GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:002261312 | Liver | Cirrhotic | ribonucleoprotein complex biogenesis | 231/4634 | 463/18723 | 3.28e-32 | 6.86e-29 | 231 |
GO:004225412 | Liver | Cirrhotic | ribosome biogenesis | 154/4634 | 299/18723 | 1.18e-23 | 6.72e-21 | 154 |
GO:000636412 | Liver | Cirrhotic | rRNA processing | 115/4634 | 225/18723 | 1.12e-17 | 1.64e-15 | 115 |
GO:00160724 | Liver | Cirrhotic | rRNA metabolic process | 119/4634 | 236/18723 | 1.19e-17 | 1.70e-15 | 119 |
GO:00224117 | Liver | Cirrhotic | cellular component disassembly | 182/4634 | 443/18723 | 1.59e-14 | 1.54e-12 | 182 |
GO:001623611 | Liver | Cirrhotic | macroautophagy | 129/4634 | 291/18723 | 1.75e-13 | 1.41e-11 | 129 |
GO:00344701 | Liver | Cirrhotic | ncRNA processing | 158/4634 | 395/18723 | 1.09e-11 | 6.96e-10 | 158 |
GO:19030084 | Liver | Cirrhotic | organelle disassembly | 59/4634 | 114/18723 | 4.82e-10 | 2.27e-08 | 59 |
GO:004259412 | Liver | Cirrhotic | response to starvation | 87/4634 | 197/18723 | 1.85e-09 | 7.78e-08 | 87 |
GO:004227412 | Liver | Cirrhotic | ribosomal small subunit biogenesis | 42/4634 | 73/18723 | 2.34e-09 | 9.73e-08 | 42 |
GO:003166712 | Liver | Cirrhotic | response to nutrient levels | 174/4634 | 474/18723 | 3.08e-09 | 1.27e-07 | 174 |
GO:00070332 | Liver | Cirrhotic | vacuole organization | 80/4634 | 180/18723 | 5.73e-09 | 2.25e-07 | 80 |
GO:007149612 | Liver | Cirrhotic | cellular response to external stimulus | 123/4634 | 320/18723 | 3.27e-08 | 1.10e-06 | 123 |
GO:00346603 | Liver | Cirrhotic | ncRNA metabolic process | 173/4634 | 485/18723 | 3.64e-08 | 1.21e-06 | 173 |
GO:00004225 | Liver | Cirrhotic | autophagy of mitochondrion | 43/4634 | 81/18723 | 4.02e-08 | 1.31e-06 | 43 |
GO:00617265 | Liver | Cirrhotic | mitochondrion disassembly | 43/4634 | 81/18723 | 4.02e-08 | 1.31e-06 | 43 |
GO:00316686 | Liver | Cirrhotic | cellular response to extracellular stimulus | 96/4634 | 246/18723 | 4.55e-07 | 1.05e-05 | 96 |
GO:00092675 | Liver | Cirrhotic | cellular response to starvation | 67/4634 | 156/18723 | 4.58e-07 | 1.05e-05 | 67 |
GO:00316695 | Liver | Cirrhotic | cellular response to nutrient levels | 85/4634 | 215/18723 | 1.08e-06 | 2.20e-05 | 85 |
GO:0000045 | Liver | Cirrhotic | autophagosome assembly | 43/4634 | 99/18723 | 3.56e-05 | 4.32e-04 | 43 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
WDR4 | SNV | Missense_Mutation | | c.504N>T | p.Lys168Asn | p.K168N | P57081 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-A2-A25C-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | SD |
WDR4 | insertion | Frame_Shift_Ins | novel | c.197_198insCTCCCAAACT | p.Thr68GlnfsTer17 | p.T68Qfs*17 | P57081 | protein_coding | | | TCGA-AN-A0FF-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
WDR4 | insertion | In_Frame_Ins | novel | c.195_196insACCTCAGGTGATCCGCTGGCCTCG | p.Leu65_Ala66insThrSerGlyAspProLeuAlaSer | p.L65_A66insTSGDPLAS | P57081 | protein_coding | | | TCGA-AN-A0FF-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
WDR4 | insertion | In_Frame_Ins | novel | c.306_307insCCACCTTCCTCTTCGCTGTCCTTCCCTGTG | p.Ala102_Arg103insProProSerSerSerLeuSerPheProVal | p.A102_R103insPPSSSLSFPV | P57081 | protein_coding | | | TCGA-BH-A0HU-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | docetaxel | SD |
WDR4 | deletion | Frame_Shift_Del | novel | c.735delN | p.Ala246ArgfsTer88 | p.A246Rfs*88 | P57081 | protein_coding | | | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD |
WDR4 | SNV | Missense_Mutation | rs144346351 | c.238G>A | p.Asp80Asn | p.D80N | P57081 | protein_coding | deleterious(0) | probably_damaging(0.975) | TCGA-A6-6141-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | 5-fu | SD |
WDR4 | SNV | Missense_Mutation | rs543569485 | c.604N>A | p.Gly202Arg | p.G202R | P57081 | protein_coding | tolerated(0.16) | benign(0.021) | TCGA-AA-A01R-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5-fluorouracil | PD |
WDR4 | SNV | Missense_Mutation | novel | c.1096G>A | p.Asp366Asn | p.D366N | P57081 | protein_coding | deleterious(0.01) | probably_damaging(0.924) | TCGA-AA-A02Y-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
WDR4 | SNV | Missense_Mutation | | c.14T>C | p.Val5Ala | p.V5A | P57081 | protein_coding | tolerated_low_confidence(1) | benign(0) | TCGA-D5-5539-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5-fu | PD |
WDR4 | deletion | Frame_Shift_Del | | c.724delN | p.Gln242ArgfsTer92 | p.Q242Rfs*92 | P57081 | protein_coding | | | TCGA-G4-6588-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |