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Gene: SKP1 |
Gene summary for SKP1 |
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Gene information | Species | Human | Gene symbol | SKP1 | Gene ID | 6500 |
Gene name | S-phase kinase associated protein 1 | |
Gene Alias | EMC19 | |
Cytomap | 5q31.1 | |
Gene Type | protein-coding | GO ID | GO:0000209 | UniProtAcc | P63208 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
6500 | SKP1 | GSM4909286 | Human | Breast | IDC | 2.73e-07 | -1.34e-01 | 0.1081 |
6500 | SKP1 | GSM4909288 | Human | Breast | IDC | 4.46e-02 | -2.51e-03 | 0.0988 |
6500 | SKP1 | GSM4909293 | Human | Breast | IDC | 5.41e-12 | 3.17e-01 | 0.1581 |
6500 | SKP1 | GSM4909294 | Human | Breast | IDC | 1.52e-36 | 3.43e-01 | 0.2022 |
6500 | SKP1 | GSM4909296 | Human | Breast | IDC | 2.02e-13 | -9.03e-02 | 0.1524 |
6500 | SKP1 | GSM4909297 | Human | Breast | IDC | 9.41e-37 | 5.68e-02 | 0.1517 |
6500 | SKP1 | GSM4909298 | Human | Breast | IDC | 4.21e-05 | 2.60e-01 | 0.1551 |
6500 | SKP1 | GSM4909299 | Human | Breast | IDC | 3.98e-05 | 2.14e-01 | 0.035 |
6500 | SKP1 | GSM4909300 | Human | Breast | IDC | 9.16e-03 | 2.58e-01 | 0.0334 |
6500 | SKP1 | GSM4909302 | Human | Breast | IDC | 2.07e-04 | -2.79e-01 | 0.1545 |
6500 | SKP1 | GSM4909305 | Human | Breast | IDC | 3.07e-07 | 3.01e-01 | 0.0436 |
6500 | SKP1 | GSM4909306 | Human | Breast | IDC | 6.40e-12 | 2.94e-01 | 0.1564 |
6500 | SKP1 | GSM4909307 | Human | Breast | IDC | 2.06e-15 | 2.92e-01 | 0.1569 |
6500 | SKP1 | GSM4909308 | Human | Breast | IDC | 1.01e-37 | 4.82e-01 | 0.158 |
6500 | SKP1 | GSM4909309 | Human | Breast | IDC | 1.64e-17 | 1.82e-01 | 0.0483 |
6500 | SKP1 | GSM4909311 | Human | Breast | IDC | 1.94e-65 | -5.43e-01 | 0.1534 |
6500 | SKP1 | GSM4909312 | Human | Breast | IDC | 2.97e-13 | -1.48e-01 | 0.1552 |
6500 | SKP1 | GSM4909313 | Human | Breast | IDC | 1.38e-06 | 9.38e-02 | 0.0391 |
6500 | SKP1 | GSM4909315 | Human | Breast | IDC | 2.12e-23 | 2.77e-01 | 0.21 |
6500 | SKP1 | GSM4909316 | Human | Breast | IDC | 1.29e-16 | 2.57e-01 | 0.21 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:19033209 | Breast | Precancer | regulation of protein modification by small protein conjugation or removal | 38/1080 | 242/18723 | 1.71e-08 | 1.17e-06 | 38 |
GO:00313969 | Breast | Precancer | regulation of protein ubiquitination | 33/1080 | 210/18723 | 1.45e-07 | 7.82e-06 | 33 |
GO:00104989 | Breast | Precancer | proteasomal protein catabolic process | 58/1080 | 490/18723 | 1.54e-07 | 8.05e-06 | 58 |
GO:00451859 | Breast | Precancer | maintenance of protein location | 19/1080 | 94/18723 | 1.43e-06 | 5.35e-05 | 19 |
GO:00512358 | Breast | Precancer | maintenance of location | 40/1080 | 327/18723 | 5.85e-06 | 1.71e-04 | 40 |
GO:00516519 | Breast | Precancer | maintenance of location in cell | 30/1080 | 214/18723 | 5.91e-06 | 1.71e-04 | 30 |
GO:00325076 | Breast | Precancer | maintenance of protein location in cell | 14/1080 | 65/18723 | 1.59e-05 | 3.89e-04 | 14 |
GO:00725954 | Breast | Precancer | maintenance of protein localization in organelle | 10/1080 | 42/18723 | 1.06e-04 | 1.93e-03 | 10 |
GO:19046668 | Breast | Precancer | regulation of ubiquitin protein ligase activity | 7/1080 | 23/18723 | 2.26e-04 | 3.42e-03 | 7 |
GO:00431619 | Breast | Precancer | proteasome-mediated ubiquitin-dependent protein catabolic process | 42/1080 | 412/18723 | 2.49e-04 | 3.72e-03 | 42 |
GO:00514386 | Breast | Precancer | regulation of ubiquitin-protein transferase activity | 10/1080 | 53/18723 | 7.88e-04 | 9.29e-03 | 10 |
GO:001049814 | Breast | IDC | proteasomal protein catabolic process | 75/1434 | 490/18723 | 5.59e-09 | 4.41e-07 | 75 |
GO:190332014 | Breast | IDC | regulation of protein modification by small protein conjugation or removal | 43/1434 | 242/18723 | 1.71e-07 | 9.16e-06 | 43 |
GO:003139614 | Breast | IDC | regulation of protein ubiquitination | 37/1434 | 210/18723 | 1.50e-06 | 6.36e-05 | 37 |
GO:005165114 | Breast | IDC | maintenance of location in cell | 37/1434 | 214/18723 | 2.39e-06 | 9.35e-05 | 37 |
GO:004518514 | Breast | IDC | maintenance of protein location | 21/1434 | 94/18723 | 6.69e-06 | 2.05e-04 | 21 |
GO:004316114 | Breast | IDC | proteasome-mediated ubiquitin-dependent protein catabolic process | 57/1434 | 412/18723 | 9.55e-06 | 2.68e-04 | 57 |
GO:005123513 | Breast | IDC | maintenance of location | 48/1434 | 327/18723 | 9.90e-06 | 2.77e-04 | 48 |
GO:003250714 | Breast | IDC | maintenance of protein location in cell | 16/1434 | 65/18723 | 2.29e-05 | 5.51e-04 | 16 |
GO:007259512 | Breast | IDC | maintenance of protein localization in organelle | 12/1434 | 42/18723 | 4.94e-05 | 1.08e-03 | 12 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0513146 | Oral cavity | EOLP | Shigellosis | 61/1218 | 247/8465 | 9.48e-06 | 5.47e-05 | 3.23e-05 | 61 |
hsa0411041 | Oral cavity | EOLP | Cell cycle | 42/1218 | 157/8465 | 3.20e-05 | 1.61e-04 | 9.52e-05 | 42 |
hsa0435022 | Oral cavity | EOLP | TGF-beta signaling pathway | 29/1218 | 108/8465 | 4.81e-04 | 1.92e-03 | 1.13e-03 | 29 |
hsa041142 | Oral cavity | EOLP | Oocyte meiosis | 33/1218 | 131/8465 | 7.09e-04 | 2.69e-03 | 1.59e-03 | 33 |
hsa0431016 | Oral cavity | EOLP | Wnt signaling pathway | 37/1218 | 171/8465 | 6.23e-03 | 1.83e-02 | 1.08e-02 | 37 |
hsa0414155 | Oral cavity | EOLP | Protein processing in endoplasmic reticulum | 70/1218 | 174/8465 | 2.84e-17 | 3.06e-15 | 1.81e-15 | 70 |
hsa0513255 | Oral cavity | EOLP | Salmonella infection | 78/1218 | 249/8465 | 3.66e-12 | 2.37e-10 | 1.40e-10 | 78 |
hsa0412053 | Oral cavity | EOLP | Ubiquitin mediated proteolysis | 48/1218 | 142/8465 | 3.55e-09 | 6.74e-08 | 3.98e-08 | 48 |
hsa0517053 | Oral cavity | EOLP | Human immunodeficiency virus 1 infection | 63/1218 | 212/8465 | 4.85e-09 | 8.71e-08 | 5.14e-08 | 63 |
hsa0513156 | Oral cavity | EOLP | Shigellosis | 61/1218 | 247/8465 | 9.48e-06 | 5.47e-05 | 3.23e-05 | 61 |
hsa0411051 | Oral cavity | EOLP | Cell cycle | 42/1218 | 157/8465 | 3.20e-05 | 1.61e-04 | 9.52e-05 | 42 |
hsa0435032 | Oral cavity | EOLP | TGF-beta signaling pathway | 29/1218 | 108/8465 | 4.81e-04 | 1.92e-03 | 1.13e-03 | 29 |
hsa041143 | Oral cavity | EOLP | Oocyte meiosis | 33/1218 | 131/8465 | 7.09e-04 | 2.69e-03 | 1.59e-03 | 33 |
hsa0431017 | Oral cavity | EOLP | Wnt signaling pathway | 37/1218 | 171/8465 | 6.23e-03 | 1.83e-02 | 1.08e-02 | 37 |
hsa0513263 | Oral cavity | NEOLP | Salmonella infection | 67/1112 | 249/8465 | 3.05e-09 | 7.46e-08 | 4.69e-08 | 67 |
hsa0412061 | Oral cavity | NEOLP | Ubiquitin mediated proteolysis | 43/1112 | 142/8465 | 5.78e-08 | 9.19e-07 | 5.78e-07 | 43 |
hsa0414162 | Oral cavity | NEOLP | Protein processing in endoplasmic reticulum | 49/1112 | 174/8465 | 9.02e-08 | 1.37e-06 | 8.59e-07 | 49 |
hsa0513163 | Oral cavity | NEOLP | Shigellosis | 62/1112 | 247/8465 | 1.93e-07 | 2.79e-06 | 1.75e-06 | 62 |
hsa0517061 | Oral cavity | NEOLP | Human immunodeficiency virus 1 infection | 49/1112 | 212/8465 | 4.05e-05 | 3.22e-04 | 2.02e-04 | 49 |
hsa0411061 | Oral cavity | NEOLP | Cell cycle | 37/1112 | 157/8465 | 2.29e-04 | 1.58e-03 | 9.95e-04 | 37 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SKP1 | SNV | Missense_Mutation | novel | c.228G>C | p.Glu76Asp | p.E76D | P63208 | protein_coding | tolerated(0.54) | benign(0.005) | TCGA-AN-A0XW-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
SKP1 | SNV | Missense_Mutation | novel | c.411N>T | p.Lys137Asn | p.K137N | P63208 | protein_coding | deleterious(0.04) | benign(0.158) | TCGA-AA-3877-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SKP1 | SNV | Missense_Mutation | novel | c.407G>C | p.Arg136Pro | p.R136P | P63208 | protein_coding | deleterious(0.01) | benign(0.012) | TCGA-AM-5820-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SKP1 | SNV | Missense_Mutation | novel | c.406N>T | p.Arg136Cys | p.R136C | P63208 | protein_coding | deleterious(0.04) | benign(0.011) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
SKP1 | SNV | Missense_Mutation | novel | c.382N>C | p.Lys128Gln | p.K128Q | P63208 | protein_coding | deleterious(0) | possibly_damaging(0.656) | TCGA-D1-A1O8-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
SKP1 | insertion | Frame_Shift_Ins | novel | c.226_227insCATCTTTATTATCTTTGCGTATAGCAATTCGTATTATTGGGCAAGAC | p.Glu76AlafsTer34 | p.E76Afs*34 | P63208 | protein_coding | TCGA-DD-A73E-01 | Liver | liver hepatocellular carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | ||
SKP1 | SNV | Missense_Mutation | c.49N>T | p.Asp17Tyr | p.D17Y | P63208 | protein_coding | deleterious(0) | possibly_damaging(0.891) | TCGA-05-4382-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
SKP1 | SNV | Missense_Mutation | novel | c.239A>G | p.Lys80Arg | p.K80R | P63208 | protein_coding | tolerated(0.27) | possibly_damaging(0.899) | TCGA-05-4427-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Chemotherapy | cisplatin | CR |
SKP1 | SNV | Missense_Mutation | novel | c.139N>G | p.Leu47Val | p.L47V | P63208 | protein_coding | tolerated(0.11) | probably_damaging(0.959) | TCGA-49-6742-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Chemotherapy | alimta | PD |
SKP1 | SNV | Missense_Mutation | novel | c.317N>G | p.Ala106Gly | p.A106G | P63208 | protein_coding | deleterious(0) | possibly_damaging(0.698) | TCGA-55-8089-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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