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Gene: ID2 |
Gene summary for ID2 |
Gene summary. |
Gene information | Species | Human | Gene symbol | ID2 | Gene ID | 3398 |
Gene name | inhibitor of DNA binding 2 | |
Gene Alias | GIG8 | |
Cytomap | 2p25.1 | |
Gene Type | protein-coding | GO ID | GO:0000082 | UniProtAcc | Q02363 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
3398 | ID2 | GSM4909280 | Human | Breast | Precancer | 3.45e-05 | 7.07e-01 | 0.0305 |
3398 | ID2 | GSM4909285 | Human | Breast | IDC | 3.00e-02 | 2.67e-01 | 0.21 |
3398 | ID2 | GSM4909290 | Human | Breast | IDC | 1.71e-02 | 3.10e-01 | 0.2096 |
3398 | ID2 | GSM4909295 | Human | Breast | IDC | 3.04e-06 | 5.81e-01 | 0.0898 |
3398 | ID2 | GSM4909297 | Human | Breast | IDC | 2.82e-06 | 1.53e-01 | 0.1517 |
3398 | ID2 | GSM4909298 | Human | Breast | IDC | 4.17e-02 | 1.74e-01 | 0.1551 |
3398 | ID2 | GSM4909304 | Human | Breast | IDC | 3.40e-07 | -3.84e-01 | 0.1636 |
3398 | ID2 | GSM4909305 | Human | Breast | IDC | 9.89e-06 | 4.04e-01 | 0.0436 |
3398 | ID2 | GSM4909306 | Human | Breast | IDC | 2.23e-03 | 3.51e-01 | 0.1564 |
3398 | ID2 | GSM4909308 | Human | Breast | IDC | 4.48e-03 | 1.93e-01 | 0.158 |
3398 | ID2 | GSM4909311 | Human | Breast | IDC | 6.06e-20 | -3.59e-01 | 0.1534 |
3398 | ID2 | GSM4909312 | Human | Breast | IDC | 1.80e-07 | -3.80e-01 | 0.1552 |
3398 | ID2 | GSM4909319 | Human | Breast | IDC | 9.66e-22 | -3.19e-01 | 0.1563 |
3398 | ID2 | GSM4909321 | Human | Breast | IDC | 3.98e-17 | 5.69e-01 | 0.1559 |
3398 | ID2 | NCCBC5 | Human | Breast | DCIS | 5.59e-03 | -2.08e-01 | 0.2046 |
3398 | ID2 | P1 | Human | Breast | IDC | 1.61e-07 | -2.36e-01 | 0.1527 |
3398 | ID2 | DCIS2 | Human | Breast | DCIS | 3.81e-27 | -1.24e-01 | 0.0085 |
3398 | ID2 | CA_HPV_1 | Human | Cervix | CC | 2.02e-05 | -9.19e-02 | 0.0264 |
3398 | ID2 | CCI_1 | Human | Cervix | CC | 2.12e-04 | -5.25e-01 | 0.528 |
3398 | ID2 | CCI_3 | Human | Cervix | CC | 8.28e-06 | -5.14e-01 | 0.516 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00302186 | Stomach | GC | erythrocyte differentiation | 16/1159 | 120/18723 | 2.97e-03 | 2.66e-02 | 16 |
GO:00506734 | Stomach | GC | epithelial cell proliferation | 42/1159 | 437/18723 | 3.13e-03 | 2.78e-02 | 42 |
GO:0009649 | Stomach | GC | entrainment of circadian clock | 7/1159 | 34/18723 | 4.21e-03 | 3.49e-02 | 7 |
GO:00485652 | Stomach | GC | digestive tract development | 16/1159 | 127/18723 | 5.22e-03 | 4.11e-02 | 16 |
GO:00076235 | Stomach | GC | circadian rhythm | 23/1159 | 210/18723 | 5.64e-03 | 4.34e-02 | 23 |
GO:00488726 | Stomach | GC | homeostasis of number of cells | 28/1159 | 272/18723 | 5.78e-03 | 4.42e-02 | 28 |
GO:004563711 | Stomach | CAG with IM | regulation of myeloid cell differentiation | 28/1050 | 210/18723 | 1.84e-05 | 5.64e-04 | 28 |
GO:190370611 | Stomach | CAG with IM | regulation of hemopoiesis | 41/1050 | 367/18723 | 2.08e-05 | 6.09e-04 | 41 |
GO:000226211 | Stomach | CAG with IM | myeloid cell homeostasis | 22/1050 | 157/18723 | 6.64e-05 | 1.62e-03 | 22 |
GO:003410111 | Stomach | CAG with IM | erythrocyte homeostasis | 19/1050 | 129/18723 | 1.04e-04 | 2.28e-03 | 19 |
GO:004873211 | Stomach | CAG with IM | gland development | 44/1050 | 436/18723 | 1.20e-04 | 2.54e-03 | 44 |
GO:00026831 | Stomach | CAG with IM | negative regulation of immune system process | 43/1050 | 434/18723 | 2.14e-04 | 3.94e-03 | 43 |
GO:003009911 | Stomach | CAG with IM | myeloid cell differentiation | 39/1050 | 381/18723 | 2.14e-04 | 3.94e-03 | 39 |
GO:00093141 | Stomach | CAG with IM | response to radiation | 44/1050 | 456/18723 | 3.24e-04 | 5.39e-03 | 44 |
GO:19021051 | Stomach | CAG with IM | regulation of leukocyte differentiation | 30/1050 | 279/18723 | 4.91e-04 | 7.43e-03 | 30 |
GO:19021061 | Stomach | CAG with IM | negative regulation of leukocyte differentiation | 15/1050 | 102/18723 | 5.49e-04 | 8.15e-03 | 15 |
GO:00456391 | Stomach | CAG with IM | positive regulation of myeloid cell differentiation | 15/1050 | 103/18723 | 6.10e-04 | 8.79e-03 | 15 |
GO:19037071 | Stomach | CAG with IM | negative regulation of hemopoiesis | 15/1050 | 106/18723 | 8.29e-04 | 1.09e-02 | 15 |
GO:00027611 | Stomach | CAG with IM | regulation of myeloid leukocyte differentiation | 16/1050 | 120/18723 | 1.09e-03 | 1.33e-02 | 16 |
GO:003021811 | Stomach | CAG with IM | erythrocyte differentiation | 16/1050 | 120/18723 | 1.09e-03 | 1.33e-02 | 16 |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa043908 | Cervix | CC | Hippo signaling pathway | 40/1267 | 157/8465 | 3.64e-04 | 1.82e-03 | 1.07e-03 | 40 |
hsa0439013 | Cervix | CC | Hippo signaling pathway | 40/1267 | 157/8465 | 3.64e-04 | 1.82e-03 | 1.07e-03 | 40 |
hsa04350 | Colorectum | SER | TGF-beta signaling pathway | 31/1580 | 108/8465 | 7.00e-03 | 3.77e-02 | 2.74e-02 | 31 |
hsa043501 | Colorectum | SER | TGF-beta signaling pathway | 31/1580 | 108/8465 | 7.00e-03 | 3.77e-02 | 2.74e-02 | 31 |
hsa04390 | Colorectum | MSS | Hippo signaling pathway | 48/1875 | 157/8465 | 8.32e-03 | 3.10e-02 | 1.90e-02 | 48 |
hsa043901 | Colorectum | MSS | Hippo signaling pathway | 48/1875 | 157/8465 | 8.32e-03 | 3.10e-02 | 1.90e-02 | 48 |
hsa043909 | Endometrium | AEH | Hippo signaling pathway | 38/1197 | 157/8465 | 4.79e-04 | 3.38e-03 | 2.47e-03 | 38 |
hsa043504 | Endometrium | AEH | TGF-beta signaling pathway | 26/1197 | 108/8465 | 3.82e-03 | 2.18e-02 | 1.59e-02 | 26 |
hsa0439014 | Endometrium | AEH | Hippo signaling pathway | 38/1197 | 157/8465 | 4.79e-04 | 3.38e-03 | 2.47e-03 | 38 |
hsa0435011 | Endometrium | AEH | TGF-beta signaling pathway | 26/1197 | 108/8465 | 3.82e-03 | 2.18e-02 | 1.59e-02 | 26 |
hsa0439023 | Endometrium | EEC | Hippo signaling pathway | 39/1237 | 157/8465 | 4.54e-04 | 3.47e-03 | 2.59e-03 | 39 |
hsa043502 | Endometrium | EEC | TGF-beta signaling pathway | 26/1237 | 108/8465 | 5.95e-03 | 3.12e-02 | 2.33e-02 | 26 |
hsa0439033 | Endometrium | EEC | Hippo signaling pathway | 39/1237 | 157/8465 | 4.54e-04 | 3.47e-03 | 2.59e-03 | 39 |
hsa043503 | Endometrium | EEC | TGF-beta signaling pathway | 26/1237 | 108/8465 | 5.95e-03 | 3.12e-02 | 2.33e-02 | 26 |
hsa043507 | Esophagus | ESCC | TGF-beta signaling pathway | 69/4205 | 108/8465 | 1.92e-03 | 5.54e-03 | 2.84e-03 | 69 |
hsa052028 | Esophagus | ESCC | Transcriptional misregulation in cancer | 116/4205 | 193/8465 | 2.08e-03 | 5.95e-03 | 3.05e-03 | 116 |
hsa0439018 | Esophagus | ESCC | Hippo signaling pathway | 92/4205 | 157/8465 | 1.46e-02 | 3.31e-02 | 1.69e-02 | 92 |
hsa0435014 | Esophagus | ESCC | TGF-beta signaling pathway | 69/4205 | 108/8465 | 1.92e-03 | 5.54e-03 | 2.84e-03 | 69 |
hsa0520213 | Esophagus | ESCC | Transcriptional misregulation in cancer | 116/4205 | 193/8465 | 2.08e-03 | 5.95e-03 | 3.05e-03 | 116 |
hsa0439019 | Esophagus | ESCC | Hippo signaling pathway | 92/4205 | 157/8465 | 1.46e-02 | 3.31e-02 | 1.69e-02 | 92 |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ID2 | SNV | Missense_Mutation | c.254T>C | p.Ile85Thr | p.I85T | Q02363 | protein_coding | tolerated(0.12) | benign(0.037) | TCGA-A1-A0SM-01 | Breast | breast invasive carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
ID2 | SNV | Missense_Mutation | c.203N>C | p.Val68Ala | p.V68A | Q02363 | protein_coding | deleterious(0) | probably_damaging(0.915) | TCGA-A5-A0VP-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ID2 | SNV | Missense_Mutation | novel | c.127N>G | p.Tyr43Asp | p.Y43D | Q02363 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AP-A1DV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ID2 | SNV | Missense_Mutation | novel | c.174G>T | p.Lys58Asn | p.K58N | Q02363 | protein_coding | tolerated(0.12) | benign(0.015) | TCGA-AX-A2HC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | PD |
ID2 | SNV | Missense_Mutation | novel | c.49G>A | p.Asp17Asn | p.D17N | Q02363 | protein_coding | deleterious(0) | benign(0.021) | TCGA-62-A470-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
ID2 | SNV | Missense_Mutation | c.47N>T | p.Ser16Leu | p.S16L | Q02363 | protein_coding | deleterious(0.03) | benign(0.086) | TCGA-69-7761-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Chemotherapy | alimta | SD | |
ID2 | SNV | Missense_Mutation | c.384N>G | p.Asp128Glu | p.D128E | Q02363 | protein_coding | tolerated(0.13) | benign(0.005) | TCGA-95-7039-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |
ID2 | SNV | Missense_Mutation | novel | c.266N>G | p.His89Arg | p.H89R | Q02363 | protein_coding | tolerated(0.33) | benign(0.039) | TCGA-BA-A4II-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
ID2 | SNV | Missense_Mutation | novel | c.38N>G | p.Asn13Ser | p.N13S | Q02363 | protein_coding | tolerated(0.77) | benign(0) | TCGA-HU-A4G8-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Chemotherapy | 5-fluorouracil | SD |
ID2 | SNV | Missense_Mutation | c.242N>T | p.Ser81Leu | p.S81L | Q02363 | protein_coding | tolerated(0.06) | benign(0) | TCGA-EM-A1YB-01 | Thyroid | thyroid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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