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Gene: PAFAH1B1 |
Gene summary for PAFAH1B1 |
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Gene information | Species | Human | Gene symbol | PAFAH1B1 | Gene ID | 5048 |
Gene name | platelet activating factor acetylhydrolase 1b regulatory subunit 1 | |
Gene Alias | LIS1 | |
Cytomap | 17p13.3 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | P43034 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
5048 | PAFAH1B1 | CA_HPV_1 | Human | Cervix | CC | 7.64e-03 | -1.33e-01 | 0.0264 |
5048 | PAFAH1B1 | CA_HPV_3 | Human | Cervix | CC | 3.54e-03 | 9.12e-02 | 0.0414 |
5048 | PAFAH1B1 | N_HPV_2 | Human | Cervix | N_HPV | 3.57e-02 | 7.58e-02 | -0.0131 |
5048 | PAFAH1B1 | CCI_1 | Human | Cervix | CC | 6.23e-06 | 9.35e-01 | 0.528 |
5048 | PAFAH1B1 | CCI_2 | Human | Cervix | CC | 6.74e-08 | 1.15e+00 | 0.5249 |
5048 | PAFAH1B1 | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.08e-05 | -2.90e-01 | 0.0155 |
5048 | PAFAH1B1 | HTA11_347_2000001011 | Human | Colorectum | AD | 6.37e-09 | 5.75e-01 | -0.1954 |
5048 | PAFAH1B1 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 1.33e-02 | -4.88e-01 | 0.2585 |
5048 | PAFAH1B1 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 1.18e-02 | -2.63e-01 | 0.3005 |
5048 | PAFAH1B1 | F007 | Human | Colorectum | FAP | 1.41e-03 | -2.21e-01 | 0.1176 |
5048 | PAFAH1B1 | A002-C-010 | Human | Colorectum | FAP | 5.59e-03 | -2.39e-01 | 0.242 |
5048 | PAFAH1B1 | A001-C-207 | Human | Colorectum | FAP | 1.29e-02 | -1.27e-01 | 0.1278 |
5048 | PAFAH1B1 | A015-C-203 | Human | Colorectum | FAP | 2.48e-35 | -4.58e-01 | -0.1294 |
5048 | PAFAH1B1 | A015-C-204 | Human | Colorectum | FAP | 2.32e-09 | -3.89e-01 | -0.0228 |
5048 | PAFAH1B1 | A014-C-040 | Human | Colorectum | FAP | 2.33e-04 | -3.02e-01 | -0.1184 |
5048 | PAFAH1B1 | A002-C-201 | Human | Colorectum | FAP | 3.37e-16 | -3.89e-01 | 0.0324 |
5048 | PAFAH1B1 | A002-C-203 | Human | Colorectum | FAP | 2.33e-08 | -3.22e-01 | 0.2786 |
5048 | PAFAH1B1 | A001-C-119 | Human | Colorectum | FAP | 1.64e-09 | -2.88e-01 | -0.1557 |
5048 | PAFAH1B1 | A001-C-108 | Human | Colorectum | FAP | 9.52e-20 | -2.40e-01 | -0.0272 |
5048 | PAFAH1B1 | A002-C-205 | Human | Colorectum | FAP | 1.05e-27 | -4.63e-01 | -0.1236 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000740919 | Thyroid | ATC | axonogenesis | 197/6293 | 418/18723 | 5.09e-09 | 1.13e-07 | 197 |
GO:001076927 | Thyroid | ATC | regulation of cell morphogenesis involved in differentiation | 59/6293 | 96/18723 | 2.08e-08 | 4.05e-07 | 59 |
GO:001072022 | Thyroid | ATC | positive regulation of cell development | 146/6293 | 298/18723 | 2.36e-08 | 4.56e-07 | 146 |
GO:0051650110 | Thyroid | ATC | establishment of vesicle localization | 87/6293 | 161/18723 | 7.16e-08 | 1.25e-06 | 87 |
GO:0030010111 | Thyroid | ATC | establishment of cell polarity | 79/6293 | 143/18723 | 8.08e-08 | 1.40e-06 | 79 |
GO:003086523 | Thyroid | ATC | cortical cytoskeleton organization | 41/6293 | 61/18723 | 8.28e-08 | 1.43e-06 | 41 |
GO:004867522 | Thyroid | ATC | axon extension | 68/6293 | 120/18723 | 1.73e-07 | 2.75e-06 | 68 |
GO:001097022 | Thyroid | ATC | transport along microtubule | 83/6293 | 155/18723 | 2.38e-07 | 3.70e-06 | 83 |
GO:0045931110 | Thyroid | ATC | positive regulation of mitotic cell cycle | 68/6293 | 121/18723 | 2.66e-07 | 4.08e-06 | 68 |
GO:005076922 | Thyroid | ATC | positive regulation of neurogenesis | 112/6293 | 225/18723 | 3.53e-07 | 5.21e-06 | 112 |
GO:005076723 | Thyroid | ATC | regulation of neurogenesis | 168/6293 | 364/18723 | 3.73e-07 | 5.48e-06 | 168 |
GO:0016358110 | Thyroid | ATC | dendrite development | 119/6293 | 243/18723 | 4.65e-07 | 6.75e-06 | 119 |
GO:004577314 | Thyroid | ATC | positive regulation of axon extension | 30/6293 | 42/18723 | 6.06e-07 | 8.44e-06 | 30 |
GO:199013824 | Thyroid | ATC | neuron projection extension | 89/6293 | 172/18723 | 6.63e-07 | 9.13e-06 | 89 |
GO:005077213 | Thyroid | ATC | positive regulation of axonogenesis | 48/6293 | 79/18723 | 6.89e-07 | 9.35e-06 | 48 |
GO:003109826 | Thyroid | ATC | stress-activated protein kinase signaling cascade | 120/6293 | 247/18723 | 7.06e-07 | 9.46e-06 | 120 |
GO:005164818 | Thyroid | ATC | vesicle localization | 91/6293 | 177/18723 | 7.21e-07 | 9.64e-06 | 91 |
GO:005123532 | Thyroid | ATC | maintenance of location | 152/6293 | 327/18723 | 7.84e-07 | 1.04e-05 | 152 |
GO:006099623 | Thyroid | ATC | dendritic spine development | 57/6293 | 99/18723 | 8.24e-07 | 1.09e-05 | 57 |
GO:004858823 | Thyroid | ATC | developmental cell growth | 114/6293 | 234/18723 | 1.11e-06 | 1.44e-05 | 114 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PAFAH1B1 | SNV | Missense_Mutation | c.1062N>C | p.Leu354Phe | p.L354F | P43034 | protein_coding | tolerated(0.06) | benign(0.112) | TCGA-A2-A04W-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD | |
PAFAH1B1 | SNV | Missense_Mutation | c.603N>T | p.Met201Ile | p.M201I | P43034 | protein_coding | tolerated(0.6) | benign(0.203) | TCGA-A8-A07P-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | 5-fluorouracil | SD | |
PAFAH1B1 | SNV | Missense_Mutation | c.170N>G | p.Ser57Cys | p.S57C | P43034 | protein_coding | deleterious(0) | probably_damaging(0.976) | TCGA-E2-A10C-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD | |
PAFAH1B1 | deletion | Frame_Shift_Del | novel | c.1045delN | p.Lys351SerfsTer4 | p.K351Sfs*4 | P43034 | protein_coding | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
PAFAH1B1 | SNV | Missense_Mutation | novel | c.19N>G | p.Gln7Glu | p.Q7E | P43034 | protein_coding | deleterious(0) | possibly_damaging(0.709) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
PAFAH1B1 | SNV | Missense_Mutation | novel | c.1162N>G | p.Phe388Val | p.F388V | P43034 | protein_coding | tolerated(0.16) | benign(0.07) | TCGA-EA-A3HU-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
PAFAH1B1 | SNV | Missense_Mutation | c.239N>T | p.Thr80Met | p.T80M | P43034 | protein_coding | tolerated(0.11) | benign(0.206) | TCGA-AA-3672-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
PAFAH1B1 | SNV | Missense_Mutation | novel | c.212N>G | p.Lys71Arg | p.K71R | P43034 | protein_coding | tolerated(1) | benign(0.005) | TCGA-AA-3845-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
PAFAH1B1 | SNV | Missense_Mutation | c.431N>A | p.Arg144Gln | p.R144Q | P43034 | protein_coding | tolerated(0.06) | benign(0.3) | TCGA-AA-3977-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
PAFAH1B1 | SNV | Missense_Mutation | c.1112N>A | p.Arg371Gln | p.R371Q | P43034 | protein_coding | deleterious(0.04) | possibly_damaging(0.5) | TCGA-CM-6162-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | oxaliplatin | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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