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Gene: WHSC1 |
Gene summary for WHSC1 |
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Gene information | Species | Human | Gene symbol | WHSC1 | Gene ID | 7468 |
Gene name | nuclear receptor binding SET domain protein 2 | |
Gene Alias | KMT3F | |
Cytomap | 4p16.3 | |
Gene Type | protein-coding | GO ID | GO:0000018 | UniProtAcc | O96028 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
7468 | WHSC1 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 3.91e-47 | 7.78e-01 | 0.294 |
7468 | WHSC1 | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 1.23e-14 | 1.10e+00 | 0.3487 |
7468 | WHSC1 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 4.35e-15 | 5.02e-01 | 0.281 |
7468 | WHSC1 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 2.21e-31 | 6.79e-01 | 0.3859 |
7468 | WHSC1 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 1.52e-20 | 6.70e-01 | 0.2585 |
7468 | WHSC1 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 2.11e-21 | 4.06e-01 | 0.3005 |
7468 | WHSC1 | P1T-E | Human | Esophagus | ESCC | 9.41e-08 | 4.54e-01 | 0.0875 |
7468 | WHSC1 | P2T-E | Human | Esophagus | ESCC | 2.66e-26 | 6.77e-01 | 0.1177 |
7468 | WHSC1 | P4T-E | Human | Esophagus | ESCC | 1.91e-05 | 2.69e-01 | 0.1323 |
7468 | WHSC1 | P5T-E | Human | Esophagus | ESCC | 5.31e-13 | 1.47e-01 | 0.1327 |
7468 | WHSC1 | P8T-E | Human | Esophagus | ESCC | 4.28e-22 | 3.89e-01 | 0.0889 |
7468 | WHSC1 | P9T-E | Human | Esophagus | ESCC | 2.34e-09 | 1.44e-01 | 0.1131 |
7468 | WHSC1 | P10T-E | Human | Esophagus | ESCC | 6.23e-10 | 2.11e-01 | 0.116 |
7468 | WHSC1 | P11T-E | Human | Esophagus | ESCC | 1.00e-03 | 1.80e-01 | 0.1426 |
7468 | WHSC1 | P12T-E | Human | Esophagus | ESCC | 1.16e-14 | 2.49e-01 | 0.1122 |
7468 | WHSC1 | P15T-E | Human | Esophagus | ESCC | 1.89e-07 | 1.65e-01 | 0.1149 |
7468 | WHSC1 | P16T-E | Human | Esophagus | ESCC | 7.41e-13 | 2.21e-01 | 0.1153 |
7468 | WHSC1 | P17T-E | Human | Esophagus | ESCC | 2.76e-07 | 4.25e-01 | 0.1278 |
7468 | WHSC1 | P20T-E | Human | Esophagus | ESCC | 1.34e-07 | 2.42e-01 | 0.1124 |
7468 | WHSC1 | P21T-E | Human | Esophagus | ESCC | 1.28e-10 | 1.52e-01 | 0.1617 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa052025 | Lung | MIAC | Transcriptional misregulation in cancer | 22/507 | 193/8465 | 2.64e-03 | 2.26e-02 | 1.64e-02 | 22 |
hsa0031052 | Lung | MIAC | Lysine degradation | 10/507 | 63/8465 | 3.93e-03 | 3.18e-02 | 2.30e-02 | 10 |
hsa052027 | Prostate | BPH | Transcriptional misregulation in cancer | 53/1718 | 193/8465 | 9.56e-03 | 2.92e-02 | 1.81e-02 | 53 |
hsa0520212 | Prostate | BPH | Transcriptional misregulation in cancer | 53/1718 | 193/8465 | 9.56e-03 | 2.92e-02 | 1.81e-02 | 53 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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