 | Oral cavity | OSCC | IL-17 signaling pathway | 64/3704 | 94/8465 | 1.48e-06 | 7.87e-06 | 4.01e-06 | 64 |
hsa05134111 | Oral cavity | OSCC | Legionellosis | 42/3704 | 57/8465 | 4.18e-06 | 2.15e-05 | 1.10e-05 | 42 |
hsa0512017 | Oral cavity | OSCC | Epithelial cell signaling in Helicobacter pylori infection | 49/3704 | 70/8465 | 7.57e-06 | 3.59e-05 | 1.83e-05 | 49 |
hsa0521916 | Oral cavity | OSCC | Bladder cancer | 32/3704 | 41/8465 | 7.73e-06 | 3.59e-05 | 1.83e-05 | 32 |
hsa0406411 | Oral cavity | OSCC | NF-kappa B signaling pathway | 67/3704 | 104/8465 | 1.57e-05 | 6.75e-05 | 3.44e-05 | 67 |
hsa0462113 | Oral cavity | OSCC | NOD-like receptor signaling pathway | 108/3704 | 186/8465 | 5.13e-05 | 2.07e-04 | 1.05e-04 | 108 |
hsa0514212 | Oral cavity | OSCC | Chagas disease | 64/3704 | 102/8465 | 8.00e-05 | 2.95e-04 | 1.50e-04 | 64 |
hsa0513313 | Oral cavity | OSCC | Pertussis | 50/3704 | 76/8465 | 8.34e-05 | 3.04e-04 | 1.55e-04 | 50 |
hsa0532319 | Oral cavity | OSCC | Rheumatoid arthritis | 56/3704 | 93/8465 | 9.72e-04 | 2.76e-03 | 1.40e-03 | 56 |
hsa0514615 | Oral cavity | OSCC | Amoebiasis | 59/3704 | 102/8465 | 2.78e-03 | 7.17e-03 | 3.65e-03 | 59 |
hsa0493612 | Oral cavity | OSCC | Alcoholic liver disease | 78/3704 | 142/8465 | 4.53e-03 | 1.12e-02 | 5.68e-03 | 78 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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