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Gene: PPP3R1 |
Gene summary for PPP3R1 |
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Gene information | Species | Human | Gene symbol | PPP3R1 | Gene ID | 5534 |
Gene name | protein phosphatase 3 regulatory subunit B, alpha | |
Gene Alias | CALNB1 | |
Cytomap | 2p14 | |
Gene Type | protein-coding | GO ID | GO:0001525 | UniProtAcc | P63098 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
5534 | PPP3R1 | AEH-subject1 | Human | Endometrium | AEH | 3.29e-14 | 4.65e-01 | -0.3059 |
5534 | PPP3R1 | AEH-subject2 | Human | Endometrium | AEH | 2.91e-06 | 3.77e-01 | -0.2525 |
5534 | PPP3R1 | AEH-subject3 | Human | Endometrium | AEH | 2.40e-06 | 3.49e-01 | -0.2576 |
5534 | PPP3R1 | AEH-subject4 | Human | Endometrium | AEH | 1.14e-04 | 3.63e-01 | -0.2657 |
5534 | PPP3R1 | AEH-subject5 | Human | Endometrium | AEH | 1.72e-19 | 5.97e-01 | -0.2953 |
5534 | PPP3R1 | EEC-subject1 | Human | Endometrium | EEC | 1.18e-12 | 5.02e-01 | -0.2682 |
5534 | PPP3R1 | EEC-subject3 | Human | Endometrium | EEC | 2.09e-02 | 2.10e-01 | -0.2525 |
5534 | PPP3R1 | GSM6177620_NYU_UCEC1_lib1_lib1 | Human | Endometrium | EEC | 4.88e-03 | 9.77e-02 | -0.1869 |
5534 | PPP3R1 | GSM6177620_NYU_UCEC1_lib2_lib2 | Human | Endometrium | EEC | 2.45e-05 | 4.03e-02 | -0.1875 |
5534 | PPP3R1 | GSM6177620_NYU_UCEC1_lib3_lib3 | Human | Endometrium | EEC | 1.21e-04 | 6.52e-02 | -0.1883 |
5534 | PPP3R1 | GSM6177622_NYU_UCEC3_lib1_lib1 | Human | Endometrium | EEC | 2.38e-05 | 1.02e-01 | -0.1917 |
5534 | PPP3R1 | GSM6177622_NYU_UCEC3_lib2_lib2 | Human | Endometrium | EEC | 1.38e-07 | 9.63e-02 | -0.1916 |
5534 | PPP3R1 | LZE4T | Human | Esophagus | ESCC | 5.99e-03 | 2.22e-02 | 0.0811 |
5534 | PPP3R1 | LZE24T | Human | Esophagus | ESCC | 1.08e-14 | 1.77e-01 | 0.0596 |
5534 | PPP3R1 | P1T-E | Human | Esophagus | ESCC | 2.58e-04 | 4.30e-01 | 0.0875 |
5534 | PPP3R1 | P2T-E | Human | Esophagus | ESCC | 8.15e-44 | 7.82e-01 | 0.1177 |
5534 | PPP3R1 | P4T-E | Human | Esophagus | ESCC | 6.56e-22 | 4.65e-01 | 0.1323 |
5534 | PPP3R1 | P5T-E | Human | Esophagus | ESCC | 3.84e-08 | 2.11e-01 | 0.1327 |
5534 | PPP3R1 | P8T-E | Human | Esophagus | ESCC | 2.56e-15 | 1.43e-01 | 0.0889 |
5534 | PPP3R1 | P9T-E | Human | Esophagus | ESCC | 5.49e-07 | 1.50e-01 | 0.1131 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:007259410 | Endometrium | AEH | establishment of protein localization to organelle | 89/2100 | 422/18723 | 2.41e-09 | 1.90e-07 | 89 |
GO:00605627 | Endometrium | AEH | epithelial tube morphogenesis | 63/2100 | 325/18723 | 9.63e-06 | 2.23e-04 | 63 |
GO:00345049 | Endometrium | AEH | protein localization to nucleus | 57/2100 | 290/18723 | 1.65e-05 | 3.42e-04 | 57 |
GO:00611384 | Endometrium | AEH | morphogenesis of a branching epithelium | 40/2100 | 182/18723 | 2.16e-05 | 4.20e-04 | 40 |
GO:00482598 | Endometrium | AEH | regulation of receptor-mediated endocytosis | 28/2100 | 110/18723 | 2.28e-05 | 4.35e-04 | 28 |
GO:00017637 | Endometrium | AEH | morphogenesis of a branching structure | 42/2100 | 196/18723 | 2.58e-05 | 4.86e-04 | 42 |
GO:00301009 | Endometrium | AEH | regulation of endocytosis | 44/2100 | 211/18723 | 3.39e-05 | 6.05e-04 | 44 |
GO:00068988 | Endometrium | AEH | receptor-mediated endocytosis | 49/2100 | 244/18723 | 3.54e-05 | 6.24e-04 | 49 |
GO:00487542 | Endometrium | AEH | branching morphogenesis of an epithelial tube | 33/2100 | 151/18723 | 1.22e-04 | 1.68e-03 | 33 |
GO:00487625 | Endometrium | AEH | mesenchymal cell differentiation | 46/2100 | 236/18723 | 1.27e-04 | 1.74e-03 | 46 |
GO:00604853 | Endometrium | AEH | mesenchyme development | 54/2100 | 291/18723 | 1.34e-04 | 1.83e-03 | 54 |
GO:00431128 | Endometrium | AEH | receptor metabolic process | 35/2100 | 166/18723 | 1.64e-04 | 2.15e-03 | 35 |
GO:00316237 | Endometrium | AEH | receptor internalization | 26/2100 | 113/18723 | 2.62e-04 | 3.08e-03 | 26 |
GO:00018375 | Endometrium | AEH | epithelial to mesenchymal transition | 33/2100 | 157/18723 | 2.64e-04 | 3.09e-03 | 33 |
GO:000691310 | Endometrium | AEH | nucleocytoplasmic transport | 54/2100 | 301/18723 | 3.24e-04 | 3.62e-03 | 54 |
GO:005116910 | Endometrium | AEH | nuclear transport | 54/2100 | 301/18723 | 3.24e-04 | 3.62e-03 | 54 |
GO:00064709 | Endometrium | AEH | protein dephosphorylation | 50/2100 | 281/18723 | 6.41e-04 | 6.23e-03 | 50 |
GO:00020902 | Endometrium | AEH | regulation of receptor internalization | 15/2100 | 56/18723 | 9.88e-04 | 8.90e-03 | 15 |
GO:00605414 | Endometrium | AEH | respiratory system development | 37/2100 | 203/18723 | 1.97e-03 | 1.54e-02 | 37 |
GO:00303246 | Endometrium | AEH | lung development | 33/2100 | 177/18723 | 2.30e-03 | 1.74e-02 | 33 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa043803 | Oral cavity | EOLP | Osteoclast differentiation | 44/1218 | 128/8465 | 8.92e-09 | 1.37e-07 | 8.10e-08 | 44 |
hsa0421855 | Oral cavity | EOLP | Cellular senescence | 50/1218 | 156/8465 | 1.27e-08 | 1.83e-07 | 1.08e-07 | 50 |
hsa0516654 | Oral cavity | EOLP | Human T-cell leukemia virus 1 infection | 64/1218 | 222/8465 | 1.37e-08 | 1.83e-07 | 1.08e-07 | 64 |
hsa046255 | Oral cavity | EOLP | C-type lectin receptor signaling pathway | 38/1218 | 104/8465 | 1.39e-08 | 1.83e-07 | 1.08e-07 | 38 |
hsa0541756 | Oral cavity | EOLP | Lipid and atherosclerosis | 62/1218 | 215/8465 | 2.28e-08 | 2.83e-07 | 1.67e-07 | 62 |
hsa0502255 | Oral cavity | EOLP | Pathways of neurodegeneration - multiple diseases | 110/1218 | 476/8465 | 1.09e-07 | 1.26e-06 | 7.40e-07 | 110 |
hsa052353 | Oral cavity | EOLP | PD-L1 expression and PD-1 checkpoint pathway in cancer | 32/1218 | 89/8465 | 2.96e-07 | 3.18e-06 | 1.88e-06 | 32 |
hsa0502055 | Oral cavity | EOLP | Prion disease | 70/1218 | 273/8465 | 4.73e-07 | 4.78e-06 | 2.82e-06 | 70 |
hsa0466031 | Oral cavity | EOLP | T cell receptor signaling pathway | 34/1218 | 104/8465 | 1.63e-06 | 1.39e-05 | 8.18e-06 | 34 |
hsa0465831 | Oral cavity | EOLP | Th1 and Th2 cell differentiation | 31/1218 | 92/8465 | 2.27e-06 | 1.79e-05 | 1.05e-05 | 31 |
hsa046623 | Oral cavity | EOLP | B cell receptor signaling pathway | 29/1218 | 84/8465 | 2.75e-06 | 2.11e-05 | 1.25e-05 | 29 |
hsa0501055 | Oral cavity | EOLP | Alzheimer disease | 87/1218 | 384/8465 | 5.79e-06 | 3.67e-05 | 2.16e-05 | 87 |
hsa046501 | Oral cavity | EOLP | Natural killer cell mediated cytotoxicity | 38/1218 | 132/8465 | 1.26e-05 | 7.01e-05 | 4.13e-05 | 38 |
hsa0515251 | Oral cavity | EOLP | Tuberculosis | 47/1218 | 180/8465 | 2.19e-05 | 1.18e-04 | 6.96e-05 | 47 |
hsa0401033 | Oral cavity | EOLP | MAPK signaling pathway | 68/1218 | 302/8465 | 7.48e-05 | 3.40e-04 | 2.01e-04 | 68 |
hsa0472013 | Oral cavity | EOLP | Long-term potentiation | 21/1218 | 67/8465 | 3.04e-04 | 1.29e-03 | 7.62e-04 | 21 |
hsa043703 | Oral cavity | EOLP | VEGF signaling pathway | 19/1218 | 59/8465 | 3.96e-04 | 1.62e-03 | 9.55e-04 | 19 |
hsa041143 | Oral cavity | EOLP | Oocyte meiosis | 33/1218 | 131/8465 | 7.09e-04 | 2.69e-03 | 1.59e-03 | 33 |
hsa0492112 | Oral cavity | EOLP | Oxytocin signaling pathway | 36/1218 | 154/8465 | 1.79e-03 | 6.08e-03 | 3.58e-03 | 36 |
hsa0431017 | Oral cavity | EOLP | Wnt signaling pathway | 37/1218 | 171/8465 | 6.23e-03 | 1.83e-02 | 1.08e-02 | 37 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PPP3R1 | SNV | Missense_Mutation | c.362G>A | p.Gly121Glu | p.G121E | P63098 | protein_coding | deleterious(0) | probably_damaging(0.992) | TCGA-BH-A1FL-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
PPP3R1 | SNV | Missense_Mutation | novel | c.299A>G | p.Asp100Gly | p.D100G | P63098 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PPP3R1 | SNV | Missense_Mutation | novel | c.187N>A | p.Asp63Asn | p.D63N | P63098 | protein_coding | deleterious(0.04) | probably_damaging(0.97) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
PPP3R1 | SNV | Missense_Mutation | c.259N>T | p.Asp87Tyr | p.D87Y | P63098 | protein_coding | deleterious(0) | possibly_damaging(0.753) | TCGA-CA-6718-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD | |
PPP3R1 | SNV | Missense_Mutation | novel | c.270N>T | p.Gln90His | p.Q90H | P63098 | protein_coding | deleterious(0.01) | benign(0.135) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
PPP3R1 | SNV | Missense_Mutation | c.71N>A | p.Gly24Glu | p.G24E | P63098 | protein_coding | tolerated(0.27) | benign(0.031) | TCGA-F5-6464-01 | Colorectum | rectum adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
PPP3R1 | SNV | Missense_Mutation | novel | c.224N>G | p.Phe75Cys | p.F75C | P63098 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
PPP3R1 | SNV | Missense_Mutation | c.170N>A | p.Arg57Gln | p.R57Q | P63098 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
PPP3R1 | SNV | Missense_Mutation | c.395N>A | p.Ile132Asn | p.I132N | P63098 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-A5-A0G9-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
PPP3R1 | SNV | Missense_Mutation | novel | c.187N>A | p.Asp63Asn | p.D63N | P63098 | protein_coding | deleterious(0.04) | probably_damaging(0.97) | TCGA-AX-A06F-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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