Tissue | Expression Dynamics | Abbreviation |
Colorectum (GSE201348) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Becker/NFATC3_pca_on_diff_genes.png) | FAP: Familial adenomatous polyposis |
CRC: Colorectal cancer |
Colorectum (HTA11) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Chen/NFATC3_pca_on_diff_genes.png) | AD: Adenomas |
SER: Sessile serrated lesions |
MSI-H: Microsatellite-high colorectal cancer |
MSS: Microsatellite stable colorectal cancer |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/NFATC3_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/NFATC3_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Lung | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Lung/NFATC3_pca_on_diff_genes.png) | AAH: Atypical adenomatous hyperplasia |
AIS: Adenocarcinoma in situ |
IAC: Invasive lung adenocarcinoma |
MIA: Minimally invasive adenocarcinoma |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/NFATC3_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Prostate | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Prostate/NFATC3_pca_on_diff_genes.png) | BPH: Benign Prostatic Hyperplasia |
Skin | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Skin/NFATC3_pca_on_diff_genes.png) | AK: Actinic keratosis |
cSCC: Cutaneous squamous cell carcinoma |
SCCIS:squamous cell carcinoma in situ |
Thyroid | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Thyroid/NFATC3_pca_on_diff_genes.png) | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0061614 | Colorectum | AD | pri-miRNA transcription by RNA polymerase II | 24/3918 | 55/18723 | 1.22e-04 | 1.78e-03 | 24 |
GO:1902893 | Colorectum | AD | regulation of pri-miRNA transcription by RNA polymerase II | 23/3918 | 54/18723 | 2.60e-04 | 3.25e-03 | 23 |
GO:00616142 | Colorectum | MSS | pri-miRNA transcription by RNA polymerase II | 19/3467 | 55/18723 | 3.47e-03 | 2.59e-02 | 19 |
GO:19028932 | Colorectum | MSS | regulation of pri-miRNA transcription by RNA polymerase II | 18/3467 | 54/18723 | 6.70e-03 | 4.38e-02 | 18 |
GO:00616143 | Colorectum | FAP | pri-miRNA transcription by RNA polymerase II | 21/2622 | 55/18723 | 7.50e-06 | 2.25e-04 | 21 |
GO:19028933 | Colorectum | FAP | regulation of pri-miRNA transcription by RNA polymerase II | 20/2622 | 54/18723 | 2.09e-05 | 5.05e-04 | 20 |
GO:0048016 | Colorectum | FAP | inositol phosphate-mediated signaling | 16/2622 | 55/18723 | 2.78e-03 | 2.15e-02 | 16 |
GO:1902894 | Colorectum | FAP | negative regulation of pri-miRNA transcription by RNA polymerase II | 7/2622 | 17/18723 | 5.62e-03 | 3.61e-02 | 7 |
GO:00616144 | Colorectum | CRC | pri-miRNA transcription by RNA polymerase II | 18/2078 | 55/18723 | 1.53e-05 | 4.70e-04 | 18 |
GO:19028934 | Colorectum | CRC | regulation of pri-miRNA transcription by RNA polymerase II | 17/2078 | 54/18723 | 4.62e-05 | 1.10e-03 | 17 |
GO:19028941 | Colorectum | CRC | negative regulation of pri-miRNA transcription by RNA polymerase II | 7/2078 | 17/18723 | 1.46e-03 | 1.57e-02 | 7 |
GO:0097720 | Colorectum | CRC | calcineurin-mediated signaling | 13/2078 | 48/18723 | 1.72e-03 | 1.77e-02 | 13 |
GO:0033173 | Colorectum | CRC | calcineurin-NFAT signaling cascade | 12/2078 | 43/18723 | 1.93e-03 | 1.96e-02 | 12 |
GO:00480161 | Colorectum | CRC | inositol phosphate-mediated signaling | 14/2078 | 55/18723 | 2.21e-03 | 2.15e-02 | 14 |
GO:00616146 | Liver | NAFLD | pri-miRNA transcription by RNA polymerase II | 13/1882 | 55/18723 | 2.64e-03 | 2.42e-02 | 13 |
GO:19028936 | Liver | NAFLD | regulation of pri-miRNA transcription by RNA polymerase II | 12/1882 | 54/18723 | 6.44e-03 | 4.69e-02 | 12 |
GO:006161412 | Liver | Cirrhotic | pri-miRNA transcription by RNA polymerase II | 22/4634 | 55/18723 | 8.94e-03 | 4.12e-02 | 22 |
GO:006161422 | Liver | HCC | pri-miRNA transcription by RNA polymerase II | 35/7958 | 55/18723 | 1.26e-03 | 6.92e-03 | 35 |
GO:190289312 | Liver | HCC | regulation of pri-miRNA transcription by RNA polymerase II | 34/7958 | 54/18723 | 1.92e-03 | 9.78e-03 | 34 |
GO:19028942 | Liver | HCC | negative regulation of pri-miRNA transcription by RNA polymerase II | 13/7958 | 17/18723 | 4.77e-03 | 2.02e-02 | 13 |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa05135110 | Oral cavity | OSCC | Yersinia infection | 94/3704 | 137/8465 | 2.85e-09 | 3.08e-08 | 1.57e-08 | 94 |
hsa05167113 | Oral cavity | OSCC | Kaposi sarcoma-associated herpesvirus infection | 125/3704 | 194/8465 | 3.67e-09 | 3.84e-08 | 1.96e-08 | 125 |
hsa05170111 | Oral cavity | OSCC | Human immunodeficiency virus 1 infection | 133/3704 | 212/8465 | 1.42e-08 | 1.40e-07 | 7.12e-08 | 133 |
hsa05163112 | Oral cavity | OSCC | Human cytomegalovirus infection | 139/3704 | 225/8465 | 2.77e-08 | 2.38e-07 | 1.21e-07 | 139 |
hsa0462512 | Oral cavity | OSCC | C-type lectin receptor signaling pathway | 73/3704 | 104/8465 | 3.83e-08 | 3.12e-07 | 1.59e-07 | 73 |
hsa05417113 | Oral cavity | OSCC | Lipid and atherosclerosis | 131/3704 | 215/8465 | 2.20e-07 | 1.45e-06 | 7.37e-07 | 131 |
hsa0516113 | Oral cavity | OSCC | Hepatitis B | 103/3704 | 162/8465 | 2.34e-07 | 1.51e-06 | 7.69e-07 | 103 |
hsa0466012 | Oral cavity | OSCC | T cell receptor signaling pathway | 67/3704 | 104/8465 | 1.57e-05 | 6.75e-05 | 3.44e-05 | 67 |
hsa0401015 | Oral cavity | OSCC | MAPK signaling pathway | 165/3704 | 302/8465 | 7.11e-05 | 2.74e-04 | 1.40e-04 | 165 |
hsa052351 | Oral cavity | OSCC | PD-L1 expression and PD-1 checkpoint pathway in cancer | 56/3704 | 89/8465 | 1.97e-04 | 6.55e-04 | 3.33e-04 | 56 |
hsa0465913 | Oral cavity | OSCC | Th17 cell differentiation | 65/3704 | 108/8465 | 4.02e-04 | 1.25e-03 | 6.35e-04 | 65 |
hsa0465811 | Oral cavity | OSCC | Th1 and Th2 cell differentiation | 53/3704 | 92/8465 | 5.00e-03 | 1.20e-02 | 6.13e-03 | 53 |
hsa0436015 | Oral cavity | OSCC | Axon guidance | 97/3704 | 182/8465 | 5.59e-03 | 1.33e-02 | 6.76e-03 | 97 |
hsa046621 | Oral cavity | OSCC | B cell receptor signaling pathway | 48/3704 | 84/8465 | 9.02e-03 | 2.01e-02 | 1.03e-02 | 48 |
hsa05166210 | Oral cavity | LP | Human T-cell leukemia virus 1 infection | 100/2418 | 222/8465 | 8.94e-08 | 1.29e-06 | 8.35e-07 | 100 |
hsa0517028 | Oral cavity | LP | Human immunodeficiency virus 1 infection | 92/2418 | 212/8465 | 2.18e-06 | 2.20e-05 | 1.42e-05 | 92 |
hsa0421827 | Oral cavity | LP | Cellular senescence | 71/2418 | 156/8465 | 4.17e-06 | 3.75e-05 | 2.42e-05 | 71 |
hsa05167210 | Oral cavity | LP | Kaposi sarcoma-associated herpesvirus infection | 84/2418 | 194/8465 | 6.66e-06 | 5.16e-05 | 3.33e-05 | 84 |
hsa0513525 | Oral cavity | LP | Yersinia infection | 59/2418 | 137/8465 | 1.81e-04 | 1.04e-03 | 6.71e-04 | 59 |
hsa05417210 | Oral cavity | LP | Lipid and atherosclerosis | 84/2418 | 215/8465 | 5.02e-04 | 2.61e-03 | 1.68e-03 | 84 |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
NFATC3 | MAST | Colorectum | AD | RPS6KA5,UBA6-AS1,PRELID2, etc. | 2.43e-01 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Colorectum/Str/TF_AD/regulons_activity_in_dotplot.png) |
NFATC3 | TH1 | Endometrium | ADJ | SMAGP,AC006064.2,S1PR1, etc. | 8.94e-03 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Endometrium/Str/TF_ADJ/regulons_activity_in_dotplot.png) |
NFATC3 | CD8TEFF | Endometrium | Healthy | SMAGP,AC006064.2,S1PR1, etc. | 2.68e-02 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Endometrium/Str/TF_Healthy/regulons_activity_in_dotplot.png) |
NFATC3 | BMEM | Endometrium | Healthy | SMAGP,AC006064.2,S1PR1, etc. | 1.43e-01 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Endometrium/Str/TF_Healthy/regulons_activity_in_dotplot.png) |
NFATC3 | BMEM | Liver | NAFLD | ZSCAN5A,AC116366.3,BICRAL, etc. | 9.23e-02 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Liver/Str/TF_NAFLD/regulons_activity_in_dotplot.png) |
NFATC3 | AT1 | Lung | Healthy | HAX1,CLDN18,ADIRF, etc. | 1.30e-01 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Lung/Str/TF_Healthy/regulons_activity_in_dotplot.png) |
NFATC3 | NK | Lung | IAC | BRWD3,TMEM14A,SBNO1, etc. | 4.77e-02 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Lung/Str/TF_IAC/regulons_activity_in_dotplot.png) |
NFATC3 | CD4TN | Lung | IAC | BRWD3,TMEM14A,SBNO1, etc. | 2.11e-01 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Lung/Str/TF_IAC/regulons_activity_in_dotplot.png) |
NFATC3 | CD8TEFF | Lung | MIAC | PPM1D,SAMD3,CCND3, etc. | 9.86e-02 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Lung/Str/TF_MIAC/regulons_activity_in_dotplot.png) |
NFATC3 | CD8TCM | Lung | MIAC | PPM1D,SAMD3,CCND3, etc. | 3.66e-02 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Lung/Str/TF_MIAC/regulons_activity_in_dotplot.png) |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
NFATC3 | SNV | Missense_Mutation | novel | c.208N>T | p.His70Tyr | p.H70Y | Q12968 | protein_coding | deleterious(0.03) | benign(0.041) | TCGA-5L-AAT1-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Hormone Therapy | letrozol | SD |
NFATC3 | SNV | Missense_Mutation | | c.1440G>T | p.Met480Ile | p.M480I | Q12968 | protein_coding | tolerated(0.35) | benign(0.101) | TCGA-A2-A25A-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | Cytoxan | SD |
NFATC3 | SNV | Missense_Mutation | novel | c.605N>T | p.Arg202Leu | p.R202L | Q12968 | protein_coding | deleterious(0) | probably_damaging(0.991) | TCGA-A7-A26F-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | SD |
NFATC3 | SNV | Missense_Mutation | rs772602157 | c.1652G>A | p.Arg551Gln | p.R551Q | Q12968 | protein_coding | deleterious(0.01) | probably_damaging(0.996) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
NFATC3 | SNV | Missense_Mutation | | c.301N>C | p.Gly101Arg | p.G101R | Q12968 | protein_coding | deleterious(0) | benign(0.244) | TCGA-AN-A0XN-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
NFATC3 | SNV | Missense_Mutation | | c.2125G>C | p.Glu709Gln | p.E709Q | Q12968 | protein_coding | deleterious(0.01) | benign(0.358) | TCGA-BH-A0DZ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | docetaxel | SD |
NFATC3 | SNV | Missense_Mutation | | c.2314G>A | p.Glu772Lys | p.E772K | Q12968 | protein_coding | tolerated_low_confidence(0.98) | benign(0.098) | TCGA-BH-A0DZ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | docetaxel | SD |
NFATC3 | SNV | Missense_Mutation | | c.1970N>A | p.Gly657Glu | p.G657E | Q12968 | protein_coding | tolerated(0.9) | benign(0.027) | TCGA-E2-A1IH-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | aromasin | SD |
NFATC3 | SNV | Missense_Mutation | novel | c.3076A>T | p.Ile1026Phe | p.I1026F | Q12968 | protein_coding | deleterious_low_confidence(0) | benign(0.386) | TCGA-E2-A574-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD |
NFATC3 | insertion | Frame_Shift_Ins | novel | c.2625_2626insT | p.Leu876SerfsTer25 | p.L876Sfs*25 | Q12968 | protein_coding | | | TCGA-A8-A08Z-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |