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Gene: CSNK2B |
Gene summary for CSNK2B |
Gene summary. |
Gene information | Species | Human | Gene symbol | CSNK2B | Gene ID | 1460 |
Gene name | casein kinase 2 beta | |
Gene Alias | CK2B | |
Cytomap | 6p21.33 | |
Gene Type | protein-coding | GO ID | GO:0001667 | UniProtAcc | A0A1U9X7J2 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
1460 | CSNK2B | CA_HPV_1 | Human | Cervix | CC | 2.11e-03 | -1.68e-01 | 0.0264 |
1460 | CSNK2B | N_HPV_2 | Human | Cervix | N_HPV | 7.03e-03 | 1.12e-01 | -0.0131 |
1460 | CSNK2B | CCI_1 | Human | Cervix | CC | 8.24e-06 | -5.08e-01 | 0.528 |
1460 | CSNK2B | CCI_2 | Human | Cervix | CC | 3.20e-05 | -5.08e-01 | 0.5249 |
1460 | CSNK2B | CCI_3 | Human | Cervix | CC | 3.50e-08 | -5.08e-01 | 0.516 |
1460 | CSNK2B | CCII_1 | Human | Cervix | CC | 8.11e-12 | -5.08e-01 | 0.3249 |
1460 | CSNK2B | sample3 | Human | Cervix | CC | 5.58e-07 | 1.96e-01 | 0.1387 |
1460 | CSNK2B | T3 | Human | Cervix | CC | 2.74e-07 | 2.19e-01 | 0.1389 |
1460 | CSNK2B | HTA11_3410_2000001011 | Human | Colorectum | AD | 5.63e-18 | 3.46e-01 | 0.0155 |
1460 | CSNK2B | HTA11_2487_2000001011 | Human | Colorectum | SER | 7.75e-24 | 5.54e-01 | -0.1808 |
1460 | CSNK2B | HTA11_2951_2000001011 | Human | Colorectum | AD | 3.03e-06 | 3.36e-01 | 0.0216 |
1460 | CSNK2B | HTA11_1938_2000001011 | Human | Colorectum | AD | 2.05e-20 | 6.33e-01 | -0.0811 |
1460 | CSNK2B | HTA11_78_2000001011 | Human | Colorectum | AD | 3.40e-20 | 4.49e-01 | -0.1088 |
1460 | CSNK2B | HTA11_347_2000001011 | Human | Colorectum | AD | 5.03e-52 | 7.85e-01 | -0.1954 |
1460 | CSNK2B | HTA11_411_2000001011 | Human | Colorectum | SER | 6.42e-18 | 9.53e-01 | -0.2602 |
1460 | CSNK2B | HTA11_2112_2000001011 | Human | Colorectum | SER | 2.75e-12 | 7.74e-01 | -0.2196 |
1460 | CSNK2B | HTA11_3361_2000001011 | Human | Colorectum | AD | 1.74e-18 | 5.72e-01 | -0.1207 |
1460 | CSNK2B | HTA11_83_2000001011 | Human | Colorectum | SER | 4.15e-23 | 5.85e-01 | -0.1526 |
1460 | CSNK2B | HTA11_696_2000001011 | Human | Colorectum | AD | 2.49e-45 | 7.53e-01 | -0.1464 |
1460 | CSNK2B | HTA11_866_2000001011 | Human | Colorectum | AD | 9.10e-25 | 4.62e-01 | -0.1001 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:009013210 | Cervix | CC | epithelium migration | 90/2311 | 360/18723 | 2.45e-11 | 6.11e-09 | 90 |
GO:00016679 | Cervix | CC | ameboidal-type cell migration | 110/2311 | 475/18723 | 2.66e-11 | 6.36e-09 | 110 |
GO:001063110 | Cervix | CC | epithelial cell migration | 89/2311 | 357/18723 | 3.72e-11 | 8.54e-09 | 89 |
GO:009013010 | Cervix | CC | tissue migration | 90/2311 | 365/18723 | 5.42e-11 | 1.05e-08 | 90 |
GO:001063210 | Cervix | CC | regulation of epithelial cell migration | 72/2311 | 292/18723 | 4.52e-09 | 4.43e-07 | 72 |
GO:00160557 | Cervix | CC | Wnt signaling pathway | 98/2311 | 444/18723 | 4.82e-09 | 4.65e-07 | 98 |
GO:01987387 | Cervix | CC | cell-cell signaling by wnt | 98/2311 | 446/18723 | 6.16e-09 | 5.58e-07 | 98 |
GO:005109810 | Cervix | CC | regulation of binding | 80/2311 | 363/18723 | 1.32e-07 | 6.42e-06 | 80 |
GO:00435427 | Cervix | CC | endothelial cell migration | 60/2311 | 279/18723 | 1.05e-05 | 2.33e-04 | 60 |
GO:00105944 | Cervix | CC | regulation of endothelial cell migration | 52/2311 | 232/18723 | 1.20e-05 | 2.54e-04 | 52 |
GO:00064708 | Cervix | CC | protein dephosphorylation | 60/2311 | 281/18723 | 1.33e-05 | 2.68e-04 | 60 |
GO:00310996 | Cervix | CC | regeneration | 46/2311 | 198/18723 | 1.43e-05 | 2.84e-04 | 46 |
GO:190165410 | Cervix | CC | response to ketone | 45/2311 | 194/18723 | 1.83e-05 | 3.44e-04 | 45 |
GO:004873210 | Cervix | CC | gland development | 84/2311 | 436/18723 | 1.93e-05 | 3.54e-04 | 84 |
GO:00512713 | Cervix | CC | negative regulation of cellular component movement | 73/2311 | 367/18723 | 2.22e-05 | 3.95e-04 | 73 |
GO:005110110 | Cervix | CC | regulation of DNA binding | 31/2311 | 118/18723 | 2.91e-05 | 4.81e-04 | 31 |
GO:00400133 | Cervix | CC | negative regulation of locomotion | 76/2311 | 391/18723 | 3.47e-05 | 5.60e-04 | 76 |
GO:20001463 | Cervix | CC | negative regulation of cell motility | 71/2311 | 359/18723 | 3.47e-05 | 5.60e-04 | 71 |
GO:00303363 | Cervix | CC | negative regulation of cell migration | 68/2311 | 344/18723 | 5.11e-05 | 7.70e-04 | 68 |
GO:00436668 | Cervix | CC | regulation of phosphoprotein phosphatase activity | 18/2311 | 58/18723 | 1.40e-04 | 1.70e-03 | 18 |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0431024 | Oral cavity | NEOLP | Wnt signaling pathway | 34/1112 | 171/8465 | 8.05e-03 | 2.88e-02 | 1.81e-02 | 34 |
hsa052354 | Oral cavity | NEOLP | PD-L1 expression and PD-1 checkpoint pathway in cancer | 20/1112 | 89/8465 | 1.03e-02 | 3.47e-02 | 2.18e-02 | 20 |
hsa0501072 | Oral cavity | NEOLP | Alzheimer disease | 97/1112 | 384/8465 | 3.97e-11 | 1.57e-09 | 9.89e-10 | 97 |
hsa0502272 | Oral cavity | NEOLP | Pathways of neurodegeneration - multiple diseases | 112/1112 | 476/8465 | 1.33e-10 | 3.84e-09 | 2.41e-09 | 112 |
hsa0502072 | Oral cavity | NEOLP | Prion disease | 73/1112 | 273/8465 | 7.94e-10 | 2.10e-08 | 1.32e-08 | 73 |
hsa0452054 | Oral cavity | NEOLP | Adherens junction | 33/1112 | 93/8465 | 3.02e-08 | 5.34e-07 | 3.36e-07 | 33 |
hsa0413772 | Oral cavity | NEOLP | Mitophagy - animal | 26/1112 | 72/8465 | 5.95e-07 | 7.88e-06 | 4.95e-06 | 26 |
hsa051627 | Oral cavity | NEOLP | Measles | 35/1112 | 139/8465 | 8.30e-05 | 6.14e-04 | 3.86e-04 | 35 |
hsa0431034 | Oral cavity | NEOLP | Wnt signaling pathway | 34/1112 | 171/8465 | 8.05e-03 | 2.88e-02 | 1.81e-02 | 34 |
hsa052355 | Oral cavity | NEOLP | PD-L1 expression and PD-1 checkpoint pathway in cancer | 20/1112 | 89/8465 | 1.03e-02 | 3.47e-02 | 2.18e-02 | 20 |
hsa0502026 | Prostate | BPH | Prion disease | 141/1718 | 273/8465 | 1.11e-31 | 1.23e-29 | 7.58e-30 | 141 |
hsa0501026 | Prostate | BPH | Alzheimer disease | 165/1718 | 384/8465 | 4.03e-25 | 1.66e-23 | 1.03e-23 | 165 |
hsa0502226 | Prostate | BPH | Pathways of neurodegeneration - multiple diseases | 180/1718 | 476/8465 | 7.70e-20 | 1.81e-18 | 1.12e-18 | 180 |
hsa0452027 | Prostate | BPH | Adherens junction | 55/1718 | 93/8465 | 1.90e-16 | 4.18e-15 | 2.59e-15 | 55 |
hsa0413726 | Prostate | BPH | Mitophagy - animal | 28/1718 | 72/8465 | 2.12e-04 | 1.13e-03 | 6.98e-04 | 28 |
hsa0431014 | Prostate | BPH | Wnt signaling pathway | 50/1718 | 171/8465 | 3.11e-03 | 1.15e-02 | 7.14e-03 | 50 |
hsa051624 | Prostate | BPH | Measles | 42/1718 | 139/8465 | 3.35e-03 | 1.23e-02 | 7.61e-03 | 42 |
hsa05020111 | Prostate | BPH | Prion disease | 141/1718 | 273/8465 | 1.11e-31 | 1.23e-29 | 7.58e-30 | 141 |
hsa05010111 | Prostate | BPH | Alzheimer disease | 165/1718 | 384/8465 | 4.03e-25 | 1.66e-23 | 1.03e-23 | 165 |
hsa05022111 | Prostate | BPH | Pathways of neurodegeneration - multiple diseases | 180/1718 | 476/8465 | 7.70e-20 | 1.81e-18 | 1.12e-18 | 180 |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CSNK2B | SNV | Missense_Mutation | novel | c.70G>A | p.Glu24Lys | p.E24K | P67870 | protein_coding | deleterious(0.01) | possibly_damaging(0.904) | TCGA-EW-A1PB-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
CSNK2B | SNV | Missense_Mutation | novel | c.283N>A | p.Ala95Thr | p.A95T | P67870 | protein_coding | tolerated(0.18) | benign(0.035) | TCGA-S3-A6ZH-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | CR |
CSNK2B | SNV | Missense_Mutation | c.608N>T | p.Ala203Val | p.A203V | P67870 | protein_coding | tolerated(0.11) | benign(0) | TCGA-AA-3710-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
CSNK2B | SNV | Missense_Mutation | c.377N>G | p.Asp126Gly | p.D126G | P67870 | protein_coding | deleterious(0) | probably_damaging(0.993) | TCGA-AD-A5EJ-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
CSNK2B | SNV | Missense_Mutation | c.52N>A | p.Gly18Ser | p.G18S | P67870 | protein_coding | deleterious(0.02) | probably_damaging(1) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
CSNK2B | SNV | Missense_Mutation | novel | c.553N>T | p.Pro185Ser | p.P185S | P67870 | protein_coding | deleterious(0.02) | benign(0.409) | TCGA-G4-6320-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | oxaliplatin | SD |
CSNK2B | SNV | Missense_Mutation | novel | c.638C>T | p.Thr213Met | p.T213M | P67870 | protein_coding | tolerated_low_confidence(0.13) | benign(0.033) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
CSNK2B | SNV | Missense_Mutation | novel | c.295G>A | p.Glu99Lys | p.E99K | P67870 | protein_coding | deleterious(0.02) | benign(0.053) | TCGA-AX-A2HH-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CSNK2B | SNV | Missense_Mutation | c.253N>A | p.Ala85Thr | p.A85T | P67870 | protein_coding | deleterious(0.01) | probably_damaging(0.961) | TCGA-D1-A1NY-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | SD | |
CSNK2B | SNV | Missense_Mutation | novel | c.101N>G | p.Phe34Cys | p.F34C | P67870 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-E6-A1M0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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