|
Gene: WASF1 |
Gene summary for WASF1 |
Gene summary. |
Gene information | Species | Human | Gene symbol | WASF1 | Gene ID | 8936 |
Gene name | WASP family member 1 | |
Gene Alias | NEDALVS | |
Cytomap | 6q21 | |
Gene Type | protein-coding | GO ID | GO:0000902 | UniProtAcc | Q92558 |
Top |
Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
8936 | WASF1 | LZE4T | Human | Esophagus | ESCC | 6.04e-09 | 4.05e-01 | 0.0811 |
8936 | WASF1 | P2T-E | Human | Esophagus | ESCC | 7.33e-10 | 1.57e-01 | 0.1177 |
8936 | WASF1 | P4T-E | Human | Esophagus | ESCC | 3.85e-16 | 3.15e-01 | 0.1323 |
8936 | WASF1 | P5T-E | Human | Esophagus | ESCC | 6.33e-04 | -3.88e-03 | 0.1327 |
8936 | WASF1 | P8T-E | Human | Esophagus | ESCC | 3.29e-04 | 8.46e-02 | 0.0889 |
8936 | WASF1 | P9T-E | Human | Esophagus | ESCC | 1.01e-09 | 2.37e-01 | 0.1131 |
8936 | WASF1 | P10T-E | Human | Esophagus | ESCC | 2.35e-45 | 8.25e-01 | 0.116 |
8936 | WASF1 | P11T-E | Human | Esophagus | ESCC | 8.60e-07 | 2.31e-01 | 0.1426 |
8936 | WASF1 | P12T-E | Human | Esophagus | ESCC | 3.88e-18 | 3.21e-01 | 0.1122 |
8936 | WASF1 | P15T-E | Human | Esophagus | ESCC | 6.53e-11 | 3.57e-01 | 0.1149 |
8936 | WASF1 | P16T-E | Human | Esophagus | ESCC | 1.35e-16 | 2.82e-01 | 0.1153 |
8936 | WASF1 | P20T-E | Human | Esophagus | ESCC | 1.44e-04 | 8.18e-02 | 0.1124 |
8936 | WASF1 | P21T-E | Human | Esophagus | ESCC | 8.33e-07 | 1.01e-01 | 0.1617 |
8936 | WASF1 | P22T-E | Human | Esophagus | ESCC | 6.22e-09 | 3.37e-02 | 0.1236 |
8936 | WASF1 | P24T-E | Human | Esophagus | ESCC | 1.79e-02 | 5.57e-02 | 0.1287 |
8936 | WASF1 | P26T-E | Human | Esophagus | ESCC | 1.10e-09 | 2.20e-01 | 0.1276 |
8936 | WASF1 | P27T-E | Human | Esophagus | ESCC | 9.32e-16 | 2.49e-01 | 0.1055 |
8936 | WASF1 | P28T-E | Human | Esophagus | ESCC | 1.28e-03 | 7.44e-02 | 0.1149 |
8936 | WASF1 | P30T-E | Human | Esophagus | ESCC | 6.19e-31 | 1.29e+00 | 0.137 |
8936 | WASF1 | P31T-E | Human | Esophagus | ESCC | 2.04e-04 | 1.84e-01 | 0.1251 |
Page: 1 2 3 |
Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:005165617 | Esophagus | ESCC | establishment of organelle localization | 273/8552 | 390/18723 | 9.13e-23 | 1.81e-20 | 273 |
GO:0043254111 | Esophagus | ESCC | regulation of protein-containing complex assembly | 278/8552 | 428/18723 | 3.81e-16 | 2.77e-14 | 278 |
GO:0031334111 | Esophagus | ESCC | positive regulation of protein-containing complex assembly | 166/8552 | 237/18723 | 2.06e-14 | 1.07e-12 | 166 |
GO:1902905111 | Esophagus | ESCC | positive regulation of supramolecular fiber organization | 142/8552 | 209/18723 | 5.51e-11 | 1.76e-09 | 142 |
GO:1902903111 | Esophagus | ESCC | regulation of supramolecular fiber organization | 237/8552 | 383/18723 | 9.06e-11 | 2.75e-09 | 237 |
GO:0016049110 | Esophagus | ESCC | cell growth | 289/8552 | 482/18723 | 1.29e-10 | 3.77e-09 | 289 |
GO:003070518 | Esophagus | ESCC | cytoskeleton-dependent intracellular transport | 133/8552 | 195/18723 | 1.48e-10 | 4.27e-09 | 133 |
GO:005149520 | Esophagus | ESCC | positive regulation of cytoskeleton organization | 147/8552 | 226/18723 | 2.93e-09 | 6.38e-08 | 147 |
GO:001097013 | Esophagus | ESCC | transport along microtubule | 107/8552 | 155/18723 | 3.17e-09 | 6.80e-08 | 107 |
GO:00723846 | Esophagus | ESCC | organelle transport along microtubule | 65/8552 | 85/18723 | 6.61e-09 | 1.35e-07 | 65 |
GO:0051258111 | Esophagus | ESCC | protein polymerization | 183/8552 | 297/18723 | 1.94e-08 | 3.75e-07 | 183 |
GO:000808810 | Esophagus | ESCC | axo-dendritic transport | 58/8552 | 75/18723 | 2.09e-08 | 4.02e-07 | 58 |
GO:000701527 | Esophagus | ESCC | actin filament organization | 259/8552 | 442/18723 | 2.37e-08 | 4.50e-07 | 259 |
GO:0032273111 | Esophagus | ESCC | positive regulation of protein polymerization | 95/8552 | 138/18723 | 2.97e-08 | 5.57e-07 | 95 |
GO:003253520 | Esophagus | ESCC | regulation of cellular component size | 227/8552 | 383/18723 | 4.77e-08 | 8.60e-07 | 227 |
GO:000726510 | Esophagus | ESCC | Ras protein signal transduction | 201/8552 | 337/18723 | 1.44e-07 | 2.30e-06 | 201 |
GO:0032970111 | Esophagus | ESCC | regulation of actin filament-based process | 231/8552 | 397/18723 | 2.91e-07 | 4.20e-06 | 231 |
GO:0032956111 | Esophagus | ESCC | regulation of actin cytoskeleton organization | 210/8552 | 358/18723 | 4.40e-07 | 6.00e-06 | 210 |
GO:0032271111 | Esophagus | ESCC | regulation of protein polymerization | 143/8552 | 233/18723 | 9.21e-07 | 1.17e-05 | 143 |
GO:011005327 | Esophagus | ESCC | regulation of actin filament organization | 166/8552 | 278/18723 | 1.54e-06 | 1.85e-05 | 166 |
Page: 1 2 3 4 5 |
Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa052316 | Liver | HCC | Choline metabolism in cancer | 57/4020 | 98/8465 | 2.14e-02 | 4.90e-02 | 2.72e-02 | 57 |
hsa0513052 | Liver | HCC | Pathogenic Escherichia coli infection | 129/4020 | 197/8465 | 2.02e-07 | 2.50e-06 | 1.39e-06 | 129 |
hsa0452052 | Liver | HCC | Adherens junction | 68/4020 | 93/8465 | 3.99e-07 | 4.46e-06 | 2.48e-06 | 68 |
hsa0513152 | Liver | HCC | Shigellosis | 150/4020 | 247/8465 | 1.53e-05 | 1.04e-04 | 5.81e-05 | 150 |
hsa0481051 | Liver | HCC | Regulation of actin cytoskeleton | 134/4020 | 229/8465 | 4.48e-04 | 1.94e-03 | 1.08e-03 | 134 |
hsa0510032 | Liver | HCC | Bacterial invasion of epithelial cells | 51/4020 | 77/8465 | 6.67e-04 | 2.72e-03 | 1.52e-03 | 51 |
hsa0466611 | Liver | HCC | Fc gamma R-mediated phagocytosis | 58/4020 | 97/8465 | 9.65e-03 | 2.52e-02 | 1.40e-02 | 58 |
hsa0523111 | Liver | HCC | Choline metabolism in cancer | 57/4020 | 98/8465 | 2.14e-02 | 4.90e-02 | 2.72e-02 | 57 |
Page: 1 2 |
Top |
Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
WASF1 | SNV | Missense_Mutation | c.692N>A | p.Pro231Gln | p.P231Q | Q92558 | protein_coding | deleterious(0.01) | benign(0.401) | TCGA-A8-A094-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
WASF1 | SNV | Missense_Mutation | novel | c.664C>A | p.His222Asn | p.H222N | Q92558 | protein_coding | deleterious(0.02) | benign(0.005) | TCGA-AC-A8OP-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
WASF1 | SNV | Missense_Mutation | c.1384G>A | p.Ala462Thr | p.A462T | Q92558 | protein_coding | tolerated_low_confidence(0.58) | benign(0.007) | TCGA-AO-A0J2-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cyclophosphamide | SD | |
WASF1 | SNV | Missense_Mutation | c.766N>T | p.Pro256Ser | p.P256S | Q92558 | protein_coding | deleterious(0.05) | probably_damaging(0.992) | TCGA-AO-A128-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD | |
WASF1 | SNV | Missense_Mutation | c.232G>C | p.Val78Leu | p.V78L | Q92558 | protein_coding | deleterious(0) | benign(0.001) | TCGA-AR-A0TX-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
WASF1 | SNV | Missense_Mutation | c.797N>C | p.Arg266Thr | p.R266T | Q92558 | protein_coding | tolerated(0.27) | probably_damaging(0.95) | TCGA-EW-A1J5-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | |
WASF1 | SNV | Missense_Mutation | c.250N>A | p.Asp84Asn | p.D84N | Q92558 | protein_coding | deleterious(0) | probably_damaging(0.962) | TCGA-EW-A1J5-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | |
WASF1 | SNV | Missense_Mutation | c.777N>C | p.Gln259His | p.Q259H | Q92558 | protein_coding | tolerated(0.12) | probably_damaging(0.969) | TCGA-C5-A1BQ-01 | Cervix | cervical & endocervical cancer | Female | >=65 | III/IV | Chemotherapy | cisplatin | CR | |
WASF1 | SNV | Missense_Mutation | novel | c.319N>G | p.Gln107Glu | p.Q107E | Q92558 | protein_coding | deleterious(0) | possibly_damaging(0.784) | TCGA-ZJ-AAXU-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
WASF1 | SNV | Missense_Mutation | c.1390N>T | p.Gly464Cys | p.G464C | Q92558 | protein_coding | deleterious_low_confidence(0.01) | probably_damaging(0.996) | TCGA-A6-6780-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
Page: 1 2 3 4 5 6 |
Top |
Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |