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Gene: POLR2J3 |
Gene summary for POLR2J3 |
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Gene information | Species | Human | Gene symbol | POLR2J3 | Gene ID | 548644 |
Gene name | RNA polymerase II subunit J3 | |
Gene Alias | POLR2J2 | |
Cytomap | 7q22.1 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | A0A0B4J2F8 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
548644 | POLR2J3 | Tumor | Human | Cervix | CC | 2.83e-26 | 4.42e-01 | 0.1241 |
548644 | POLR2J3 | sample1 | Human | Cervix | CC | 5.12e-11 | 4.82e-01 | 0.0959 |
548644 | POLR2J3 | sample3 | Human | Cervix | CC | 6.57e-44 | 6.23e-01 | 0.1387 |
548644 | POLR2J3 | H2 | Human | Cervix | HSIL_HPV | 3.77e-22 | 4.36e-01 | 0.0632 |
548644 | POLR2J3 | L1 | Human | Cervix | CC | 1.91e-07 | 4.21e-01 | 0.0802 |
548644 | POLR2J3 | T1 | Human | Cervix | CC | 1.48e-28 | 6.31e-01 | 0.0918 |
548644 | POLR2J3 | T2 | Human | Cervix | CC | 1.12e-06 | 3.85e-01 | 0.0709 |
548644 | POLR2J3 | T3 | Human | Cervix | CC | 1.29e-41 | 6.06e-01 | 0.1389 |
548644 | POLR2J3 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 3.49e-32 | 5.42e-01 | 0.294 |
548644 | POLR2J3 | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 1.23e-14 | 1.20e+00 | 0.3487 |
548644 | POLR2J3 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 5.00e-45 | 1.17e+00 | 0.281 |
548644 | POLR2J3 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 6.56e-26 | 5.32e-01 | 0.3859 |
548644 | POLR2J3 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 5.11e-23 | 7.50e-01 | 0.2585 |
548644 | POLR2J3 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 8.56e-30 | 5.45e-01 | 0.3005 |
548644 | POLR2J3 | AEH-subject2 | Human | Endometrium | AEH | 1.57e-07 | -3.40e-01 | -0.2525 |
548644 | POLR2J3 | AEH-subject3 | Human | Endometrium | AEH | 6.11e-11 | -3.72e-01 | -0.2576 |
548644 | POLR2J3 | AEH-subject5 | Human | Endometrium | AEH | 3.92e-16 | -4.83e-01 | -0.2953 |
548644 | POLR2J3 | EEC-subject1 | Human | Endometrium | EEC | 2.48e-13 | -3.88e-01 | -0.2682 |
548644 | POLR2J3 | EEC-subject2 | Human | Endometrium | EEC | 2.88e-11 | -3.97e-01 | -0.2607 |
548644 | POLR2J3 | EEC-subject3 | Human | Endometrium | EEC | 4.74e-18 | -4.93e-01 | -0.2525 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0302021 | Esophagus | ESCC | RNA polymerase | 28/4205 | 34/8465 | 8.19e-05 | 3.35e-04 | 1.71e-04 | 28 |
hsa0501638 | Esophagus | ESCC | Huntington disease | 226/4205 | 306/8465 | 1.38e-18 | 8.72e-17 | 4.46e-17 | 226 |
hsa0342032 | Esophagus | ESCC | Nucleotide excision repair | 54/4205 | 63/8465 | 2.01e-09 | 2.17e-08 | 1.11e-08 | 54 |
hsa0302031 | Esophagus | ESCC | RNA polymerase | 28/4205 | 34/8465 | 8.19e-05 | 3.35e-04 | 1.71e-04 | 28 |
hsa0501614 | Liver | Cirrhotic | Huntington disease | 172/2530 | 306/8465 | 1.65e-22 | 1.10e-20 | 6.77e-21 | 172 |
hsa03420 | Liver | Cirrhotic | Nucleotide excision repair | 29/2530 | 63/8465 | 4.81e-03 | 1.74e-02 | 1.07e-02 | 29 |
hsa0501615 | Liver | Cirrhotic | Huntington disease | 172/2530 | 306/8465 | 1.65e-22 | 1.10e-20 | 6.77e-21 | 172 |
hsa034201 | Liver | Cirrhotic | Nucleotide excision repair | 29/2530 | 63/8465 | 4.81e-03 | 1.74e-02 | 1.07e-02 | 29 |
hsa0501622 | Liver | HCC | Huntington disease | 219/4020 | 306/8465 | 3.06e-18 | 3.42e-16 | 1.90e-16 | 219 |
hsa034202 | Liver | HCC | Nucleotide excision repair | 41/4020 | 63/8465 | 3.59e-03 | 1.12e-02 | 6.22e-03 | 41 |
hsa03020 | Liver | HCC | RNA polymerase | 24/4020 | 34/8465 | 5.40e-03 | 1.57e-02 | 8.75e-03 | 24 |
hsa0501632 | Liver | HCC | Huntington disease | 219/4020 | 306/8465 | 3.06e-18 | 3.42e-16 | 1.90e-16 | 219 |
hsa034203 | Liver | HCC | Nucleotide excision repair | 41/4020 | 63/8465 | 3.59e-03 | 1.12e-02 | 6.22e-03 | 41 |
hsa030201 | Liver | HCC | RNA polymerase | 24/4020 | 34/8465 | 5.40e-03 | 1.57e-02 | 8.75e-03 | 24 |
hsa0501642 | Liver | Cyst | Huntington disease | 42/339 | 306/8465 | 1.27e-12 | 4.06e-11 | 3.35e-11 | 42 |
hsa0501652 | Liver | Cyst | Huntington disease | 42/339 | 306/8465 | 1.27e-12 | 4.06e-11 | 3.35e-11 | 42 |
hsa0501628 | Oral cavity | OSCC | Huntington disease | 204/3704 | 306/8465 | 1.70e-16 | 7.13e-15 | 3.63e-15 | 204 |
hsa034204 | Oral cavity | OSCC | Nucleotide excision repair | 49/3704 | 63/8465 | 3.48e-08 | 2.91e-07 | 1.48e-07 | 49 |
hsa030204 | Oral cavity | OSCC | RNA polymerase | 25/3704 | 34/8465 | 4.12e-04 | 1.27e-03 | 6.45e-04 | 25 |
hsa05016112 | Oral cavity | OSCC | Huntington disease | 204/3704 | 306/8465 | 1.70e-16 | 7.13e-15 | 3.63e-15 | 204 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
POLR2J3 | SNV | Missense_Mutation | novel | c.89G>A | p.Cys30Tyr | p.C30Y | protein_coding | tolerated(0.07) | benign(0.011) | TCGA-EA-A411-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
POLR2J3 | SNV | Missense_Mutation | rs767362640 | c.109N>A | p.Glu37Lys | p.E37K | protein_coding | deleterious(0) | probably_damaging(0.991) | TCGA-CV-6961-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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