Tissue | Expression Dynamics | Abbreviation |
Cervix | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Cervix/STAT3_pca_on_diff_genes.png) | CC: Cervix cancer |
HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions |
N_HPV: HPV-infected normal cervix |
Colorectum (GSE201348) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Becker/STAT3_pca_on_diff_genes.png) | FAP: Familial adenomatous polyposis |
CRC: Colorectal cancer |
Colorectum (HTA11) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Chen/STAT3_pca_on_diff_genes.png) | AD: Adenomas |
SER: Sessile serrated lesions |
MSI-H: Microsatellite-high colorectal cancer |
MSS: Microsatellite stable colorectal cancer |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/STAT3_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/STAT3_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Lung | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Lung/STAT3_pca_on_diff_genes.png) | AAH: Atypical adenomatous hyperplasia |
AIS: Adenocarcinoma in situ |
IAC: Invasive lung adenocarcinoma |
MIA: Minimally invasive adenocarcinoma |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/STAT3_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Prostate | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Prostate/STAT3_pca_on_diff_genes.png) | BPH: Benign Prostatic Hyperplasia |
Skin | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Skin/STAT3_pca_on_diff_genes.png) | AK: Actinic keratosis |
cSCC: Cutaneous squamous cell carcinoma |
SCCIS:squamous cell carcinoma in situ |
Thyroid | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Thyroid/STAT3_pca_on_diff_genes.png) | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:004603410 | Cervix | CC | ATP metabolic process | 90/2311 | 277/18723 | 7.90e-19 | 2.36e-15 | 90 |
GO:005254710 | Cervix | CC | regulation of peptidase activity | 112/2311 | 461/18723 | 6.70e-13 | 3.08e-10 | 112 |
GO:004586210 | Cervix | CC | positive regulation of proteolysis | 95/2311 | 372/18723 | 1.84e-12 | 6.86e-10 | 95 |
GO:005254810 | Cervix | CC | regulation of endopeptidase activity | 103/2311 | 432/18723 | 1.89e-11 | 5.14e-09 | 103 |
GO:00725949 | Cervix | CC | establishment of protein localization to organelle | 99/2311 | 422/18723 | 1.23e-10 | 2.11e-08 | 99 |
GO:00421108 | Cervix | CC | T cell activation | 107/2311 | 487/18723 | 1.24e-09 | 1.46e-07 | 107 |
GO:00506737 | Cervix | CC | epithelial cell proliferation | 98/2311 | 437/18723 | 2.01e-09 | 2.15e-07 | 98 |
GO:00060919 | Cervix | CC | generation of precursor metabolites and energy | 105/2311 | 490/18723 | 7.40e-09 | 6.61e-07 | 105 |
GO:001095210 | Cervix | CC | positive regulation of peptidase activity | 54/2311 | 197/18723 | 8.06e-09 | 6.99e-07 | 54 |
GO:00069139 | Cervix | CC | nucleocytoplasmic transport | 71/2311 | 301/18723 | 4.04e-08 | 2.54e-06 | 71 |
GO:00511699 | Cervix | CC | nuclear transport | 71/2311 | 301/18723 | 4.04e-08 | 2.54e-06 | 71 |
GO:00345048 | Cervix | CC | protein localization to nucleus | 68/2311 | 290/18723 | 9.91e-08 | 5.25e-06 | 68 |
GO:003133010 | Cervix | CC | negative regulation of cellular catabolic process | 63/2311 | 262/18723 | 1.10e-07 | 5.68e-06 | 63 |
GO:001095010 | Cervix | CC | positive regulation of endopeptidase activity | 48/2311 | 179/18723 | 1.12e-07 | 5.71e-06 | 48 |
GO:003009910 | Cervix | CC | myeloid cell differentiation | 83/2311 | 381/18723 | 1.31e-07 | 6.42e-06 | 83 |
GO:00506787 | Cervix | CC | regulation of epithelial cell proliferation | 83/2311 | 381/18723 | 1.31e-07 | 6.42e-06 | 83 |
GO:190370610 | Cervix | CC | regulation of hemopoiesis | 80/2311 | 367/18723 | 2.14e-07 | 9.55e-06 | 80 |
GO:000226210 | Cervix | CC | myeloid cell homeostasis | 43/2311 | 157/18723 | 2.66e-07 | 1.12e-05 | 43 |
GO:00075689 | Cervix | CC | aging | 75/2311 | 339/18723 | 2.75e-07 | 1.13e-05 | 75 |
GO:00091449 | Cervix | CC | purine nucleoside triphosphate metabolic process | 29/2311 | 88/18723 | 3.62e-07 | 1.45e-05 | 29 |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0514531 | Liver | HCC | Toxoplasmosis | 70/4020 | 112/8465 | 9.25e-04 | 3.52e-03 | 1.96e-03 | 70 |
hsa0516031 | Liver | HCC | Hepatitis C | 94/4020 | 157/8465 | 1.11e-03 | 4.10e-03 | 2.28e-03 | 94 |
hsa049203 | Liver | HCC | Adipocytokine signaling pathway | 45/4020 | 69/8465 | 2.19e-03 | 7.55e-03 | 4.20e-03 | 45 |
hsa0493311 | Liver | HCC | AGE-RAGE signaling pathway in diabetic complications | 62/4020 | 100/8465 | 2.35e-03 | 7.95e-03 | 4.42e-03 | 62 |
hsa052033 | Liver | HCC | Viral carcinogenesis | 117/4020 | 204/8465 | 2.68e-03 | 8.98e-03 | 5.00e-03 | 117 |
hsa0522311 | Liver | HCC | Non-small cell lung cancer | 46/4020 | 72/8465 | 3.61e-03 | 1.12e-02 | 6.22e-03 | 46 |
hsa0516731 | Liver | HCC | Kaposi sarcoma-associated herpesvirus infection | 111/4020 | 194/8465 | 3.78e-03 | 1.16e-02 | 6.45e-03 | 111 |
hsa0152131 | Liver | HCC | EGFR tyrosine kinase inhibitor resistance | 48/4020 | 79/8465 | 1.19e-02 | 2.99e-02 | 1.66e-02 | 48 |
hsa049171 | Liver | HCC | Prolactin signaling pathway | 43/4020 | 70/8465 | 1.30e-02 | 3.19e-02 | 1.78e-02 | 43 |
hsa0516111 | Liver | HCC | Hepatitis B | 91/4020 | 162/8465 | 1.56e-02 | 3.76e-02 | 2.09e-02 | 91 |
hsa052211 | Liver | HCC | Acute myeloid leukemia | 41/4020 | 67/8465 | 1.64e-02 | 3.90e-02 | 2.17e-02 | 41 |
hsa0541752 | Liver | HCC | Lipid and atherosclerosis | 118/4020 | 215/8465 | 1.66e-02 | 3.92e-02 | 2.18e-02 | 118 |
hsa0517116 | Lung | IAC | Coronavirus disease - COVID-19 | 102/1053 | 232/8465 | 5.89e-34 | 1.91e-31 | 1.27e-31 | 102 |
hsa0520512 | Lung | IAC | Proteoglycans in cancer | 53/1053 | 205/8465 | 9.47e-08 | 6.16e-06 | 4.09e-06 | 53 |
hsa0516716 | Lung | IAC | Kaposi sarcoma-associated herpesvirus infection | 46/1053 | 194/8465 | 8.58e-06 | 2.14e-04 | 1.42e-04 | 46 |
hsa0541716 | Lung | IAC | Lipid and atherosclerosis | 48/1053 | 215/8465 | 3.02e-05 | 6.14e-04 | 4.08e-04 | 48 |
hsa0516314 | Lung | IAC | Human cytomegalovirus infection | 47/1053 | 225/8465 | 2.01e-04 | 2.42e-03 | 1.61e-03 | 47 |
hsa052034 | Lung | IAC | Viral carcinogenesis | 43/1053 | 204/8465 | 3.02e-04 | 3.07e-03 | 2.04e-03 | 43 |
hsa04659 | Lung | IAC | Th17 cell differentiation | 26/1053 | 108/8465 | 5.91e-04 | 5.34e-03 | 3.54e-03 | 26 |
hsa049335 | Lung | IAC | AGE-RAGE signaling pathway in diabetic complications | 24/1053 | 100/8465 | 9.91e-04 | 7.32e-03 | 4.86e-03 | 24 |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
STAT3 | TREG | Endometrium | ADJ | GNA12,STAT5B,TNFRSF9, etc. | 6.57e-02 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Endometrium/Str/TF_ADJ/regulons_activity_in_dotplot.png) |
STAT3 | TREG | Endometrium | AEH | GNA12,STAT5B,TNFRSF9, etc. | 1.64e-01 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Endometrium/Str/TF_AEH/regulons_activity_in_dotplot.png) |
STAT3 | CD8TEREX | Endometrium | AEH | GNA12,STAT5B,TNFRSF9, etc. | 1.21e-01 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Endometrium/Str/TF_AEH/regulons_activity_in_dotplot.png) |
STAT3 | TREG | Endometrium | EEC | GNA12,STAT5B,TNFRSF9, etc. | 1.34e-01 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Endometrium/Str/TF_EEC/regulons_activity_in_dotplot.png) |
STAT3 | CD8TEREX | Endometrium | EEC | GNA12,STAT5B,TNFRSF9, etc. | 2.12e-01 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Endometrium/Str/TF_EEC/regulons_activity_in_dotplot.png) |
STAT3 | STM | Esophagus | ESCC | ALDH9A1,MALAT1,ETV6, etc. | 4.44e-01 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Esophagus/Str/TF_ESCC/regulons_activity_in_dotplot.png) |
STAT3 | CD8TEXINT | Lung | ADJ | SLC2A3,CRYBG1,RAPGEF6, etc. | 1.13e-01 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Lung/Str/TF_ADJ/regulons_activity_in_dotplot.png) |
STAT3 | CD8TEXP | Lung | ADJ | SLC2A3,CRYBG1,RAPGEF6, etc. | 1.21e-01 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Lung/Str/TF_ADJ/regulons_activity_in_dotplot.png) |
STAT3 | MDSC | Lung | Healthy | TAPBP,RSPH3,WARS, etc. | 8.71e-01 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Lung/Str/TF_Healthy/regulons_activity_in_dotplot.png) |
STAT3 | MAIT | Oral cavity | NEOLP | HBP1,DPY19L1,VPS37B, etc. | 1.89e-01 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/OralCavity/Str/TF_NEOLP/regulons_activity_in_dotplot.png) |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
STAT3 | SNV | Missense_Mutation | novel | c.28C>G | p.Leu10Val | p.L10V | P40763 | protein_coding | deleterious(0) | probably_damaging(0.982) | TCGA-A7-A6VX-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | docetaxel | CR |
STAT3 | SNV | Missense_Mutation | | c.2171N>C | p.Leu724Pro | p.L724P | P40763 | protein_coding | tolerated(0.13) | possibly_damaging(0.641) | TCGA-A8-A09Z-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
STAT3 | SNV | Missense_Mutation | novel | c.1692N>T | p.Trp564Cys | p.W564C | P40763 | protein_coding | deleterious(0.02) | benign(0.015) | TCGA-AC-A8OS-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
STAT3 | SNV | Missense_Mutation | | c.1229N>G | p.His410Arg | p.H410R | P40763 | protein_coding | deleterious(0) | probably_damaging(0.927) | TCGA-AO-A128-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD |
STAT3 | SNV | Missense_Mutation | rs113994137 | c.1268N>A | p.Arg423Gln | p.R423Q | P40763 | protein_coding | deleterious(0.01) | probably_damaging(0.979) | TCGA-BH-A0B0-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | CR |
STAT3 | SNV | Missense_Mutation | | c.1855G>C | p.Val619Leu | p.V619L | P40763 | protein_coding | deleterious(0) | benign(0.029) | TCGA-BH-A1F0-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
STAT3 | SNV | Missense_Mutation | | c.1151T>A | p.Phe384Tyr | p.F384Y | P40763 | protein_coding | deleterious(0.02) | probably_damaging(0.978) | TCGA-D8-A1JK-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
STAT3 | SNV | Missense_Mutation | | c.364N>A | p.Ala122Thr | p.A122T | P40763 | protein_coding | tolerated(0.59) | benign(0.006) | TCGA-E9-A1R7-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | fareston | SD |
STAT3 | SNV | Missense_Mutation | | c.1907N>T | p.Ser636Phe | p.S636F | P40763 | protein_coding | deleterious(0) | probably_damaging(0.993) | TCGA-GM-A2D9-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD |
STAT3 | SNV | Missense_Mutation | novel | c.934C>A | p.Leu312Met | p.L312M | P40763 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-OL-A6VQ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
6774 | STAT3 | DRUGGABLE GENOME, CLINICALLY ACTIONABLE, NUCLEAR HORMONE RECEPTOR, TRANSCRIPTION FACTOR COMPLEX, TUMOR SUPPRESSOR, KINASE | | NICLOSAMIDE | NICLOSAMIDE | |
6774 | STAT3 | DRUGGABLE GENOME, CLINICALLY ACTIONABLE, NUCLEAR HORMONE RECEPTOR, TRANSCRIPTION FACTOR COMPLEX, TUMOR SUPPRESSOR, KINASE | | Gold-complexed thiosaccharide derivative 3 | | |
6774 | STAT3 | DRUGGABLE GENOME, CLINICALLY ACTIONABLE, NUCLEAR HORMONE RECEPTOR, TRANSCRIPTION FACTOR COMPLEX, TUMOR SUPPRESSOR, KINASE | | Platinum IV complexe 1 | | |
6774 | STAT3 | DRUGGABLE GENOME, CLINICALLY ACTIONABLE, NUCLEAR HORMONE RECEPTOR, TRANSCRIPTION FACTOR COMPLEX, TUMOR SUPPRESSOR, KINASE | | GNF-PF-1399 | CHEMBL578504 | |
6774 | STAT3 | DRUGGABLE GENOME, CLINICALLY ACTIONABLE, NUCLEAR HORMONE RECEPTOR, TRANSCRIPTION FACTOR COMPLEX, TUMOR SUPPRESSOR, KINASE | | Salicylic acid derivative 3 | | |
6774 | STAT3 | DRUGGABLE GENOME, CLINICALLY ACTIONABLE, NUCLEAR HORMONE RECEPTOR, TRANSCRIPTION FACTOR COMPLEX, TUMOR SUPPRESSOR, KINASE | | Peptide analog 7 | | |
6774 | STAT3 | DRUGGABLE GENOME, CLINICALLY ACTIONABLE, NUCLEAR HORMONE RECEPTOR, TRANSCRIPTION FACTOR COMPLEX, TUMOR SUPPRESSOR, KINASE | | CELECOXIB | CELECOXIB | 21678971 |
6774 | STAT3 | DRUGGABLE GENOME, CLINICALLY ACTIONABLE, NUCLEAR HORMONE RECEPTOR, TRANSCRIPTION FACTOR COMPLEX, TUMOR SUPPRESSOR, KINASE | | TAK-114 | | |
6774 | STAT3 | DRUGGABLE GENOME, CLINICALLY ACTIONABLE, NUCLEAR HORMONE RECEPTOR, TRANSCRIPTION FACTOR COMPLEX, TUMOR SUPPRESSOR, KINASE | | Salicylic acid derivative 1 | | |
6774 | STAT3 | DRUGGABLE GENOME, CLINICALLY ACTIONABLE, NUCLEAR HORMONE RECEPTOR, TRANSCRIPTION FACTOR COMPLEX, TUMOR SUPPRESSOR, KINASE | | AZD-1480 | AZD-1480 | 21138246,24978112 |