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Gene: RPS11 |
Gene summary for RPS11 |
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Gene information | Species | Human | Gene symbol | RPS11 | Gene ID | 6205 |
Gene name | ribosomal protein S11 | |
Gene Alias | S11 | |
Cytomap | 19q13.33 | |
Gene Type | protein-coding | GO ID | GO:0002181 | UniProtAcc | P62280 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
6205 | RPS11 | CA_HPV_1 | Human | Cervix | CC | 5.43e-11 | -3.05e-01 | 0.0264 |
6205 | RPS11 | HSIL_HPV_1 | Human | Cervix | HSIL_HPV | 3.91e-04 | 1.15e-01 | 0.0116 |
6205 | RPS11 | N_HPV_2 | Human | Cervix | N_HPV | 8.22e-22 | -2.38e-01 | -0.0131 |
6205 | RPS11 | CCI_1 | Human | Cervix | CC | 1.83e-54 | -1.81e+00 | 0.528 |
6205 | RPS11 | CCI_2 | Human | Cervix | CC | 4.65e-46 | -1.57e+00 | 0.5249 |
6205 | RPS11 | CCI_3 | Human | Cervix | CC | 1.73e-65 | -1.75e+00 | 0.516 |
6205 | RPS11 | CCII_1 | Human | Cervix | CC | 7.47e-86 | -1.75e+00 | 0.3249 |
6205 | RPS11 | Tumor | Human | Cervix | CC | 1.38e-09 | -1.77e-01 | 0.1241 |
6205 | RPS11 | sample1 | Human | Cervix | CC | 1.17e-21 | -5.02e-01 | 0.0959 |
6205 | RPS11 | sample3 | Human | Cervix | CC | 1.31e-30 | -2.48e-01 | 0.1387 |
6205 | RPS11 | H2 | Human | Cervix | HSIL_HPV | 9.94e-29 | -3.90e-01 | 0.0632 |
6205 | RPS11 | L1 | Human | Cervix | CC | 1.57e-04 | -2.85e-01 | 0.0802 |
6205 | RPS11 | T1 | Human | Cervix | CC | 1.11e-44 | -5.71e-01 | 0.0918 |
6205 | RPS11 | T3 | Human | Cervix | CC | 1.01e-32 | -2.71e-01 | 0.1389 |
6205 | RPS11 | HTA11_3410_2000001011 | Human | Colorectum | AD | 3.72e-96 | 1.88e+00 | 0.0155 |
6205 | RPS11 | HTA11_2487_2000001011 | Human | Colorectum | SER | 2.47e-64 | 2.69e+00 | -0.1808 |
6205 | RPS11 | HTA11_2951_2000001011 | Human | Colorectum | AD | 1.37e-33 | 2.77e+00 | 0.0216 |
6205 | RPS11 | HTA11_1938_2000001011 | Human | Colorectum | AD | 1.17e-62 | 2.69e+00 | -0.0811 |
6205 | RPS11 | HTA11_78_2000001011 | Human | Colorectum | AD | 4.82e-41 | 1.37e+00 | -0.1088 |
6205 | RPS11 | HTA11_347_2000001011 | Human | Colorectum | AD | 1.23e-97 | 2.72e+00 | -0.1954 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000218110 | Cervix | CC | cytoplasmic translation | 96/2311 | 148/18723 | 4.87e-51 | 2.91e-47 | 96 |
GO:000218115 | Cervix | HSIL_HPV | cytoplasmic translation | 86/737 | 148/18723 | 3.97e-82 | 1.91e-78 | 86 |
GO:000218125 | Cervix | N_HPV | cytoplasmic translation | 42/534 | 148/18723 | 2.61e-30 | 1.19e-26 | 42 |
GO:0002181 | Colorectum | AD | cytoplasmic translation | 109/3918 | 148/18723 | 3.40e-43 | 2.13e-39 | 109 |
GO:00021811 | Colorectum | SER | cytoplasmic translation | 102/2897 | 148/18723 | 1.38e-48 | 8.49e-45 | 102 |
GO:00021812 | Colorectum | MSS | cytoplasmic translation | 108/3467 | 148/18723 | 1.78e-47 | 1.11e-43 | 108 |
GO:00021813 | Colorectum | MSI-H | cytoplasmic translation | 100/1319 | 148/18723 | 1.50e-79 | 8.31e-76 | 100 |
GO:00021814 | Colorectum | FAP | cytoplasmic translation | 76/2622 | 148/18723 | 3.31e-27 | 2.03e-23 | 76 |
GO:00021815 | Colorectum | CRC | cytoplasmic translation | 70/2078 | 148/18723 | 1.53e-28 | 9.16e-25 | 70 |
GO:000218116 | Endometrium | AEH | cytoplasmic translation | 104/2100 | 148/18723 | 1.01e-64 | 6.07e-61 | 104 |
GO:000218117 | Endometrium | EEC | cytoplasmic translation | 104/2168 | 148/18723 | 2.53e-63 | 1.52e-59 | 104 |
GO:000218127 | Esophagus | HGIN | cytoplasmic translation | 108/2587 | 148/18723 | 1.70e-60 | 1.02e-56 | 108 |
GO:0022613111 | Esophagus | ESCC | ribonucleoprotein complex biogenesis | 365/8552 | 463/18723 | 1.74e-49 | 1.11e-45 | 365 |
GO:0042254111 | Esophagus | ESCC | ribosome biogenesis | 252/8552 | 299/18723 | 3.27e-44 | 1.04e-40 | 252 |
GO:003447015 | Esophagus | ESCC | ncRNA processing | 300/8552 | 395/18723 | 3.09e-35 | 3.26e-32 | 300 |
GO:0016072110 | Esophagus | ESCC | rRNA metabolic process | 197/8552 | 236/18723 | 1.31e-33 | 1.18e-30 | 197 |
GO:0006364110 | Esophagus | ESCC | rRNA processing | 189/8552 | 225/18723 | 4.88e-33 | 3.87e-30 | 189 |
GO:0002181111 | Esophagus | ESCC | cytoplasmic translation | 135/8552 | 148/18723 | 4.17e-32 | 2.65e-29 | 135 |
GO:003466012 | Esophagus | ESCC | ncRNA metabolic process | 346/8552 | 485/18723 | 4.35e-31 | 2.51e-28 | 346 |
GO:014005313 | Esophagus | ESCC | mitochondrial gene expression | 93/8552 | 108/18723 | 1.96e-18 | 2.03e-16 | 93 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa030104 | Colorectum | MSS | Ribosome | 96/1875 | 167/8465 | 1.82e-23 | 2.03e-21 | 1.24e-21 | 96 |
hsa051714 | Colorectum | MSS | Coronavirus disease - COVID-19 | 108/1875 | 232/8465 | 6.50e-17 | 1.67e-15 | 1.03e-15 | 108 |
hsa030105 | Colorectum | MSS | Ribosome | 96/1875 | 167/8465 | 1.82e-23 | 2.03e-21 | 1.24e-21 | 96 |
hsa051715 | Colorectum | MSS | Coronavirus disease - COVID-19 | 108/1875 | 232/8465 | 6.50e-17 | 1.67e-15 | 1.03e-15 | 108 |
hsa030106 | Colorectum | MSI-H | Ribosome | 87/797 | 167/8465 | 5.55e-46 | 1.80e-43 | 1.51e-43 | 87 |
hsa051716 | Colorectum | MSI-H | Coronavirus disease - COVID-19 | 91/797 | 232/8465 | 2.21e-35 | 3.58e-33 | 3.00e-33 | 91 |
hsa030107 | Colorectum | MSI-H | Ribosome | 87/797 | 167/8465 | 5.55e-46 | 1.80e-43 | 1.51e-43 | 87 |
hsa051717 | Colorectum | MSI-H | Coronavirus disease - COVID-19 | 91/797 | 232/8465 | 2.21e-35 | 3.58e-33 | 3.00e-33 | 91 |
hsa051718 | Colorectum | FAP | Coronavirus disease - COVID-19 | 78/1404 | 232/8465 | 9.94e-11 | 1.11e-08 | 6.73e-09 | 78 |
hsa030108 | Colorectum | FAP | Ribosome | 59/1404 | 167/8465 | 2.38e-09 | 1.32e-07 | 8.05e-08 | 59 |
hsa051719 | Colorectum | FAP | Coronavirus disease - COVID-19 | 78/1404 | 232/8465 | 9.94e-11 | 1.11e-08 | 6.73e-09 | 78 |
hsa030109 | Colorectum | FAP | Ribosome | 59/1404 | 167/8465 | 2.38e-09 | 1.32e-07 | 8.05e-08 | 59 |
hsa0301010 | Colorectum | CRC | Ribosome | 60/1091 | 167/8465 | 1.43e-14 | 2.78e-12 | 1.88e-12 | 60 |
hsa0517110 | Colorectum | CRC | Coronavirus disease - COVID-19 | 74/1091 | 232/8465 | 1.66e-14 | 2.78e-12 | 1.88e-12 | 74 |
hsa0301011 | Colorectum | CRC | Ribosome | 60/1091 | 167/8465 | 1.43e-14 | 2.78e-12 | 1.88e-12 | 60 |
hsa0517111 | Colorectum | CRC | Coronavirus disease - COVID-19 | 74/1091 | 232/8465 | 1.66e-14 | 2.78e-12 | 1.88e-12 | 74 |
hsa0301026 | Endometrium | AEH | Ribosome | 89/1197 | 167/8465 | 1.88e-33 | 6.09e-31 | 4.46e-31 | 89 |
hsa0517126 | Endometrium | AEH | Coronavirus disease - COVID-19 | 99/1197 | 232/8465 | 5.19e-27 | 3.37e-25 | 2.47e-25 | 99 |
hsa03010112 | Endometrium | AEH | Ribosome | 89/1197 | 167/8465 | 1.88e-33 | 6.09e-31 | 4.46e-31 | 89 |
hsa05171112 | Endometrium | AEH | Coronavirus disease - COVID-19 | 99/1197 | 232/8465 | 5.19e-27 | 3.37e-25 | 2.47e-25 | 99 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
RPS11 | SNV | Missense_Mutation | rs11549537 | c.415N>T | p.Arg139Cys | p.R139C | P62280 | protein_coding | tolerated(0.09) | benign(0.029) | TCGA-AD-A5EJ-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
RPS11 | SNV | Missense_Mutation | c.107N>G | p.Tyr36Cys | p.Y36C | P62280 | protein_coding | deleterious(0) | possibly_damaging(0.765) | TCGA-AZ-4308-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Targeted Molecular therapy | avastin | CR | |
RPS11 | deletion | Frame_Shift_Del | c.158_161delNNNN | p.Gly53AlafsTer24 | p.G53Afs*24 | P62280 | protein_coding | TCGA-AA-A01K-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | folinic | CR | |||
RPS11 | SNV | Missense_Mutation | rs746359465 | c.290G>A | p.Arg97His | p.R97H | P62280 | protein_coding | tolerated(0.15) | possibly_damaging(0.903) | TCGA-AX-A1C5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unspecific | Carboplatin | SD |
RPS11 | SNV | Missense_Mutation | c.448G>A | p.Gly150Ser | p.G150S | P62280 | protein_coding | tolerated(0.23) | benign(0.056) | TCGA-B5-A11E-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
RPS11 | SNV | Missense_Mutation | novel | c.153N>G | p.Ile51Met | p.I51M | P62280 | protein_coding | deleterious(0.01) | benign(0.015) | TCGA-B5-A1MR-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
RPS11 | SNV | Missense_Mutation | rs746359465 | c.290N>A | p.Arg97His | p.R97H | P62280 | protein_coding | tolerated(0.15) | possibly_damaging(0.903) | TCGA-FI-A2D0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
RPS11 | SNV | Missense_Mutation | novel | c.409N>G | p.Thr137Ala | p.T137A | P62280 | protein_coding | deleterious(0) | possibly_damaging(0.682) | TCGA-05-4427-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Chemotherapy | cisplatin | CR |
RPS11 | SNV | Missense_Mutation | novel | c.208G>A | p.Gly70Arg | p.G70R | P62280 | protein_coding | deleterious(0.02) | probably_damaging(0.992) | TCGA-NC-A5HT-01 | Lung | lung squamous cell carcinoma | Male | >=65 | III/IV | Chemotherapy | carboplatin | PR |
RPS11 | SNV | Missense_Mutation | c.95N>C | p.Lys32Thr | p.K32T | P62280 | protein_coding | deleterious(0.02) | benign(0.056) | TCGA-QU-A6IM-01 | Prostate | prostate adenocarcinoma | Male | <65 | 7 | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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