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Gene: UQCRC1 |
Gene summary for UQCRC1 |
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Gene information | Species | Human | Gene symbol | UQCRC1 | Gene ID | 7384 |
Gene name | ubiquinol-cytochrome c reductase core protein 1 | |
Gene Alias | D3S3191 | |
Cytomap | 3p21.31 | |
Gene Type | protein-coding | GO ID | GO:0006091 | UniProtAcc | P31930 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
7384 | UQCRC1 | HTA11_3410_2000001011 | Human | Colorectum | AD | 2.08e-12 | 4.45e-01 | 0.0155 |
7384 | UQCRC1 | HTA11_2487_2000001011 | Human | Colorectum | SER | 6.69e-37 | 1.19e+00 | -0.1808 |
7384 | UQCRC1 | HTA11_2951_2000001011 | Human | Colorectum | AD | 2.35e-06 | 6.58e-01 | 0.0216 |
7384 | UQCRC1 | HTA11_1938_2000001011 | Human | Colorectum | AD | 1.92e-25 | 1.10e+00 | -0.0811 |
7384 | UQCRC1 | HTA11_78_2000001011 | Human | Colorectum | AD | 1.37e-18 | 8.18e-01 | -0.1088 |
7384 | UQCRC1 | HTA11_347_2000001011 | Human | Colorectum | AD | 1.28e-60 | 1.38e+00 | -0.1954 |
7384 | UQCRC1 | HTA11_411_2000001011 | Human | Colorectum | SER | 1.17e-13 | 1.56e+00 | -0.2602 |
7384 | UQCRC1 | HTA11_2112_2000001011 | Human | Colorectum | SER | 5.27e-11 | 1.34e+00 | -0.2196 |
7384 | UQCRC1 | HTA11_3361_2000001011 | Human | Colorectum | AD | 5.05e-26 | 1.02e+00 | -0.1207 |
7384 | UQCRC1 | HTA11_83_2000001011 | Human | Colorectum | SER | 6.07e-34 | 1.39e+00 | -0.1526 |
7384 | UQCRC1 | HTA11_696_2000001011 | Human | Colorectum | AD | 2.24e-67 | 1.44e+00 | -0.1464 |
7384 | UQCRC1 | HTA11_866_2000001011 | Human | Colorectum | AD | 3.01e-47 | 1.01e+00 | -0.1001 |
7384 | UQCRC1 | HTA11_1391_2000001011 | Human | Colorectum | AD | 3.45e-42 | 1.41e+00 | -0.059 |
7384 | UQCRC1 | HTA11_2992_2000001011 | Human | Colorectum | SER | 1.26e-12 | 1.17e+00 | -0.1706 |
7384 | UQCRC1 | HTA11_5212_2000001011 | Human | Colorectum | AD | 3.34e-20 | 1.33e+00 | -0.2061 |
7384 | UQCRC1 | HTA11_5216_2000001011 | Human | Colorectum | SER | 3.26e-13 | 1.22e+00 | -0.1462 |
7384 | UQCRC1 | HTA11_546_2000001011 | Human | Colorectum | AD | 4.89e-17 | 1.07e+00 | -0.0842 |
7384 | UQCRC1 | HTA11_9341_2000001011 | Human | Colorectum | SER | 2.45e-08 | 8.74e-01 | -0.00410000000000005 |
7384 | UQCRC1 | HTA11_7862_2000001011 | Human | Colorectum | AD | 6.29e-17 | 8.66e-01 | -0.0179 |
7384 | UQCRC1 | HTA11_866_3004761011 | Human | Colorectum | AD | 7.86e-26 | 7.87e-01 | 0.096 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000609126 | Skin | AK | generation of precursor metabolites and energy | 69/1910 | 490/18723 | 3.59e-03 | 2.16e-02 | 69 |
GO:00148234 | Skin | AK | response to activity | 16/1910 | 76/18723 | 3.73e-03 | 2.22e-02 | 16 |
GO:190260019 | Skin | AK | proton transmembrane transport | 27/1910 | 157/18723 | 4.70e-03 | 2.69e-02 | 27 |
GO:0009060111 | Skin | cSCC | aerobic respiration | 118/4864 | 189/18723 | 3.71e-26 | 1.22e-23 | 118 |
GO:0045333111 | Skin | cSCC | cellular respiration | 131/4864 | 230/18723 | 1.57e-23 | 3.39e-21 | 131 |
GO:0006091111 | Skin | cSCC | generation of precursor metabolites and energy | 224/4864 | 490/18723 | 1.13e-21 | 2.21e-19 | 224 |
GO:002290026 | Skin | cSCC | electron transport chain | 104/4864 | 175/18723 | 7.28e-21 | 1.23e-18 | 104 |
GO:0006119112 | Skin | cSCC | oxidative phosphorylation | 89/4864 | 141/18723 | 1.56e-20 | 2.49e-18 | 89 |
GO:004277326 | Skin | cSCC | ATP synthesis coupled electron transport | 68/4864 | 95/18723 | 1.59e-20 | 2.49e-18 | 68 |
GO:004277526 | Skin | cSCC | mitochondrial ATP synthesis coupled electron transport | 68/4864 | 95/18723 | 1.59e-20 | 2.49e-18 | 68 |
GO:0046034112 | Skin | cSCC | ATP metabolic process | 142/4864 | 277/18723 | 1.38e-19 | 1.96e-17 | 142 |
GO:002290426 | Skin | cSCC | respiratory electron transport chain | 74/4864 | 114/18723 | 2.52e-18 | 3.29e-16 | 74 |
GO:001598026 | Skin | cSCC | energy derivation by oxidation of organic compounds | 154/4864 | 318/18723 | 4.19e-18 | 5.15e-16 | 154 |
GO:001964626 | Skin | cSCC | aerobic electron transport chain | 61/4864 | 87/18723 | 7.73e-18 | 8.97e-16 | 61 |
GO:000612220 | Skin | cSCC | mitochondrial electron transport, ubiquinol to cytochrome c | 8/4864 | 11/18723 | 1.56e-03 | 9.60e-03 | 8 |
GO:1902600110 | Skin | cSCC | proton transmembrane transport | 57/4864 | 157/18723 | 2.66e-03 | 1.50e-02 | 57 |
GO:00460346 | Stomach | GC | ATP metabolic process | 73/1159 | 277/18723 | 5.03e-27 | 1.37e-23 | 73 |
GO:00061196 | Stomach | GC | oxidative phosphorylation | 46/1159 | 141/18723 | 1.23e-21 | 2.24e-18 | 46 |
GO:00060916 | Stomach | GC | generation of precursor metabolites and energy | 88/1159 | 490/18723 | 6.82e-20 | 9.27e-17 | 88 |
GO:00090606 | Stomach | GC | aerobic respiration | 49/1159 | 189/18723 | 3.25e-18 | 3.54e-15 | 49 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa05012 | Colorectum | AD | Parkinson disease | 147/2092 | 266/8465 | 2.53e-27 | 8.48e-25 | 5.41e-25 | 147 |
hsa05208 | Colorectum | AD | Chemical carcinogenesis - reactive oxygen species | 126/2092 | 223/8465 | 1.01e-24 | 1.68e-22 | 1.07e-22 | 126 |
hsa00190 | Colorectum | AD | Oxidative phosphorylation | 86/2092 | 134/8465 | 2.47e-22 | 2.76e-20 | 1.76e-20 | 86 |
hsa05415 | Colorectum | AD | Diabetic cardiomyopathy | 114/2092 | 203/8465 | 3.65e-22 | 3.06e-20 | 1.95e-20 | 114 |
hsa05010 | Colorectum | AD | Alzheimer disease | 174/2092 | 384/8465 | 1.82e-19 | 9.26e-18 | 5.91e-18 | 174 |
hsa05016 | Colorectum | AD | Huntington disease | 147/2092 | 306/8465 | 1.93e-19 | 9.26e-18 | 5.91e-18 | 147 |
hsa04714 | Colorectum | AD | Thermogenesis | 120/2092 | 232/8465 | 2.76e-19 | 1.16e-17 | 7.37e-18 | 120 |
hsa04932 | Colorectum | AD | Non-alcoholic fatty liver disease | 90/2092 | 155/8465 | 4.83e-19 | 1.80e-17 | 1.15e-17 | 90 |
hsa05020 | Colorectum | AD | Prion disease | 133/2092 | 273/8465 | 2.47e-18 | 8.29e-17 | 5.29e-17 | 133 |
hsa05014 | Colorectum | AD | Amyotrophic lateral sclerosis | 164/2092 | 364/8465 | 4.28e-18 | 1.27e-16 | 8.09e-17 | 164 |
hsa05022 | Colorectum | AD | Pathways of neurodegeneration - multiple diseases | 201/2092 | 476/8465 | 4.54e-18 | 1.27e-16 | 8.09e-17 | 201 |
hsa04260 | Colorectum | AD | Cardiac muscle contraction | 32/2092 | 87/8465 | 7.92e-03 | 3.13e-02 | 2.00e-02 | 32 |
hsa050121 | Colorectum | AD | Parkinson disease | 147/2092 | 266/8465 | 2.53e-27 | 8.48e-25 | 5.41e-25 | 147 |
hsa052081 | Colorectum | AD | Chemical carcinogenesis - reactive oxygen species | 126/2092 | 223/8465 | 1.01e-24 | 1.68e-22 | 1.07e-22 | 126 |
hsa001901 | Colorectum | AD | Oxidative phosphorylation | 86/2092 | 134/8465 | 2.47e-22 | 2.76e-20 | 1.76e-20 | 86 |
hsa054151 | Colorectum | AD | Diabetic cardiomyopathy | 114/2092 | 203/8465 | 3.65e-22 | 3.06e-20 | 1.95e-20 | 114 |
hsa050101 | Colorectum | AD | Alzheimer disease | 174/2092 | 384/8465 | 1.82e-19 | 9.26e-18 | 5.91e-18 | 174 |
hsa050161 | Colorectum | AD | Huntington disease | 147/2092 | 306/8465 | 1.93e-19 | 9.26e-18 | 5.91e-18 | 147 |
hsa047141 | Colorectum | AD | Thermogenesis | 120/2092 | 232/8465 | 2.76e-19 | 1.16e-17 | 7.37e-18 | 120 |
hsa049321 | Colorectum | AD | Non-alcoholic fatty liver disease | 90/2092 | 155/8465 | 4.83e-19 | 1.80e-17 | 1.15e-17 | 90 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
UQCRC1 | SNV | Missense_Mutation | c.688G>C | p.Val230Leu | p.V230L | P31930 | protein_coding | deleterious(0) | probably_damaging(0.987) | TCGA-A8-A07O-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | CR | ||
UQCRC1 | SNV | Missense_Mutation | c.1235N>G | p.Asp412Gly | p.D412G | P31930 | protein_coding | deleterious(0) | possibly_damaging(0.592) | TCGA-D8-A1JK-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
UQCRC1 | deletion | In_Frame_Del | novel | c.755_775delNNNNNNNNNNNNNNNNNNNNN | p.Gly252_Ala258del | p.G252_A258del | P31930 | protein_coding | TCGA-A1-A0SO-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | SD | |||
UQCRC1 | deletion | Frame_Shift_Del | novel | c.931_938delATCGGCCA | p.Ile311LeufsTer2 | p.I311Lfs*2 | P31930 | protein_coding | TCGA-AC-A3HN-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
UQCRC1 | insertion | Frame_Shift_Ins | novel | c.838_839insCACACTT | p.Asp280AlafsTer38 | p.D280Afs*38 | P31930 | protein_coding | TCGA-BH-A0B8-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | arimidex | SD | ||
UQCRC1 | SNV | Missense_Mutation | c.1435N>T | p.Arg479Cys | p.R479C | P31930 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-AA-3821-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
UQCRC1 | SNV | Missense_Mutation | c.244N>A | p.Glu82Lys | p.E82K | P31930 | protein_coding | deleterious(0) | probably_damaging(0.993) | TCGA-AA-A01S-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
UQCRC1 | SNV | Missense_Mutation | c.537N>A | p.Met179Ile | p.M179I | P31930 | protein_coding | tolerated(0.08) | benign(0.037) | TCGA-AA-A02R-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
UQCRC1 | SNV | Missense_Mutation | c.133N>A | p.Val45Met | p.V45M | P31930 | protein_coding | tolerated(0.14) | benign(0.099) | TCGA-AZ-6599-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
UQCRC1 | SNV | Missense_Mutation | rs376087580 | c.1244G>A | p.Arg415His | p.R415H | P31930 | protein_coding | deleterious(0) | possibly_damaging(0.879) | TCGA-G4-6302-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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