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Gene: IL2RG |
Gene summary for IL2RG |
Gene summary. |
Gene information | Species | Human | Gene symbol | IL2RG | Gene ID | 3561 |
Gene name | interleukin 2 receptor subunit gamma | |
Gene Alias | CD132 | |
Cytomap | Xq13.1 | |
Gene Type | protein-coding | GO ID | GO:0002376 | UniProtAcc | P31785 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
3561 | IL2RG | HTA11_2487_2000001011 | Human | Colorectum | SER | 5.63e-22 | 7.47e-01 | -0.1808 |
3561 | IL2RG | HTA11_1938_2000001011 | Human | Colorectum | AD | 8.28e-25 | 7.24e-01 | -0.0811 |
3561 | IL2RG | HTA11_78_2000001011 | Human | Colorectum | AD | 7.85e-13 | 3.52e-01 | -0.1088 |
3561 | IL2RG | HTA11_347_2000001011 | Human | Colorectum | AD | 2.61e-17 | 3.88e-01 | -0.1954 |
3561 | IL2RG | HTA11_411_2000001011 | Human | Colorectum | SER | 2.63e-25 | 1.94e+00 | -0.2602 |
3561 | IL2RG | HTA11_2112_2000001011 | Human | Colorectum | SER | 2.67e-18 | 1.31e+00 | -0.2196 |
3561 | IL2RG | HTA11_3361_2000001011 | Human | Colorectum | AD | 5.46e-03 | 1.80e-01 | -0.1207 |
3561 | IL2RG | HTA11_83_2000001011 | Human | Colorectum | SER | 2.83e-15 | 4.76e-01 | -0.1526 |
3561 | IL2RG | HTA11_696_2000001011 | Human | Colorectum | AD | 4.40e-09 | 2.13e-01 | -0.1464 |
3561 | IL2RG | HTA11_866_2000001011 | Human | Colorectum | AD | 2.05e-06 | 2.16e-01 | -0.1001 |
3561 | IL2RG | HTA11_1391_2000001011 | Human | Colorectum | AD | 1.68e-07 | 2.25e-01 | -0.059 |
3561 | IL2RG | HTA11_2992_2000001011 | Human | Colorectum | SER | 7.86e-21 | 8.48e-01 | -0.1706 |
3561 | IL2RG | HTA11_5212_2000001011 | Human | Colorectum | AD | 2.09e-30 | 1.32e+00 | -0.2061 |
3561 | IL2RG | HTA11_866_3004761011 | Human | Colorectum | AD | 3.98e-03 | 1.18e-01 | 0.096 |
3561 | IL2RG | HTA11_4255_2000001011 | Human | Colorectum | SER | 3.40e-03 | 2.22e-01 | 0.0446 |
3561 | IL2RG | HTA11_10711_2000001011 | Human | Colorectum | AD | 6.02e-03 | 1.35e-01 | 0.0338 |
3561 | IL2RG | HTA11_6818_2000001021 | Human | Colorectum | AD | 1.59e-10 | 4.08e-01 | 0.0588 |
3561 | IL2RG | HTA11_99999970781_79442 | Human | Colorectum | MSS | 9.04e-05 | 1.37e-01 | 0.294 |
3561 | IL2RG | HTA11_99999965104_69814 | Human | Colorectum | MSS | 3.86e-11 | 3.30e-01 | 0.281 |
3561 | IL2RG | HTA11_99999971662_82457 | Human | Colorectum | MSS | 1.12e-26 | 6.07e-01 | 0.3859 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0098760 | Colorectum | AD | response to interleukin-7 | 10/3918 | 15/18723 | 1.68e-04 | 2.29e-03 | 10 |
GO:0098761 | Colorectum | AD | cellular response to interleukin-7 | 10/3918 | 15/18723 | 1.68e-04 | 2.29e-03 | 10 |
GO:00987601 | Colorectum | SER | response to interleukin-7 | 8/2897 | 15/18723 | 7.51e-04 | 9.68e-03 | 8 |
GO:00987611 | Colorectum | SER | cellular response to interleukin-7 | 8/2897 | 15/18723 | 7.51e-04 | 9.68e-03 | 8 |
GO:00987602 | Colorectum | MSS | response to interleukin-7 | 10/3467 | 15/18723 | 5.64e-05 | 9.87e-04 | 10 |
GO:00987612 | Colorectum | MSS | cellular response to interleukin-7 | 10/3467 | 15/18723 | 5.64e-05 | 9.87e-04 | 10 |
GO:009876019 | Esophagus | HGIN | response to interleukin-7 | 8/2587 | 15/18723 | 3.41e-04 | 5.55e-03 | 8 |
GO:009876119 | Esophagus | HGIN | cellular response to interleukin-7 | 8/2587 | 15/18723 | 3.41e-04 | 5.55e-03 | 8 |
GO:0098760110 | Esophagus | ESCC | response to interleukin-7 | 14/8552 | 15/18723 | 1.47e-04 | 9.85e-04 | 14 |
GO:0098761110 | Esophagus | ESCC | cellular response to interleukin-7 | 14/8552 | 15/18723 | 1.47e-04 | 9.85e-04 | 14 |
GO:00987607 | Liver | Cirrhotic | response to interleukin-7 | 10/4634 | 15/18723 | 7.26e-04 | 5.36e-03 | 10 |
GO:00987617 | Liver | Cirrhotic | cellular response to interleukin-7 | 10/4634 | 15/18723 | 7.26e-04 | 5.36e-03 | 10 |
GO:00713532 | Liver | Cirrhotic | cellular response to interleukin-4 | 17/4634 | 33/18723 | 8.32e-04 | 6.06e-03 | 17 |
GO:00706702 | Liver | Cirrhotic | response to interleukin-4 | 17/4634 | 36/18723 | 2.82e-03 | 1.63e-02 | 17 |
GO:009876012 | Liver | HCC | response to interleukin-7 | 12/7958 | 15/18723 | 3.56e-03 | 1.59e-02 | 12 |
GO:009876112 | Liver | HCC | cellular response to interleukin-7 | 12/7958 | 15/18723 | 3.56e-03 | 1.59e-02 | 12 |
GO:007135311 | Liver | HCC | cellular response to interleukin-4 | 21/7958 | 33/18723 | 1.16e-02 | 4.28e-02 | 21 |
GO:009876017 | Oral cavity | OSCC | response to interleukin-7 | 14/7305 | 15/18723 | 1.79e-05 | 1.74e-04 | 14 |
GO:009876117 | Oral cavity | OSCC | cellular response to interleukin-7 | 14/7305 | 15/18723 | 1.79e-05 | 1.74e-04 | 14 |
GO:00192214 | Oral cavity | OSCC | cytokine-mediated signaling pathway | 222/7305 | 472/18723 | 2.02e-04 | 1.35e-03 | 222 |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0414437 | Esophagus | ESCC | Endocytosis | 186/4205 | 251/8465 | 9.74e-16 | 4.66e-14 | 2.39e-14 | 186 |
hsa05166310 | Esophagus | ESCC | Human T-cell leukemia virus 1 infection | 164/4205 | 222/8465 | 8.13e-14 | 2.09e-12 | 1.07e-12 | 164 |
hsa0516213 | Esophagus | ESCC | Measles | 90/4205 | 139/8465 | 2.16e-04 | 7.87e-04 | 4.03e-04 | 90 |
hsa0465914 | Esophagus | ESCC | Th17 cell differentiation | 68/4205 | 108/8465 | 3.53e-03 | 9.30e-03 | 4.76e-03 | 68 |
hsa0465812 | Esophagus | ESCC | Th1 and Th2 cell differentiation | 58/4205 | 92/8465 | 6.49e-03 | 1.60e-02 | 8.19e-03 | 58 |
hsa0415114 | Esophagus | ESCC | PI3K-Akt signaling pathway | 197/4205 | 354/8465 | 1.24e-02 | 2.83e-02 | 1.45e-02 | 197 |
hsa0414412 | Liver | Cirrhotic | Endocytosis | 119/2530 | 251/8465 | 2.33e-09 | 4.56e-08 | 2.81e-08 | 119 |
hsa0516614 | Liver | Cirrhotic | Human T-cell leukemia virus 1 infection | 87/2530 | 222/8465 | 1.69e-03 | 8.01e-03 | 4.94e-03 | 87 |
hsa0414413 | Liver | Cirrhotic | Endocytosis | 119/2530 | 251/8465 | 2.33e-09 | 4.56e-08 | 2.81e-08 | 119 |
hsa0516615 | Liver | Cirrhotic | Human T-cell leukemia virus 1 infection | 87/2530 | 222/8465 | 1.69e-03 | 8.01e-03 | 4.94e-03 | 87 |
hsa0414422 | Liver | HCC | Endocytosis | 178/4020 | 251/8465 | 2.03e-14 | 5.22e-13 | 2.91e-13 | 178 |
hsa0516622 | Liver | HCC | Human T-cell leukemia virus 1 infection | 139/4020 | 222/8465 | 3.17e-06 | 2.79e-05 | 1.55e-05 | 139 |
hsa0414432 | Liver | HCC | Endocytosis | 178/4020 | 251/8465 | 2.03e-14 | 5.22e-13 | 2.91e-13 | 178 |
hsa0516632 | Liver | HCC | Human T-cell leukemia virus 1 infection | 139/4020 | 222/8465 | 3.17e-06 | 2.79e-05 | 1.55e-05 | 139 |
hsa0414427 | Oral cavity | OSCC | Endocytosis | 174/3704 | 251/8465 | 9.42e-17 | 4.51e-15 | 2.29e-15 | 174 |
hsa0516630 | Oral cavity | OSCC | Human T-cell leukemia virus 1 infection | 150/3704 | 222/8465 | 3.68e-13 | 7.26e-12 | 3.70e-12 | 150 |
hsa051628 | Oral cavity | OSCC | Measles | 90/3704 | 139/8465 | 4.10e-07 | 2.50e-06 | 1.27e-06 | 90 |
hsa046598 | Oral cavity | OSCC | Th17 cell differentiation | 65/3704 | 108/8465 | 4.02e-04 | 1.25e-03 | 6.35e-04 | 65 |
hsa041516 | Oral cavity | OSCC | PI3K-Akt signaling pathway | 185/3704 | 354/8465 | 6.26e-04 | 1.86e-03 | 9.49e-04 | 185 |
hsa046584 | Oral cavity | OSCC | Th1 and Th2 cell differentiation | 53/3704 | 92/8465 | 5.00e-03 | 1.20e-02 | 6.13e-03 | 53 |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
IL7 | IL7R_IL2RG | IL7_IL7R_IL2RG | IL2 | Cervix | CC |
IL7 | IL7R_IL2RG | IL7_IL7R_IL2RG | IL2 | CRC | ADJ |
IL7 | IL7R_IL2RG | IL7_IL7R_IL2RG | IL2 | CRC | MSI-H |
IL7 | IL7R_IL2RG | IL7_IL7R_IL2RG | IL2 | Endometrium | ADJ |
IL7 | IL7R_IL2RG | IL7_IL7R_IL2RG | IL2 | Endometrium | AEH |
IL7 | IL7R_IL2RG | IL7_IL7R_IL2RG | IL2 | Endometrium | EEC |
IL7 | IL7R_IL2RG | IL7_IL7R_IL2RG | IL2 | Endometrium | Healthy |
IL7 | IL7R_IL2RG | IL7_IL7R_IL2RG | IL2 | GC | ADJ |
IL7 | IL7R_IL2RG | IL7_IL7R_IL2RG | IL2 | GC | GC |
IL7 | IL7R_IL2RG | IL7_IL7R_IL2RG | IL2 | HNSCC | ADJ |
IL7 | IL7R_IL2RG | IL7_IL7R_IL2RG | IL2 | HNSCC | Precancer |
IL7 | IL7R_IL2RG | IL7_IL7R_IL2RG | IL2 | Liver | Healthy |
IL7 | IL7R_IL2RG | IL7_IL7R_IL2RG | IL2 | Lung | AAH |
IL7 | IL7R_IL2RG | IL7_IL7R_IL2RG | IL2 | Lung | ADJ |
IL7 | IL7R_IL2RG | IL7_IL7R_IL2RG | IL2 | Lung | AIS |
IL7 | IL7R_IL2RG | IL7_IL7R_IL2RG | IL2 | Lung | IAC |
IL7 | IL7R_IL2RG | IL7_IL7R_IL2RG | IL2 | Lung | MIAC |
IL7 | IL7R_IL2RG | IL7_IL7R_IL2RG | IL2 | Lung | Precancer |
IL7 | IL7R_IL2RG | IL7_IL7R_IL2RG | IL2 | Skin | AK |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
IL2RG | SNV | Missense_Mutation | c.266A>T | p.Tyr89Phe | p.Y89F | P31785 | protein_coding | deleterious(0.02) | probably_damaging(0.959) | TCGA-A2-A0EN-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | SD | |
IL2RG | SNV | Missense_Mutation | c.788N>C | p.Val263Ala | p.V263A | P31785 | protein_coding | deleterious(0.04) | probably_damaging(0.991) | TCGA-D8-A1XK-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicine+cyclophosphamide | SD | |
IL2RG | insertion | Frame_Shift_Ins | rs745545309 | c.1082_1083insC | p.Cys362MetfsTer7 | p.C362Mfs*7 | P31785 | protein_coding | TCGA-BH-A0BR-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
IL2RG | SNV | Missense_Mutation | c.1036N>T | p.Pro346Ser | p.P346S | P31785 | protein_coding | tolerated_low_confidence(0.14) | benign(0.003) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
IL2RG | SNV | Missense_Mutation | c.665G>A | p.Arg222His | p.R222H | P31785 | protein_coding | tolerated(0.36) | benign(0.314) | TCGA-AY-6386-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | 5-fu | SD | |
IL2RG | SNV | Missense_Mutation | novel | c.448A>C | p.Asn150His | p.N150H | P31785 | protein_coding | deleterious(0.01) | possibly_damaging(0.898) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
IL2RG | SNV | Missense_Mutation | c.994G>A | p.Val332Ile | p.V332I | P31785 | protein_coding | deleterious(0.03) | probably_damaging(0.992) | TCGA-CK-5916-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
IL2RG | SNV | Missense_Mutation | c.597A>T | p.Glu199Asp | p.E199D | P31785 | protein_coding | tolerated(0.07) | benign(0.232) | TCGA-F4-6570-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
IL2RG | SNV | Missense_Mutation | novel | c.841T>G | p.Phe281Val | p.F281V | P31785 | protein_coding | tolerated(0.77) | benign(0) | TCGA-EI-6917-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5fluorouracil+oxaciplatina+l-folinian | SD |
IL2RG | SNV | Missense_Mutation | rs767758983 | c.857N>T | p.Thr286Met | p.T286M | P31785 | protein_coding | tolerated(0.09) | benign(0.226) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
3561 | IL2RG | CELL SURFACE, EXTERNAL SIDE OF PLASMA MEMBRANE, DRUGGABLE GENOME | CHEMBL1201550 | DENILEUKIN DIFTITOX | ||
3561 | IL2RG | CELL SURFACE, EXTERNAL SIDE OF PLASMA MEMBRANE, DRUGGABLE GENOME | inhibitor | CHEMBL1201605 | DACLIZUMAB | |
3561 | IL2RG | CELL SURFACE, EXTERNAL SIDE OF PLASMA MEMBRANE, DRUGGABLE GENOME | INTERLEUKIN-2 EXPRESSING PLASMID | |||
3561 | IL2RG | CELL SURFACE, EXTERNAL SIDE OF PLASMA MEMBRANE, DRUGGABLE GENOME | agonist | CHEMBL1201438 | ALDESLEUKIN | |
3561 | IL2RG | CELL SURFACE, EXTERNAL SIDE OF PLASMA MEMBRANE, DRUGGABLE GENOME | ALDESLEUKIN | ALDESLEUKIN | ||
3561 | IL2RG | CELL SURFACE, EXTERNAL SIDE OF PLASMA MEMBRANE, DRUGGABLE GENOME | DENILEUKIN DIFTITOX | |||
3561 | IL2RG | CELL SURFACE, EXTERNAL SIDE OF PLASMA MEMBRANE, DRUGGABLE GENOME | CYT-107 | |||
3561 | IL2RG | CELL SURFACE, EXTERNAL SIDE OF PLASMA MEMBRANE, DRUGGABLE GENOME | IL-2 | ALDESLEUKIN | ||
3561 | IL2RG | CELL SURFACE, EXTERNAL SIDE OF PLASMA MEMBRANE, DRUGGABLE GENOME | INTERLEUKIN 2 | |||
3561 | IL2RG | CELL SURFACE, EXTERNAL SIDE OF PLASMA MEMBRANE, DRUGGABLE GENOME | ALDESLEUKIN | ALDESLEUKIN |
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