Tissue | Expression Dynamics | Abbreviation |
Cervix | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Cervix/NDUFB11_pca_on_diff_genes.png) | CC: Cervix cancer |
HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions |
N_HPV: HPV-infected normal cervix |
Colorectum (GSE201348) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Becker/NDUFB11_pca_on_diff_genes.png) | FAP: Familial adenomatous polyposis |
CRC: Colorectal cancer |
Colorectum (HTA11) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Chen/NDUFB11_pca_on_diff_genes.png) | AD: Adenomas |
SER: Sessile serrated lesions |
MSI-H: Microsatellite-high colorectal cancer |
MSS: Microsatellite stable colorectal cancer |
Endometrium | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Endometrium/NDUFB11_pca_on_diff_genes.png) | AEH: Atypical endometrial hyperplasia |
EEC: Endometrioid Cancer |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/NDUFB11_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
GC | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/GC/NDUFB11_pca_on_diff_genes.png) | CAG: Chronic atrophic gastritis |
CAG with IM: Chronic atrophic gastritis with intestinal metaplasia |
CSG: Chronic superficial gastritis |
GC: Gastric cancer |
SIM: Severe intestinal metaplasia |
WIM: Wild intestinal metaplasia |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/NDUFB11_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/NDUFB11_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Prostate | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Prostate/NDUFB11_pca_on_diff_genes.png) | BPH: Benign Prostatic Hyperplasia |
Skin | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Skin/NDUFB11_pca_on_diff_genes.png) | AK: Actinic keratosis |
cSCC: Cutaneous squamous cell carcinoma |
SCCIS:squamous cell carcinoma in situ |
Thyroid | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Thyroid/NDUFB11_pca_on_diff_genes.png) | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00102579 | Cervix | CC | NADH dehydrogenase complex assembly | 22/2311 | 57/18723 | 4.28e-07 | 1.67e-05 | 22 |
GO:00329819 | Cervix | CC | mitochondrial respiratory chain complex I assembly | 22/2311 | 57/18723 | 4.28e-07 | 1.67e-05 | 22 |
GO:00331089 | Cervix | CC | mitochondrial respiratory chain complex assembly | 26/2311 | 93/18723 | 3.97e-05 | 6.18e-04 | 26 |
GO:001025714 | Cervix | N_HPV | NADH dehydrogenase complex assembly | 10/534 | 57/18723 | 4.24e-06 | 1.65e-04 | 10 |
GO:003298114 | Cervix | N_HPV | mitochondrial respiratory chain complex I assembly | 10/534 | 57/18723 | 4.24e-06 | 1.65e-04 | 10 |
GO:003310814 | Cervix | N_HPV | mitochondrial respiratory chain complex assembly | 10/534 | 93/18723 | 3.17e-04 | 4.75e-03 | 10 |
GO:0010257 | Colorectum | AD | NADH dehydrogenase complex assembly | 34/3918 | 57/18723 | 2.15e-10 | 1.89e-08 | 34 |
GO:0032981 | Colorectum | AD | mitochondrial respiratory chain complex I assembly | 34/3918 | 57/18723 | 2.15e-10 | 1.89e-08 | 34 |
GO:0033108 | Colorectum | AD | mitochondrial respiratory chain complex assembly | 46/3918 | 93/18723 | 8.95e-10 | 6.91e-08 | 46 |
GO:00102571 | Colorectum | SER | NADH dehydrogenase complex assembly | 30/2897 | 57/18723 | 7.92e-11 | 1.19e-08 | 30 |
GO:00329811 | Colorectum | SER | mitochondrial respiratory chain complex I assembly | 30/2897 | 57/18723 | 7.92e-11 | 1.19e-08 | 30 |
GO:00331081 | Colorectum | SER | mitochondrial respiratory chain complex assembly | 39/2897 | 93/18723 | 8.13e-10 | 8.74e-08 | 39 |
GO:00102572 | Colorectum | MSS | NADH dehydrogenase complex assembly | 33/3467 | 57/18723 | 4.07e-11 | 4.86e-09 | 33 |
GO:00329812 | Colorectum | MSS | mitochondrial respiratory chain complex I assembly | 33/3467 | 57/18723 | 4.07e-11 | 4.86e-09 | 33 |
GO:00331082 | Colorectum | MSS | mitochondrial respiratory chain complex assembly | 44/3467 | 93/18723 | 2.17e-10 | 2.09e-08 | 44 |
GO:00102573 | Colorectum | MSI-H | NADH dehydrogenase complex assembly | 25/1319 | 57/18723 | 1.40e-14 | 3.53e-12 | 25 |
GO:00329813 | Colorectum | MSI-H | mitochondrial respiratory chain complex I assembly | 25/1319 | 57/18723 | 1.40e-14 | 3.53e-12 | 25 |
GO:00331083 | Colorectum | MSI-H | mitochondrial respiratory chain complex assembly | 30/1319 | 93/18723 | 5.71e-13 | 1.27e-10 | 30 |
GO:001025710 | Endometrium | AEH | NADH dehydrogenase complex assembly | 25/2100 | 57/18723 | 4.20e-10 | 4.20e-08 | 25 |
GO:003298110 | Endometrium | AEH | mitochondrial respiratory chain complex I assembly | 25/2100 | 57/18723 | 4.20e-10 | 4.20e-08 | 25 |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0019032 | Liver | HCC | Oxidative phosphorylation | 103/4020 | 134/8465 | 2.39e-12 | 5.01e-11 | 2.79e-11 | 103 |
hsa0502232 | Liver | HCC | Pathways of neurodegeneration - multiple diseases | 298/4020 | 476/8465 | 6.59e-12 | 1.30e-10 | 7.22e-11 | 298 |
hsa0501242 | Liver | Cyst | Parkinson disease | 46/339 | 266/8465 | 1.10e-17 | 1.06e-15 | 8.75e-16 | 46 |
hsa0520862 | Liver | Cyst | Chemical carcinogenesis - reactive oxygen species | 40/339 | 223/8465 | 4.80e-16 | 3.45e-14 | 2.85e-14 | 40 |
hsa0019042 | Liver | Cyst | Oxidative phosphorylation | 30/339 | 134/8465 | 5.65e-15 | 3.25e-13 | 2.69e-13 | 30 |
hsa0493262 | Liver | Cyst | Non-alcoholic fatty liver disease | 32/339 | 155/8465 | 7.91e-15 | 3.80e-13 | 3.14e-13 | 32 |
hsa0502042 | Liver | Cyst | Prion disease | 42/339 | 273/8465 | 2.36e-14 | 9.70e-13 | 8.01e-13 | 42 |
hsa0541542 | Liver | Cyst | Diabetic cardiomyopathy | 34/339 | 203/8465 | 6.93e-13 | 2.50e-11 | 2.06e-11 | 34 |
hsa0501642 | Liver | Cyst | Huntington disease | 42/339 | 306/8465 | 1.27e-12 | 4.06e-11 | 3.35e-11 | 42 |
hsa0501442 | Liver | Cyst | Amyotrophic lateral sclerosis | 46/339 | 364/8465 | 1.99e-12 | 5.74e-11 | 4.75e-11 | 46 |
hsa0471442 | Liver | Cyst | Thermogenesis | 34/339 | 232/8465 | 3.33e-11 | 8.73e-10 | 7.21e-10 | 34 |
hsa0502242 | Liver | Cyst | Pathways of neurodegeneration - multiple diseases | 51/339 | 476/8465 | 6.22e-11 | 1.49e-09 | 1.23e-09 | 51 |
hsa0501042 | Liver | Cyst | Alzheimer disease | 44/339 | 384/8465 | 1.72e-10 | 3.81e-09 | 3.15e-09 | 44 |
hsa0472322 | Liver | Cyst | Retrograde endocannabinoid signaling | 17/339 | 148/8465 | 8.32e-05 | 1.20e-03 | 9.90e-04 | 17 |
hsa0501252 | Liver | Cyst | Parkinson disease | 46/339 | 266/8465 | 1.10e-17 | 1.06e-15 | 8.75e-16 | 46 |
hsa0520872 | Liver | Cyst | Chemical carcinogenesis - reactive oxygen species | 40/339 | 223/8465 | 4.80e-16 | 3.45e-14 | 2.85e-14 | 40 |
hsa0019052 | Liver | Cyst | Oxidative phosphorylation | 30/339 | 134/8465 | 5.65e-15 | 3.25e-13 | 2.69e-13 | 30 |
hsa0493272 | Liver | Cyst | Non-alcoholic fatty liver disease | 32/339 | 155/8465 | 7.91e-15 | 3.80e-13 | 3.14e-13 | 32 |
hsa0502052 | Liver | Cyst | Prion disease | 42/339 | 273/8465 | 2.36e-14 | 9.70e-13 | 8.01e-13 | 42 |
hsa0541552 | Liver | Cyst | Diabetic cardiomyopathy | 34/339 | 203/8465 | 6.93e-13 | 2.50e-11 | 2.06e-11 | 34 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
NDUFB11 | SNV | Missense_Mutation | novel | c.406G>T | p.Val136Leu | p.V136L | Q9NX14 | protein_coding | tolerated(0.25) | possibly_damaging(0.472) | TCGA-E9-A22A-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | SD |
NDUFB11 | SNV | Missense_Mutation | rs781871228 | c.140G>A | p.Arg47Gln | p.R47Q | Q9NX14 | protein_coding | tolerated(0.19) | benign(0.086) | TCGA-C5-A2LZ-01 | Cervix | cervical & endocervical cancer | Female | >=65 | III/IV | Unknown | Unknown | PD |
NDUFB11 | SNV | Missense_Mutation | rs782460503 | c.386N>A | p.Arg129His | p.R129H | Q9NX14 | protein_coding | deleterious(0.02) | benign(0.103) | TCGA-EA-A3HT-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD |
NDUFB11 | SNV | Missense_Mutation | | c.263N>C | p.Arg88Pro | p.R88P | Q9NX14 | protein_coding | deleterious(0) | probably_damaging(0.946) | TCGA-Q1-A73P-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
NDUFB11 | SNV | Missense_Mutation | novel | c.11N>A | p.Gly4Glu | p.G4E | Q9NX14 | protein_coding | tolerated_low_confidence(0.07) | benign(0.031) | TCGA-AA-A01P-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD |
NDUFB11 | SNV | Missense_Mutation | novel | c.233A>C | p.Lys78Thr | p.K78T | Q9NX14 | protein_coding | tolerated(0.19) | benign(0.122) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
NDUFB11 | SNV | Missense_Mutation | rs782682185 | c.283G>A | p.Val95Ile | p.V95I | Q9NX14 | protein_coding | tolerated(1) | benign(0.009) | TCGA-AJ-A3BG-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | PD |
NDUFB11 | SNV | Missense_Mutation | rs782460503 | c.386N>A | p.Arg129His | p.R129H | Q9NX14 | protein_coding | deleterious(0.02) | benign(0.103) | TCGA-AJ-A3EL-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
NDUFB11 | SNV | Missense_Mutation | rs782460503 | c.386N>A | p.Arg129His | p.R129H | Q9NX14 | protein_coding | deleterious(0.02) | benign(0.103) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
NDUFB11 | SNV | Missense_Mutation | | c.263N>A | p.Arg88Gln | p.R88Q | Q9NX14 | protein_coding | tolerated(0.09) | benign(0.095) | TCGA-AP-A1DV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |