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Gene: ATP5MC1 |
Gene summary for ATP5MC1 |
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Gene information | Species | Human | Gene symbol | ATP5MC1 | Gene ID | 516 |
Gene name | ATP synthase membrane subunit c locus 1 | |
Gene Alias | ATP5A | |
Cytomap | 17q21.32 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | P05496 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
516 | ATP5MC1 | GSM4909281 | Human | Breast | IDC | 5.71e-12 | 4.63e-01 | 0.21 |
516 | ATP5MC1 | GSM4909282 | Human | Breast | IDC | 4.05e-09 | 4.53e-01 | -0.0288 |
516 | ATP5MC1 | GSM4909285 | Human | Breast | IDC | 2.93e-24 | 5.34e-01 | 0.21 |
516 | ATP5MC1 | GSM4909286 | Human | Breast | IDC | 1.37e-37 | 6.97e-01 | 0.1081 |
516 | ATP5MC1 | GSM4909287 | Human | Breast | IDC | 6.18e-19 | 5.63e-01 | 0.2057 |
516 | ATP5MC1 | GSM4909288 | Human | Breast | IDC | 1.05e-05 | 3.89e-01 | 0.0988 |
516 | ATP5MC1 | GSM4909293 | Human | Breast | IDC | 1.67e-09 | 1.94e-01 | 0.1581 |
516 | ATP5MC1 | GSM4909294 | Human | Breast | IDC | 3.36e-04 | 4.32e-01 | 0.2022 |
516 | ATP5MC1 | GSM4909295 | Human | Breast | IDC | 5.77e-03 | 2.57e-01 | 0.0898 |
516 | ATP5MC1 | GSM4909297 | Human | Breast | IDC | 6.82e-06 | -3.91e-02 | 0.1517 |
516 | ATP5MC1 | GSM4909298 | Human | Breast | IDC | 9.36e-18 | 5.14e-01 | 0.1551 |
516 | ATP5MC1 | GSM4909300 | Human | Breast | IDC | 2.82e-03 | 3.31e-01 | 0.0334 |
516 | ATP5MC1 | GSM4909301 | Human | Breast | IDC | 2.21e-02 | 3.51e-01 | 0.1577 |
516 | ATP5MC1 | GSM4909302 | Human | Breast | IDC | 1.23e-04 | 2.53e-01 | 0.1545 |
516 | ATP5MC1 | GSM4909303 | Human | Breast | IDC | 2.19e-03 | 3.55e-01 | 0.0438 |
516 | ATP5MC1 | GSM4909304 | Human | Breast | IDC | 8.64e-03 | 2.24e-01 | 0.1636 |
516 | ATP5MC1 | GSM4909305 | Human | Breast | IDC | 4.04e-08 | 2.90e-01 | 0.0436 |
516 | ATP5MC1 | GSM4909306 | Human | Breast | IDC | 2.44e-04 | 3.73e-01 | 0.1564 |
516 | ATP5MC1 | GSM4909307 | Human | Breast | IDC | 2.44e-21 | 6.56e-01 | 0.1569 |
516 | ATP5MC1 | GSM4909308 | Human | Breast | IDC | 4.07e-30 | 6.11e-01 | 0.158 |
Page: 1 2 3 4 5 6 7 8 9 10 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00460349 | Breast | Precancer | ATP metabolic process | 82/1080 | 277/18723 | 1.94e-36 | 5.19e-33 | 82 |
GO:19026008 | Breast | Precancer | proton transmembrane transport | 39/1080 | 157/18723 | 4.18e-15 | 1.18e-12 | 39 |
GO:00159857 | Breast | Precancer | energy coupled proton transport, down electrochemical gradient | 16/1080 | 26/18723 | 4.15e-14 | 9.65e-12 | 16 |
GO:00159867 | Breast | Precancer | ATP synthesis coupled proton transport | 16/1080 | 26/18723 | 4.15e-14 | 9.65e-12 | 16 |
GO:00067547 | Breast | Precancer | ATP biosynthetic process | 21/1080 | 57/18723 | 2.31e-12 | 4.26e-10 | 21 |
GO:00092067 | Breast | Precancer | purine ribonucleoside triphosphate biosynthetic process | 22/1080 | 68/18723 | 1.41e-11 | 1.88e-09 | 22 |
GO:00091457 | Breast | Precancer | purine nucleoside triphosphate biosynthetic process | 22/1080 | 69/18723 | 1.95e-11 | 2.43e-09 | 22 |
GO:00092017 | Breast | Precancer | ribonucleoside triphosphate biosynthetic process | 22/1080 | 74/18723 | 9.18e-11 | 1.00e-08 | 22 |
GO:00091448 | Breast | Precancer | purine nucleoside triphosphate metabolic process | 24/1080 | 88/18723 | 9.66e-11 | 1.03e-08 | 24 |
GO:00092057 | Breast | Precancer | purine ribonucleoside triphosphate metabolic process | 23/1080 | 82/18723 | 1.27e-10 | 1.34e-08 | 23 |
GO:00091427 | Breast | Precancer | nucleoside triphosphate biosynthetic process | 23/1080 | 85/18723 | 2.82e-10 | 2.69e-08 | 23 |
GO:00091997 | Breast | Precancer | ribonucleoside triphosphate metabolic process | 23/1080 | 89/18723 | 7.65e-10 | 6.66e-08 | 23 |
GO:00091418 | Breast | Precancer | nucleoside triphosphate metabolic process | 26/1080 | 112/18723 | 7.72e-10 | 6.66e-08 | 26 |
GO:00196938 | Breast | Precancer | ribose phosphate metabolic process | 49/1080 | 396/18723 | 3.81e-07 | 1.78e-05 | 49 |
GO:00091528 | Breast | Precancer | purine ribonucleotide biosynthetic process | 28/1080 | 169/18723 | 4.17e-07 | 1.89e-05 | 28 |
GO:00463907 | Breast | Precancer | ribose phosphate biosynthetic process | 30/1080 | 190/18723 | 4.75e-07 | 2.11e-05 | 30 |
GO:00092607 | Breast | Precancer | ribonucleotide biosynthetic process | 29/1080 | 182/18723 | 6.05e-07 | 2.55e-05 | 29 |
GO:00091509 | Breast | Precancer | purine ribonucleotide metabolic process | 46/1080 | 368/18723 | 6.47e-07 | 2.71e-05 | 46 |
GO:00091179 | Breast | Precancer | nucleotide metabolic process | 56/1080 | 489/18723 | 7.40e-07 | 3.00e-05 | 56 |
GO:00092598 | Breast | Precancer | ribonucleotide metabolic process | 47/1080 | 385/18723 | 9.69e-07 | 3.84e-05 | 47 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0501221 | Stomach | CAG with IM | Parkinson disease | 72/640 | 266/8465 | 7.97e-23 | 8.45e-21 | 5.93e-21 | 72 |
hsa0520821 | Stomach | CAG with IM | Chemical carcinogenesis - reactive oxygen species | 65/640 | 223/8465 | 1.37e-22 | 1.09e-20 | 7.65e-21 | 65 |
hsa0019021 | Stomach | CAG with IM | Oxidative phosphorylation | 49/640 | 134/8465 | 5.18e-22 | 3.29e-20 | 2.31e-20 | 49 |
hsa0502021 | Stomach | CAG with IM | Prion disease | 67/640 | 273/8465 | 8.84e-19 | 4.69e-17 | 3.29e-17 | 67 |
hsa0541521 | Stomach | CAG with IM | Diabetic cardiomyopathy | 56/640 | 203/8465 | 2.41e-18 | 1.10e-16 | 7.69e-17 | 56 |
hsa0501621 | Stomach | CAG with IM | Huntington disease | 68/640 | 306/8465 | 1.31e-16 | 5.21e-15 | 3.66e-15 | 68 |
hsa0501421 | Stomach | CAG with IM | Amyotrophic lateral sclerosis | 75/640 | 364/8465 | 2.71e-16 | 9.58e-15 | 6.72e-15 | 75 |
hsa0471421 | Stomach | CAG with IM | Thermogenesis | 55/640 | 232/8465 | 7.01e-15 | 2.23e-13 | 1.56e-13 | 55 |
hsa0502221 | Stomach | CAG with IM | Pathways of neurodegeneration - multiple diseases | 82/640 | 476/8465 | 4.27e-13 | 1.24e-11 | 8.67e-12 | 82 |
hsa0501021 | Stomach | CAG with IM | Alzheimer disease | 71/640 | 384/8465 | 5.65e-13 | 1.38e-11 | 9.70e-12 | 71 |
hsa0501231 | Stomach | CAG with IM | Parkinson disease | 72/640 | 266/8465 | 7.97e-23 | 8.45e-21 | 5.93e-21 | 72 |
hsa0520831 | Stomach | CAG with IM | Chemical carcinogenesis - reactive oxygen species | 65/640 | 223/8465 | 1.37e-22 | 1.09e-20 | 7.65e-21 | 65 |
hsa0019031 | Stomach | CAG with IM | Oxidative phosphorylation | 49/640 | 134/8465 | 5.18e-22 | 3.29e-20 | 2.31e-20 | 49 |
hsa0502031 | Stomach | CAG with IM | Prion disease | 67/640 | 273/8465 | 8.84e-19 | 4.69e-17 | 3.29e-17 | 67 |
hsa0541531 | Stomach | CAG with IM | Diabetic cardiomyopathy | 56/640 | 203/8465 | 2.41e-18 | 1.10e-16 | 7.69e-17 | 56 |
hsa0501631 | Stomach | CAG with IM | Huntington disease | 68/640 | 306/8465 | 1.31e-16 | 5.21e-15 | 3.66e-15 | 68 |
hsa0501431 | Stomach | CAG with IM | Amyotrophic lateral sclerosis | 75/640 | 364/8465 | 2.71e-16 | 9.58e-15 | 6.72e-15 | 75 |
hsa0471431 | Stomach | CAG with IM | Thermogenesis | 55/640 | 232/8465 | 7.01e-15 | 2.23e-13 | 1.56e-13 | 55 |
hsa0502231 | Stomach | CAG with IM | Pathways of neurodegeneration - multiple diseases | 82/640 | 476/8465 | 4.27e-13 | 1.24e-11 | 8.67e-12 | 82 |
hsa0501031 | Stomach | CAG with IM | Alzheimer disease | 71/640 | 384/8465 | 5.65e-13 | 1.38e-11 | 9.70e-12 | 71 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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