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Gene: TRIP13 |
Gene summary for TRIP13 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | TRIP13 | Gene ID | 9319 |
| Gene name | thyroid hormone receptor interactor 13 | |
| Gene Alias | 16E1BP | |
| Cytomap | 5p15.33 | |
| Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | Q15645 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 9319 | TRIP13 | LZE2T | Human | Esophagus | ESCC | 1.52e-08 | 5.95e-01 | 0.082 |
| 9319 | TRIP13 | LZE8T | Human | Esophagus | ESCC | 2.72e-03 | 1.43e-01 | 0.067 |
| 9319 | TRIP13 | LZE22T | Human | Esophagus | ESCC | 1.57e-02 | 2.96e-01 | 0.068 |
| 9319 | TRIP13 | LZE24T | Human | Esophagus | ESCC | 9.19e-06 | 2.20e-01 | 0.0596 |
| 9319 | TRIP13 | LZE6T | Human | Esophagus | ESCC | 1.55e-08 | 3.84e-01 | 0.0845 |
| 9319 | TRIP13 | P1T-E | Human | Esophagus | ESCC | 4.62e-03 | 1.91e-01 | 0.0875 |
| 9319 | TRIP13 | P2T-E | Human | Esophagus | ESCC | 5.71e-10 | 2.92e-01 | 0.1177 |
| 9319 | TRIP13 | P4T-E | Human | Esophagus | ESCC | 4.58e-21 | 5.72e-01 | 0.1323 |
| 9319 | TRIP13 | P5T-E | Human | Esophagus | ESCC | 3.30e-21 | 5.03e-01 | 0.1327 |
| 9319 | TRIP13 | P8T-E | Human | Esophagus | ESCC | 5.67e-06 | 2.57e-01 | 0.0889 |
| 9319 | TRIP13 | P9T-E | Human | Esophagus | ESCC | 2.41e-06 | 1.96e-01 | 0.1131 |
| 9319 | TRIP13 | P10T-E | Human | Esophagus | ESCC | 3.19e-13 | 3.81e-01 | 0.116 |
| 9319 | TRIP13 | P15T-E | Human | Esophagus | ESCC | 5.26e-03 | 1.22e-01 | 0.1149 |
| 9319 | TRIP13 | P16T-E | Human | Esophagus | ESCC | 1.79e-02 | 1.12e-01 | 0.1153 |
| 9319 | TRIP13 | P17T-E | Human | Esophagus | ESCC | 3.52e-10 | 6.91e-01 | 0.1278 |
| 9319 | TRIP13 | P19T-E | Human | Esophagus | ESCC | 5.57e-05 | 6.85e-01 | 0.1662 |
| 9319 | TRIP13 | P20T-E | Human | Esophagus | ESCC | 2.16e-09 | 2.26e-01 | 0.1124 |
| 9319 | TRIP13 | P21T-E | Human | Esophagus | ESCC | 5.39e-24 | 7.38e-01 | 0.1617 |
| 9319 | TRIP13 | P22T-E | Human | Esophagus | ESCC | 5.35e-03 | 1.03e-01 | 0.1236 |
| 9319 | TRIP13 | P23T-E | Human | Esophagus | ESCC | 2.24e-10 | 2.71e-01 | 0.108 |
| Page: 1 2 3 4 5 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease | ||
| Oral Cavity |  | EOLP: Erosive Oral lichen planus |
| LP: leukoplakia | ||
| NEOLP: Non-erosive oral lichen planus | ||
| OSCC: Oral squamous cell carcinoma | ||
| Skin |  | AK: Actinic keratosis |
| cSCC: Cutaneous squamous cell carcinoma | ||
| SCCIS:squamous cell carcinoma in situ | ||
| Thyroid |  | ATC: Anaplastic thyroid cancer |
| HT: Hashimoto's thyroiditis | ||
| PTC: Papillary thyroid cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:19058183 | Skin | cSCC | regulation of chromosome separation | 41/4864 | 72/18723 | 2.48e-08 | 6.89e-07 | 41 |
| GO:00300713 | Skin | cSCC | regulation of mitotic metaphase/anaphase transition | 36/4864 | 60/18723 | 2.71e-08 | 7.41e-07 | 36 |
| GO:00109653 | Skin | cSCC | regulation of mitotic sister chromatid separation | 38/4864 | 65/18723 | 3.03e-08 | 8.18e-07 | 38 |
| GO:190198714 | Skin | cSCC | regulation of cell cycle phase transition | 150/4864 | 390/18723 | 3.21e-08 | 8.61e-07 | 150 |
| GO:00070884 | Skin | cSCC | regulation of mitotic nuclear division | 55/4864 | 110/18723 | 5.62e-08 | 1.44e-06 | 55 |
| GO:00513063 | Skin | cSCC | mitotic sister chromatid separation | 38/4864 | 67/18723 | 9.27e-08 | 2.22e-06 | 38 |
| GO:00447843 | Skin | cSCC | metaphase/anaphase transition of cell cycle | 37/4864 | 65/18723 | 1.20e-07 | 2.79e-06 | 37 |
| GO:19020993 | Skin | cSCC | regulation of metaphase/anaphase transition of cell cycle | 36/4864 | 63/18723 | 1.55e-07 | 3.51e-06 | 36 |
| GO:00517832 | Skin | cSCC | regulation of nuclear division | 64/4864 | 139/18723 | 2.49e-07 | 5.25e-06 | 64 |
| GO:20012514 | Skin | cSCC | negative regulation of chromosome organization | 43/4864 | 86/18723 | 1.53e-06 | 2.61e-05 | 43 |
| GO:190199114 | Skin | cSCC | negative regulation of mitotic cell cycle phase transition | 75/4864 | 179/18723 | 2.38e-06 | 3.84e-05 | 75 |
| GO:00330473 | Skin | cSCC | regulation of mitotic sister chromatid segregation | 27/4864 | 46/18723 | 2.71e-06 | 4.30e-05 | 27 |
| GO:004593014 | Skin | cSCC | negative regulation of mitotic cell cycle | 93/4864 | 235/18723 | 3.14e-06 | 4.89e-05 | 93 |
| GO:004578613 | Skin | cSCC | negative regulation of cell cycle | 140/4864 | 385/18723 | 3.64e-06 | 5.50e-05 | 140 |
| GO:00458394 | Skin | cSCC | negative regulation of mitotic nuclear division | 27/4864 | 48/18723 | 8.24e-06 | 1.10e-04 | 27 |
| GO:00517844 | Skin | cSCC | negative regulation of nuclear division | 30/4864 | 56/18723 | 9.93e-06 | 1.30e-04 | 30 |
| GO:00513043 | Skin | cSCC | chromosome separation | 44/4864 | 96/18723 | 2.05e-05 | 2.40e-04 | 44 |
| GO:00458413 | Skin | cSCC | negative regulation of mitotic metaphase/anaphase transition | 23/4864 | 40/18723 | 2.37e-05 | 2.72e-04 | 23 |
| GO:190198812 | Skin | cSCC | negative regulation of cell cycle phase transition | 94/4864 | 249/18723 | 2.65e-05 | 3.00e-04 | 94 |
| GO:001094812 | Skin | cSCC | negative regulation of cell cycle process | 108/4864 | 294/18723 | 2.75e-05 | 3.09e-04 | 108 |
| Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| hsa0411023 | Esophagus | ESCC | Cell cycle | 126/4205 | 157/8465 | 1.34e-15 | 5.60e-14 | 2.87e-14 | 126 |
| hsa0411033 | Esophagus | ESCC | Cell cycle | 126/4205 | 157/8465 | 1.34e-15 | 5.60e-14 | 2.87e-14 | 126 |
| hsa041102 | Liver | HCC | Cell cycle | 106/4020 | 157/8465 | 2.54e-07 | 3.04e-06 | 1.69e-06 | 106 |
| hsa041103 | Liver | HCC | Cell cycle | 106/4020 | 157/8465 | 2.54e-07 | 3.04e-06 | 1.69e-06 | 106 |
| hsa041108 | Oral cavity | OSCC | Cell cycle | 118/3704 | 157/8465 | 7.15e-16 | 2.66e-14 | 1.35e-14 | 118 |
| hsa0411015 | Oral cavity | OSCC | Cell cycle | 118/3704 | 157/8465 | 7.15e-16 | 2.66e-14 | 1.35e-14 | 118 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| TRIP13 | SNV | Missense_Mutation | c.1029N>G | p.Ile343Met | p.I343M | Q15645 | protein_coding | deleterious(0) | possibly_damaging(0.779) | TCGA-BH-A0AW-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | SD | |
| TRIP13 | SNV | Missense_Mutation | c.386C>T | p.Ala129Val | p.A129V | Q15645 | protein_coding | deleterious(0.03) | benign(0.282) | TCGA-BH-A18G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
| TRIP13 | SNV | Missense_Mutation | novel | c.769N>G | p.Leu257Val | p.L257V | Q15645 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-JW-A5VL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
| TRIP13 | SNV | Missense_Mutation | c.571N>T | p.Ala191Ser | p.A191S | Q15645 | protein_coding | deleterious(0) | probably_damaging(0.985) | TCGA-A6-2679-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
| TRIP13 | SNV | Missense_Mutation | c.1039C>T | p.Arg347Cys | p.R347C | Q15645 | protein_coding | deleterious(0.03) | possibly_damaging(0.517) | TCGA-AA-3710-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
| TRIP13 | SNV | Missense_Mutation | novel | c.333N>G | p.Asn111Lys | p.N111K | Q15645 | protein_coding | tolerated(0.62) | benign(0.013) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
| TRIP13 | SNV | Missense_Mutation | novel | c.803C>A | p.Thr268Asn | p.T268N | Q15645 | protein_coding | tolerated(0.09) | benign(0.01) | TCGA-AP-A0LG-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| TRIP13 | SNV | Missense_Mutation | novel | c.401G>A | p.Gly134Glu | p.G134E | Q15645 | protein_coding | deleterious(0.01) | probably_damaging(0.913) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
| TRIP13 | SNV | Missense_Mutation | rs149881196 | c.614N>A | p.Arg205Gln | p.R205Q | Q15645 | protein_coding | tolerated(0.6) | benign(0.001) | TCGA-AP-A1DV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| TRIP13 | SNV | Missense_Mutation | novel | c.709N>A | p.Gln237Lys | p.Q237K | Q15645 | protein_coding | tolerated(0.17) | benign(0.047) | TCGA-AX-A0J0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| Page: 1 2 3 4 5 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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