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Gene: WASL |
Gene summary for WASL |
Gene summary. |
Gene information | Species | Human | Gene symbol | WASL | Gene ID | 8976 |
Gene name | WASP like actin nucleation promoting factor | |
Gene Alias | N-WASP | |
Cytomap | 7q31.32 | |
Gene Type | protein-coding | GO ID | GO:0000902 | UniProtAcc | O00401 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
8976 | WASL | HTA11_3410_2000001011 | Human | Colorectum | AD | 5.83e-20 | -6.15e-01 | 0.0155 |
8976 | WASL | HTA11_2487_2000001011 | Human | Colorectum | SER | 6.37e-03 | -3.98e-01 | -0.1808 |
8976 | WASL | HTA11_2951_2000001011 | Human | Colorectum | AD | 2.58e-02 | -6.47e-01 | 0.0216 |
8976 | WASL | HTA11_3361_2000001011 | Human | Colorectum | AD | 1.18e-02 | -4.68e-01 | -0.1207 |
8976 | WASL | HTA11_866_2000001011 | Human | Colorectum | AD | 2.49e-04 | -3.22e-01 | -0.1001 |
8976 | WASL | HTA11_1391_2000001011 | Human | Colorectum | AD | 4.47e-03 | -4.01e-01 | -0.059 |
8976 | WASL | HTA11_866_3004761011 | Human | Colorectum | AD | 4.57e-10 | -5.15e-01 | 0.096 |
8976 | WASL | HTA11_8622_2000001021 | Human | Colorectum | SER | 2.87e-03 | -6.09e-01 | 0.0528 |
8976 | WASL | HTA11_10623_2000001011 | Human | Colorectum | AD | 4.32e-02 | -5.33e-01 | -0.0177 |
8976 | WASL | HTA11_10711_2000001011 | Human | Colorectum | AD | 8.96e-07 | -5.46e-01 | 0.0338 |
8976 | WASL | HTA11_7696_3000711011 | Human | Colorectum | AD | 5.48e-16 | -5.04e-01 | 0.0674 |
8976 | WASL | HTA11_11156_2000001011 | Human | Colorectum | AD | 3.94e-02 | -6.81e-01 | 0.0397 |
8976 | WASL | HTA11_6818_2000001021 | Human | Colorectum | AD | 3.98e-05 | -5.48e-01 | 0.0588 |
8976 | WASL | HTA11_99999970781_79442 | Human | Colorectum | MSS | 2.31e-11 | -4.41e-01 | 0.294 |
8976 | WASL | HTA11_99999971662_82457 | Human | Colorectum | MSS | 2.02e-12 | -4.63e-01 | 0.3859 |
8976 | WASL | HTA11_99999974143_84620 | Human | Colorectum | MSS | 2.91e-21 | -5.56e-01 | 0.3005 |
8976 | WASL | A002-C-010 | Human | Colorectum | FAP | 1.41e-03 | -2.50e-01 | 0.242 |
8976 | WASL | A001-C-207 | Human | Colorectum | FAP | 5.38e-07 | -3.22e-01 | 0.1278 |
8976 | WASL | A015-C-203 | Human | Colorectum | FAP | 5.25e-28 | -5.31e-01 | -0.1294 |
8976 | WASL | A015-C-204 | Human | Colorectum | FAP | 1.24e-07 | -3.31e-01 | -0.0228 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00512584 | Colorectum | FAP | protein polymerization | 73/2622 | 297/18723 | 7.11e-07 | 3.32e-05 | 73 |
GO:00308324 | Colorectum | FAP | regulation of actin filament length | 52/2622 | 189/18723 | 7.91e-07 | 3.64e-05 | 52 |
GO:00068982 | Colorectum | FAP | receptor-mediated endocytosis | 62/2622 | 244/18723 | 1.47e-06 | 6.39e-05 | 62 |
GO:00313463 | Colorectum | FAP | positive regulation of cell projection organization | 82/2622 | 353/18723 | 1.78e-06 | 7.35e-05 | 82 |
GO:01060273 | Colorectum | FAP | neuron projection organization | 31/2622 | 93/18723 | 1.79e-06 | 7.35e-05 | 31 |
GO:00322734 | Colorectum | FAP | positive regulation of protein polymerization | 40/2622 | 138/18723 | 3.55e-06 | 1.26e-04 | 40 |
GO:00995153 | Colorectum | FAP | actin filament-based transport | 12/2622 | 21/18723 | 4.76e-06 | 1.57e-04 | 12 |
GO:00308384 | Colorectum | FAP | positive regulation of actin filament polymerization | 31/2622 | 99/18723 | 7.77e-06 | 2.32e-04 | 31 |
GO:00458072 | Colorectum | FAP | positive regulation of endocytosis | 31/2622 | 100/18723 | 9.77e-06 | 2.85e-04 | 31 |
GO:00300503 | Colorectum | FAP | vesicle transport along actin filament | 11/2622 | 19/18723 | 1.01e-05 | 2.93e-04 | 11 |
GO:00163583 | Colorectum | FAP | dendrite development | 59/2622 | 243/18723 | 1.19e-05 | 3.31e-04 | 59 |
GO:00970613 | Colorectum | FAP | dendritic spine organization | 27/2622 | 84/18723 | 1.73e-05 | 4.42e-04 | 27 |
GO:00508083 | Colorectum | FAP | synapse organization | 91/2622 | 426/18723 | 1.90e-05 | 4.74e-04 | 91 |
GO:00301003 | Colorectum | FAP | regulation of endocytosis | 52/2622 | 211/18723 | 2.47e-05 | 5.77e-04 | 52 |
GO:00991733 | Colorectum | FAP | postsynapse organization | 42/2622 | 168/18723 | 1.01e-04 | 1.70e-03 | 42 |
GO:00307053 | Colorectum | FAP | cytoskeleton-dependent intracellular transport | 47/2622 | 195/18723 | 1.06e-04 | 1.76e-03 | 47 |
GO:00482602 | Colorectum | FAP | positive regulation of receptor-mediated endocytosis | 18/2622 | 52/18723 | 1.48e-04 | 2.29e-03 | 18 |
GO:00482592 | Colorectum | FAP | regulation of receptor-mediated endocytosis | 30/2622 | 110/18723 | 1.89e-04 | 2.76e-03 | 30 |
GO:00488131 | Colorectum | FAP | dendrite morphogenesis | 37/2622 | 146/18723 | 1.90e-04 | 2.77e-03 | 37 |
GO:0099518 | Colorectum | FAP | vesicle cytoskeletal trafficking | 22/2622 | 73/18723 | 2.88e-04 | 3.77e-03 | 22 |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa04144 | Colorectum | AD | Endocytosis | 111/2092 | 251/8465 | 5.95e-12 | 1.42e-10 | 9.08e-11 | 111 |
hsa05131 | Colorectum | AD | Shigellosis | 109/2092 | 247/8465 | 1.09e-11 | 2.44e-10 | 1.55e-10 | 109 |
hsa05100 | Colorectum | AD | Bacterial invasion of epithelial cells | 44/2092 | 77/8465 | 1.13e-09 | 2.22e-08 | 1.42e-08 | 44 |
hsa04520 | Colorectum | AD | Adherens junction | 50/2092 | 93/8465 | 1.52e-09 | 2.83e-08 | 1.81e-08 | 50 |
hsa05132 | Colorectum | AD | Salmonella infection | 102/2092 | 249/8465 | 7.65e-09 | 1.28e-07 | 8.17e-08 | 102 |
hsa05130 | Colorectum | AD | Pathogenic Escherichia coli infection | 79/2092 | 197/8465 | 1.05e-06 | 1.36e-05 | 8.65e-06 | 79 |
hsa05135 | Colorectum | AD | Yersinia infection | 58/2092 | 137/8465 | 3.90e-06 | 4.35e-05 | 2.78e-05 | 58 |
hsa04810 | Colorectum | AD | Regulation of actin cytoskeleton | 75/2092 | 229/8465 | 3.36e-03 | 1.76e-02 | 1.12e-02 | 75 |
hsa041441 | Colorectum | AD | Endocytosis | 111/2092 | 251/8465 | 5.95e-12 | 1.42e-10 | 9.08e-11 | 111 |
hsa051311 | Colorectum | AD | Shigellosis | 109/2092 | 247/8465 | 1.09e-11 | 2.44e-10 | 1.55e-10 | 109 |
hsa051001 | Colorectum | AD | Bacterial invasion of epithelial cells | 44/2092 | 77/8465 | 1.13e-09 | 2.22e-08 | 1.42e-08 | 44 |
hsa045201 | Colorectum | AD | Adherens junction | 50/2092 | 93/8465 | 1.52e-09 | 2.83e-08 | 1.81e-08 | 50 |
hsa051321 | Colorectum | AD | Salmonella infection | 102/2092 | 249/8465 | 7.65e-09 | 1.28e-07 | 8.17e-08 | 102 |
hsa051301 | Colorectum | AD | Pathogenic Escherichia coli infection | 79/2092 | 197/8465 | 1.05e-06 | 1.36e-05 | 8.65e-06 | 79 |
hsa051351 | Colorectum | AD | Yersinia infection | 58/2092 | 137/8465 | 3.90e-06 | 4.35e-05 | 2.78e-05 | 58 |
hsa048101 | Colorectum | AD | Regulation of actin cytoskeleton | 75/2092 | 229/8465 | 3.36e-03 | 1.76e-02 | 1.12e-02 | 75 |
hsa051312 | Colorectum | SER | Shigellosis | 87/1580 | 247/8465 | 3.07e-10 | 7.27e-09 | 5.28e-09 | 87 |
hsa051002 | Colorectum | SER | Bacterial invasion of epithelial cells | 36/1580 | 77/8465 | 1.56e-08 | 3.45e-07 | 2.50e-07 | 36 |
hsa041442 | Colorectum | SER | Endocytosis | 81/1580 | 251/8465 | 1.14e-07 | 2.36e-06 | 1.71e-06 | 81 |
hsa045202 | Colorectum | SER | Adherens junction | 37/1580 | 93/8465 | 1.54e-06 | 2.35e-05 | 1.71e-05 | 37 |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
WASL | SNV | Missense_Mutation | novel | c.588G>T | p.Lys196Asn | p.K196N | O00401 | protein_coding | deleterious(0) | benign(0.247) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
WASL | SNV | Missense_Mutation | c.670N>C | p.Asp224His | p.D224H | O00401 | protein_coding | tolerated(0.07) | probably_damaging(0.999) | TCGA-D8-A1JA-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | PD | |
WASL | SNV | Missense_Mutation | novel | c.989N>A | p.Pro330Gln | p.P330Q | O00401 | protein_coding | tolerated(0.63) | possibly_damaging(0.526) | TCGA-D8-A1XQ-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
WASL | SNV | Missense_Mutation | c.1364A>T | p.Glu455Val | p.E455V | O00401 | protein_coding | tolerated(0.09) | probably_damaging(0.931) | TCGA-C5-A7UE-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD | |
WASL | SNV | Missense_Mutation | c.422N>A | p.Arg141Gln | p.R141Q | O00401 | protein_coding | deleterious(0) | probably_damaging(0.929) | TCGA-AA-3510-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
WASL | SNV | Missense_Mutation | novel | c.799N>T | p.Ala267Ser | p.A267S | O00401 | protein_coding | tolerated(0.08) | probably_damaging(0.978) | TCGA-AA-3811-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD |
WASL | SNV | Missense_Mutation | c.584A>C | p.Lys195Thr | p.K195T | O00401 | protein_coding | deleterious(0.01) | benign(0.309) | TCGA-AA-3977-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
WASL | SNV | Missense_Mutation | c.709N>A | p.Asp237Asn | p.D237N | O00401 | protein_coding | deleterious(0.02) | probably_damaging(0.996) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
WASL | SNV | Missense_Mutation | c.443N>T | p.Arg148Ile | p.R148I | O00401 | protein_coding | deleterious(0.01) | benign(0) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
WASL | SNV | Missense_Mutation | c.337N>T | p.Asp113Tyr | p.D113Y | O00401 | protein_coding | deleterious(0.02) | probably_damaging(0.952) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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