Tissue | Expression Dynamics | Abbreviation |
Colorectum (GSE201348) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Becker/TP53_pca_on_diff_genes.png) | FAP: Familial adenomatous polyposis |
CRC: Colorectal cancer |
Colorectum (HTA11) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Chen/TP53_pca_on_diff_genes.png) | AD: Adenomas |
SER: Sessile serrated lesions |
MSI-H: Microsatellite-high colorectal cancer |
MSS: Microsatellite stable colorectal cancer |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/TP53_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/TP53_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Skin | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Skin/TP53_pca_on_diff_genes.png) | AK: Actinic keratosis |
cSCC: Cutaneous squamous cell carcinoma |
SCCIS:squamous cell carcinoma in situ |
Thyroid | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Thyroid/TP53_pca_on_diff_genes.png) | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:007092011 | Skin | cSCC | regulation of production of small RNA involved in gene silencing by RNA | 13/4864 | 26/18723 | 7.35e-03 | 3.47e-02 | 13 |
GO:0061614110 | Skin | cSCC | pri-miRNA transcription by RNA polymerase II | 23/4864 | 55/18723 | 7.54e-03 | 3.53e-02 | 23 |
GO:00431532 | Skin | cSCC | entrainment of circadian clock by photoperiod | 14/4864 | 29/18723 | 8.08e-03 | 3.74e-02 | 14 |
GO:004352319 | Skin | cSCC | regulation of neuron apoptotic process | 71/4864 | 212/18723 | 8.71e-03 | 4.01e-02 | 71 |
GO:2000279 | Skin | cSCC | negative regulation of DNA biosynthetic process | 17/4864 | 38/18723 | 9.41e-03 | 4.25e-02 | 17 |
GO:00702655 | Skin | cSCC | necrotic cell death | 25/4864 | 62/18723 | 9.44e-03 | 4.25e-02 | 25 |
GO:19904407 | Skin | cSCC | positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress | 7/4864 | 11/18723 | 9.45e-03 | 4.25e-02 | 7 |
GO:004886317 | Skin | cSCC | stem cell differentiation | 69/4864 | 206/18723 | 9.56e-03 | 4.30e-02 | 69 |
GO:00067404 | Skin | cSCC | NADPH regeneration | 9/4864 | 16/18723 | 9.73e-03 | 4.31e-02 | 9 |
GO:00092994 | Skin | cSCC | mRNA transcription | 9/4864 | 16/18723 | 9.73e-03 | 4.31e-02 | 9 |
GO:000600610 | Skin | cSCC | glucose metabolic process | 66/4864 | 196/18723 | 9.75e-03 | 4.32e-02 | 66 |
GO:003600320 | Skin | cSCC | positive regulation of transcription from RNA polymerase II promoter in response to stress | 12/4864 | 24/18723 | 9.91e-03 | 4.35e-02 | 12 |
GO:009719330 | Thyroid | HT | intrinsic apoptotic signaling pathway | 52/1272 | 288/18723 | 7.65e-11 | 1.06e-08 | 52 |
GO:007233130 | Thyroid | HT | signal transduction by p53 class mediator | 31/1272 | 163/18723 | 1.52e-07 | 8.45e-06 | 31 |
GO:190121628 | Thyroid | HT | positive regulation of neuron death | 20/1272 | 97/18723 | 6.68e-06 | 1.96e-04 | 20 |
GO:007233229 | Thyroid | HT | intrinsic apoptotic signaling pathway by p53 class mediator | 17/1272 | 76/18723 | 1.04e-05 | 2.81e-04 | 17 |
GO:007099730 | Thyroid | HT | neuron death | 45/1272 | 361/18723 | 5.89e-05 | 1.12e-03 | 45 |
GO:190121427 | Thyroid | HT | regulation of neuron death | 40/1272 | 319/18723 | 1.31e-04 | 2.08e-03 | 40 |
GO:0009896113 | Thyroid | PTC | positive regulation of catabolic process | 278/5968 | 492/18723 | 3.35e-30 | 2.64e-27 | 278 |
GO:0031331113 | Thyroid | PTC | positive regulation of cellular catabolic process | 249/5968 | 427/18723 | 5.28e-30 | 3.58e-27 | 249 |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
TP53 | MSC | Breast | DCIS | ATP1B2,CTNNB1,F2R, etc. | 1.47e-02 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Breast/Str/TF_DCIS/regulons_activity_in_dotplot.png) |
TP53 | FIB | Breast | Healthy | ATP1B2,CTNNB1,F2R, etc. | 4.25e-02 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Breast/Str/TF_Healthy/regulons_activity_in_dotplot.png) |
TP53 | FIB | Breast | Precancer | ATP1B2,CTNNB1,F2R, etc. | 1.56e-02 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Breast/Str/TF_Precancer/regulons_activity_in_dotplot.png) |
TP53 | ASC | Colorectum | ADJ | CATSPERE,AP000446.1,TMEM69, etc. | 1.30e-01 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Colorectum/Str/TF_ADJ/regulons_activity_in_dotplot.png) |
TP53 | TAC | Colorectum | Healthy | ESYT1,ATAD5,GNL3, etc. | 7.42e-02 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Colorectum/Str/TF_Healthy/regulons_activity_in_dotplot.png) |
TP53 | CD8TEXINT | Lung | AAH | APOLD1,RAB27A,PHACTR2-AS1, etc. | 3.56e-01 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Lung/Str/TF_AAH/regulons_activity_in_dotplot.png) |
TP53 | TH1 | Lung | Healthy | TRAT1,MRPL43,LSM14A, etc. | 8.15e-03 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Lung/Str/TF_Healthy/regulons_activity_in_dotplot.png) |
TP53 | CD8TCM | Lung | IAC | TTC4,ELMOD3,RNASE1, etc. | 4.42e-02 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Lung/Str/TF_IAC/regulons_activity_in_dotplot.png) |
TP53 | CD8TEFF | Lung | IAC | TTC4,ELMOD3,RNASE1, etc. | 3.87e-02 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Lung/Str/TF_IAC/regulons_activity_in_dotplot.png) |
TP53 | PVA | Lung | Healthy | HDX,LINC00960,NHEJ1, etc. | 1.10e-01 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Lung/Str/TF_Healthy/regulons_activity_in_dotplot.png) |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TP53 | SNV | Missense_Mutation | rs28934578 | c.524N>A | p.Arg175His | p.R175H | P04637 | protein_coding | tolerated(0.11) | benign(0.319) | TCGA-A1-A0SI-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TP53 | SNV | Missense_Mutation | | c.398N>A | p.Met133Lys | p.M133K | P04637 | protein_coding | deleterious(0) | benign(0.061) | TCGA-A1-A0SK-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
TP53 | SNV | Missense_Mutation | rs121912666 | c.659A>G | p.Tyr220Cys | p.Y220C | P04637 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-A1-A0SO-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | | SD |
TP53 | SNV | Missense_Mutation | rs28934576 | c.818N>A | p.Arg273His | p.R273H | P04637 | protein_coding | tolerated(0.13) | possibly_damaging(0.643) | TCGA-A2-A04T-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cyclophosphamide | SD |
TP53 | SNV | Missense_Mutation | | c.623N>G | p.Asp208Gly | p.D208G | P04637 | protein_coding | deleterious(0.04) | probably_damaging(0.988) | TCGA-A2-A04T-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cyclophosphamide | SD |
TP53 | SNV | Missense_Mutation | rs121912657 | c.814N>A | p.Val272Met | p.V272M | P04637 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-A2-A04W-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD |
TP53 | SNV | Missense_Mutation | rs28934576 | c.818G>T | p.Arg273Leu | p.R273L | P04637 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-A2-A0CL-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cytoxan | SD |
TP53 | SNV | Missense_Mutation | | c.691A>C | p.Thr231Pro | p.T231P | P04637 | protein_coding | deleterious(0) | probably_damaging(0.981) | TCGA-A2-A0CS-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Hormone Therapy | anastrozole | SD |
TP53 | SNV | Missense_Mutation | rs587780073 | c.701N>G | p.Tyr234Cys | p.Y234C | P04637 | protein_coding | deleterious(0) | probably_damaging(0.98) | TCGA-A2-A0EY-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD |
TP53 | SNV | Missense_Mutation | rs148924904 | c.488N>G | p.Tyr163Cys | p.Y163C | P04637 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-A2-A0ST-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
7157 | TP53 | CLINICALLY ACTIONABLE, TRANSCRIPTION FACTOR COMPLEX, TUMOR SUPPRESSOR, DRUGGABLE GENOME, KINASE, DRUG RESISTANCE, TRANSPORTER | | CAULIBUGULONE D | CAULIBUGULONE D | |
7157 | TP53 | CLINICALLY ACTIONABLE, TRANSCRIPTION FACTOR COMPLEX, TUMOR SUPPRESSOR, DRUGGABLE GENOME, KINASE, DRUG RESISTANCE, TRANSPORTER | | fluorouracil | FLUOROURACIL | |
7157 | TP53 | CLINICALLY ACTIONABLE, TRANSCRIPTION FACTOR COMPLEX, TUMOR SUPPRESSOR, DRUGGABLE GENOME, KINASE, DRUG RESISTANCE, TRANSPORTER | | CID 867101 | CHEMBL406557 | |
7157 | TP53 | CLINICALLY ACTIONABLE, TRANSCRIPTION FACTOR COMPLEX, TUMOR SUPPRESSOR, DRUGGABLE GENOME, KINASE, DRUG RESISTANCE, TRANSPORTER | | SJ000276790 | CHEMBL602922 | |
7157 | TP53 | CLINICALLY ACTIONABLE, TRANSCRIPTION FACTOR COMPLEX, TUMOR SUPPRESSOR, DRUGGABLE GENOME, KINASE, DRUG RESISTANCE, TRANSPORTER | | OLEOYL DOPAMINE | OLEOYL DOPAMINE | |
7157 | TP53 | CLINICALLY ACTIONABLE, TRANSCRIPTION FACTOR COMPLEX, TUMOR SUPPRESSOR, DRUGGABLE GENOME, KINASE, DRUG RESISTANCE, TRANSPORTER | | DNDI1417085 | CHEMBL1522984 | |
7157 | TP53 | CLINICALLY ACTIONABLE, TRANSCRIPTION FACTOR COMPLEX, TUMOR SUPPRESSOR, DRUGGABLE GENOME, KINASE, DRUG RESISTANCE, TRANSPORTER | | DNDI1340257 | CHEMBL1702181 | |
7157 | TP53 | CLINICALLY ACTIONABLE, TRANSCRIPTION FACTOR COMPLEX, TUMOR SUPPRESSOR, DRUGGABLE GENOME, KINASE, DRUG RESISTANCE, TRANSPORTER | | TEBUFENPYRAD | TEBUFENPYRAD | |
7157 | TP53 | CLINICALLY ACTIONABLE, TRANSCRIPTION FACTOR COMPLEX, TUMOR SUPPRESSOR, DRUGGABLE GENOME, KINASE, DRUG RESISTANCE, TRANSPORTER | | CTX-1 | | 26883273 |
7157 | TP53 | CLINICALLY ACTIONABLE, TRANSCRIPTION FACTOR COMPLEX, TUMOR SUPPRESSOR, DRUGGABLE GENOME, KINASE, DRUG RESISTANCE, TRANSPORTER | | ZM-336372 | CHEMBL186526 | |