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Gene: TBC1D4 |
Gene summary for TBC1D4 |
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Gene information | Species | Human | Gene symbol | TBC1D4 | Gene ID | 9882 |
Gene name | TBC1 domain family member 4 | |
Gene Alias | AS160 | |
Cytomap | 13q22.2 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | O60343 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9882 | TBC1D4 | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.24e-11 | -5.70e-01 | 0.0155 |
9882 | TBC1D4 | HTA11_2487_2000001011 | Human | Colorectum | SER | 5.57e-03 | -5.19e-01 | -0.1808 |
9882 | TBC1D4 | HTA11_2951_2000001011 | Human | Colorectum | AD | 4.40e-05 | -8.35e-01 | 0.0216 |
9882 | TBC1D4 | HTA11_3361_2000001011 | Human | Colorectum | AD | 7.92e-04 | -5.89e-01 | -0.1207 |
9882 | TBC1D4 | HTA11_696_2000001011 | Human | Colorectum | AD | 2.43e-07 | -3.90e-01 | -0.1464 |
9882 | TBC1D4 | HTA11_866_2000001011 | Human | Colorectum | AD | 1.23e-06 | -4.09e-01 | -0.1001 |
9882 | TBC1D4 | HTA11_8622_2000001021 | Human | Colorectum | SER | 6.42e-03 | -6.51e-01 | 0.0528 |
9882 | TBC1D4 | HTA11_10711_2000001011 | Human | Colorectum | AD | 3.54e-04 | -5.23e-01 | 0.0338 |
9882 | TBC1D4 | HTA11_7696_3000711011 | Human | Colorectum | AD | 1.27e-02 | -3.37e-01 | 0.0674 |
9882 | TBC1D4 | HTA11_6818_2000001021 | Human | Colorectum | AD | 4.06e-03 | -5.69e-01 | 0.0588 |
9882 | TBC1D4 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 1.62e-03 | -2.26e-01 | 0.294 |
9882 | TBC1D4 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 3.11e-08 | 6.90e-01 | 0.281 |
9882 | TBC1D4 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 1.59e-13 | -4.84e-01 | 0.3005 |
9882 | TBC1D4 | A002-C-010 | Human | Colorectum | FAP | 2.42e-05 | -1.91e-01 | 0.242 |
9882 | TBC1D4 | A001-C-207 | Human | Colorectum | FAP | 9.09e-03 | -2.85e-01 | 0.1278 |
9882 | TBC1D4 | A015-C-203 | Human | Colorectum | FAP | 2.03e-24 | -3.07e-01 | -0.1294 |
9882 | TBC1D4 | A015-C-204 | Human | Colorectum | FAP | 9.43e-05 | -3.17e-01 | -0.0228 |
9882 | TBC1D4 | A014-C-040 | Human | Colorectum | FAP | 4.83e-03 | -4.04e-01 | -0.1184 |
9882 | TBC1D4 | A002-C-201 | Human | Colorectum | FAP | 3.17e-14 | -4.93e-01 | 0.0324 |
9882 | TBC1D4 | A002-C-203 | Human | Colorectum | FAP | 6.73e-07 | -2.94e-01 | 0.2786 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0010639 | Colorectum | AD | negative regulation of organelle organization | 114/3918 | 348/18723 | 1.41e-07 | 6.49e-06 | 114 |
GO:0016050 | Colorectum | AD | vesicle organization | 101/3918 | 300/18723 | 1.65e-07 | 7.17e-06 | 101 |
GO:0032868 | Colorectum | AD | response to insulin | 91/3918 | 264/18723 | 2.02e-07 | 8.48e-06 | 91 |
GO:1901653 | Colorectum | AD | cellular response to peptide | 114/3918 | 359/18723 | 8.32e-07 | 2.88e-05 | 114 |
GO:0032869 | Colorectum | AD | cellular response to insulin stimulus | 72/3918 | 203/18723 | 1.10e-06 | 3.68e-05 | 72 |
GO:0071375 | Colorectum | AD | cellular response to peptide hormone stimulus | 95/3918 | 290/18723 | 1.50e-06 | 4.66e-05 | 95 |
GO:0043087 | Colorectum | AD | regulation of GTPase activity | 110/3918 | 348/18723 | 1.64e-06 | 5.03e-05 | 110 |
GO:0043434 | Colorectum | AD | response to peptide hormone | 126/3918 | 414/18723 | 2.70e-06 | 7.86e-05 | 126 |
GO:0043547 | Colorectum | AD | positive regulation of GTPase activity | 75/3918 | 255/18723 | 7.95e-04 | 7.91e-03 | 75 |
GO:0048284 | Colorectum | AD | organelle fusion | 42/3918 | 141/18723 | 8.04e-03 | 4.73e-02 | 42 |
GO:00106391 | Colorectum | SER | negative regulation of organelle organization | 90/2897 | 348/18723 | 3.14e-07 | 1.69e-05 | 90 |
GO:00328681 | Colorectum | SER | response to insulin | 65/2897 | 264/18723 | 6.70e-05 | 1.53e-03 | 65 |
GO:19016531 | Colorectum | SER | cellular response to peptide | 83/2897 | 359/18723 | 8.03e-05 | 1.77e-03 | 83 |
GO:00434341 | Colorectum | SER | response to peptide hormone | 93/2897 | 414/18723 | 9.61e-05 | 2.04e-03 | 93 |
GO:00713751 | Colorectum | SER | cellular response to peptide hormone stimulus | 68/2897 | 290/18723 | 2.20e-04 | 3.89e-03 | 68 |
GO:00328691 | Colorectum | SER | cellular response to insulin stimulus | 51/2897 | 203/18723 | 2.30e-04 | 3.96e-03 | 51 |
GO:00160501 | Colorectum | SER | vesicle organization | 69/2897 | 300/18723 | 3.59e-04 | 5.61e-03 | 69 |
GO:00430871 | Colorectum | SER | regulation of GTPase activity | 77/2897 | 348/18723 | 5.90e-04 | 8.07e-03 | 77 |
GO:0051051 | Colorectum | SER | negative regulation of transport | 98/2897 | 470/18723 | 1.01e-03 | 1.19e-02 | 98 |
GO:00160502 | Colorectum | MSS | vesicle organization | 93/3467 | 300/18723 | 1.04e-07 | 4.97e-06 | 93 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0491910 | Colorectum | CRC | Thyroid hormone signaling pathway | 35/1091 | 121/8465 | 2.05e-06 | 6.85e-05 | 4.64e-05 | 35 |
hsa049314 | Colorectum | CRC | Insulin resistance | 28/1091 | 108/8465 | 1.78e-04 | 2.37e-03 | 1.61e-03 | 28 |
hsa0491911 | Colorectum | CRC | Thyroid hormone signaling pathway | 35/1091 | 121/8465 | 2.05e-06 | 6.85e-05 | 4.64e-05 | 35 |
hsa049315 | Colorectum | CRC | Insulin resistance | 28/1091 | 108/8465 | 1.78e-04 | 2.37e-03 | 1.61e-03 | 28 |
hsa05415211 | Esophagus | ESCC | Diabetic cardiomyopathy | 146/4205 | 203/8465 | 5.81e-11 | 7.78e-10 | 3.99e-10 | 146 |
hsa0491928 | Esophagus | ESCC | Thyroid hormone signaling pathway | 78/4205 | 121/8465 | 6.79e-04 | 2.23e-03 | 1.14e-03 | 78 |
hsa049318 | Esophagus | ESCC | Insulin resistance | 69/4205 | 108/8465 | 1.92e-03 | 5.54e-03 | 2.84e-03 | 69 |
hsa0541538 | Esophagus | ESCC | Diabetic cardiomyopathy | 146/4205 | 203/8465 | 5.81e-11 | 7.78e-10 | 3.99e-10 | 146 |
hsa04919113 | Esophagus | ESCC | Thyroid hormone signaling pathway | 78/4205 | 121/8465 | 6.79e-04 | 2.23e-03 | 1.14e-03 | 78 |
hsa0493113 | Esophagus | ESCC | Insulin resistance | 69/4205 | 108/8465 | 1.92e-03 | 5.54e-03 | 2.84e-03 | 69 |
hsa0541522 | Liver | HCC | Diabetic cardiomyopathy | 151/4020 | 203/8465 | 2.72e-15 | 1.01e-13 | 5.63e-14 | 151 |
hsa0493121 | Liver | HCC | Insulin resistance | 77/4020 | 108/8465 | 3.89e-07 | 4.46e-06 | 2.48e-06 | 77 |
hsa0491912 | Liver | HCC | Thyroid hormone signaling pathway | 75/4020 | 121/8465 | 8.76e-04 | 3.38e-03 | 1.88e-03 | 75 |
hsa0541532 | Liver | HCC | Diabetic cardiomyopathy | 151/4020 | 203/8465 | 2.72e-15 | 1.01e-13 | 5.63e-14 | 151 |
hsa0493131 | Liver | HCC | Insulin resistance | 77/4020 | 108/8465 | 3.89e-07 | 4.46e-06 | 2.48e-06 | 77 |
hsa0491913 | Liver | HCC | Thyroid hormone signaling pathway | 75/4020 | 121/8465 | 8.76e-04 | 3.38e-03 | 1.88e-03 | 75 |
hsa0491921 | Lung | AIS | Thyroid hormone signaling pathway | 27/961 | 121/8465 | 3.92e-04 | 3.85e-03 | 2.47e-03 | 27 |
hsa0491931 | Lung | AIS | Thyroid hormone signaling pathway | 27/961 | 121/8465 | 3.92e-04 | 3.85e-03 | 2.47e-03 | 27 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TBC1D4 | SNV | Missense_Mutation | c.782G>A | p.Gly261Glu | p.G261E | O60343 | protein_coding | tolerated(0.19) | benign(0.021) | TCGA-A2-A25B-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | PD | |
TBC1D4 | SNV | Missense_Mutation | c.1826C>T | p.Ser609Phe | p.S609F | O60343 | protein_coding | deleterious(0.01) | benign(0.02) | TCGA-AC-A23C-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | chemo | CR | |
TBC1D4 | SNV | Missense_Mutation | c.1153A>T | p.Ile385Phe | p.I385F | O60343 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AN-A0AK-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
TBC1D4 | SNV | Missense_Mutation | c.208N>A | p.Glu70Lys | p.E70K | O60343 | protein_coding | tolerated(0.68) | benign(0.078) | TCGA-AN-A0XO-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
TBC1D4 | SNV | Missense_Mutation | novel | c.1715N>G | p.Glu572Gly | p.E572G | O60343 | protein_coding | deleterious(0) | possibly_damaging(0.701) | TCGA-B6-A0IK-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
TBC1D4 | SNV | Missense_Mutation | c.2619N>C | p.Arg873Ser | p.R873S | O60343 | protein_coding | tolerated(0.07) | probably_damaging(0.954) | TCGA-B6-A1KN-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
TBC1D4 | SNV | Missense_Mutation | c.1370N>G | p.Pro457Arg | p.P457R | O60343 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-BH-A18G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
TBC1D4 | SNV | Missense_Mutation | c.3340G>A | p.Glu1114Lys | p.E1114K | O60343 | protein_coding | deleterious(0) | benign(0.297) | TCGA-BH-A18P-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |
TBC1D4 | SNV | Missense_Mutation | c.3589G>A | p.Glu1197Lys | p.E1197K | O60343 | protein_coding | deleterious(0.01) | possibly_damaging(0.725) | TCGA-C8-A12T-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
TBC1D4 | SNV | Missense_Mutation | rs370555579 | c.982G>A | p.Glu328Lys | p.E328K | O60343 | protein_coding | tolerated(0.13) | benign(0.419) | TCGA-C8-A130-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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