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Gene: ATP5D |
Gene summary for ATP5D |
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Gene information | Species | Human | Gene symbol | ATP5D | Gene ID | 513 |
Gene name | ATP synthase F1 subunit delta | |
Gene Alias | ATP5D | |
Cytomap | 19p13.3 | |
Gene Type | protein-coding | GO ID | GO:0006091 | UniProtAcc | P30049 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
513 | ATP5D | GSM4909281 | Human | Breast | IDC | 4.25e-21 | -4.30e-01 | 0.21 |
513 | ATP5D | GSM4909282 | Human | Breast | IDC | 7.78e-22 | -4.30e-01 | -0.0288 |
513 | ATP5D | GSM4909285 | Human | Breast | IDC | 7.78e-22 | -4.30e-01 | 0.21 |
513 | ATP5D | GSM4909286 | Human | Breast | IDC | 4.25e-21 | -4.30e-01 | 0.1081 |
513 | ATP5D | GSM4909287 | Human | Breast | IDC | 5.98e-21 | -4.30e-01 | 0.2057 |
513 | ATP5D | GSM4909288 | Human | Breast | IDC | 8.39e-05 | -4.30e-01 | 0.0988 |
513 | ATP5D | GSM4909289 | Human | Breast | IDC | 2.83e-03 | -4.30e-01 | 0.1064 |
513 | ATP5D | GSM4909290 | Human | Breast | IDC | 5.57e-15 | -4.30e-01 | 0.2096 |
513 | ATP5D | GSM4909291 | Human | Breast | IDC | 4.05e-12 | -4.30e-01 | 0.1753 |
513 | ATP5D | GSM4909293 | Human | Breast | IDC | 4.25e-21 | -4.30e-01 | 0.1581 |
513 | ATP5D | GSM4909294 | Human | Breast | IDC | 1.82e-21 | -4.30e-01 | 0.2022 |
513 | ATP5D | GSM4909295 | Human | Breast | IDC | 1.70e-09 | -4.30e-01 | 0.0898 |
513 | ATP5D | GSM4909296 | Human | Breast | IDC | 1.82e-21 | -4.30e-01 | 0.1524 |
513 | ATP5D | GSM4909297 | Human | Breast | IDC | 2.52e-23 | -4.30e-01 | 0.1517 |
513 | ATP5D | GSM4909298 | Human | Breast | IDC | 7.78e-22 | -4.30e-01 | 0.1551 |
513 | ATP5D | GSM4909299 | Human | Breast | IDC | 1.82e-21 | -4.30e-01 | 0.035 |
513 | ATP5D | GSM4909300 | Human | Breast | IDC | 2.31e-08 | -4.30e-01 | 0.0334 |
513 | ATP5D | GSM4909301 | Human | Breast | IDC | 3.31e-22 | -4.30e-01 | 0.1577 |
513 | ATP5D | GSM4909302 | Human | Breast | IDC | 1.20e-20 | -4.30e-01 | 0.1545 |
513 | ATP5D | GSM4909303 | Human | Breast | IDC | 1.72e-05 | -4.30e-01 | 0.0438 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0019032 | Liver | HCC | Oxidative phosphorylation | 103/4020 | 134/8465 | 2.39e-12 | 5.01e-11 | 2.79e-11 | 103 |
hsa0502232 | Liver | HCC | Pathways of neurodegeneration - multiple diseases | 298/4020 | 476/8465 | 6.59e-12 | 1.30e-10 | 7.22e-11 | 298 |
hsa0520816 | Lung | IAC | Chemical carcinogenesis - reactive oxygen species | 51/1053 | 223/8465 | 8.45e-06 | 2.14e-04 | 1.42e-04 | 51 |
hsa0471416 | Lung | IAC | Thermogenesis | 46/1053 | 232/8465 | 7.85e-04 | 6.38e-03 | 4.23e-03 | 46 |
hsa0501216 | Lung | IAC | Parkinson disease | 47/1053 | 266/8465 | 7.53e-03 | 3.02e-02 | 2.01e-02 | 47 |
hsa0520817 | Lung | IAC | Chemical carcinogenesis - reactive oxygen species | 51/1053 | 223/8465 | 8.45e-06 | 2.14e-04 | 1.42e-04 | 51 |
hsa0471417 | Lung | IAC | Thermogenesis | 46/1053 | 232/8465 | 7.85e-04 | 6.38e-03 | 4.23e-03 | 46 |
hsa0501217 | Lung | IAC | Parkinson disease | 47/1053 | 266/8465 | 7.53e-03 | 3.02e-02 | 2.01e-02 | 47 |
hsa0520823 | Lung | AIS | Chemical carcinogenesis - reactive oxygen species | 47/961 | 223/8465 | 1.63e-05 | 3.77e-04 | 2.41e-04 | 47 |
hsa0471423 | Lung | AIS | Thermogenesis | 43/961 | 232/8465 | 7.36e-04 | 6.28e-03 | 4.02e-03 | 43 |
hsa0501223 | Lung | AIS | Parkinson disease | 44/961 | 266/8465 | 6.25e-03 | 2.98e-02 | 1.91e-02 | 44 |
hsa0520833 | Lung | AIS | Chemical carcinogenesis - reactive oxygen species | 47/961 | 223/8465 | 1.63e-05 | 3.77e-04 | 2.41e-04 | 47 |
hsa0471433 | Lung | AIS | Thermogenesis | 43/961 | 232/8465 | 7.36e-04 | 6.28e-03 | 4.02e-03 | 43 |
hsa0501233 | Lung | AIS | Parkinson disease | 44/961 | 266/8465 | 6.25e-03 | 2.98e-02 | 1.91e-02 | 44 |
hsa0501228 | Prostate | BPH | Parkinson disease | 143/1718 | 266/8465 | 1.19e-34 | 3.94e-32 | 2.44e-32 | 143 |
hsa0502026 | Prostate | BPH | Prion disease | 141/1718 | 273/8465 | 1.11e-31 | 1.23e-29 | 7.58e-30 | 141 |
hsa0501626 | Prostate | BPH | Huntington disease | 149/1718 | 306/8465 | 8.82e-30 | 7.27e-28 | 4.50e-28 | 149 |
hsa0019026 | Prostate | BPH | Oxidative phosphorylation | 83/1718 | 134/8465 | 3.75e-26 | 2.48e-24 | 1.53e-24 | 83 |
hsa0520828 | Prostate | BPH | Chemical carcinogenesis - reactive oxygen species | 114/1718 | 223/8465 | 3.05e-25 | 1.44e-23 | 8.91e-24 | 114 |
hsa0501026 | Prostate | BPH | Alzheimer disease | 165/1718 | 384/8465 | 4.03e-25 | 1.66e-23 | 1.03e-23 | 165 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ATP5D | SNV | Missense_Mutation | c.217N>T | p.His73Tyr | p.H73Y | P30049 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-EX-A1H6-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
ATP5D | SNV | Missense_Mutation | rs781350269 | c.416C>T | p.Ala139Val | p.A139V | P30049 | protein_coding | deleterious(0.01) | benign(0.284) | TCGA-AA-A022-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ATP5D | SNV | Missense_Mutation | c.217C>T | p.His73Tyr | p.H73Y | P30049 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AH-6644-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
ATP5D | SNV | Missense_Mutation | rs753537314 | c.349N>A | p.Glu117Lys | p.E117K | P30049 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-B5-A0JY-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | SD |
ATP5D | SNV | Missense_Mutation | novel | c.196N>A | p.Ala66Thr | p.A66T | P30049 | protein_coding | tolerated(0.17) | benign(0.02) | TCGA-DF-A2KU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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