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Gene: RHOG |
Gene summary for RHOG |
Gene summary. |
Gene information | Species | Human | Gene symbol | RHOG | Gene ID | 391 |
Gene name | ras homolog family member G | |
Gene Alias | ARHG | |
Cytomap | 11p15.4 | |
Gene Type | protein-coding | GO ID | GO:0000902 | UniProtAcc | P84095 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
391 | RHOG | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.82e-04 | 1.44e-01 | 0.0155 |
391 | RHOG | HTA11_2487_2000001011 | Human | Colorectum | SER | 5.96e-16 | 6.85e-01 | -0.1808 |
391 | RHOG | HTA11_1938_2000001011 | Human | Colorectum | AD | 3.35e-06 | 3.22e-01 | -0.0811 |
391 | RHOG | HTA11_78_2000001011 | Human | Colorectum | AD | 3.42e-04 | 1.85e-01 | -0.1088 |
391 | RHOG | HTA11_347_2000001011 | Human | Colorectum | AD | 1.25e-12 | 3.31e-01 | -0.1954 |
391 | RHOG | HTA11_411_2000001011 | Human | Colorectum | SER | 2.13e-03 | 1.15e+00 | -0.2602 |
391 | RHOG | HTA11_2112_2000001011 | Human | Colorectum | SER | 4.23e-05 | 4.57e-01 | -0.2196 |
391 | RHOG | HTA11_3361_2000001011 | Human | Colorectum | AD | 8.24e-06 | 3.30e-01 | -0.1207 |
391 | RHOG | HTA11_83_2000001011 | Human | Colorectum | SER | 2.15e-02 | 2.21e-01 | -0.1526 |
391 | RHOG | HTA11_696_2000001011 | Human | Colorectum | AD | 5.80e-10 | 3.22e-01 | -0.1464 |
391 | RHOG | HTA11_866_2000001011 | Human | Colorectum | AD | 4.96e-02 | 2.14e-01 | -0.1001 |
391 | RHOG | HTA11_1391_2000001011 | Human | Colorectum | AD | 1.41e-18 | 5.71e-01 | -0.059 |
391 | RHOG | HTA11_5212_2000001011 | Human | Colorectum | AD | 5.25e-13 | 7.28e-01 | -0.2061 |
391 | RHOG | HTA11_546_2000001011 | Human | Colorectum | AD | 6.68e-03 | 2.83e-01 | -0.0842 |
391 | RHOG | HTA11_866_3004761011 | Human | Colorectum | AD | 7.72e-05 | 2.17e-01 | 0.096 |
391 | RHOG | HTA11_8622_2000001021 | Human | Colorectum | SER | 2.22e-03 | 3.16e-01 | 0.0528 |
391 | RHOG | HTA11_6801_2000001011 | Human | Colorectum | SER | 5.92e-03 | 4.20e-01 | 0.0171 |
391 | RHOG | HTA11_10711_2000001011 | Human | Colorectum | AD | 1.02e-02 | 2.08e-01 | 0.0338 |
391 | RHOG | HTA11_7696_3000711011 | Human | Colorectum | AD | 4.80e-08 | 3.37e-01 | 0.0674 |
391 | RHOG | HTA11_6818_2000001011 | Human | Colorectum | AD | 3.50e-02 | 2.42e-01 | 0.0112 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0072659 | Colorectum | AD | protein localization to plasma membrane | 122/3918 | 284/18723 | 2.86e-17 | 1.49e-14 | 122 |
GO:0007015 | Colorectum | AD | actin filament organization | 167/3918 | 442/18723 | 1.65e-16 | 7.94e-14 | 167 |
GO:1990778 | Colorectum | AD | protein localization to cell periphery | 129/3918 | 333/18723 | 5.51e-14 | 1.15e-11 | 129 |
GO:1903829 | Colorectum | AD | positive regulation of cellular protein localization | 110/3918 | 276/18723 | 4.58e-13 | 8.44e-11 | 110 |
GO:0032970 | Colorectum | AD | regulation of actin filament-based process | 142/3918 | 397/18723 | 4.05e-12 | 5.90e-10 | 142 |
GO:0032956 | Colorectum | AD | regulation of actin cytoskeleton organization | 127/3918 | 358/18723 | 1.03e-10 | 1.04e-08 | 127 |
GO:1905475 | Colorectum | AD | regulation of protein localization to membrane | 73/3918 | 175/18723 | 3.37e-10 | 2.93e-08 | 73 |
GO:0022604 | Colorectum | AD | regulation of cell morphogenesis | 109/3918 | 309/18723 | 3.08e-09 | 2.07e-07 | 109 |
GO:1903076 | Colorectum | AD | regulation of protein localization to plasma membrane | 48/3918 | 104/18723 | 7.17e-09 | 4.36e-07 | 48 |
GO:1904375 | Colorectum | AD | regulation of protein localization to cell periphery | 54/3918 | 125/18723 | 1.52e-08 | 9.00e-07 | 54 |
GO:1905477 | Colorectum | AD | positive regulation of protein localization to membrane | 46/3918 | 106/18723 | 1.47e-07 | 6.64e-06 | 46 |
GO:0007163 | Colorectum | AD | establishment or maintenance of cell polarity | 77/3918 | 218/18723 | 5.72e-07 | 2.08e-05 | 77 |
GO:0043087 | Colorectum | AD | regulation of GTPase activity | 110/3918 | 348/18723 | 1.64e-06 | 5.03e-05 | 110 |
GO:0008360 | Colorectum | AD | regulation of cell shape | 56/3918 | 154/18723 | 7.01e-06 | 1.73e-04 | 56 |
GO:0007265 | Colorectum | AD | Ras protein signal transduction | 104/3918 | 337/18723 | 1.01e-05 | 2.35e-04 | 104 |
GO:1903078 | Colorectum | AD | positive regulation of protein localization to plasma membrane | 28/3918 | 62/18723 | 1.57e-05 | 3.34e-04 | 28 |
GO:1904377 | Colorectum | AD | positive regulation of protein localization to cell periphery | 30/3918 | 69/18723 | 1.98e-05 | 4.05e-04 | 30 |
GO:0007409 | Colorectum | AD | axonogenesis | 122/3918 | 418/18723 | 3.36e-05 | 6.15e-04 | 122 |
GO:0061564 | Colorectum | AD | axon development | 132/3918 | 467/18723 | 8.40e-05 | 1.31e-03 | 132 |
GO:0016601 | Colorectum | AD | Rac protein signal transduction | 20/3918 | 42/18723 | 1.02e-04 | 1.53e-03 | 20 |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa05100114 | Esophagus | HGIN | Bacterial invasion of epithelial cells | 30/1383 | 77/8465 | 1.49e-06 | 2.31e-05 | 1.84e-05 | 30 |
hsa05132115 | Esophagus | HGIN | Salmonella infection | 69/1383 | 249/8465 | 3.02e-06 | 4.47e-05 | 3.55e-05 | 69 |
hsa05132211 | Esophagus | ESCC | Salmonella infection | 191/4205 | 249/8465 | 6.51e-19 | 5.45e-17 | 2.79e-17 | 191 |
hsa0513526 | Esophagus | ESCC | Yersinia infection | 100/4205 | 137/8465 | 1.80e-08 | 1.59e-07 | 8.12e-08 | 100 |
hsa05100211 | Esophagus | ESCC | Bacterial invasion of epithelial cells | 59/4205 | 77/8465 | 1.05e-06 | 6.76e-06 | 3.46e-06 | 59 |
hsa05132310 | Esophagus | ESCC | Salmonella infection | 191/4205 | 249/8465 | 6.51e-19 | 5.45e-17 | 2.79e-17 | 191 |
hsa05135111 | Esophagus | ESCC | Yersinia infection | 100/4205 | 137/8465 | 1.80e-08 | 1.59e-07 | 8.12e-08 | 100 |
hsa05100310 | Esophagus | ESCC | Bacterial invasion of epithelial cells | 59/4205 | 77/8465 | 1.05e-06 | 6.76e-06 | 3.46e-06 | 59 |
hsa0513222 | Liver | Cirrhotic | Salmonella infection | 121/2530 | 249/8465 | 2.47e-10 | 5.13e-09 | 3.16e-09 | 121 |
hsa0510014 | Liver | Cirrhotic | Bacterial invasion of epithelial cells | 40/2530 | 77/8465 | 3.92e-05 | 2.84e-04 | 1.75e-04 | 40 |
hsa0513522 | Liver | Cirrhotic | Yersinia infection | 57/2530 | 137/8465 | 2.16e-03 | 9.41e-03 | 5.80e-03 | 57 |
hsa0513232 | Liver | Cirrhotic | Salmonella infection | 121/2530 | 249/8465 | 2.47e-10 | 5.13e-09 | 3.16e-09 | 121 |
hsa0510015 | Liver | Cirrhotic | Bacterial invasion of epithelial cells | 40/2530 | 77/8465 | 3.92e-05 | 2.84e-04 | 1.75e-04 | 40 |
hsa0513532 | Liver | Cirrhotic | Yersinia infection | 57/2530 | 137/8465 | 2.16e-03 | 9.41e-03 | 5.80e-03 | 57 |
hsa0513242 | Liver | HCC | Salmonella infection | 178/4020 | 249/8465 | 5.90e-15 | 1.98e-13 | 1.10e-13 | 178 |
hsa0513542 | Liver | HCC | Yersinia infection | 92/4020 | 137/8465 | 2.25e-06 | 2.19e-05 | 1.22e-05 | 92 |
hsa0510022 | Liver | HCC | Bacterial invasion of epithelial cells | 51/4020 | 77/8465 | 6.67e-04 | 2.72e-03 | 1.52e-03 | 51 |
hsa0513252 | Liver | HCC | Salmonella infection | 178/4020 | 249/8465 | 5.90e-15 | 1.98e-13 | 1.10e-13 | 178 |
hsa0513552 | Liver | HCC | Yersinia infection | 92/4020 | 137/8465 | 2.25e-06 | 2.19e-05 | 1.22e-05 | 92 |
hsa0510032 | Liver | HCC | Bacterial invasion of epithelial cells | 51/4020 | 77/8465 | 6.67e-04 | 2.72e-03 | 1.52e-03 | 51 |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
RHOG | SNV | Missense_Mutation | novel | c.546N>G | p.Ile182Met | p.I182M | P84095 | protein_coding | tolerated(0.12) | benign(0.019) | TCGA-JW-A5VL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
RHOG | SNV | Missense_Mutation | c.197G>A | p.Arg66His | p.R66H | P84095 | protein_coding | deleterious(0.01) | possibly_damaging(0.573) | TCGA-A6-2686-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
RHOG | SNV | Missense_Mutation | novel | c.236T>C | p.Val79Ala | p.V79A | P84095 | protein_coding | deleterious(0) | benign(0.186) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
RHOG | SNV | Missense_Mutation | novel | c.359G>A | p.Arg120Lys | p.R120K | P84095 | protein_coding | deleterious(0.01) | probably_damaging(0.96) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
RHOG | SNV | Missense_Mutation | novel | c.55N>A | p.Leu19Met | p.L19M | P84095 | protein_coding | tolerated(0.18) | probably_damaging(0.949) | TCGA-A5-A0GI-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
RHOG | SNV | Missense_Mutation | rs762134439 | c.79N>A | p.Ala27Thr | p.A27T | P84095 | protein_coding | tolerated(0.07) | benign(0.226) | TCGA-A5-A0GP-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
RHOG | SNV | Missense_Mutation | rs762134439 | c.79G>A | p.Ala27Thr | p.A27T | P84095 | protein_coding | tolerated(0.07) | benign(0.226) | TCGA-AJ-A3EL-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
RHOG | SNV | Missense_Mutation | rs762777142 | c.383G>A | p.Arg128His | p.R128H | P84095 | protein_coding | deleterious(0.02) | benign(0.038) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
RHOG | SNV | Missense_Mutation | rs747848607 | c.235N>A | p.Val79Ile | p.V79I | P84095 | protein_coding | tolerated(0.23) | benign(0.007) | TCGA-AX-A2HD-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
RHOG | SNV | Missense_Mutation | novel | c.498N>T | p.Lys166Asn | p.K166N | P84095 | protein_coding | deleterious(0.02) | possibly_damaging(0.613) | TCGA-AX-A2HG-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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