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Gene: PPP2R5B |
Gene summary for PPP2R5B |
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Gene information | Species | Human | Gene symbol | PPP2R5B | Gene ID | 5526 |
Gene name | protein phosphatase 2 regulatory subunit B'beta | |
Gene Alias | B56B | |
Cytomap | 11q13.1 | |
Gene Type | protein-coding | GO ID | GO:0001932 | UniProtAcc | A0A024R593 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
5526 | PPP2R5B | LZE24T | Human | Esophagus | ESCC | 9.26e-07 | 2.42e-01 | 0.0596 |
5526 | PPP2R5B | P1T-E | Human | Esophagus | ESCC | 3.57e-02 | 2.05e-01 | 0.0875 |
5526 | PPP2R5B | P2T-E | Human | Esophagus | ESCC | 3.60e-04 | 7.85e-02 | 0.1177 |
5526 | PPP2R5B | P4T-E | Human | Esophagus | ESCC | 4.35e-13 | 2.80e-01 | 0.1323 |
5526 | PPP2R5B | P5T-E | Human | Esophagus | ESCC | 7.14e-11 | 1.19e-01 | 0.1327 |
5526 | PPP2R5B | P8T-E | Human | Esophagus | ESCC | 1.47e-13 | 1.57e-01 | 0.0889 |
5526 | PPP2R5B | P9T-E | Human | Esophagus | ESCC | 2.71e-03 | 1.32e-01 | 0.1131 |
5526 | PPP2R5B | P10T-E | Human | Esophagus | ESCC | 1.01e-04 | 1.39e-01 | 0.116 |
5526 | PPP2R5B | P11T-E | Human | Esophagus | ESCC | 1.62e-10 | 3.98e-01 | 0.1426 |
5526 | PPP2R5B | P12T-E | Human | Esophagus | ESCC | 1.88e-11 | 1.95e-01 | 0.1122 |
5526 | PPP2R5B | P16T-E | Human | Esophagus | ESCC | 4.48e-09 | 1.49e-01 | 0.1153 |
5526 | PPP2R5B | P17T-E | Human | Esophagus | ESCC | 1.43e-04 | 2.36e-01 | 0.1278 |
5526 | PPP2R5B | P19T-E | Human | Esophagus | ESCC | 2.86e-07 | 5.28e-01 | 0.1662 |
5526 | PPP2R5B | P20T-E | Human | Esophagus | ESCC | 5.13e-07 | 1.97e-01 | 0.1124 |
5526 | PPP2R5B | P21T-E | Human | Esophagus | ESCC | 1.65e-21 | 4.50e-01 | 0.1617 |
5526 | PPP2R5B | P22T-E | Human | Esophagus | ESCC | 5.54e-06 | 4.56e-02 | 0.1236 |
5526 | PPP2R5B | P23T-E | Human | Esophagus | ESCC | 2.22e-06 | 2.11e-01 | 0.108 |
5526 | PPP2R5B | P24T-E | Human | Esophagus | ESCC | 2.58e-07 | 1.29e-01 | 0.1287 |
5526 | PPP2R5B | P26T-E | Human | Esophagus | ESCC | 6.62e-15 | 2.46e-01 | 0.1276 |
5526 | PPP2R5B | P27T-E | Human | Esophagus | ESCC | 7.38e-12 | 1.97e-01 | 0.1055 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0043254111 | Esophagus | ESCC | regulation of protein-containing complex assembly | 278/8552 | 428/18723 | 3.81e-16 | 2.77e-14 | 278 |
GO:0031334111 | Esophagus | ESCC | positive regulation of protein-containing complex assembly | 166/8552 | 237/18723 | 2.06e-14 | 1.07e-12 | 166 |
GO:00457865 | Esophagus | ESCC | negative regulation of cell cycle | 236/8552 | 385/18723 | 3.62e-10 | 9.93e-09 | 236 |
GO:001631110 | Esophagus | ESCC | dephosphorylation | 251/8552 | 417/18723 | 1.26e-09 | 2.99e-08 | 251 |
GO:000647018 | Esophagus | ESCC | protein dephosphorylation | 177/8552 | 281/18723 | 3.13e-09 | 6.72e-08 | 177 |
GO:00109484 | Esophagus | ESCC | negative regulation of cell cycle process | 177/8552 | 294/18723 | 3.26e-07 | 4.59e-06 | 177 |
GO:00510908 | Esophagus | ESCC | regulation of DNA-binding transcription factor activity | 252/8552 | 440/18723 | 5.22e-07 | 6.97e-06 | 252 |
GO:004677710 | Esophagus | ESCC | protein autophosphorylation | 138/8552 | 227/18723 | 2.98e-06 | 3.38e-05 | 138 |
GO:00510918 | Esophagus | ESCC | positive regulation of DNA-binding transcription factor activity | 155/8552 | 260/18723 | 3.83e-06 | 4.14e-05 | 155 |
GO:003134616 | Esophagus | ESCC | positive regulation of cell projection organization | 201/8552 | 353/18723 | 1.19e-05 | 1.11e-04 | 201 |
GO:001097516 | Esophagus | ESCC | regulation of neuron projection development | 240/8552 | 445/18723 | 2.48e-04 | 1.53e-03 | 240 |
GO:00182124 | Esophagus | ESCC | peptidyl-tyrosine modification | 202/8552 | 378/18723 | 1.34e-03 | 6.39e-03 | 202 |
GO:00181084 | Esophagus | ESCC | peptidyl-tyrosine phosphorylation | 200/8552 | 375/18723 | 1.60e-03 | 7.45e-03 | 200 |
GO:00507303 | Esophagus | ESCC | regulation of peptidyl-tyrosine phosphorylation | 144/8552 | 264/18723 | 2.22e-03 | 9.78e-03 | 144 |
GO:00319521 | Esophagus | ESCC | regulation of protein autophosphorylation | 29/8552 | 43/18723 | 3.25e-03 | 1.35e-02 | 29 |
GO:00109764 | Esophagus | ESCC | positive regulation of neuron projection development | 91/8552 | 163/18723 | 5.72e-03 | 2.13e-02 | 91 |
GO:0048011 | Esophagus | ESCC | neurotrophin TRK receptor signaling pathway | 17/8552 | 24/18723 | 1.13e-02 | 3.81e-02 | 17 |
GO:004325420 | Oral cavity | OSCC | regulation of protein-containing complex assembly | 255/7305 | 428/18723 | 2.94e-18 | 3.15e-16 | 255 |
GO:003133420 | Oral cavity | OSCC | positive regulation of protein-containing complex assembly | 153/7305 | 237/18723 | 1.18e-15 | 8.33e-14 | 153 |
GO:000647015 | Oral cavity | OSCC | protein dephosphorylation | 162/7305 | 281/18723 | 1.56e-10 | 4.56e-09 | 162 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa04114 | Oral cavity | OSCC | Oocyte meiosis | 74/3704 | 131/8465 | 2.13e-03 | 5.75e-03 | 2.92e-03 | 74 |
hsa0411015 | Oral cavity | OSCC | Cell cycle | 118/3704 | 157/8465 | 7.15e-16 | 2.66e-14 | 1.35e-14 | 118 |
hsa0301513 | Oral cavity | OSCC | mRNA surveillance pathway | 75/3704 | 97/8465 | 1.30e-11 | 2.01e-10 | 1.02e-10 | 75 |
hsa0516514 | Oral cavity | OSCC | Human papillomavirus infection | 200/3704 | 331/8465 | 3.83e-10 | 4.93e-09 | 2.51e-09 | 200 |
hsa0407115 | Oral cavity | OSCC | Sphingolipid signaling pathway | 82/3704 | 121/8465 | 6.97e-08 | 5.08e-07 | 2.58e-07 | 82 |
hsa0415113 | Oral cavity | OSCC | PI3K-Akt signaling pathway | 185/3704 | 354/8465 | 6.26e-04 | 1.86e-03 | 9.49e-04 | 185 |
hsa0415212 | Oral cavity | OSCC | AMPK signaling pathway | 71/3704 | 121/8465 | 6.29e-04 | 1.86e-03 | 9.49e-04 | 71 |
hsa041141 | Oral cavity | OSCC | Oocyte meiosis | 74/3704 | 131/8465 | 2.13e-03 | 5.75e-03 | 2.92e-03 | 74 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PPP2R5B | SNV | Missense_Mutation | c.457N>C | p.Glu153Gln | p.E153Q | Q15173 | protein_coding | deleterious(0) | probably_damaging(0.986) | TCGA-A8-A09X-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
PPP2R5B | SNV | Missense_Mutation | c.652C>A | p.His218Asn | p.H218N | Q15173 | protein_coding | deleterious(0) | possibly_damaging(0.869) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
PPP2R5B | SNV | Missense_Mutation | rs557535443 | c.628N>T | p.Arg210Cys | p.R210C | Q15173 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AO-A128-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD |
PPP2R5B | SNV | Missense_Mutation | c.1007N>C | p.Leu336Pro | p.L336P | Q15173 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-BH-A18V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
PPP2R5B | SNV | Missense_Mutation | novel | c.979N>G | p.Thr327Ala | p.T327A | Q15173 | protein_coding | deleterious(0.01) | possibly_damaging(0.817) | TCGA-E2-A15A-06 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cyclophosphamide | SD |
PPP2R5B | deletion | Frame_Shift_Del | novel | c.552delC | p.Val185TrpfsTer12 | p.V185Wfs*12 | Q15173 | protein_coding | TCGA-EW-A2FV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | docetaxel | SD | ||
PPP2R5B | SNV | Missense_Mutation | novel | c.538N>C | p.Asp180His | p.D180H | Q15173 | protein_coding | deleterious(0) | probably_damaging(0.988) | TCGA-C5-A1MP-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
PPP2R5B | SNV | Missense_Mutation | novel | c.59N>G | p.Ser20Trp | p.S20W | Q15173 | protein_coding | deleterious_low_confidence(0) | benign(0) | TCGA-C5-A8XH-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
PPP2R5B | SNV | Missense_Mutation | novel | c.334N>C | p.Glu112Gln | p.E112Q | Q15173 | protein_coding | deleterious(0) | possibly_damaging(0.731) | TCGA-HM-A4S6-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Chemotherapy | cisplatin | CR |
PPP2R5B | SNV | Missense_Mutation | novel | c.1014G>C | p.Glu338Asp | p.E338D | Q15173 | protein_coding | deleterious(0) | probably_damaging(0.987) | TCGA-VS-AA62-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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