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Gene: WIPI2 |
Gene summary for WIPI2 |
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Gene information | Species | Human | Gene symbol | WIPI2 | Gene ID | 26100 |
Gene name | WD repeat domain, phosphoinositide interacting 2 | |
Gene Alias | ATG18B | |
Cytomap | 7p22.1 | |
Gene Type | protein-coding | GO ID | GO:0000045 | UniProtAcc | Q9Y4P8 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
26100 | WIPI2 | HTA11_2487_2000001011 | Human | Colorectum | SER | 3.68e-02 | 2.15e-01 | -0.1808 |
26100 | WIPI2 | HTA11_1938_2000001011 | Human | Colorectum | AD | 5.14e-04 | 4.05e-01 | -0.0811 |
26100 | WIPI2 | HTA11_78_2000001011 | Human | Colorectum | AD | 2.93e-03 | 3.84e-01 | -0.1088 |
26100 | WIPI2 | HTA11_347_2000001011 | Human | Colorectum | AD | 6.13e-14 | 4.53e-01 | -0.1954 |
26100 | WIPI2 | HTA11_411_2000001011 | Human | Colorectum | SER | 3.21e-03 | 6.78e-01 | -0.2602 |
26100 | WIPI2 | HTA11_3361_2000001011 | Human | Colorectum | AD | 5.94e-03 | 2.98e-01 | -0.1207 |
26100 | WIPI2 | HTA11_696_2000001011 | Human | Colorectum | AD | 2.15e-12 | 3.87e-01 | -0.1464 |
26100 | WIPI2 | HTA11_866_2000001011 | Human | Colorectum | AD | 8.49e-05 | 2.90e-01 | -0.1001 |
26100 | WIPI2 | HTA11_1391_2000001011 | Human | Colorectum | AD | 3.57e-12 | 5.53e-01 | -0.059 |
26100 | WIPI2 | HTA11_546_2000001011 | Human | Colorectum | AD | 4.49e-04 | 4.18e-01 | -0.0842 |
26100 | WIPI2 | HTA11_866_3004761011 | Human | Colorectum | AD | 1.30e-06 | 3.74e-01 | 0.096 |
26100 | WIPI2 | HTA11_8622_2000001021 | Human | Colorectum | SER | 1.44e-02 | 2.90e-01 | 0.0528 |
26100 | WIPI2 | HTA11_7696_3000711011 | Human | Colorectum | AD | 1.27e-07 | 4.19e-01 | 0.0674 |
26100 | WIPI2 | HTA11_6818_2000001021 | Human | Colorectum | AD | 7.47e-05 | 3.20e-01 | 0.0588 |
26100 | WIPI2 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 5.04e-07 | 3.23e-01 | 0.294 |
26100 | WIPI2 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 2.98e-02 | 3.88e-01 | 0.281 |
26100 | WIPI2 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 8.54e-12 | 4.90e-01 | 0.3859 |
26100 | WIPI2 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 3.20e-03 | 5.61e-01 | 0.2585 |
26100 | WIPI2 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 1.66e-12 | 4.54e-01 | 0.3005 |
26100 | WIPI2 | LZE4T | Human | Esophagus | ESCC | 4.86e-06 | 8.03e-02 | 0.0811 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000004511 | Prostate | Tumor | autophagosome assembly | 27/3246 | 99/18723 | 8.94e-03 | 3.87e-02 | 27 |
GO:0022411112 | Skin | cSCC | cellular component disassembly | 201/4864 | 443/18723 | 4.09e-19 | 5.69e-17 | 201 |
GO:001623619 | Skin | cSCC | macroautophagy | 136/4864 | 291/18723 | 1.36e-14 | 9.78e-13 | 136 |
GO:190300817 | Skin | cSCC | organelle disassembly | 65/4864 | 114/18723 | 2.03e-12 | 1.12e-10 | 65 |
GO:000042219 | Skin | cSCC | autophagy of mitochondrion | 44/4864 | 81/18723 | 5.28e-08 | 1.36e-06 | 44 |
GO:006172619 | Skin | cSCC | mitochondrion disassembly | 44/4864 | 81/18723 | 5.28e-08 | 1.36e-06 | 44 |
GO:007149628 | Skin | cSCC | cellular response to external stimulus | 125/4864 | 320/18723 | 1.63e-07 | 3.65e-06 | 125 |
GO:00070337 | Skin | cSCC | vacuole organization | 77/4864 | 180/18723 | 6.65e-07 | 1.26e-05 | 77 |
GO:003166825 | Skin | cSCC | cellular response to extracellular stimulus | 94/4864 | 246/18723 | 1.52e-05 | 1.87e-04 | 94 |
GO:000926722 | Skin | cSCC | cellular response to starvation | 64/4864 | 156/18723 | 2.79e-05 | 3.12e-04 | 64 |
GO:0042594110 | Skin | cSCC | response to starvation | 77/4864 | 197/18723 | 3.52e-05 | 3.82e-04 | 77 |
GO:00000456 | Skin | cSCC | autophagosome assembly | 44/4864 | 99/18723 | 5.18e-05 | 5.30e-04 | 44 |
GO:19050376 | Skin | cSCC | autophagosome organization | 45/4864 | 103/18723 | 7.11e-05 | 6.85e-04 | 45 |
GO:003166728 | Skin | cSCC | response to nutrient levels | 160/4864 | 474/18723 | 8.44e-05 | 8.02e-04 | 160 |
GO:003166925 | Skin | cSCC | cellular response to nutrient levels | 80/4864 | 215/18723 | 1.76e-04 | 1.50e-03 | 80 |
GO:00619129 | Skin | cSCC | selective autophagy | 30/4864 | 68/18723 | 8.91e-04 | 6.10e-03 | 30 |
GO:0022411113 | Thyroid | PTC | cellular component disassembly | 232/5968 | 443/18723 | 1.36e-19 | 1.75e-17 | 232 |
GO:0016236110 | Thyroid | PTC | macroautophagy | 167/5968 | 291/18723 | 1.51e-19 | 1.91e-17 | 167 |
GO:190300818 | Thyroid | PTC | organelle disassembly | 73/5968 | 114/18723 | 1.60e-12 | 7.12e-11 | 73 |
GO:0000422110 | Thyroid | PTC | autophagy of mitochondrion | 55/5968 | 81/18723 | 2.95e-11 | 1.10e-09 | 55 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa05010 | Colorectum | AD | Alzheimer disease | 174/2092 | 384/8465 | 1.82e-19 | 9.26e-18 | 5.91e-18 | 174 |
hsa05016 | Colorectum | AD | Huntington disease | 147/2092 | 306/8465 | 1.93e-19 | 9.26e-18 | 5.91e-18 | 147 |
hsa05014 | Colorectum | AD | Amyotrophic lateral sclerosis | 164/2092 | 364/8465 | 4.28e-18 | 1.27e-16 | 8.09e-17 | 164 |
hsa05022 | Colorectum | AD | Pathways of neurodegeneration - multiple diseases | 201/2092 | 476/8465 | 4.54e-18 | 1.27e-16 | 8.09e-17 | 201 |
hsa05131 | Colorectum | AD | Shigellosis | 109/2092 | 247/8465 | 1.09e-11 | 2.44e-10 | 1.55e-10 | 109 |
hsa05017 | Colorectum | AD | Spinocerebellar ataxia | 60/2092 | 143/8465 | 3.78e-06 | 4.35e-05 | 2.78e-05 | 60 |
hsa04140 | Colorectum | AD | Autophagy - animal | 49/2092 | 141/8465 | 4.58e-03 | 2.20e-02 | 1.40e-02 | 49 |
hsa050101 | Colorectum | AD | Alzheimer disease | 174/2092 | 384/8465 | 1.82e-19 | 9.26e-18 | 5.91e-18 | 174 |
hsa050161 | Colorectum | AD | Huntington disease | 147/2092 | 306/8465 | 1.93e-19 | 9.26e-18 | 5.91e-18 | 147 |
hsa050141 | Colorectum | AD | Amyotrophic lateral sclerosis | 164/2092 | 364/8465 | 4.28e-18 | 1.27e-16 | 8.09e-17 | 164 |
hsa050221 | Colorectum | AD | Pathways of neurodegeneration - multiple diseases | 201/2092 | 476/8465 | 4.54e-18 | 1.27e-16 | 8.09e-17 | 201 |
hsa051311 | Colorectum | AD | Shigellosis | 109/2092 | 247/8465 | 1.09e-11 | 2.44e-10 | 1.55e-10 | 109 |
hsa050171 | Colorectum | AD | Spinocerebellar ataxia | 60/2092 | 143/8465 | 3.78e-06 | 4.35e-05 | 2.78e-05 | 60 |
hsa041401 | Colorectum | AD | Autophagy - animal | 49/2092 | 141/8465 | 4.58e-03 | 2.20e-02 | 1.40e-02 | 49 |
hsa050162 | Colorectum | SER | Huntington disease | 127/1580 | 306/8465 | 3.29e-21 | 1.37e-19 | 9.92e-20 | 127 |
hsa050102 | Colorectum | SER | Alzheimer disease | 146/1580 | 384/8465 | 6.52e-20 | 2.40e-18 | 1.75e-18 | 146 |
hsa050222 | Colorectum | SER | Pathways of neurodegeneration - multiple diseases | 168/1580 | 476/8465 | 6.23e-19 | 2.07e-17 | 1.50e-17 | 168 |
hsa050142 | Colorectum | SER | Amyotrophic lateral sclerosis | 138/1580 | 364/8465 | 9.89e-19 | 2.99e-17 | 2.17e-17 | 138 |
hsa051312 | Colorectum | SER | Shigellosis | 87/1580 | 247/8465 | 3.07e-10 | 7.27e-09 | 5.28e-09 | 87 |
hsa050172 | Colorectum | SER | Spinocerebellar ataxia | 46/1580 | 143/8465 | 6.78e-05 | 7.51e-04 | 5.45e-04 | 46 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
WIPI2 | SNV | Missense_Mutation | rs371973214 | c.725N>A | p.Arg242Gln | p.R242Q | Q9Y4P8 | protein_coding | deleterious(0.02) | possibly_damaging(0.751) | TCGA-C8-A132-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
WIPI2 | SNV | Missense_Mutation | rs375365426 | c.1028C>T | p.Pro343Leu | p.P343L | Q9Y4P8 | protein_coding | tolerated(0.57) | benign(0.012) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
WIPI2 | SNV | Missense_Mutation | c.544N>A | p.Gly182Arg | p.G182R | Q9Y4P8 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-A6-5666-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
WIPI2 | SNV | Missense_Mutation | c.724N>T | p.Arg242Trp | p.R242W | Q9Y4P8 | protein_coding | deleterious(0) | benign(0.104) | TCGA-AA-3510-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
WIPI2 | SNV | Missense_Mutation | c.1229N>C | p.Val410Ala | p.V410A | Q9Y4P8 | protein_coding | tolerated(0.86) | benign(0) | TCGA-AA-3831-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
WIPI2 | SNV | Missense_Mutation | c.328N>C | p.Ile110Leu | p.I110L | Q9Y4P8 | protein_coding | tolerated(0.09) | possibly_damaging(0.452) | TCGA-AZ-6598-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
WIPI2 | SNV | Missense_Mutation | rs375365426 | c.1028N>T | p.Pro343Leu | p.P343L | Q9Y4P8 | protein_coding | tolerated(0.57) | benign(0.012) | TCGA-D5-6530-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
WIPI2 | SNV | Missense_Mutation | rs759604469 | c.488C>T | p.Ala163Val | p.A163V | Q9Y4P8 | protein_coding | deleterious(0.04) | benign(0.245) | TCGA-F4-6856-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Ancillary | leucovorin | CR |
WIPI2 | insertion | Frame_Shift_Ins | novel | c.682dupA | p.Arg228LysfsTer13 | p.R228Kfs*13 | Q9Y4P8 | protein_coding | TCGA-EI-6509-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | folfox | PD | ||
WIPI2 | SNV | Missense_Mutation | rs759604469 | c.488C>T | p.Ala163Val | p.A163V | Q9Y4P8 | protein_coding | deleterious(0.04) | benign(0.245) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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