Tissue | Expression Dynamics | Abbreviation |
Breast | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Breast/GNAS_pca_on_diff_genes.png) | IDC: Invasive ductal carcinoma |
DCIS: Ductal carcinoma in situ |
Precancer(BRCA1-mut): Precancerous lesion from BRCA1 mutation carriers |
Cervix | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Cervix/GNAS_pca_on_diff_genes.png) | CC: Cervix cancer |
HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions |
N_HPV: HPV-infected normal cervix |
Colorectum (GSE201348) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Becker/GNAS_pca_on_diff_genes.png) | FAP: Familial adenomatous polyposis |
CRC: Colorectal cancer |
Colorectum (HTA11) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Chen/GNAS_pca_on_diff_genes.png) | AD: Adenomas |
SER: Sessile serrated lesions |
MSI-H: Microsatellite-high colorectal cancer |
MSS: Microsatellite stable colorectal cancer |
Endometrium | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Endometrium/GNAS_pca_on_diff_genes.png) | AEH: Atypical endometrial hyperplasia |
EEC: Endometrioid Cancer |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/GNAS_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
GC | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/GC/GNAS_pca_on_diff_genes.png) | CAG: Chronic atrophic gastritis |
CAG with IM: Chronic atrophic gastritis with intestinal metaplasia |
CSG: Chronic superficial gastritis |
GC: Gastric cancer |
SIM: Severe intestinal metaplasia |
WIM: Wild intestinal metaplasia |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/GNAS_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Lung | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Lung/GNAS_pca_on_diff_genes.png) | AAH: Atypical adenomatous hyperplasia |
AIS: Adenocarcinoma in situ |
IAC: Invasive lung adenocarcinoma |
MIA: Minimally invasive adenocarcinoma |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/GNAS_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Prostate | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Prostate/GNAS_pca_on_diff_genes.png) | BPH: Benign Prostatic Hyperplasia |
Skin | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Skin/GNAS_pca_on_diff_genes.png) | AK: Actinic keratosis |
cSCC: Cutaneous squamous cell carcinoma |
SCCIS:squamous cell carcinoma in situ |
Thyroid | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Thyroid/GNAS_pca_on_diff_genes.png) | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa05207 | Colorectum | CRC | Chemical carcinogenesis - receptor activation | 42/1091 | 212/8465 | 2.62e-03 | 1.75e-02 | 1.19e-02 | 42 |
hsa049702 | Colorectum | CRC | Salivary secretion | 22/1091 | 93/8465 | 3.03e-03 | 1.91e-02 | 1.29e-02 | 22 |
hsa049288 | Colorectum | CRC | Parathyroid hormone synthesis, secretion and action | 24/1091 | 106/8465 | 3.71e-03 | 2.29e-02 | 1.55e-02 | 24 |
hsa042612 | Colorectum | CRC | Adrenergic signaling in cardiomyocytes | 32/1091 | 154/8465 | 3.81e-03 | 2.31e-02 | 1.57e-02 | 32 |
hsa049228 | Colorectum | CRC | Glucagon signaling pathway | 24/1091 | 107/8465 | 4.21e-03 | 2.47e-02 | 1.67e-02 | 24 |
hsa049154 | Colorectum | CRC | Estrogen signaling pathway | 29/1091 | 138/8465 | 4.83e-03 | 2.66e-02 | 1.80e-02 | 29 |
hsa047288 | Colorectum | CRC | Dopaminergic synapse | 28/1091 | 132/8465 | 4.86e-03 | 2.66e-02 | 1.80e-02 | 28 |
hsa047132 | Colorectum | CRC | Circadian entrainment | 22/1091 | 97/8465 | 5.21e-03 | 2.72e-02 | 1.84e-02 | 22 |
hsa049112 | Colorectum | CRC | Insulin secretion | 20/1091 | 86/8465 | 5.61e-03 | 2.88e-02 | 1.95e-02 | 20 |
hsa049252 | Colorectum | CRC | Aldosterone synthesis and secretion | 22/1091 | 98/8465 | 5.92e-03 | 3.00e-02 | 2.03e-02 | 22 |
hsa04724 | Colorectum | CRC | Glutamatergic synapse | 24/1091 | 115/8465 | 1.07e-02 | 4.74e-02 | 3.21e-02 | 24 |
hsa042702 | Colorectum | CRC | Vascular smooth muscle contraction | 27/1091 | 134/8465 | 1.13e-02 | 4.90e-02 | 3.32e-02 | 27 |
hsa049729 | Colorectum | CRC | Pancreatic secretion | 32/1091 | 102/8465 | 7.86e-07 | 4.37e-05 | 2.96e-05 | 32 |
hsa040159 | Colorectum | CRC | Rap1 signaling pathway | 48/1091 | 210/8465 | 4.00e-05 | 8.70e-04 | 5.90e-04 | 48 |
hsa049619 | Colorectum | CRC | Endocrine and other factor-regulated calcium reabsorption | 18/1091 | 53/8465 | 6.36e-05 | 1.12e-03 | 7.57e-04 | 18 |
hsa049719 | Colorectum | CRC | Gastric acid secretion | 22/1091 | 76/8465 | 1.57e-04 | 2.18e-03 | 1.48e-03 | 22 |
hsa049129 | Colorectum | CRC | GnRH signaling pathway | 25/1091 | 93/8465 | 2.11e-04 | 2.71e-03 | 1.84e-03 | 25 |
hsa040243 | Colorectum | CRC | cAMP signaling pathway | 47/1091 | 225/8465 | 4.57e-04 | 4.77e-03 | 3.23e-03 | 47 |
hsa051639 | Colorectum | CRC | Human cytomegalovirus infection | 45/1091 | 225/8465 | 1.54e-03 | 1.17e-02 | 7.94e-03 | 45 |
hsa049355 | Colorectum | CRC | Growth hormone synthesis, secretion and action | 27/1091 | 120/8465 | 2.37e-03 | 1.69e-02 | 1.14e-02 | 27 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
GNAS | SNV | Missense_Mutation | rs11554273 | c.2530C>T | p.Arg844Cys | p.R844C | Q5JWF2 | protein_coding | deleterious(0.01) | probably_damaging(1) | TCGA-A8-A09T-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | anastrozole | SD |
GNAS | SNV | Missense_Mutation | | c.437N>A | p.Gly146Asp | p.G146D | Q5JWF2 | protein_coding | tolerated_low_confidence(0.09) | benign(0.003) | TCGA-A8-A09Z-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
GNAS | SNV | Missense_Mutation | | c.964C>G | p.Pro322Ala | p.P322A | Q5JWF2 | protein_coding | tolerated_low_confidence(0.08) | benign(0.013) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
GNAS | SNV | Missense_Mutation | | c.3094N>T | p.Arg1032Cys | p.R1032C | Q5JWF2 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
GNAS | SNV | Missense_Mutation | | c.2782A>G | p.Ile928Val | p.I928V | Q5JWF2 | protein_coding | deleterious(0.04) | probably_damaging(0.935) | TCGA-AR-A1AW-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | docetaxel | SD |
GNAS | SNV | Missense_Mutation | | c.1004C>T | p.Pro335Leu | p.P335L | Q5JWF2 | protein_coding | deleterious_low_confidence(0.03) | benign(0.02) | TCGA-E2-A570-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | anastrozole | SD |
GNAS | SNV | Missense_Mutation | | c.3057C>G | p.Phe1019Leu | p.F1019L | Q5JWF2 | protein_coding | deleterious(0.02) | probably_damaging(0.999) | TCGA-GM-A2D9-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD |
GNAS | SNV | Missense_Mutation | | c.513G>C | p.Gln171His | p.Q171H | Q5JWF2 | protein_coding | deleterious_low_confidence(0.04) | benign(0.01) | TCGA-PE-A5DE-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | CR |
GNAS | insertion | Frame_Shift_Ins | novel | c.2106_2107insA | p.Met703AsnfsTer7 | p.M703Nfs*7 | Q5JWF2 | protein_coding | | | TCGA-AN-A0FF-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
GNAS | insertion | Frame_Shift_Ins | novel | c.1827dupC | p.Asn610GlnfsTer15 | p.N610Qfs*15 | Q5JWF2 | protein_coding | | | TCGA-AO-A1KT-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | fluorouracil | SD |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
2778 | GNAS | DRUGGABLE GENOME, CLINICALLY ACTIONABLE, G PROTEIN COUPLED RECEPTOR, DRUG RESISTANCE, TRANSPORTER | | GARCINONE E | GARCINONE E | |
2778 | GNAS | DRUGGABLE GENOME, CLINICALLY ACTIONABLE, G PROTEIN COUPLED RECEPTOR, DRUG RESISTANCE, TRANSPORTER | | BAS 01152706 | CHEMBL2002487 | |
2778 | GNAS | DRUGGABLE GENOME, CLINICALLY ACTIONABLE, G PROTEIN COUPLED RECEPTOR, DRUG RESISTANCE, TRANSPORTER | | N-(3,4-DICHLOROPHENYL)BENZAMIDE | CHEMBL560296 | |
2778 | GNAS | DRUGGABLE GENOME, CLINICALLY ACTIONABLE, G PROTEIN COUPLED RECEPTOR, DRUG RESISTANCE, TRANSPORTER | | TETRAETHYLAMMONIUM CHLORIDE | TETRAETHYLAMMONIUM CHLORIDE | |
2778 | GNAS | DRUGGABLE GENOME, CLINICALLY ACTIONABLE, G PROTEIN COUPLED RECEPTOR, DRUG RESISTANCE, TRANSPORTER | | TCMDC-125620 | CHEMBL530291 | |
2778 | GNAS | DRUGGABLE GENOME, CLINICALLY ACTIONABLE, G PROTEIN COUPLED RECEPTOR, DRUG RESISTANCE, TRANSPORTER | | CISPLATIN | CISPLATIN | 19274060 |
2778 | GNAS | DRUGGABLE GENOME, CLINICALLY ACTIONABLE, G PROTEIN COUPLED RECEPTOR, DRUG RESISTANCE, TRANSPORTER | | TCMDC-124353 | CHEMBL529918 | |
2778 | GNAS | DRUGGABLE GENOME, CLINICALLY ACTIONABLE, G PROTEIN COUPLED RECEPTOR, DRUG RESISTANCE, TRANSPORTER | | FLUOROURACIL | FLUOROURACIL | 19274060 |
2778 | GNAS | DRUGGABLE GENOME, CLINICALLY ACTIONABLE, G PROTEIN COUPLED RECEPTOR, DRUG RESISTANCE, TRANSPORTER | | NICLOSAMIDE | NICLOSAMIDE | |
2778 | GNAS | DRUGGABLE GENOME, CLINICALLY ACTIONABLE, G PROTEIN COUPLED RECEPTOR, DRUG RESISTANCE, TRANSPORTER | | 9,10-PHENANTHRENEQUINONE | 9,10-PHENANTHRENEQUINONE | |