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Gene: ATP5F1E |
Gene summary for ATP5F1E |
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Gene information | Species | Human | Gene symbol | ATP5F1E | Gene ID | 514 |
Gene name | ATP synthase F1 subunit epsilon | |
Gene Alias | ATP5E | |
Cytomap | 20q13.32 | |
Gene Type | protein-coding | GO ID | GO:0006091 | UniProtAcc | P56381 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
514 | ATP5F1E | GSM4909281 | Human | Breast | IDC | 2.59e-20 | 3.75e-01 | 0.21 |
514 | ATP5F1E | GSM4909282 | Human | Breast | IDC | 6.02e-23 | 5.15e-01 | -0.0288 |
514 | ATP5F1E | GSM4909285 | Human | Breast | IDC | 5.53e-35 | 2.69e-01 | 0.21 |
514 | ATP5F1E | GSM4909286 | Human | Breast | IDC | 5.99e-32 | 5.51e-01 | 0.1081 |
514 | ATP5F1E | GSM4909287 | Human | Breast | IDC | 2.39e-31 | 5.99e-01 | 0.2057 |
514 | ATP5F1E | GSM4909289 | Human | Breast | IDC | 1.97e-07 | 5.66e-01 | 0.1064 |
514 | ATP5F1E | GSM4909290 | Human | Breast | IDC | 1.59e-31 | 6.51e-01 | 0.2096 |
514 | ATP5F1E | GSM4909291 | Human | Breast | IDC | 6.17e-30 | 6.76e-01 | 0.1753 |
514 | ATP5F1E | GSM4909293 | Human | Breast | IDC | 7.20e-55 | 7.54e-01 | 0.1581 |
514 | ATP5F1E | GSM4909294 | Human | Breast | IDC | 9.29e-35 | 7.31e-01 | 0.2022 |
514 | ATP5F1E | GSM4909295 | Human | Breast | IDC | 3.16e-09 | 4.75e-01 | 0.0898 |
514 | ATP5F1E | GSM4909296 | Human | Breast | IDC | 1.30e-27 | 6.74e-01 | 0.1524 |
514 | ATP5F1E | GSM4909297 | Human | Breast | IDC | 5.82e-32 | 6.23e-01 | 0.1517 |
514 | ATP5F1E | GSM4909298 | Human | Breast | IDC | 5.11e-49 | 7.58e-01 | 0.1551 |
514 | ATP5F1E | GSM4909299 | Human | Breast | IDC | 5.87e-25 | 5.76e-01 | 0.035 |
514 | ATP5F1E | GSM4909300 | Human | Breast | IDC | 1.43e-13 | 5.15e-01 | 0.0334 |
514 | ATP5F1E | GSM4909301 | Human | Breast | IDC | 4.92e-108 | 9.88e-01 | 0.1577 |
514 | ATP5F1E | GSM4909302 | Human | Breast | IDC | 3.46e-20 | 5.01e-01 | 0.1545 |
514 | ATP5F1E | GSM4909303 | Human | Breast | IDC | 1.44e-14 | 6.74e-01 | 0.0438 |
514 | ATP5F1E | GSM4909304 | Human | Breast | IDC | 9.25e-81 | 8.84e-01 | 0.1636 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00460349 | Breast | Precancer | ATP metabolic process | 82/1080 | 277/18723 | 1.94e-36 | 5.19e-33 | 82 |
GO:00061199 | Breast | Precancer | oxidative phosphorylation | 53/1080 | 141/18723 | 1.15e-29 | 2.04e-26 | 53 |
GO:00090608 | Breast | Precancer | aerobic respiration | 58/1080 | 189/18723 | 5.69e-27 | 7.62e-24 | 58 |
GO:00060918 | Breast | Precancer | generation of precursor metabolites and energy | 94/1080 | 490/18723 | 1.54e-25 | 1.64e-22 | 94 |
GO:00453338 | Breast | Precancer | cellular respiration | 59/1080 | 230/18723 | 5.97e-23 | 5.32e-20 | 59 |
GO:00159808 | Breast | Precancer | energy derivation by oxidation of organic compounds | 70/1080 | 318/18723 | 8.33e-23 | 6.37e-20 | 70 |
GO:19026008 | Breast | Precancer | proton transmembrane transport | 39/1080 | 157/18723 | 4.18e-15 | 1.18e-12 | 39 |
GO:00159857 | Breast | Precancer | energy coupled proton transport, down electrochemical gradient | 16/1080 | 26/18723 | 4.15e-14 | 9.65e-12 | 16 |
GO:00159867 | Breast | Precancer | ATP synthesis coupled proton transport | 16/1080 | 26/18723 | 4.15e-14 | 9.65e-12 | 16 |
GO:00427766 | Breast | Precancer | mitochondrial ATP synthesis coupled proton transport | 13/1080 | 19/18723 | 1.43e-12 | 2.74e-10 | 13 |
GO:00067547 | Breast | Precancer | ATP biosynthetic process | 21/1080 | 57/18723 | 2.31e-12 | 4.26e-10 | 21 |
GO:00068398 | Breast | Precancer | mitochondrial transport | 45/1080 | 254/18723 | 1.37e-11 | 1.88e-09 | 45 |
GO:00092067 | Breast | Precancer | purine ribonucleoside triphosphate biosynthetic process | 22/1080 | 68/18723 | 1.41e-11 | 1.88e-09 | 22 |
GO:00091457 | Breast | Precancer | purine nucleoside triphosphate biosynthetic process | 22/1080 | 69/18723 | 1.95e-11 | 2.43e-09 | 22 |
GO:00092017 | Breast | Precancer | ribonucleoside triphosphate biosynthetic process | 22/1080 | 74/18723 | 9.18e-11 | 1.00e-08 | 22 |
GO:00091448 | Breast | Precancer | purine nucleoside triphosphate metabolic process | 24/1080 | 88/18723 | 9.66e-11 | 1.03e-08 | 24 |
GO:00092057 | Breast | Precancer | purine ribonucleoside triphosphate metabolic process | 23/1080 | 82/18723 | 1.27e-10 | 1.34e-08 | 23 |
GO:00091427 | Breast | Precancer | nucleoside triphosphate biosynthetic process | 23/1080 | 85/18723 | 2.82e-10 | 2.69e-08 | 23 |
GO:00091997 | Breast | Precancer | ribonucleoside triphosphate metabolic process | 23/1080 | 89/18723 | 7.65e-10 | 6.66e-08 | 23 |
GO:00091418 | Breast | Precancer | nucleoside triphosphate metabolic process | 26/1080 | 112/18723 | 7.72e-10 | 6.66e-08 | 26 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0019032 | Liver | HCC | Oxidative phosphorylation | 103/4020 | 134/8465 | 2.39e-12 | 5.01e-11 | 2.79e-11 | 103 |
hsa0502232 | Liver | HCC | Pathways of neurodegeneration - multiple diseases | 298/4020 | 476/8465 | 6.59e-12 | 1.30e-10 | 7.22e-11 | 298 |
hsa0520816 | Lung | IAC | Chemical carcinogenesis - reactive oxygen species | 51/1053 | 223/8465 | 8.45e-06 | 2.14e-04 | 1.42e-04 | 51 |
hsa0471416 | Lung | IAC | Thermogenesis | 46/1053 | 232/8465 | 7.85e-04 | 6.38e-03 | 4.23e-03 | 46 |
hsa0541516 | Lung | IAC | Diabetic cardiomyopathy | 38/1053 | 203/8465 | 6.01e-03 | 2.57e-02 | 1.71e-02 | 38 |
hsa0501216 | Lung | IAC | Parkinson disease | 47/1053 | 266/8465 | 7.53e-03 | 3.02e-02 | 2.01e-02 | 47 |
hsa0520817 | Lung | IAC | Chemical carcinogenesis - reactive oxygen species | 51/1053 | 223/8465 | 8.45e-06 | 2.14e-04 | 1.42e-04 | 51 |
hsa0471417 | Lung | IAC | Thermogenesis | 46/1053 | 232/8465 | 7.85e-04 | 6.38e-03 | 4.23e-03 | 46 |
hsa0541517 | Lung | IAC | Diabetic cardiomyopathy | 38/1053 | 203/8465 | 6.01e-03 | 2.57e-02 | 1.71e-02 | 38 |
hsa0501217 | Lung | IAC | Parkinson disease | 47/1053 | 266/8465 | 7.53e-03 | 3.02e-02 | 2.01e-02 | 47 |
hsa0501428 | Oral cavity | OSCC | Amyotrophic lateral sclerosis | 246/3704 | 364/8465 | 6.65e-21 | 1.11e-18 | 5.67e-19 | 246 |
hsa0501230 | Oral cavity | OSCC | Parkinson disease | 188/3704 | 266/8465 | 1.82e-19 | 1.52e-17 | 7.75e-18 | 188 |
hsa0501628 | Oral cavity | OSCC | Huntington disease | 204/3704 | 306/8465 | 1.70e-16 | 7.13e-15 | 3.63e-15 | 204 |
hsa0501028 | Oral cavity | OSCC | Alzheimer disease | 244/3704 | 384/8465 | 1.18e-15 | 3.60e-14 | 1.83e-14 | 244 |
hsa0502228 | Oral cavity | OSCC | Pathways of neurodegeneration - multiple diseases | 292/3704 | 476/8465 | 1.60e-15 | 4.47e-14 | 2.28e-14 | 292 |
hsa0502028 | Oral cavity | OSCC | Prion disease | 181/3704 | 273/8465 | 2.05e-14 | 5.30e-13 | 2.70e-13 | 181 |
hsa0520830 | Oral cavity | OSCC | Chemical carcinogenesis - reactive oxygen species | 150/3704 | 223/8465 | 6.45e-13 | 1.20e-11 | 6.11e-12 | 150 |
hsa0541529 | Oral cavity | OSCC | Diabetic cardiomyopathy | 131/3704 | 203/8465 | 1.33e-09 | 1.49e-08 | 7.57e-09 | 131 |
hsa0471430 | Oral cavity | OSCC | Thermogenesis | 138/3704 | 232/8465 | 7.67e-07 | 4.35e-06 | 2.22e-06 | 138 |
hsa05014112 | Oral cavity | OSCC | Amyotrophic lateral sclerosis | 246/3704 | 364/8465 | 6.65e-21 | 1.11e-18 | 5.67e-19 | 246 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
514 | ATP5F1E | TRANSPORTER | glucocorticoids | 26307125 | ||
514 | ATP5F1E | TRANSPORTER | etanercept | ETANERCEPT | 26307125 | |
514 | ATP5F1E | TRANSPORTER | adalimumab | ADALIMUMAB | 26307125 | |
514 | ATP5F1E | TRANSPORTER | certolizumab pegol | 26307125 | ||
514 | ATP5F1E | TRANSPORTER | methotrexate | METHOTREXATE | 26307125 | |
514 | ATP5F1E | TRANSPORTER | infliximab | INFLIXIMAB | 26307125 |
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