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Gene: PLCE1 |
Gene summary for PLCE1 |
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Gene information | Species | Human | Gene symbol | PLCE1 | Gene ID | 51196 |
Gene name | phospholipase C epsilon 1 | |
Gene Alias | NPHS3 | |
Cytomap | 10q23.33 | |
Gene Type | protein-coding | GO ID | GO:0000165 | UniProtAcc | Q9P212 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
51196 | PLCE1 | HTA11_3410_2000001011 | Human | Colorectum | AD | 3.71e-40 | -9.04e-01 | 0.0155 |
51196 | PLCE1 | HTA11_2951_2000001011 | Human | Colorectum | AD | 3.45e-08 | -1.08e+00 | 0.0216 |
51196 | PLCE1 | HTA11_78_2000001011 | Human | Colorectum | AD | 6.05e-06 | 1.78e-01 | -0.1088 |
51196 | PLCE1 | HTA11_347_2000001011 | Human | Colorectum | AD | 1.17e-30 | 1.12e+00 | -0.1954 |
51196 | PLCE1 | HTA11_3361_2000001011 | Human | Colorectum | AD | 8.26e-03 | -5.53e-01 | -0.1207 |
51196 | PLCE1 | HTA11_696_2000001011 | Human | Colorectum | AD | 1.15e-02 | 4.03e-02 | -0.1464 |
51196 | PLCE1 | HTA11_546_2000001011 | Human | Colorectum | AD | 7.34e-05 | 4.33e-01 | -0.0842 |
51196 | PLCE1 | HTA11_866_3004761011 | Human | Colorectum | AD | 5.40e-34 | -1.01e+00 | 0.096 |
51196 | PLCE1 | HTA11_9408_2000001011 | Human | Colorectum | AD | 2.91e-02 | -8.27e-01 | 0.0451 |
51196 | PLCE1 | HTA11_8622_2000001021 | Human | Colorectum | SER | 2.17e-07 | -8.36e-01 | 0.0528 |
51196 | PLCE1 | HTA11_10711_2000001011 | Human | Colorectum | AD | 2.73e-06 | -6.54e-01 | 0.0338 |
51196 | PLCE1 | HTA11_7696_3000711011 | Human | Colorectum | AD | 1.13e-26 | -7.27e-01 | 0.0674 |
51196 | PLCE1 | HTA11_6818_2000001011 | Human | Colorectum | AD | 2.89e-06 | -7.10e-01 | 0.0112 |
51196 | PLCE1 | HTA11_7469_2000001011 | Human | Colorectum | AD | 8.63e-05 | -4.12e-01 | -0.0124 |
51196 | PLCE1 | HTA11_11156_2000001011 | Human | Colorectum | AD | 1.21e-06 | -1.02e+00 | 0.0397 |
51196 | PLCE1 | HTA11_6818_2000001021 | Human | Colorectum | AD | 9.66e-11 | -8.46e-01 | 0.0588 |
51196 | PLCE1 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 5.29e-56 | -1.01e+00 | 0.294 |
51196 | PLCE1 | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 2.85e-04 | -1.15e+00 | 0.3487 |
51196 | PLCE1 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 2.29e-19 | -9.85e-01 | 0.281 |
51196 | PLCE1 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 5.49e-65 | -1.20e+00 | 0.3859 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0038127 | Colorectum | AD | ERBB signaling pathway | 55/3918 | 121/18723 | 1.19e-09 | 8.85e-08 | 55 |
GO:0007173 | Colorectum | AD | epidermal growth factor receptor signaling pathway | 50/3918 | 108/18723 | 3.08e-09 | 2.07e-07 | 50 |
GO:0016049 | Colorectum | AD | cell growth | 143/3918 | 482/18723 | 2.83e-06 | 8.09e-05 | 143 |
GO:0001558 | Colorectum | AD | regulation of cell growth | 124/3918 | 414/18723 | 7.67e-06 | 1.86e-04 | 124 |
GO:0007265 | Colorectum | AD | Ras protein signal transduction | 104/3918 | 337/18723 | 1.01e-05 | 2.35e-04 | 104 |
GO:0051056 | Colorectum | AD | regulation of small GTPase mediated signal transduction | 94/3918 | 302/18723 | 1.81e-05 | 3.76e-04 | 94 |
GO:1902743 | Colorectum | AD | regulation of lamellipodium organization | 25/3918 | 54/18723 | 2.63e-05 | 5.01e-04 | 25 |
GO:1902745 | Colorectum | AD | positive regulation of lamellipodium organization | 19/3918 | 37/18723 | 4.08e-05 | 7.26e-04 | 19 |
GO:0016042 | Colorectum | AD | lipid catabolic process | 97/3918 | 320/18723 | 4.31e-05 | 7.56e-04 | 97 |
GO:0097581 | Colorectum | AD | lamellipodium organization | 35/3918 | 90/18723 | 7.39e-05 | 1.18e-03 | 35 |
GO:0031346 | Colorectum | AD | positive regulation of cell projection organization | 104/3918 | 353/18723 | 8.26e-05 | 1.30e-03 | 104 |
GO:0010592 | Colorectum | AD | positive regulation of lamellipodium assembly | 15/3918 | 29/18723 | 2.38e-04 | 3.03e-03 | 15 |
GO:0010591 | Colorectum | AD | regulation of lamellipodium assembly | 18/3918 | 42/18723 | 1.09e-03 | 1.01e-02 | 18 |
GO:0090257 | Colorectum | AD | regulation of muscle system process | 73/3918 | 252/18723 | 1.46e-03 | 1.24e-02 | 73 |
GO:0030032 | Colorectum | AD | lamellipodium assembly | 26/3918 | 72/18723 | 2.12e-03 | 1.68e-02 | 26 |
GO:0046578 | Colorectum | AD | regulation of Ras protein signal transduction | 56/3918 | 189/18723 | 2.85e-03 | 2.14e-02 | 56 |
GO:0048017 | Colorectum | AD | inositol lipid-mediated signaling | 53/3918 | 182/18723 | 5.35e-03 | 3.52e-02 | 53 |
GO:0048015 | Colorectum | AD | phosphatidylinositol-mediated signaling | 52/3918 | 178/18723 | 5.37e-03 | 3.54e-02 | 52 |
GO:0120034 | Colorectum | AD | positive regulation of plasma membrane bounded cell projection assembly | 33/3918 | 105/18723 | 7.49e-03 | 4.55e-02 | 33 |
GO:0045017 | Colorectum | AD | glycerolipid biosynthetic process | 69/3918 | 252/18723 | 8.33e-03 | 4.88e-02 | 69 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa051315 | Colorectum | MSS | Shigellosis | 94/1875 | 247/8465 | 6.82e-09 | 1.34e-07 | 8.23e-08 | 94 |
hsa049195 | Colorectum | MSS | Thyroid hormone signaling pathway | 46/1875 | 121/8465 | 5.04e-05 | 4.97e-04 | 3.05e-04 | 46 |
hsa052055 | Colorectum | MSS | Proteoglycans in cancer | 65/1875 | 205/8465 | 8.66e-04 | 5.38e-03 | 3.29e-03 | 65 |
hsa040155 | Colorectum | MSS | Rap1 signaling pathway | 66/1875 | 210/8465 | 1.03e-03 | 5.94e-03 | 3.64e-03 | 66 |
hsa051316 | Colorectum | MSI-H | Shigellosis | 40/797 | 247/8465 | 4.28e-04 | 5.34e-03 | 4.47e-03 | 40 |
hsa049196 | Colorectum | MSI-H | Thyroid hormone signaling pathway | 21/797 | 121/8465 | 4.18e-03 | 4.10e-02 | 3.44e-02 | 21 |
hsa051317 | Colorectum | MSI-H | Shigellosis | 40/797 | 247/8465 | 4.28e-04 | 5.34e-03 | 4.47e-03 | 40 |
hsa049197 | Colorectum | MSI-H | Thyroid hormone signaling pathway | 21/797 | 121/8465 | 4.18e-03 | 4.10e-02 | 3.44e-02 | 21 |
hsa051318 | Colorectum | FAP | Shigellosis | 76/1404 | 247/8465 | 1.57e-08 | 5.84e-07 | 3.55e-07 | 76 |
hsa049198 | Colorectum | FAP | Thyroid hormone signaling pathway | 41/1404 | 121/8465 | 2.28e-06 | 4.28e-05 | 2.60e-05 | 41 |
hsa052056 | Colorectum | FAP | Proteoglycans in cancer | 57/1404 | 205/8465 | 3.05e-05 | 3.29e-04 | 2.00e-04 | 57 |
hsa040156 | Colorectum | FAP | Rap1 signaling pathway | 53/1404 | 210/8465 | 7.93e-04 | 5.14e-03 | 3.13e-03 | 53 |
hsa04933 | Colorectum | FAP | AGE-RAGE signaling pathway in diabetic complications | 27/1404 | 100/8465 | 5.55e-03 | 2.15e-02 | 1.31e-02 | 27 |
hsa04024 | Colorectum | FAP | cAMP signaling pathway | 51/1404 | 225/8465 | 1.02e-02 | 3.68e-02 | 2.24e-02 | 51 |
hsa051319 | Colorectum | FAP | Shigellosis | 76/1404 | 247/8465 | 1.57e-08 | 5.84e-07 | 3.55e-07 | 76 |
hsa049199 | Colorectum | FAP | Thyroid hormone signaling pathway | 41/1404 | 121/8465 | 2.28e-06 | 4.28e-05 | 2.60e-05 | 41 |
hsa052057 | Colorectum | FAP | Proteoglycans in cancer | 57/1404 | 205/8465 | 3.05e-05 | 3.29e-04 | 2.00e-04 | 57 |
hsa040157 | Colorectum | FAP | Rap1 signaling pathway | 53/1404 | 210/8465 | 7.93e-04 | 5.14e-03 | 3.13e-03 | 53 |
hsa049331 | Colorectum | FAP | AGE-RAGE signaling pathway in diabetic complications | 27/1404 | 100/8465 | 5.55e-03 | 2.15e-02 | 1.31e-02 | 27 |
hsa040241 | Colorectum | FAP | cAMP signaling pathway | 51/1404 | 225/8465 | 1.02e-02 | 3.68e-02 | 2.24e-02 | 51 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PLCE1 | SNV | Missense_Mutation | novel | c.5357G>A | p.Arg1786Lys | p.R1786K | Q9P212 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-5L-AAT1-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Hormone Therapy | letrozol | SD |
PLCE1 | SNV | Missense_Mutation | c.5692G>C | p.Gly1898Arg | p.G1898R | Q9P212 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-A1-A0SN-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | ac | SD | |
PLCE1 | SNV | Missense_Mutation | c.6235N>A | p.Pro2079Thr | p.P2079T | Q9P212 | protein_coding | tolerated(0.08) | benign(0.279) | TCGA-A1-A0SQ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | ac | SD | |
PLCE1 | SNV | Missense_Mutation | novel | c.380N>G | p.Asn127Ser | p.N127S | Q9P212 | protein_coding | tolerated_low_confidence(0.19) | benign(0.003) | TCGA-A7-A425-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | adriamycin | PD |
PLCE1 | SNV | Missense_Mutation | c.3342N>T | p.Glu1114Asp | p.E1114D | Q9P212 | protein_coding | tolerated(0.09) | possibly_damaging(0.883) | TCGA-A8-A08G-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | 5-fluorouracil | CR | |
PLCE1 | SNV | Missense_Mutation | c.3628N>A | p.Asp1210Asn | p.D1210N | Q9P212 | protein_coding | tolerated(0.1) | probably_damaging(0.929) | TCGA-A8-A09I-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | anastrozole | SD | |
PLCE1 | SNV | Missense_Mutation | c.5266N>A | p.His1756Asn | p.H1756N | Q9P212 | protein_coding | deleterious(0.01) | probably_damaging(0.987) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
PLCE1 | SNV | Missense_Mutation | c.4060G>A | p.Glu1354Lys | p.E1354K | Q9P212 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AR-A0TQ-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | SD | |
PLCE1 | SNV | Missense_Mutation | c.1956N>C | p.Arg652Ser | p.R652S | Q9P212 | protein_coding | tolerated(0.06) | probably_damaging(0.984) | TCGA-AR-A255-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Targeted Molecular therapy | trastuzumab | SD | |
PLCE1 | SNV | Missense_Mutation | c.3655N>A | p.Val1219Ile | p.V1219I | Q9P212 | protein_coding | tolerated(0.13) | benign(0.023) | TCGA-BH-A0HF-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
51196 | PLCE1 | PHOSPHOLIPASE, DRUGGABLE GENOME, ENZYME | hydrochlorothiazide | HYDROCHLOROTHIAZIDE | 31327267 |
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