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Gene: U2AF1 |
Gene summary for U2AF1 |
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Gene information | Species | Human | Gene symbol | U2AF1 | Gene ID | 7307 |
Gene name | U2 small nuclear RNA auxiliary factor 1 | |
Gene Alias | FP793 | |
Cytomap | 21q22.3 | |
Gene Type | protein-coding | GO ID | GO:0000375 | UniProtAcc | Q01081 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
7307 | U2AF1 | HTA11_3410_2000001011 | Human | Colorectum | AD | 3.05e-03 | 1.11e-01 | 0.0155 |
7307 | U2AF1 | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.95e-08 | 3.31e-01 | -0.1808 |
7307 | U2AF1 | HTA11_1938_2000001011 | Human | Colorectum | AD | 1.72e-08 | 3.54e-01 | -0.0811 |
7307 | U2AF1 | HTA11_78_2000001011 | Human | Colorectum | AD | 5.43e-07 | 2.88e-01 | -0.1088 |
7307 | U2AF1 | HTA11_347_2000001011 | Human | Colorectum | AD | 2.52e-19 | 4.62e-01 | -0.1954 |
7307 | U2AF1 | HTA11_411_2000001011 | Human | Colorectum | SER | 7.74e-04 | 4.55e-01 | -0.2602 |
7307 | U2AF1 | HTA11_3361_2000001011 | Human | Colorectum | AD | 4.35e-04 | 2.61e-01 | -0.1207 |
7307 | U2AF1 | HTA11_696_2000001011 | Human | Colorectum | AD | 2.65e-10 | 3.06e-01 | -0.1464 |
7307 | U2AF1 | HTA11_866_2000001011 | Human | Colorectum | AD | 5.29e-06 | 2.19e-01 | -0.1001 |
7307 | U2AF1 | HTA11_1391_2000001011 | Human | Colorectum | AD | 2.41e-17 | 4.51e-01 | -0.059 |
7307 | U2AF1 | HTA11_546_2000001011 | Human | Colorectum | AD | 1.88e-03 | 3.30e-01 | -0.0842 |
7307 | U2AF1 | HTA11_7663_2000001011 | Human | Colorectum | SER | 1.78e-10 | 5.47e-01 | 0.0131 |
7307 | U2AF1 | HTA11_10623_2000001011 | Human | Colorectum | AD | 9.14e-05 | 4.03e-01 | -0.0177 |
7307 | U2AF1 | HTA11_7696_3000711011 | Human | Colorectum | AD | 2.03e-08 | 2.55e-01 | 0.0674 |
7307 | U2AF1 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 4.79e-07 | 2.42e-01 | 0.294 |
7307 | U2AF1 | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 7.71e-06 | 7.05e-01 | 0.3487 |
7307 | U2AF1 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 5.53e-22 | 6.94e-01 | 0.281 |
7307 | U2AF1 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 1.96e-10 | 3.53e-01 | 0.3859 |
7307 | U2AF1 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 3.12e-02 | 2.24e-01 | 0.2585 |
7307 | U2AF1 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 1.29e-08 | 3.26e-01 | 0.3005 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0008380 | Colorectum | AD | RNA splicing | 169/3918 | 434/18723 | 3.59e-18 | 2.04e-15 | 169 |
GO:0000377 | Colorectum | AD | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile | 130/3918 | 320/18723 | 5.88e-16 | 2.16e-13 | 130 |
GO:0000398 | Colorectum | AD | mRNA splicing, via spliceosome | 130/3918 | 320/18723 | 5.88e-16 | 2.16e-13 | 130 |
GO:0000375 | Colorectum | AD | RNA splicing, via transesterification reactions | 131/3918 | 324/18723 | 7.11e-16 | 2.22e-13 | 131 |
GO:00083801 | Colorectum | SER | RNA splicing | 123/2897 | 434/18723 | 3.84e-12 | 8.41e-10 | 123 |
GO:00003751 | Colorectum | SER | RNA splicing, via transesterification reactions | 90/2897 | 324/18723 | 8.68e-09 | 7.50e-07 | 90 |
GO:00003771 | Colorectum | SER | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile | 89/2897 | 320/18723 | 9.82e-09 | 8.14e-07 | 89 |
GO:00003981 | Colorectum | SER | mRNA splicing, via spliceosome | 89/2897 | 320/18723 | 9.82e-09 | 8.14e-07 | 89 |
GO:00083802 | Colorectum | MSS | RNA splicing | 159/3467 | 434/18723 | 1.75e-19 | 1.22e-16 | 159 |
GO:00003772 | Colorectum | MSS | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile | 121/3467 | 320/18723 | 2.52e-16 | 8.27e-14 | 121 |
GO:00003982 | Colorectum | MSS | mRNA splicing, via spliceosome | 121/3467 | 320/18723 | 2.52e-16 | 8.27e-14 | 121 |
GO:00003752 | Colorectum | MSS | RNA splicing, via transesterification reactions | 122/3467 | 324/18723 | 2.75e-16 | 8.58e-14 | 122 |
GO:00083803 | Colorectum | MSI-H | RNA splicing | 82/1319 | 434/18723 | 1.22e-16 | 4.53e-14 | 82 |
GO:00003753 | Colorectum | MSI-H | RNA splicing, via transesterification reactions | 67/1319 | 324/18723 | 7.99e-16 | 2.61e-13 | 67 |
GO:00003773 | Colorectum | MSI-H | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile | 66/1319 | 320/18723 | 1.51e-15 | 4.41e-13 | 66 |
GO:00003983 | Colorectum | MSI-H | mRNA splicing, via spliceosome | 66/1319 | 320/18723 | 1.51e-15 | 4.41e-13 | 66 |
GO:000838016 | Endometrium | AEH | RNA splicing | 111/2100 | 434/18723 | 2.42e-17 | 1.12e-14 | 111 |
GO:000037515 | Endometrium | AEH | RNA splicing, via transesterification reactions | 88/2100 | 324/18723 | 1.11e-15 | 3.91e-13 | 88 |
GO:000037715 | Endometrium | AEH | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile | 87/2100 | 320/18723 | 1.51e-15 | 4.78e-13 | 87 |
GO:000039815 | Endometrium | AEH | mRNA splicing, via spliceosome | 87/2100 | 320/18723 | 1.51e-15 | 4.78e-13 | 87 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0513136 | Endometrium | EEC | Shigellosis | 79/1237 | 247/8465 | 1.80e-12 | 3.95e-11 | 2.95e-11 | 79 |
hsa0304034 | Endometrium | EEC | Spliceosome | 54/1237 | 217/8465 | 3.78e-05 | 3.88e-04 | 2.89e-04 | 54 |
hsa0304018 | Esophagus | HGIN | Spliceosome | 79/1383 | 217/8465 | 3.22e-13 | 7.00e-12 | 5.56e-12 | 79 |
hsa0513139 | Esophagus | HGIN | Shigellosis | 71/1383 | 247/8465 | 4.89e-07 | 7.98e-06 | 6.34e-06 | 71 |
hsa0304019 | Esophagus | HGIN | Spliceosome | 79/1383 | 217/8465 | 3.22e-13 | 7.00e-12 | 5.56e-12 | 79 |
hsa05131114 | Esophagus | HGIN | Shigellosis | 71/1383 | 247/8465 | 4.89e-07 | 7.98e-06 | 6.34e-06 | 71 |
hsa05131211 | Esophagus | ESCC | Shigellosis | 176/4205 | 247/8465 | 2.27e-12 | 4.01e-11 | 2.05e-11 | 176 |
hsa0304027 | Esophagus | ESCC | Spliceosome | 128/4205 | 217/8465 | 3.31e-03 | 8.79e-03 | 4.50e-03 | 128 |
hsa05131310 | Esophagus | ESCC | Shigellosis | 176/4205 | 247/8465 | 2.27e-12 | 4.01e-11 | 2.05e-11 | 176 |
hsa0304037 | Esophagus | ESCC | Spliceosome | 128/4205 | 217/8465 | 3.31e-03 | 8.79e-03 | 4.50e-03 | 128 |
hsa0513142 | Liver | HCC | Shigellosis | 150/4020 | 247/8465 | 1.53e-05 | 1.04e-04 | 5.81e-05 | 150 |
hsa0304022 | Liver | HCC | Spliceosome | 122/4020 | 217/8465 | 5.55e-03 | 1.60e-02 | 8.91e-03 | 122 |
hsa0513152 | Liver | HCC | Shigellosis | 150/4020 | 247/8465 | 1.53e-05 | 1.04e-04 | 5.81e-05 | 150 |
hsa0304032 | Liver | HCC | Spliceosome | 122/4020 | 217/8465 | 5.55e-03 | 1.60e-02 | 8.91e-03 | 122 |
hsa0513130 | Oral cavity | OSCC | Shigellosis | 150/3704 | 247/8465 | 3.96e-08 | 3.12e-07 | 1.59e-07 | 150 |
hsa0304016 | Oral cavity | OSCC | Spliceosome | 123/3704 | 217/8465 | 7.21e-05 | 2.74e-04 | 1.40e-04 | 123 |
hsa05131113 | Oral cavity | OSCC | Shigellosis | 150/3704 | 247/8465 | 3.96e-08 | 3.12e-07 | 1.59e-07 | 150 |
hsa0304017 | Oral cavity | OSCC | Spliceosome | 123/3704 | 217/8465 | 7.21e-05 | 2.74e-04 | 1.40e-04 | 123 |
hsa0513129 | Prostate | Tumor | Shigellosis | 94/1791 | 247/8465 | 5.56e-10 | 9.69e-09 | 6.01e-09 | 94 |
hsa0304025 | Prostate | Tumor | Spliceosome | 66/1791 | 217/8465 | 7.53e-04 | 3.59e-03 | 2.23e-03 | 66 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
U2AF1 | PERI | Pancreas | PDAC | SEPP1,ATP5F1E,RACK1, etc. | 1.45e-01 | ![]() |
U2AF1 | ICAF | Pancreas | PDAC | SEPP1,ATP5F1E,RACK1, etc. | 1.54e-01 | ![]() |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
U2AF1 | SNV | Missense_Mutation | c.291G>T | p.Glu97Asp | p.E97D | Q01081 | protein_coding | tolerated(0.07) | benign(0.047) | TCGA-CM-5861-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |
U2AF1 | SNV | Missense_Mutation | c.343N>A | p.Val115Ile | p.V115I | Q01081 | protein_coding | tolerated(0.17) | benign(0.044) | TCGA-BR-6452-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
7307 | U2AF1 | CLINICALLY ACTIONABLE | N/A | 25465125,22389253,22158538 | ||
7307 | U2AF1 | CLINICALLY ACTIONABLE | H3B-8800 |
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