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Gene: ATP6V1D |
Gene summary for ATP6V1D |
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Gene information | Species | Human | Gene symbol | ATP6V1D | Gene ID | 51382 |
Gene name | ATPase H+ transporting V1 subunit D | |
Gene Alias | ATP6M | |
Cytomap | 14q23.3 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | A0A024R683 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
51382 | ATP6V1D | LZE4T | Human | Esophagus | ESCC | 3.68e-12 | 4.59e-01 | 0.0811 |
51382 | ATP6V1D | LZE7T | Human | Esophagus | ESCC | 1.69e-05 | 2.63e-01 | 0.0667 |
51382 | ATP6V1D | LZE8T | Human | Esophagus | ESCC | 5.44e-04 | 1.48e-01 | 0.067 |
51382 | ATP6V1D | LZE20T | Human | Esophagus | ESCC | 8.64e-10 | 4.37e-01 | 0.0662 |
51382 | ATP6V1D | LZE22T | Human | Esophagus | ESCC | 6.65e-03 | 8.05e-01 | 0.068 |
51382 | ATP6V1D | LZE24T | Human | Esophagus | ESCC | 1.21e-10 | 4.60e-01 | 0.0596 |
51382 | ATP6V1D | LZE21T | Human | Esophagus | ESCC | 1.77e-02 | -2.22e-02 | 0.0655 |
51382 | ATP6V1D | LZE6T | Human | Esophagus | ESCC | 2.50e-03 | 1.54e-01 | 0.0845 |
51382 | ATP6V1D | P1T-E | Human | Esophagus | ESCC | 6.93e-04 | 2.66e-01 | 0.0875 |
51382 | ATP6V1D | P2T-E | Human | Esophagus | ESCC | 2.27e-26 | 5.14e-01 | 0.1177 |
51382 | ATP6V1D | P4T-E | Human | Esophagus | ESCC | 1.17e-36 | 8.73e-01 | 0.1323 |
51382 | ATP6V1D | P5T-E | Human | Esophagus | ESCC | 3.90e-20 | 5.66e-01 | 0.1327 |
51382 | ATP6V1D | P8T-E | Human | Esophagus | ESCC | 7.84e-29 | 4.56e-01 | 0.0889 |
51382 | ATP6V1D | P9T-E | Human | Esophagus | ESCC | 1.44e-08 | 2.61e-01 | 0.1131 |
51382 | ATP6V1D | P10T-E | Human | Esophagus | ESCC | 1.16e-37 | 7.62e-01 | 0.116 |
51382 | ATP6V1D | P11T-E | Human | Esophagus | ESCC | 5.99e-14 | 6.08e-01 | 0.1426 |
51382 | ATP6V1D | P12T-E | Human | Esophagus | ESCC | 8.90e-28 | 5.81e-01 | 0.1122 |
51382 | ATP6V1D | P15T-E | Human | Esophagus | ESCC | 7.71e-33 | 7.97e-01 | 0.1149 |
51382 | ATP6V1D | P16T-E | Human | Esophagus | ESCC | 7.11e-26 | 5.50e-01 | 0.1153 |
51382 | ATP6V1D | P17T-E | Human | Esophagus | ESCC | 2.33e-07 | 8.17e-01 | 0.1278 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:001623617 | Esophagus | ESCC | macroautophagy | 216/8552 | 291/18723 | 1.94e-23 | 4.57e-21 | 216 |
GO:001050617 | Esophagus | ESCC | regulation of autophagy | 220/8552 | 317/18723 | 6.72e-18 | 6.36e-16 | 220 |
GO:001624114 | Esophagus | ESCC | regulation of macroautophagy | 102/8552 | 141/18723 | 1.09e-10 | 3.27e-09 | 102 |
GO:190260018 | Esophagus | ESCC | proton transmembrane transport | 88/8552 | 157/18723 | 5.62e-03 | 2.10e-02 | 88 |
GO:001623611 | Liver | Cirrhotic | macroautophagy | 129/4634 | 291/18723 | 1.75e-13 | 1.41e-11 | 129 |
GO:001050611 | Liver | Cirrhotic | regulation of autophagy | 132/4634 | 317/18723 | 2.17e-11 | 1.33e-09 | 132 |
GO:00162414 | Liver | Cirrhotic | regulation of macroautophagy | 60/4634 | 141/18723 | 2.57e-06 | 4.63e-05 | 60 |
GO:001623621 | Liver | HCC | macroautophagy | 204/7958 | 291/18723 | 8.66e-22 | 1.41e-19 | 204 |
GO:001050621 | Liver | HCC | regulation of autophagy | 210/7958 | 317/18723 | 7.59e-18 | 8.45e-16 | 210 |
GO:001624111 | Liver | HCC | regulation of macroautophagy | 96/7958 | 141/18723 | 6.82e-10 | 2.14e-08 | 96 |
GO:19026007 | Liver | HCC | proton transmembrane transport | 87/7958 | 157/18723 | 7.27e-04 | 4.42e-03 | 87 |
GO:001623610 | Oral cavity | OSCC | macroautophagy | 192/7305 | 291/18723 | 7.01e-21 | 1.14e-18 | 192 |
GO:001050610 | Oral cavity | OSCC | regulation of autophagy | 198/7305 | 317/18723 | 1.63e-17 | 1.51e-15 | 198 |
GO:00162417 | Oral cavity | OSCC | regulation of macroautophagy | 96/7305 | 141/18723 | 2.33e-12 | 9.75e-11 | 96 |
GO:001623615 | Oral cavity | LP | macroautophagy | 135/4623 | 291/18723 | 4.71e-16 | 6.70e-14 | 135 |
GO:001050615 | Oral cavity | LP | regulation of autophagy | 132/4623 | 317/18723 | 1.82e-11 | 1.28e-09 | 132 |
GO:001624113 | Oral cavity | LP | regulation of macroautophagy | 61/4623 | 141/18723 | 1.00e-06 | 2.50e-05 | 61 |
GO:00162369 | Prostate | BPH | macroautophagy | 85/3107 | 291/18723 | 4.68e-08 | 1.29e-06 | 85 |
GO:190260015 | Prostate | BPH | proton transmembrane transport | 52/3107 | 157/18723 | 2.81e-07 | 6.06e-06 | 52 |
GO:00105069 | Prostate | BPH | regulation of autophagy | 86/3107 | 317/18723 | 1.29e-06 | 2.24e-05 | 86 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0019015 | Liver | Cirrhotic | Oxidative phosphorylation | 83/2530 | 134/8465 | 1.03e-14 | 3.44e-13 | 2.12e-13 | 83 |
hsa0414515 | Liver | Cirrhotic | Phagosome | 73/2530 | 152/8465 | 1.61e-06 | 1.78e-05 | 1.10e-05 | 73 |
hsa0511011 | Liver | Cirrhotic | Vibrio cholerae infection | 29/2530 | 50/8465 | 3.19e-05 | 2.47e-04 | 1.52e-04 | 29 |
hsa0512011 | Liver | Cirrhotic | Epithelial cell signaling in Helicobacter pylori infection | 34/2530 | 70/8465 | 7.42e-04 | 4.33e-03 | 2.67e-03 | 34 |
hsa051651 | Liver | Cirrhotic | Human papillomavirus infection | 124/2530 | 331/8465 | 1.55e-03 | 7.83e-03 | 4.83e-03 | 124 |
hsa0532311 | Liver | Cirrhotic | Rheumatoid arthritis | 38/2530 | 93/8465 | 1.52e-02 | 4.57e-02 | 2.82e-02 | 38 |
hsa0019022 | Liver | HCC | Oxidative phosphorylation | 103/4020 | 134/8465 | 2.39e-12 | 5.01e-11 | 2.79e-11 | 103 |
hsa051202 | Liver | HCC | Epithelial cell signaling in Helicobacter pylori infection | 50/4020 | 70/8465 | 3.96e-05 | 2.16e-04 | 1.20e-04 | 50 |
hsa051652 | Liver | HCC | Human papillomavirus infection | 188/4020 | 331/8465 | 3.34e-04 | 1.49e-03 | 8.29e-04 | 188 |
hsa0414521 | Liver | HCC | Phagosome | 93/4020 | 152/8465 | 4.27e-04 | 1.88e-03 | 1.05e-03 | 93 |
hsa041502 | Liver | HCC | mTOR signaling pathway | 95/4020 | 156/8465 | 4.70e-04 | 1.99e-03 | 1.11e-03 | 95 |
hsa0511021 | Liver | HCC | Vibrio cholerae infection | 35/4020 | 50/8465 | 1.04e-03 | 3.87e-03 | 2.15e-03 | 35 |
hsa0019032 | Liver | HCC | Oxidative phosphorylation | 103/4020 | 134/8465 | 2.39e-12 | 5.01e-11 | 2.79e-11 | 103 |
hsa051203 | Liver | HCC | Epithelial cell signaling in Helicobacter pylori infection | 50/4020 | 70/8465 | 3.96e-05 | 2.16e-04 | 1.20e-04 | 50 |
hsa051653 | Liver | HCC | Human papillomavirus infection | 188/4020 | 331/8465 | 3.34e-04 | 1.49e-03 | 8.29e-04 | 188 |
hsa0414531 | Liver | HCC | Phagosome | 93/4020 | 152/8465 | 4.27e-04 | 1.88e-03 | 1.05e-03 | 93 |
hsa0415011 | Liver | HCC | mTOR signaling pathway | 95/4020 | 156/8465 | 4.70e-04 | 1.99e-03 | 1.11e-03 | 95 |
hsa0511031 | Liver | HCC | Vibrio cholerae infection | 35/4020 | 50/8465 | 1.04e-03 | 3.87e-03 | 2.15e-03 | 35 |
hsa051659 | Oral cavity | OSCC | Human papillomavirus infection | 200/3704 | 331/8465 | 3.83e-10 | 4.93e-09 | 2.51e-09 | 200 |
hsa0019028 | Oral cavity | OSCC | Oxidative phosphorylation | 88/3704 | 134/8465 | 2.15e-07 | 1.44e-06 | 7.32e-07 | 88 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ATP6V1D | SNV | Missense_Mutation | novel | c.503N>A | p.Arg168His | p.R168H | Q9Y5K8 | protein_coding | deleterious(0.01) | probably_damaging(0.997) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ATP6V1D | SNV | Missense_Mutation | c.461C>G | p.Ser154Cys | p.S154C | Q9Y5K8 | protein_coding | tolerated(0.07) | benign(0.412) | TCGA-D8-A27G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ATP6V1D | SNV | Missense_Mutation | novel | c.17N>A | p.Arg6Gln | p.R6Q | Q9Y5K8 | protein_coding | deleterious(0.05) | possibly_damaging(0.51) | TCGA-XX-A899-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cytoxan | CR |
ATP6V1D | insertion | Frame_Shift_Ins | novel | c.240-1_240insTCATAAAA | p.Thr81HisfsTer15 | p.T81Hfs*15 | Q9Y5K8 | protein_coding | TCGA-AN-A0FX-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
ATP6V1D | SNV | Missense_Mutation | c.211N>A | p.Glu71Lys | p.E71K | Q9Y5K8 | protein_coding | deleterious(0.04) | benign(0.119) | TCGA-AZ-6600-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | cpt-11 | PD | |
ATP6V1D | SNV | Missense_Mutation | novel | c.314N>A | p.Thr105Asn | p.T105N | Q9Y5K8 | protein_coding | tolerated(0.32) | benign(0.033) | TCGA-DM-A1D0-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ATP6V1D | SNV | Missense_Mutation | novel | c.512C>T | p.Ala171Val | p.A171V | Q9Y5K8 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ATP6V1D | SNV | Missense_Mutation | novel | c.726G>T | p.Glu242Asp | p.E242D | Q9Y5K8 | protein_coding | tolerated(0.23) | benign(0.007) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
ATP6V1D | SNV | Missense_Mutation | novel | c.456G>T | p.Gln152His | p.Q152H | Q9Y5K8 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ATP6V1D | SNV | Missense_Mutation | novel | c.178N>A | p.Glu60Lys | p.E60K | Q9Y5K8 | protein_coding | tolerated(0.23) | benign(0.059) | TCGA-AJ-A3NE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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