Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: WASL

Gene summary for WASL

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

WASL

Gene ID

8976

Gene nameWASP like actin nucleation promoting factor
Gene AliasN-WASP
Cytomap7q31.32
Gene Typeprotein-coding
GO ID

GO:0000902

UniProtAcc

O00401


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
8976WASLHTA11_3410_2000001011HumanColorectumAD5.83e-20-6.15e-010.0155
8976WASLHTA11_2487_2000001011HumanColorectumSER6.37e-03-3.98e-01-0.1808
8976WASLHTA11_2951_2000001011HumanColorectumAD2.58e-02-6.47e-010.0216
8976WASLHTA11_3361_2000001011HumanColorectumAD1.18e-02-4.68e-01-0.1207
8976WASLHTA11_866_2000001011HumanColorectumAD2.49e-04-3.22e-01-0.1001
8976WASLHTA11_1391_2000001011HumanColorectumAD4.47e-03-4.01e-01-0.059
8976WASLHTA11_866_3004761011HumanColorectumAD4.57e-10-5.15e-010.096
8976WASLHTA11_8622_2000001021HumanColorectumSER2.87e-03-6.09e-010.0528
8976WASLHTA11_10623_2000001011HumanColorectumAD4.32e-02-5.33e-01-0.0177
8976WASLHTA11_10711_2000001011HumanColorectumAD8.96e-07-5.46e-010.0338
8976WASLHTA11_7696_3000711011HumanColorectumAD5.48e-16-5.04e-010.0674
8976WASLHTA11_11156_2000001011HumanColorectumAD3.94e-02-6.81e-010.0397
8976WASLHTA11_6818_2000001021HumanColorectumAD3.98e-05-5.48e-010.0588
8976WASLHTA11_99999970781_79442HumanColorectumMSS2.31e-11-4.41e-010.294
8976WASLHTA11_99999971662_82457HumanColorectumMSS2.02e-12-4.63e-010.3859
8976WASLHTA11_99999974143_84620HumanColorectumMSS2.91e-21-5.56e-010.3005
8976WASLA002-C-010HumanColorectumFAP1.41e-03-2.50e-010.242
8976WASLA001-C-207HumanColorectumFAP5.38e-07-3.22e-010.1278
8976WASLA015-C-203HumanColorectumFAP5.25e-28-5.31e-01-0.1294
8976WASLA015-C-204HumanColorectumFAP1.24e-07-3.31e-01-0.0228
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
Colorectum (GSE201348)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.FAP: Familial adenomatous polyposis
CRC: Colorectal cancer
Colorectum (HTA11)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AD: Adenomas
SER: Sessile serrated lesions
MSI-H: Microsatellite-high colorectal cancer
MSS: Microsatellite stable colorectal cancer
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
LiverThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.HCC: Hepatocellular carcinoma
NAFLD: Non-alcoholic fatty liver disease
Oral CavityThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.EOLP: Erosive Oral lichen planus
LP: leukoplakia
NEOLP: Non-erosive oral lichen planus
OSCC: Oral squamous cell carcinoma
ProstateThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.BPH: Benign Prostatic Hyperplasia
ThyroidThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ATC: Anaplastic thyroid cancer
HT: Hashimoto's thyroiditis
PTC: Papillary thyroid cancer
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:00512584ColorectumFAPprotein polymerization73/2622297/187237.11e-073.32e-0573
GO:00308324ColorectumFAPregulation of actin filament length52/2622189/187237.91e-073.64e-0552
GO:00068982ColorectumFAPreceptor-mediated endocytosis62/2622244/187231.47e-066.39e-0562
GO:00313463ColorectumFAPpositive regulation of cell projection organization82/2622353/187231.78e-067.35e-0582
GO:01060273ColorectumFAPneuron projection organization31/262293/187231.79e-067.35e-0531
GO:00322734ColorectumFAPpositive regulation of protein polymerization40/2622138/187233.55e-061.26e-0440
GO:00995153ColorectumFAPactin filament-based transport12/262221/187234.76e-061.57e-0412
GO:00308384ColorectumFAPpositive regulation of actin filament polymerization31/262299/187237.77e-062.32e-0431
GO:00458072ColorectumFAPpositive regulation of endocytosis31/2622100/187239.77e-062.85e-0431
GO:00300503ColorectumFAPvesicle transport along actin filament11/262219/187231.01e-052.93e-0411
GO:00163583ColorectumFAPdendrite development59/2622243/187231.19e-053.31e-0459
GO:00970613ColorectumFAPdendritic spine organization27/262284/187231.73e-054.42e-0427
GO:00508083ColorectumFAPsynapse organization91/2622426/187231.90e-054.74e-0491
GO:00301003ColorectumFAPregulation of endocytosis52/2622211/187232.47e-055.77e-0452
GO:00991733ColorectumFAPpostsynapse organization42/2622168/187231.01e-041.70e-0342
GO:00307053ColorectumFAPcytoskeleton-dependent intracellular transport47/2622195/187231.06e-041.76e-0347
GO:00482602ColorectumFAPpositive regulation of receptor-mediated endocytosis18/262252/187231.48e-042.29e-0318
GO:00482592ColorectumFAPregulation of receptor-mediated endocytosis30/2622110/187231.89e-042.76e-0330
GO:00488131ColorectumFAPdendrite morphogenesis37/2622146/187231.90e-042.77e-0337
GO:0099518ColorectumFAPvesicle cytoskeletal trafficking22/262273/187232.88e-043.77e-0322
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
hsa04144ColorectumADEndocytosis111/2092251/84655.95e-121.42e-109.08e-11111
hsa05131ColorectumADShigellosis109/2092247/84651.09e-112.44e-101.55e-10109
hsa05100ColorectumADBacterial invasion of epithelial cells44/209277/84651.13e-092.22e-081.42e-0844
hsa04520ColorectumADAdherens junction50/209293/84651.52e-092.83e-081.81e-0850
hsa05132ColorectumADSalmonella infection102/2092249/84657.65e-091.28e-078.17e-08102
hsa05130ColorectumADPathogenic Escherichia coli infection79/2092197/84651.05e-061.36e-058.65e-0679
hsa05135ColorectumADYersinia infection58/2092137/84653.90e-064.35e-052.78e-0558
hsa04810ColorectumADRegulation of actin cytoskeleton75/2092229/84653.36e-031.76e-021.12e-0275
hsa041441ColorectumADEndocytosis111/2092251/84655.95e-121.42e-109.08e-11111
hsa051311ColorectumADShigellosis109/2092247/84651.09e-112.44e-101.55e-10109
hsa051001ColorectumADBacterial invasion of epithelial cells44/209277/84651.13e-092.22e-081.42e-0844
hsa045201ColorectumADAdherens junction50/209293/84651.52e-092.83e-081.81e-0850
hsa051321ColorectumADSalmonella infection102/2092249/84657.65e-091.28e-078.17e-08102
hsa051301ColorectumADPathogenic Escherichia coli infection79/2092197/84651.05e-061.36e-058.65e-0679
hsa051351ColorectumADYersinia infection58/2092137/84653.90e-064.35e-052.78e-0558
hsa048101ColorectumADRegulation of actin cytoskeleton75/2092229/84653.36e-031.76e-021.12e-0275
hsa051312ColorectumSERShigellosis87/1580247/84653.07e-107.27e-095.28e-0987
hsa051002ColorectumSERBacterial invasion of epithelial cells36/158077/84651.56e-083.45e-072.50e-0736
hsa041442ColorectumSEREndocytosis81/1580251/84651.14e-072.36e-061.71e-0681
hsa045202ColorectumSERAdherens junction37/158093/84651.54e-062.35e-051.71e-0537
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
WASLSNVMissense_Mutationnovelc.588G>Tp.Lys196Asnp.K196NO00401protein_codingdeleterious(0)benign(0.247)TCGA-AN-A046-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
WASLSNVMissense_Mutationc.670N>Cp.Asp224Hisp.D224HO00401protein_codingtolerated(0.07)probably_damaging(0.999)TCGA-D8-A1JA-01Breastbreast invasive carcinomaFemale<65III/IVChemotherapyadriamycinPD
WASLSNVMissense_Mutationnovelc.989N>Ap.Pro330Glnp.P330QO00401protein_codingtolerated(0.63)possibly_damaging(0.526)TCGA-D8-A1XQ-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
WASLSNVMissense_Mutationc.1364A>Tp.Glu455Valp.E455VO00401protein_codingtolerated(0.09)probably_damaging(0.931)TCGA-C5-A7UE-01Cervixcervical & endocervical cancerFemale<65I/IIChemotherapycisplatinSD
WASLSNVMissense_Mutationc.422N>Ap.Arg141Glnp.R141QO00401protein_codingdeleterious(0)probably_damaging(0.929)TCGA-AA-3510-01Colorectumcolon adenocarcinomaMale>=65I/IIUnknownUnknownSD
WASLSNVMissense_Mutationnovelc.799N>Tp.Ala267Serp.A267SO00401protein_codingtolerated(0.08)probably_damaging(0.978)TCGA-AA-3811-01Colorectumcolon adenocarcinomaFemale>=65III/IVUnknownUnknownPD
WASLSNVMissense_Mutationc.584A>Cp.Lys195Thrp.K195TO00401protein_codingdeleterious(0.01)benign(0.309)TCGA-AA-3977-01Colorectumcolon adenocarcinomaMale>=65I/IIUnknownUnknownSD
WASLSNVMissense_Mutationc.709N>Ap.Asp237Asnp.D237NO00401protein_codingdeleterious(0.02)probably_damaging(0.996)TCGA-AA-A00N-01Colorectumcolon adenocarcinomaMale>=65I/IIUnknownUnknownPD
WASLSNVMissense_Mutationc.443N>Tp.Arg148Ilep.R148IO00401protein_codingdeleterious(0.01)benign(0)TCGA-AA-A010-01Colorectumcolon adenocarcinomaFemale<65I/IIChemotherapyfolinicCR
WASLSNVMissense_Mutationc.337N>Tp.Asp113Tyrp.D113YO00401protein_codingdeleterious(0.02)probably_damaging(0.952)TCGA-AA-A010-01Colorectumcolon adenocarcinomaFemale<65I/IIChemotherapyfolinicCR
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
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