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Gene: SOX4 |
Gene summary for SOX4 |
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Gene information | Species | Human | Gene symbol | SOX4 | Gene ID | 6659 |
Gene name | SRY-box transcription factor 4 | |
Gene Alias | CSS10 | |
Cytomap | 6p22.3 | |
Gene Type | protein-coding | GO ID | GO:0000075 | UniProtAcc | Q06945 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
6659 | SOX4 | GSM4909280 | Human | Breast | Precancer | 3.15e-02 | 2.05e-01 | 0.0305 |
6659 | SOX4 | GSM4909281 | Human | Breast | IDC | 1.62e-19 | 4.90e-01 | 0.21 |
6659 | SOX4 | GSM4909282 | Human | Breast | IDC | 5.35e-05 | 3.25e-01 | -0.0288 |
6659 | SOX4 | GSM4909285 | Human | Breast | IDC | 1.84e-09 | 3.15e-01 | 0.21 |
6659 | SOX4 | GSM4909286 | Human | Breast | IDC | 4.56e-33 | 5.72e-01 | 0.1081 |
6659 | SOX4 | GSM4909293 | Human | Breast | IDC | 3.76e-03 | 1.30e-01 | 0.1581 |
6659 | SOX4 | GSM4909294 | Human | Breast | IDC | 4.88e-06 | -4.46e-01 | 0.2022 |
6659 | SOX4 | GSM4909296 | Human | Breast | IDC | 8.39e-03 | 7.04e-02 | 0.1524 |
6659 | SOX4 | GSM4909297 | Human | Breast | IDC | 1.63e-10 | -4.43e-02 | 0.1517 |
6659 | SOX4 | GSM4909302 | Human | Breast | IDC | 1.25e-13 | -5.79e-01 | 0.1545 |
6659 | SOX4 | GSM4909304 | Human | Breast | IDC | 9.88e-04 | -2.44e-01 | 0.1636 |
6659 | SOX4 | GSM4909311 | Human | Breast | IDC | 3.84e-33 | -3.33e-01 | 0.1534 |
6659 | SOX4 | GSM4909313 | Human | Breast | IDC | 2.12e-05 | 2.96e-01 | 0.0391 |
6659 | SOX4 | GSM4909315 | Human | Breast | IDC | 2.72e-12 | 1.93e-01 | 0.21 |
6659 | SOX4 | GSM4909316 | Human | Breast | IDC | 5.26e-04 | -3.50e-01 | 0.21 |
6659 | SOX4 | GSM4909317 | Human | Breast | IDC | 4.98e-07 | 3.98e-01 | 0.1355 |
6659 | SOX4 | GSM4909319 | Human | Breast | IDC | 1.32e-48 | -8.41e-01 | 0.1563 |
6659 | SOX4 | GSM4909320 | Human | Breast | IDC | 3.57e-02 | 1.83e-01 | 0.1575 |
6659 | SOX4 | GSM4909321 | Human | Breast | IDC | 5.88e-05 | -4.46e-02 | 0.1559 |
6659 | SOX4 | ctrl6 | Human | Breast | Precancer | 3.33e-12 | 5.34e-01 | -0.0061 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000974951 | Stomach | SIM | response to glucose | 20/708 | 212/18723 | 1.66e-04 | 3.56e-03 | 20 |
GO:005122251 | Stomach | SIM | positive regulation of protein transport | 25/708 | 303/18723 | 2.30e-04 | 4.61e-03 | 25 |
GO:00713334 | Stomach | SIM | cellular response to glucose stimulus | 15/708 | 151/18723 | 6.14e-04 | 9.21e-03 | 15 |
GO:00713314 | Stomach | SIM | cellular response to hexose stimulus | 15/708 | 153/18723 | 7.05e-04 | 1.01e-02 | 15 |
GO:00713264 | Stomach | SIM | cellular response to monosaccharide stimulus | 15/708 | 154/18723 | 7.54e-04 | 1.06e-02 | 15 |
GO:000167831 | Stomach | SIM | cellular glucose homeostasis | 16/708 | 172/18723 | 8.42e-04 | 1.15e-02 | 16 |
GO:19021072 | Stomach | SIM | positive regulation of leukocyte differentiation | 15/708 | 157/18723 | 9.21e-04 | 1.24e-02 | 15 |
GO:19037082 | Stomach | SIM | positive regulation of hemopoiesis | 15/708 | 157/18723 | 9.21e-04 | 1.24e-02 | 15 |
GO:00026965 | Stomach | SIM | positive regulation of leukocyte activation | 29/708 | 409/18723 | 9.32e-04 | 1.25e-02 | 29 |
GO:000641751 | Stomach | SIM | regulation of translation | 32/708 | 468/18723 | 9.56e-04 | 1.27e-02 | 32 |
GO:007132241 | Stomach | SIM | cellular response to carbohydrate stimulus | 15/708 | 163/18723 | 1.35e-03 | 1.66e-02 | 15 |
GO:00512514 | Stomach | SIM | positive regulation of lymphocyte activation | 26/708 | 362/18723 | 1.40e-03 | 1.70e-02 | 26 |
GO:00508675 | Stomach | SIM | positive regulation of cell activation | 29/708 | 420/18723 | 1.40e-03 | 1.70e-02 | 29 |
GO:004887241 | Stomach | SIM | homeostasis of number of cells | 21/708 | 272/18723 | 1.63e-03 | 1.89e-02 | 21 |
GO:004259331 | Stomach | SIM | glucose homeostasis | 20/708 | 258/18723 | 1.99e-03 | 2.16e-02 | 20 |
GO:003350031 | Stomach | SIM | carbohydrate homeostasis | 20/708 | 259/18723 | 2.08e-03 | 2.23e-02 | 20 |
GO:00507145 | Stomach | SIM | positive regulation of protein secretion | 13/708 | 137/18723 | 2.10e-03 | 2.24e-02 | 13 |
GO:19021054 | Stomach | SIM | regulation of leukocyte differentiation | 21/708 | 279/18723 | 2.22e-03 | 2.30e-02 | 21 |
GO:005160431 | Stomach | SIM | protein maturation | 21/708 | 294/18723 | 4.11e-03 | 3.70e-02 | 21 |
GO:00303305 | Stomach | SIM | DNA damage response, signal transduction by p53 class mediator | 8/708 | 72/18723 | 5.70e-03 | 4.67e-02 | 8 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SOX4 | SNV | Missense_Mutation | rs777539753 | c.1172N>T | p.Ser391Phe | p.S391F | Q06945 | protein_coding | deleterious(0) | possibly_damaging(0.854) | TCGA-A7-A6VW-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | CR |
SOX4 | SNV | Missense_Mutation | novel | c.1367A>T | p.Glu456Val | p.E456V | Q06945 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-AC-A8OP-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SOX4 | SNV | Missense_Mutation | novel | c.1210N>T | p.Asp404Tyr | p.D404Y | Q06945 | protein_coding | deleterious(0.01) | probably_damaging(0.936) | TCGA-MY-A5BD-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
SOX4 | SNV | Missense_Mutation | novel | c.1390G>C | p.Glu464Gln | p.E464Q | Q06945 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-VS-A9UC-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD |
SOX4 | SNV | Missense_Mutation | c.331G>C | p.Glu111Gln | p.E111Q | Q06945 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-CM-6674-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
SOX4 | SNV | Missense_Mutation | c.299N>G | p.Leu100Arg | p.L100R | Q06945 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-G4-6588-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
SOX4 | SNV | Missense_Mutation | c.237N>T | p.Glu79Asp | p.E79D | Q06945 | protein_coding | tolerated(0.06) | benign(0.444) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
SOX4 | SNV | Missense_Mutation | c.237N>T | p.Glu79Asp | p.E79D | Q06945 | protein_coding | tolerated(0.06) | benign(0.444) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
SOX4 | SNV | Missense_Mutation | novel | c.1252T>G | p.Ser418Ala | p.S418A | Q06945 | protein_coding | tolerated(0.16) | benign(0.021) | TCGA-AP-A1DV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SOX4 | SNV | Missense_Mutation | novel | c.1166N>G | p.Ser389Cys | p.S389C | Q06945 | protein_coding | deleterious(0) | benign(0.009) | TCGA-AX-A3G3-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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