![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: MAOA |
Gene summary for MAOA |
![]() |
Gene information | Species | Human | Gene symbol | MAOA | Gene ID | 4128 |
Gene name | monoamine oxidase A | |
Gene Alias | BRNRS | |
Cytomap | Xp11.3 | |
Gene Type | protein-coding | GO ID | GO:0001505 | UniProtAcc | P21397 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
4128 | MAOA | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.98e-17 | -6.92e-01 | 0.0155 |
4128 | MAOA | HTA11_2951_2000001011 | Human | Colorectum | AD | 1.33e-02 | -7.88e-01 | 0.0216 |
4128 | MAOA | HTA11_347_2000001011 | Human | Colorectum | AD | 3.00e-12 | 7.22e-01 | -0.1954 |
4128 | MAOA | HTA11_2992_2000001011 | Human | Colorectum | SER | 1.01e-03 | 7.24e-01 | -0.1706 |
4128 | MAOA | HTA11_866_3004761011 | Human | Colorectum | AD | 1.18e-07 | -5.41e-01 | 0.096 |
4128 | MAOA | HTA11_9408_2000001011 | Human | Colorectum | AD | 2.09e-02 | -8.98e-01 | 0.0451 |
4128 | MAOA | HTA11_10711_2000001011 | Human | Colorectum | AD | 2.88e-04 | -6.18e-01 | 0.0338 |
4128 | MAOA | HTA11_7696_3000711011 | Human | Colorectum | AD | 3.51e-23 | -5.66e-01 | 0.0674 |
4128 | MAOA | HTA11_6818_2000001021 | Human | Colorectum | AD | 4.63e-09 | -7.98e-01 | 0.0588 |
4128 | MAOA | HTA11_99999970781_79442 | Human | Colorectum | MSS | 7.12e-12 | -5.28e-01 | 0.294 |
4128 | MAOA | HTA11_99999971662_82457 | Human | Colorectum | MSS | 2.14e-15 | -6.57e-01 | 0.3859 |
4128 | MAOA | HTA11_99999973899_84307 | Human | Colorectum | MSS | 4.77e-11 | -9.01e-01 | 0.2585 |
4128 | MAOA | HTA11_99999974143_84620 | Human | Colorectum | MSS | 4.58e-39 | -8.97e-01 | 0.3005 |
4128 | MAOA | F007 | Human | Colorectum | FAP | 6.22e-17 | -8.92e-01 | 0.1176 |
4128 | MAOA | A002-C-010 | Human | Colorectum | FAP | 1.71e-10 | -6.50e-01 | 0.242 |
4128 | MAOA | A001-C-207 | Human | Colorectum | FAP | 3.00e-12 | -6.78e-01 | 0.1278 |
4128 | MAOA | A015-C-203 | Human | Colorectum | FAP | 6.94e-39 | -7.59e-01 | -0.1294 |
4128 | MAOA | A015-C-204 | Human | Colorectum | FAP | 4.58e-11 | -6.47e-01 | -0.0228 |
4128 | MAOA | A014-C-040 | Human | Colorectum | FAP | 8.01e-10 | -8.97e-01 | -0.1184 |
4128 | MAOA | A002-C-201 | Human | Colorectum | FAP | 1.51e-23 | -7.46e-01 | 0.0324 |
Page: 1 2 3 4 5 6 7 8 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0019439 | Colorectum | AD | aromatic compound catabolic process | 146/3918 | 467/18723 | 7.48e-08 | 3.84e-06 | 146 |
GO:1901361 | Colorectum | AD | organic cyclic compound catabolic process | 153/3918 | 495/18723 | 8.23e-08 | 4.18e-06 | 153 |
GO:19013611 | Colorectum | SER | organic cyclic compound catabolic process | 104/2897 | 495/18723 | 5.46e-04 | 7.63e-03 | 104 |
GO:00194391 | Colorectum | SER | aromatic compound catabolic process | 98/2897 | 467/18723 | 8.09e-04 | 1.01e-02 | 98 |
GO:19013612 | Colorectum | MSS | organic cyclic compound catabolic process | 148/3467 | 495/18723 | 3.47e-10 | 3.18e-08 | 148 |
GO:00194392 | Colorectum | MSS | aromatic compound catabolic process | 140/3467 | 467/18723 | 8.56e-10 | 6.85e-08 | 140 |
GO:00194394 | Colorectum | FAP | aromatic compound catabolic process | 100/2622 | 467/18723 | 6.75e-06 | 2.08e-04 | 100 |
GO:19013614 | Colorectum | FAP | organic cyclic compound catabolic process | 101/2622 | 495/18723 | 4.87e-05 | 9.93e-04 | 101 |
GO:00194395 | Colorectum | CRC | aromatic compound catabolic process | 77/2078 | 467/18723 | 2.42e-04 | 4.00e-03 | 77 |
GO:19013615 | Colorectum | CRC | organic cyclic compound catabolic process | 80/2078 | 495/18723 | 3.52e-04 | 5.34e-03 | 80 |
GO:001943917 | Esophagus | HGIN | aromatic compound catabolic process | 105/2587 | 467/18723 | 1.89e-07 | 9.31e-06 | 105 |
GO:190136117 | Esophagus | HGIN | organic cyclic compound catabolic process | 106/2587 | 495/18723 | 1.94e-06 | 7.13e-05 | 106 |
GO:001943918 | Esophagus | ESCC | aromatic compound catabolic process | 295/8552 | 467/18723 | 1.09e-14 | 5.98e-13 | 295 |
GO:190136118 | Esophagus | ESCC | organic cyclic compound catabolic process | 307/8552 | 495/18723 | 9.99e-14 | 4.80e-12 | 307 |
GO:190136111 | Liver | Cirrhotic | organic cyclic compound catabolic process | 213/4634 | 495/18723 | 1.58e-19 | 3.67e-17 | 213 |
GO:001943911 | Liver | Cirrhotic | aromatic compound catabolic process | 202/4634 | 467/18723 | 6.93e-19 | 1.28e-16 | 202 |
GO:00424021 | Liver | Cirrhotic | cellular biogenic amine catabolic process | 15/4634 | 27/18723 | 5.96e-04 | 4.63e-03 | 15 |
GO:0044106 | Liver | Cirrhotic | cellular amine metabolic process | 43/4634 | 113/18723 | 1.15e-03 | 7.83e-03 | 43 |
GO:00093101 | Liver | Cirrhotic | amine catabolic process | 15/4634 | 29/18723 | 1.59e-03 | 1.03e-02 | 15 |
GO:0006576 | Liver | Cirrhotic | cellular biogenic amine metabolic process | 38/4634 | 101/18723 | 2.72e-03 | 1.59e-02 | 38 |
Page: 1 2 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa00380 | Colorectum | FAP | Tryptophan metabolism | 13/1404 | 42/8465 | 1.54e-02 | 4.99e-02 | 3.03e-02 | 13 |
hsa050129 | Colorectum | FAP | Parkinson disease | 80/1404 | 266/8465 | 2.04e-08 | 6.20e-07 | 3.77e-07 | 80 |
hsa047287 | Colorectum | FAP | Dopaminergic synapse | 34/1404 | 132/8465 | 4.59e-03 | 1.89e-02 | 1.15e-02 | 34 |
hsa003801 | Colorectum | FAP | Tryptophan metabolism | 13/1404 | 42/8465 | 1.54e-02 | 4.99e-02 | 3.03e-02 | 13 |
hsa047288 | Colorectum | CRC | Dopaminergic synapse | 28/1091 | 132/8465 | 4.86e-03 | 2.66e-02 | 1.80e-02 | 28 |
hsa047289 | Colorectum | CRC | Dopaminergic synapse | 28/1091 | 132/8465 | 4.86e-03 | 2.66e-02 | 1.80e-02 | 28 |
hsa0501239 | Esophagus | HGIN | Parkinson disease | 124/1383 | 266/8465 | 5.95e-32 | 9.70e-30 | 7.70e-30 | 124 |
hsa05012114 | Esophagus | HGIN | Parkinson disease | 124/1383 | 266/8465 | 5.95e-32 | 9.70e-30 | 7.70e-30 | 124 |
hsa05012211 | Esophagus | ESCC | Parkinson disease | 201/4205 | 266/8465 | 1.56e-18 | 8.72e-17 | 4.46e-17 | 201 |
hsa05012310 | Esophagus | ESCC | Parkinson disease | 201/4205 | 266/8465 | 1.56e-18 | 8.72e-17 | 4.46e-17 | 201 |
hsa0501214 | Liver | Cirrhotic | Parkinson disease | 158/2530 | 266/8465 | 3.62e-24 | 6.02e-22 | 3.71e-22 | 158 |
hsa00260 | Liver | Cirrhotic | Glycine, serine and threonine metabolism | 22/2530 | 40/8465 | 7.85e-04 | 4.51e-03 | 2.78e-03 | 22 |
hsa003802 | Liver | Cirrhotic | Tryptophan metabolism | 22/2530 | 42/8465 | 1.85e-03 | 8.37e-03 | 5.16e-03 | 22 |
hsa003308 | Liver | Cirrhotic | Arginine and proline metabolism | 25/2530 | 50/8465 | 2.18e-03 | 9.41e-03 | 5.80e-03 | 25 |
hsa0501215 | Liver | Cirrhotic | Parkinson disease | 158/2530 | 266/8465 | 3.62e-24 | 6.02e-22 | 3.71e-22 | 158 |
hsa002601 | Liver | Cirrhotic | Glycine, serine and threonine metabolism | 22/2530 | 40/8465 | 7.85e-04 | 4.51e-03 | 2.78e-03 | 22 |
hsa0038011 | Liver | Cirrhotic | Tryptophan metabolism | 22/2530 | 42/8465 | 1.85e-03 | 8.37e-03 | 5.16e-03 | 22 |
hsa0033011 | Liver | Cirrhotic | Arginine and proline metabolism | 25/2530 | 50/8465 | 2.18e-03 | 9.41e-03 | 5.80e-03 | 25 |
hsa0501222 | Liver | HCC | Parkinson disease | 198/4020 | 266/8465 | 9.40e-20 | 1.58e-17 | 8.76e-18 | 198 |
hsa002602 | Liver | HCC | Glycine, serine and threonine metabolism | 28/4020 | 40/8465 | 3.28e-03 | 1.07e-02 | 5.93e-03 | 28 |
Page: 1 2 3 4 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MAOA | SNV | Missense_Mutation | novel | c.458A>C | p.Asp153Ala | p.D153A | P21397 | protein_coding | deleterious(0.02) | probably_damaging(0.967) | TCGA-A7-A0CJ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD |
MAOA | SNV | Missense_Mutation | rs772520550 | c.760N>G | p.Ile254Val | p.I254V | P21397 | protein_coding | tolerated(1) | benign(0) | TCGA-AR-A1AK-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | anastrozole | SD |
MAOA | insertion | Nonsense_Mutation | novel | c.456_457insATTCTTTACATCAGGCATAGTCTGTAGTCTA | p.Asp153IlefsTer9 | p.D153Ifs*9 | P21397 | protein_coding | TCGA-A7-A0CJ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD | ||
MAOA | insertion | Nonsense_Mutation | novel | c.381_382insATGGGTCTCTTCTTAGATGATTTTAAAATTTAAAGCA | p.Trp128MetfsTer11 | p.W128Mfs*11 | P21397 | protein_coding | TCGA-B6-A0I5-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
MAOA | insertion | Frame_Shift_Ins | novel | c.1267_1268insT | p.Arg424SerfsTer27 | p.R424Sfs*27 | P21397 | protein_coding | TCGA-BH-A0H9-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD | ||
MAOA | SNV | Missense_Mutation | c.59N>A | p.Gly20Glu | p.G20E | P21397 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-DR-A0ZM-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unspecific | Cisplatin | SD | |
MAOA | SNV | Missense_Mutation | novel | c.1018N>C | p.Thr340Pro | p.T340P | P21397 | protein_coding | deleterious(0) | probably_damaging(0.946) | TCGA-ZJ-AAXU-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
MAOA | SNV | Missense_Mutation | c.572N>T | p.Ala191Val | p.A191V | P21397 | protein_coding | tolerated(0.36) | benign(0.003) | TCGA-AA-A02R-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
MAOA | deletion | Frame_Shift_Del | c.1210delN | p.Gly405AlafsTer12 | p.G405Afs*12 | P21397 | protein_coding | TCGA-AA-3672-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |||
MAOA | insertion | In_Frame_Ins | novel | c.1194_1195insGAG | p.Glu400dup | p.E400dup | P21397 | protein_coding | TCGA-AG-3742-01 | Colorectum | rectum adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
Page: 1 2 3 4 5 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
4128 | MAOA | DRUGGABLE GENOME, ENZYME | Cyclic peptide derivative 1 | |||
4128 | MAOA | DRUGGABLE GENOME, ENZYME | inhibitor | CHEMBL1200895 | PHENELZINE SULFATE | |
4128 | MAOA | DRUGGABLE GENOME, ENZYME | Tarnylcypromine derivative 3 | |||
4128 | MAOA | DRUGGABLE GENOME, ENZYME | PMID25399762-Compound-Figure3-Lycojaponicumin C | |||
4128 | MAOA | DRUGGABLE GENOME, ENZYME | METHAMPHETAMINE | METHAMPHETAMINE | ||
4128 | MAOA | DRUGGABLE GENOME, ENZYME | Heteroaryl-cyclopropylamine derivative 1 | |||
4128 | MAOA | DRUGGABLE GENOME, ENZYME | Psoralen | PSORALEN | ||
4128 | MAOA | DRUGGABLE GENOME, ENZYME | 8-{[(4-BROMOPHENYL)METHYL]SULFANYL}CAFFEINE | CHEMBL1927670 | 22055712 | |
4128 | MAOA | DRUGGABLE GENOME, ENZYME | IncarviatoneA | |||
4128 | MAOA | DRUGGABLE GENOME, ENZYME | Tetra-hydro-isoquinoline derivative 3 |
Page: 1 2 3 4 5 6 7 8 9 |