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Gene: C8A |
Gene summary for C8A |
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Gene information | Species | Human | Gene symbol | C8A | Gene ID | 731 |
Gene name | complement C8 alpha chain | |
Gene Alias | C8A | |
Cytomap | 1p32.2 | |
Gene Type | protein-coding | GO ID | GO:0002250 | UniProtAcc | P07357 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
731 | C8A | NAFLD1 | Human | Liver | NAFLD | 6.58e-14 | 1.25e+00 | -0.04 |
731 | C8A | S41 | Human | Liver | Cirrhotic | 3.82e-02 | 4.49e-01 | -0.0343 |
731 | C8A | S43 | Human | Liver | Cirrhotic | 1.26e-06 | -2.58e-01 | -0.0187 |
731 | C8A | HCC1_Meng | Human | Liver | HCC | 3.82e-88 | -9.69e-02 | 0.0246 |
731 | C8A | HCC2_Meng | Human | Liver | HCC | 9.13e-08 | -3.28e-01 | 0.0107 |
731 | C8A | cirrhotic1 | Human | Liver | Cirrhotic | 3.17e-07 | -3.17e-01 | 0.0202 |
731 | C8A | cirrhotic2 | Human | Liver | Cirrhotic | 1.83e-07 | -3.15e-01 | 0.0201 |
731 | C8A | cirrhotic3 | Human | Liver | Cirrhotic | 6.73e-03 | -3.23e-01 | 0.0215 |
731 | C8A | Pt13.a | Human | Liver | HCC | 2.91e-05 | -3.03e-01 | 0.021 |
731 | C8A | Pt13.b | Human | Liver | HCC | 2.20e-03 | -2.86e-01 | 0.0251 |
731 | C8A | Pt14.d | Human | Liver | HCC | 3.45e-02 | -2.26e-01 | 0.0143 |
731 | C8A | S015 | Human | Liver | HCC | 1.45e-03 | 4.05e-01 | 0.2375 |
731 | C8A | S027 | Human | Liver | HCC | 4.12e-09 | 1.10e+00 | 0.2446 |
731 | C8A | S028 | Human | Liver | HCC | 7.54e-16 | 7.56e-01 | 0.2503 |
731 | C8A | S029 | Human | Liver | HCC | 7.57e-27 | 1.43e+00 | 0.2581 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:001593116 | Esophagus | HGIN | nucleobase-containing compound transport | 57/2587 | 222/18723 | 1.76e-06 | 6.52e-05 | 57 |
GO:190495120 | Esophagus | HGIN | positive regulation of establishment of protein localization | 73/2587 | 319/18723 | 6.99e-06 | 2.14e-04 | 73 |
GO:005122220 | Esophagus | HGIN | positive regulation of protein transport | 67/2587 | 303/18723 | 5.13e-05 | 1.22e-03 | 67 |
GO:001593117 | Esophagus | ESCC | nucleobase-containing compound transport | 162/8552 | 222/18723 | 9.87e-17 | 7.93e-15 | 162 |
GO:000170119 | Esophagus | ESCC | in utero embryonic development | 243/8552 | 367/18723 | 1.00e-15 | 6.86e-14 | 243 |
GO:1904951111 | Esophagus | ESCC | positive regulation of establishment of protein localization | 216/8552 | 319/18723 | 1.01e-15 | 6.86e-14 | 216 |
GO:0051222111 | Esophagus | ESCC | positive regulation of protein transport | 204/8552 | 303/18723 | 1.56e-14 | 8.38e-13 | 204 |
GO:000931419 | Esophagus | ESCC | response to radiation | 277/8552 | 456/18723 | 4.42e-11 | 1.43e-09 | 277 |
GO:003253520 | Esophagus | ESCC | regulation of cellular component size | 227/8552 | 383/18723 | 4.77e-08 | 8.60e-07 | 227 |
GO:00073698 | Esophagus | ESCC | gastrulation | 115/8552 | 185/18723 | 4.35e-06 | 4.64e-05 | 115 |
GO:000941611 | Esophagus | ESCC | response to light stimulus | 183/8552 | 320/18723 | 2.03e-05 | 1.76e-04 | 183 |
GO:00069707 | Esophagus | ESCC | response to osmotic stress | 57/8552 | 84/18723 | 3.26e-05 | 2.70e-04 | 57 |
GO:00301984 | Esophagus | ESCC | extracellular matrix organization | 171/8552 | 301/18723 | 6.08e-05 | 4.67e-04 | 171 |
GO:00430624 | Esophagus | ESCC | extracellular structure organization | 171/8552 | 302/18723 | 7.73e-05 | 5.76e-04 | 171 |
GO:00452294 | Esophagus | ESCC | external encapsulating structure organization | 172/8552 | 304/18723 | 7.80e-05 | 5.80e-04 | 172 |
GO:00083619 | Esophagus | ESCC | regulation of cell size | 107/8552 | 181/18723 | 1.81e-04 | 1.16e-03 | 107 |
GO:19031317 | Esophagus | ESCC | mononuclear cell differentiation | 226/8552 | 426/18723 | 1.20e-03 | 5.88e-03 | 226 |
GO:000166720 | Esophagus | ESCC | ameboidal-type cell migration | 250/8552 | 475/18723 | 1.22e-03 | 5.97e-03 | 250 |
GO:00454454 | Esophagus | ESCC | myoblast differentiation | 52/8552 | 84/18723 | 1.98e-03 | 8.90e-03 | 52 |
GO:000930617 | Esophagus | ESCC | protein secretion | 190/8552 | 359/18723 | 3.22e-03 | 1.34e-02 | 190 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa046105 | Liver | HCC | Complement and coagulation cascades | 57/4020 | 86/8465 | 3.19e-04 | 1.45e-03 | 8.04e-04 | 57 |
hsa0481051 | Liver | HCC | Regulation of actin cytoskeleton | 134/4020 | 229/8465 | 4.48e-04 | 1.94e-03 | 1.08e-03 | 134 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
C8A | SNV | Missense_Mutation | rs749738757 | c.281C>T | p.Ala94Val | p.A94V | P07357 | protein_coding | tolerated(0.29) | benign(0.119) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
C8A | SNV | Missense_Mutation | novel | c.979T>C | p.Tyr327His | p.Y327H | P07357 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
C8A | SNV | Missense_Mutation | c.555G>C | p.Trp185Cys | p.W185C | P07357 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AR-A2LH-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | PD | |
C8A | SNV | Missense_Mutation | rs753968787 | c.332N>A | p.Arg111His | p.R111H | P07357 | protein_coding | deleterious(0.01) | probably_damaging(0.995) | TCGA-BH-A0E9-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | CR |
C8A | insertion | Frame_Shift_Ins | novel | c.1083_1084insGAACAAAGAGAGC | p.Met362GlufsTer28 | p.M362Efs*28 | P07357 | protein_coding | TCGA-AR-A0U0-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
C8A | deletion | Frame_Shift_Del | novel | c.1446_1456delNNNNNNNNNNN | p.Arg484GlyfsTer36 | p.R484Gfs*36 | P07357 | protein_coding | TCGA-S3-AA10-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | cytoxan | CR | ||
C8A | SNV | Missense_Mutation | c.403N>A | p.Ala135Thr | p.A135T | P07357 | protein_coding | tolerated(0.57) | benign(0.001) | TCGA-A6-6141-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | 5-fu | SD | |
C8A | SNV | Missense_Mutation | rs143726641 | c.1742N>T | p.Thr581Met | p.T581M | P07357 | protein_coding | deleterious(0) | probably_damaging(0.987) | TCGA-AA-3856-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
C8A | SNV | Missense_Mutation | c.1111N>T | p.Asp371Tyr | p.D371Y | P07357 | protein_coding | tolerated(0.06) | possibly_damaging(0.663) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
C8A | SNV | Missense_Mutation | c.370N>A | p.Gly124Ser | p.G124S | P07357 | protein_coding | tolerated(0.18) | possibly_damaging(0.723) | TCGA-AD-6889-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Chemotherapy | xeloda | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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