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Gene: IKBKG |
Gene summary for IKBKG |
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Gene information | Species | Human | Gene symbol | IKBKG | Gene ID | 8517 |
Gene name | inhibitor of nuclear factor kappa B kinase regulatory subunit gamma | |
Gene Alias | AMCBX1 | |
Cytomap | Xq28 | |
Gene Type | protein-coding | GO ID | GO:0002253 | UniProtAcc | Q9Y6K9 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
8517 | IKBKG | LZE4T | Human | Esophagus | ESCC | 9.56e-12 | 3.45e-01 | 0.0811 |
8517 | IKBKG | LZE7T | Human | Esophagus | ESCC | 9.56e-23 | 7.24e-01 | 0.0667 |
8517 | IKBKG | LZE8T | Human | Esophagus | ESCC | 2.72e-03 | 1.33e-01 | 0.067 |
8517 | IKBKG | LZE20T | Human | Esophagus | ESCC | 3.16e-03 | 1.42e-01 | 0.0662 |
8517 | IKBKG | LZE22D1 | Human | Esophagus | HGIN | 5.14e-03 | 1.82e-01 | 0.0595 |
8517 | IKBKG | LZE22T | Human | Esophagus | ESCC | 1.00e-09 | 5.15e-01 | 0.068 |
8517 | IKBKG | LZE24T | Human | Esophagus | ESCC | 1.02e-31 | 6.14e-01 | 0.0596 |
8517 | IKBKG | LZE21T | Human | Esophagus | ESCC | 9.73e-05 | 3.44e-01 | 0.0655 |
8517 | IKBKG | P1T-E | Human | Esophagus | ESCC | 1.42e-19 | 8.50e-01 | 0.0875 |
8517 | IKBKG | P2T-E | Human | Esophagus | ESCC | 3.19e-23 | 3.71e-01 | 0.1177 |
8517 | IKBKG | P4T-E | Human | Esophagus | ESCC | 2.45e-12 | 2.61e-01 | 0.1323 |
8517 | IKBKG | P5T-E | Human | Esophagus | ESCC | 3.52e-19 | 3.20e-01 | 0.1327 |
8517 | IKBKG | P8T-E | Human | Esophagus | ESCC | 7.31e-14 | 2.95e-01 | 0.0889 |
8517 | IKBKG | P9T-E | Human | Esophagus | ESCC | 1.36e-37 | 6.93e-01 | 0.1131 |
8517 | IKBKG | P10T-E | Human | Esophagus | ESCC | 9.74e-22 | 4.32e-01 | 0.116 |
8517 | IKBKG | P11T-E | Human | Esophagus | ESCC | 6.27e-12 | 4.02e-01 | 0.1426 |
8517 | IKBKG | P12T-E | Human | Esophagus | ESCC | 5.17e-27 | 5.01e-01 | 0.1122 |
8517 | IKBKG | P15T-E | Human | Esophagus | ESCC | 1.87e-22 | 4.81e-01 | 0.1149 |
8517 | IKBKG | P16T-E | Human | Esophagus | ESCC | 9.56e-08 | 1.36e-01 | 0.1153 |
8517 | IKBKG | P17T-E | Human | Esophagus | ESCC | 9.15e-12 | 3.87e-01 | 0.1278 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000989626 | Esophagus | HGIN | positive regulation of catabolic process | 126/2587 | 492/18723 | 1.46e-12 | 2.09e-10 | 126 |
GO:003133126 | Esophagus | HGIN | positive regulation of cellular catabolic process | 112/2587 | 427/18723 | 5.15e-12 | 6.72e-10 | 112 |
GO:001050616 | Esophagus | HGIN | regulation of autophagy | 84/2587 | 317/18723 | 1.39e-09 | 1.08e-07 | 84 |
GO:001623616 | Esophagus | HGIN | macroautophagy | 77/2587 | 291/18723 | 7.15e-09 | 4.61e-07 | 77 |
GO:005165616 | Esophagus | HGIN | establishment of organelle localization | 90/2587 | 390/18723 | 4.27e-07 | 1.94e-05 | 90 |
GO:004312220 | Esophagus | HGIN | regulation of I-kappaB kinase/NF-kappaB signaling | 63/2587 | 249/18723 | 8.91e-07 | 3.61e-05 | 63 |
GO:000724918 | Esophagus | HGIN | I-kappaB kinase/NF-kappaB signaling | 67/2587 | 281/18723 | 3.84e-06 | 1.29e-04 | 67 |
GO:004312317 | Esophagus | HGIN | positive regulation of I-kappaB kinase/NF-kappaB signaling | 49/2587 | 186/18723 | 4.22e-06 | 1.40e-04 | 49 |
GO:007099727 | Esophagus | HGIN | neuron death | 81/2587 | 361/18723 | 5.01e-06 | 1.61e-04 | 81 |
GO:00162418 | Esophagus | HGIN | regulation of macroautophagy | 38/2587 | 141/18723 | 2.80e-05 | 7.21e-04 | 38 |
GO:190121424 | Esophagus | HGIN | regulation of neuron death | 68/2587 | 319/18723 | 1.46e-04 | 2.91e-03 | 68 |
GO:005165010 | Esophagus | HGIN | establishment of vesicle localization | 35/2587 | 161/18723 | 3.89e-03 | 3.54e-02 | 35 |
GO:190121510 | Esophagus | HGIN | negative regulation of neuron death | 43/2587 | 208/18723 | 4.04e-03 | 3.64e-02 | 43 |
GO:000961517 | Esophagus | HGIN | response to virus | 69/2587 | 367/18723 | 4.39e-03 | 3.86e-02 | 69 |
GO:00105088 | Esophagus | HGIN | positive regulation of autophagy | 28/2587 | 124/18723 | 5.34e-03 | 4.39e-02 | 28 |
GO:005164810 | Esophagus | HGIN | vesicle localization | 37/2587 | 177/18723 | 6.03e-03 | 4.87e-02 | 37 |
GO:001623617 | Esophagus | ESCC | macroautophagy | 216/8552 | 291/18723 | 1.94e-23 | 4.57e-21 | 216 |
GO:0009896111 | Esophagus | ESCC | positive regulation of catabolic process | 332/8552 | 492/18723 | 4.36e-23 | 9.22e-21 | 332 |
GO:005165617 | Esophagus | ESCC | establishment of organelle localization | 273/8552 | 390/18723 | 9.13e-23 | 1.81e-20 | 273 |
GO:0031331111 | Esophagus | ESCC | positive regulation of cellular catabolic process | 292/8552 | 427/18723 | 8.67e-22 | 1.53e-19 | 292 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa049365 | Oral cavity | OSCC | Alcoholic liver disease | 78/3704 | 142/8465 | 4.53e-03 | 1.12e-02 | 5.68e-03 | 78 |
hsa046584 | Oral cavity | OSCC | Th1 and Th2 cell differentiation | 53/3704 | 92/8465 | 5.00e-03 | 1.20e-02 | 6.13e-03 | 53 |
hsa04623 | Oral cavity | OSCC | Cytosolic DNA-sensing pathway | 44/3704 | 75/8465 | 6.44e-03 | 1.51e-02 | 7.68e-03 | 44 |
hsa04620 | Oral cavity | OSCC | Toll-like receptor signaling pathway | 58/3704 | 104/8465 | 8.77e-03 | 1.98e-02 | 1.01e-02 | 58 |
hsa04662 | Oral cavity | OSCC | B cell receptor signaling pathway | 48/3704 | 84/8465 | 9.02e-03 | 2.01e-02 | 1.03e-02 | 48 |
hsa04622 | Oral cavity | OSCC | RIG-I-like receptor signaling pathway | 41/3704 | 71/8465 | 1.20e-02 | 2.63e-02 | 1.34e-02 | 41 |
hsa05132114 | Oral cavity | OSCC | Salmonella infection | 174/3704 | 249/8465 | 2.67e-17 | 1.49e-15 | 7.58e-16 | 174 |
hsa05169113 | Oral cavity | OSCC | Epstein-Barr virus infection | 144/3704 | 202/8465 | 1.08e-15 | 3.60e-14 | 1.83e-14 | 144 |
hsa05010112 | Oral cavity | OSCC | Alzheimer disease | 244/3704 | 384/8465 | 1.18e-15 | 3.60e-14 | 1.83e-14 | 244 |
hsa05171114 | Oral cavity | OSCC | Coronavirus disease - COVID-19 | 156/3704 | 232/8465 | 2.30e-13 | 5.14e-12 | 2.62e-12 | 156 |
hsa0421019 | Oral cavity | OSCC | Apoptosis | 101/3704 | 136/8465 | 3.34e-13 | 7.00e-12 | 3.56e-12 | 101 |
hsa05166113 | Oral cavity | OSCC | Human T-cell leukemia virus 1 infection | 150/3704 | 222/8465 | 3.68e-13 | 7.26e-12 | 3.70e-12 | 150 |
hsa05208114 | Oral cavity | OSCC | Chemical carcinogenesis - reactive oxygen species | 150/3704 | 223/8465 | 6.45e-13 | 1.20e-11 | 6.11e-12 | 150 |
hsa0516419 | Oral cavity | OSCC | Influenza A | 116/3704 | 171/8465 | 1.23e-10 | 1.78e-09 | 9.08e-10 | 116 |
hsa0521215 | Oral cavity | OSCC | Pancreatic cancer | 60/3704 | 76/8465 | 3.32e-10 | 4.45e-09 | 2.26e-09 | 60 |
hsa0516514 | Oral cavity | OSCC | Human papillomavirus infection | 200/3704 | 331/8465 | 3.83e-10 | 4.93e-09 | 2.51e-09 | 200 |
hsa05130114 | Oral cavity | OSCC | Pathogenic Escherichia coli infection | 129/3704 | 197/8465 | 4.32e-10 | 5.17e-09 | 2.63e-09 | 129 |
hsa0466816 | Oral cavity | OSCC | TNF signaling pathway | 82/3704 | 114/8465 | 8.30e-10 | 9.59e-09 | 4.88e-09 | 82 |
hsa05135110 | Oral cavity | OSCC | Yersinia infection | 94/3704 | 137/8465 | 2.85e-09 | 3.08e-08 | 1.57e-08 | 94 |
hsa05167113 | Oral cavity | OSCC | Kaposi sarcoma-associated herpesvirus infection | 125/3704 | 194/8465 | 3.67e-09 | 3.84e-08 | 1.96e-08 | 125 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
IKBKG | SNV | Missense_Mutation | novel | c.671N>T | p.Ser224Ile | p.S224I | Q9Y6K9 | protein_coding | deleterious(0.01) | possibly_damaging(0.868) | TCGA-AA-3947-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
IKBKG | SNV | Missense_Mutation | novel | c.1042N>A | p.Val348Met | p.V348M | Q9Y6K9 | protein_coding | tolerated(0.17) | benign(0.242) | TCGA-AG-3731-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | folinic | PR |
IKBKG | SNV | Missense_Mutation | novel | c.710N>A | p.Ala237Asp | p.A237D | Q9Y6K9 | protein_coding | tolerated(0.32) | benign(0.112) | TCGA-DY-A1DG-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
IKBKG | SNV | Missense_Mutation | novel | c.272A>C | p.Asp91Ala | p.D91A | Q9Y6K9 | protein_coding | deleterious(0.01) | possibly_damaging(0.465) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
IKBKG | SNV | Missense_Mutation | c.658G>A | p.Glu220Lys | p.E220K | Q9Y6K9 | protein_coding | deleterious(0) | possibly_damaging(0.695) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
IKBKG | SNV | Missense_Mutation | novel | c.491N>C | p.Lys164Thr | p.K164T | Q9Y6K9 | protein_coding | deleterious(0) | possibly_damaging(0.901) | TCGA-A5-A2K5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
IKBKG | SNV | Missense_Mutation | novel | c.1048N>A | p.Asp350Asn | p.D350N | Q9Y6K9 | protein_coding | deleterious(0) | probably_damaging(0.987) | TCGA-A5-A2K5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
IKBKG | SNV | Missense_Mutation | novel | c.639N>T | p.Gln213His | p.Q213H | Q9Y6K9 | protein_coding | deleterious(0.01) | probably_damaging(0.934) | TCGA-AJ-A3EL-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
IKBKG | SNV | Missense_Mutation | rs782201526 | c.149N>A | p.Arg50His | p.R50H | Q9Y6K9 | protein_coding | deleterious_low_confidence(0.03) | benign(0.003) | TCGA-AP-A056-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
IKBKG | SNV | Missense_Mutation | novel | c.1089G>A | p.Met363Ile | p.M363I | Q9Y6K9 | protein_coding | deleterious(0.03) | benign(0.006) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
8517 | IKBKG | KINASE, DRUGGABLE GENOME | artesunate | ARTESUNATE | ||
8517 | IKBKG | KINASE, DRUGGABLE GENOME | primaquine | PRIMAQUINE | ||
8517 | IKBKG | KINASE, DRUGGABLE GENOME | sulfadoxine | SULFADOXINE | ||
8517 | IKBKG | KINASE, DRUGGABLE GENOME | pyrimethamine | PYRIMETHAMINE |
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