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Gene: EIF2AK1 |
Gene summary for EIF2AK1 |
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Gene information | Species | Human | Gene symbol | EIF2AK1 | Gene ID | 27102 |
Gene name | eukaryotic translation initiation factor 2 alpha kinase 1 | |
Gene Alias | HCR | |
Cytomap | 7p22.1 | |
Gene Type | protein-coding | GO ID | GO:0001932 | UniProtAcc | Q9BQI3 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
27102 | EIF2AK1 | HTA11_1938_2000001011 | Human | Colorectum | AD | 9.58e-04 | 5.75e-01 | -0.0811 |
27102 | EIF2AK1 | HTA11_78_2000001011 | Human | Colorectum | AD | 3.07e-05 | 5.12e-01 | -0.1088 |
27102 | EIF2AK1 | HTA11_347_2000001011 | Human | Colorectum | AD | 2.84e-15 | 6.63e-01 | -0.1954 |
27102 | EIF2AK1 | HTA11_1391_2000001011 | Human | Colorectum | AD | 1.26e-02 | 4.34e-01 | -0.059 |
27102 | EIF2AK1 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 1.80e-04 | 4.34e-01 | 0.294 |
27102 | EIF2AK1 | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 2.83e-02 | 9.72e-01 | 0.3487 |
27102 | EIF2AK1 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 4.04e-05 | 6.05e-01 | 0.281 |
27102 | EIF2AK1 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 5.11e-07 | 5.43e-01 | 0.3859 |
27102 | EIF2AK1 | A015-C-203 | Human | Colorectum | FAP | 1.35e-09 | -1.56e-01 | -0.1294 |
27102 | EIF2AK1 | A002-C-201 | Human | Colorectum | FAP | 2.74e-02 | -7.97e-02 | 0.0324 |
27102 | EIF2AK1 | A001-C-108 | Human | Colorectum | FAP | 2.38e-03 | -1.13e-01 | -0.0272 |
27102 | EIF2AK1 | A002-C-205 | Human | Colorectum | FAP | 3.85e-05 | -7.96e-02 | -0.1236 |
27102 | EIF2AK1 | A015-C-006 | Human | Colorectum | FAP | 4.38e-03 | -9.76e-02 | -0.0994 |
27102 | EIF2AK1 | A002-C-114 | Human | Colorectum | FAP | 4.53e-05 | -1.37e-01 | -0.1561 |
27102 | EIF2AK1 | A015-C-104 | Human | Colorectum | FAP | 8.93e-09 | -1.71e-01 | -0.1899 |
27102 | EIF2AK1 | A001-C-014 | Human | Colorectum | FAP | 4.57e-02 | -1.63e-02 | 0.0135 |
27102 | EIF2AK1 | A002-C-016 | Human | Colorectum | FAP | 6.48e-05 | -9.40e-02 | 0.0521 |
27102 | EIF2AK1 | A002-C-116 | Human | Colorectum | FAP | 1.25e-11 | -8.11e-02 | -0.0452 |
27102 | EIF2AK1 | A014-C-008 | Human | Colorectum | FAP | 2.87e-03 | -8.93e-02 | -0.191 |
27102 | EIF2AK1 | A018-E-020 | Human | Colorectum | FAP | 3.56e-07 | -2.23e-01 | -0.2034 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0030099 | Colorectum | AD | myeloid cell differentiation | 119/3918 | 381/18723 | 1.24e-06 | 4.01e-05 | 119 |
GO:0006417 | Colorectum | AD | regulation of translation | 141/3918 | 468/18723 | 1.32e-06 | 4.22e-05 | 141 |
GO:0055076 | Colorectum | AD | transition metal ion homeostasis | 53/3918 | 138/18723 | 1.89e-06 | 5.65e-05 | 53 |
GO:0031667 | Colorectum | AD | response to nutrient levels | 138/3918 | 474/18723 | 1.22e-05 | 2.68e-04 | 138 |
GO:0006413 | Colorectum | AD | translational initiation | 45/3918 | 118/18723 | 1.35e-05 | 2.92e-04 | 45 |
GO:0046777 | Colorectum | AD | protein autophosphorylation | 74/3918 | 227/18723 | 2.48e-05 | 4.76e-04 | 74 |
GO:0042594 | Colorectum | AD | response to starvation | 63/3918 | 197/18723 | 1.77e-04 | 2.38e-03 | 63 |
GO:0055072 | Colorectum | AD | iron ion homeostasis | 32/3918 | 85/18723 | 2.97e-04 | 3.60e-03 | 32 |
GO:0006446 | Colorectum | AD | regulation of translational initiation | 28/3918 | 79/18723 | 2.02e-03 | 1.63e-02 | 28 |
GO:0002573 | Colorectum | AD | myeloid leukocyte differentiation | 60/3918 | 208/18723 | 4.03e-03 | 2.81e-02 | 60 |
GO:00064172 | Colorectum | MSS | regulation of translation | 134/3467 | 468/18723 | 4.43e-08 | 2.38e-06 | 134 |
GO:00300992 | Colorectum | MSS | myeloid cell differentiation | 110/3467 | 381/18723 | 4.48e-07 | 1.75e-05 | 110 |
GO:00064132 | Colorectum | MSS | translational initiation | 43/3467 | 118/18723 | 3.19e-06 | 9.38e-05 | 43 |
GO:00316672 | Colorectum | MSS | response to nutrient levels | 125/3467 | 474/18723 | 1.24e-05 | 2.88e-04 | 125 |
GO:00550762 | Colorectum | MSS | transition metal ion homeostasis | 45/3467 | 138/18723 | 4.99e-05 | 9.02e-04 | 45 |
GO:00467772 | Colorectum | MSS | protein autophosphorylation | 63/3467 | 227/18723 | 3.96e-04 | 4.91e-03 | 63 |
GO:00425942 | Colorectum | MSS | response to starvation | 56/3467 | 197/18723 | 4.25e-04 | 5.21e-03 | 56 |
GO:00550722 | Colorectum | MSS | iron ion homeostasis | 29/3467 | 85/18723 | 4.44e-04 | 5.32e-03 | 29 |
GO:00025731 | Colorectum | MSS | myeloid leukocyte differentiation | 57/3467 | 208/18723 | 1.01e-03 | 1.01e-02 | 57 |
GO:00064461 | Colorectum | MSS | regulation of translational initiation | 26/3467 | 79/18723 | 1.56e-03 | 1.42e-02 | 26 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0414115 | Liver | Cirrhotic | Protein processing in endoplasmic reticulum | 114/2530 | 174/8465 | 1.16e-22 | 9.67e-21 | 5.96e-21 | 114 |
hsa0516012 | Liver | Cirrhotic | Hepatitis C | 63/2530 | 157/8465 | 3.67e-03 | 1.49e-02 | 9.20e-03 | 63 |
hsa0414122 | Liver | HCC | Protein processing in endoplasmic reticulum | 146/4020 | 174/8465 | 7.34e-24 | 2.46e-21 | 1.37e-21 | 146 |
hsa0516021 | Liver | HCC | Hepatitis C | 94/4020 | 157/8465 | 1.11e-03 | 4.10e-03 | 2.28e-03 | 94 |
hsa0414132 | Liver | HCC | Protein processing in endoplasmic reticulum | 146/4020 | 174/8465 | 7.34e-24 | 2.46e-21 | 1.37e-21 | 146 |
hsa0516031 | Liver | HCC | Hepatitis C | 94/4020 | 157/8465 | 1.11e-03 | 4.10e-03 | 2.28e-03 | 94 |
hsa0414130 | Oral cavity | OSCC | Protein processing in endoplasmic reticulum | 143/3704 | 174/8465 | 6.82e-26 | 2.28e-23 | 1.16e-23 | 143 |
hsa051608 | Oral cavity | OSCC | Hepatitis C | 103/3704 | 157/8465 | 2.17e-08 | 1.96e-07 | 9.99e-08 | 103 |
hsa051628 | Oral cavity | OSCC | Measles | 90/3704 | 139/8465 | 4.10e-07 | 2.50e-06 | 1.27e-06 | 90 |
hsa04141113 | Oral cavity | OSCC | Protein processing in endoplasmic reticulum | 143/3704 | 174/8465 | 6.82e-26 | 2.28e-23 | 1.16e-23 | 143 |
hsa0516015 | Oral cavity | OSCC | Hepatitis C | 103/3704 | 157/8465 | 2.17e-08 | 1.96e-07 | 9.99e-08 | 103 |
hsa0516212 | Oral cavity | OSCC | Measles | 90/3704 | 139/8465 | 4.10e-07 | 2.50e-06 | 1.27e-06 | 90 |
hsa04141210 | Oral cavity | LP | Protein processing in endoplasmic reticulum | 113/2418 | 174/8465 | 8.74e-24 | 5.82e-22 | 3.76e-22 | 113 |
hsa0516024 | Oral cavity | LP | Hepatitis C | 73/2418 | 157/8465 | 1.14e-06 | 1.36e-05 | 8.74e-06 | 73 |
hsa0516221 | Oral cavity | LP | Measles | 59/2418 | 139/8465 | 2.90e-04 | 1.60e-03 | 1.03e-03 | 59 |
hsa0414138 | Oral cavity | LP | Protein processing in endoplasmic reticulum | 113/2418 | 174/8465 | 8.74e-24 | 5.82e-22 | 3.76e-22 | 113 |
hsa0516034 | Oral cavity | LP | Hepatitis C | 73/2418 | 157/8465 | 1.14e-06 | 1.36e-05 | 8.74e-06 | 73 |
hsa0516231 | Oral cavity | LP | Measles | 59/2418 | 139/8465 | 2.90e-04 | 1.60e-03 | 1.03e-03 | 59 |
hsa0414129 | Prostate | Tumor | Protein processing in endoplasmic reticulum | 99/1791 | 174/8465 | 2.58e-25 | 1.71e-23 | 1.06e-23 | 99 |
hsa0516023 | Prostate | Tumor | Hepatitis C | 51/1791 | 157/8465 | 5.67e-04 | 2.89e-03 | 1.79e-03 | 51 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
EIF2AK1 | SNV | Missense_Mutation | novel | c.794N>T | p.Glu265Val | p.E265V | Q9BQI3 | protein_coding | deleterious(0.01) | benign(0.023) | TCGA-A2-A3XU-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | arimidex | PD |
EIF2AK1 | SNV | Missense_Mutation | c.880G>A | p.Glu294Lys | p.E294K | Q9BQI3 | protein_coding | tolerated(0.25) | benign(0.001) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
EIF2AK1 | SNV | Missense_Mutation | c.1228N>A | p.Ala410Thr | p.A410T | Q9BQI3 | protein_coding | tolerated(0.11) | benign(0.124) | TCGA-AN-A0AK-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
EIF2AK1 | SNV | Missense_Mutation | c.686N>T | p.Tyr229Phe | p.Y229F | Q9BQI3 | protein_coding | deleterious(0.03) | probably_damaging(0.986) | TCGA-GM-A2DC-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | xeloda | CR | |
EIF2AK1 | insertion | In_Frame_Ins | novel | c.1243_1244insCCCGACATTTTTCTG | p.Met415delinsThrArgHisPheSerVal | p.M415delinsTRHFSV | Q9BQI3 | protein_coding | TCGA-A2-A0CU-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
EIF2AK1 | insertion | Frame_Shift_Ins | novel | c.1241_1242insCTCTGCTCTCC | p.Met415SerfsTer17 | p.M415Sfs*17 | Q9BQI3 | protein_coding | TCGA-A2-A0CU-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
EIF2AK1 | insertion | Nonsense_Mutation | novel | c.1126_1127insGAGGCATTCCAGATGATTGAATC | p.Tyr376Ter | p.Y376* | Q9BQI3 | protein_coding | TCGA-A7-A0CJ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD | ||
EIF2AK1 | deletion | Frame_Shift_Del | novel | c.1277delN | p.Leu426TrpfsTer2 | p.L426Wfs*2 | Q9BQI3 | protein_coding | TCGA-EW-A2FV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | docetaxel | SD | ||
EIF2AK1 | SNV | Missense_Mutation | novel | c.1483C>G | p.Leu495Val | p.L495V | Q9BQI3 | protein_coding | tolerated(0.3) | possibly_damaging(0.759) | TCGA-DS-A1OB-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | carboplatin | PD |
EIF2AK1 | SNV | Missense_Mutation | c.1348N>T | p.Leu450Phe | p.L450F | Q9BQI3 | protein_coding | deleterious(0) | possibly_damaging(0.719) | TCGA-EK-A3GK-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
27102 | EIF2AK1 | DRUGGABLE GENOME, KINASE, SERINE THREONINE KINASE, ENZYME | inhibitor | 381118865 | ||
27102 | EIF2AK1 | DRUGGABLE GENOME, KINASE, SERINE THREONINE KINASE, ENZYME | inhibitor | 249565848 | ||
27102 | EIF2AK1 | DRUGGABLE GENOME, KINASE, SERINE THREONINE KINASE, ENZYME | TCMDC-123956 | CHEMBL534675 | 22153346 |
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