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Gene: TMEM59 |
Gene summary for TMEM59 |
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Gene information | Species | Human | Gene symbol | TMEM59 | Gene ID | 9528 |
Gene name | transmembrane protein 59 | |
Gene Alias | C1orf8 | |
Cytomap | 1p32.3 | |
Gene Type | protein-coding | GO ID | GO:0006464 | UniProtAcc | D3DQ48 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9528 | TMEM59 | GSM4909280 | Human | Breast | Precancer | 2.06e-02 | -6.36e-01 | 0.0305 |
9528 | TMEM59 | GSM4909282 | Human | Breast | IDC | 7.17e-18 | 4.60e-01 | -0.0288 |
9528 | TMEM59 | GSM4909285 | Human | Breast | IDC | 1.01e-03 | 2.86e-01 | 0.21 |
9528 | TMEM59 | GSM4909293 | Human | Breast | IDC | 1.94e-05 | -1.45e-01 | 0.1581 |
9528 | TMEM59 | GSM4909294 | Human | Breast | IDC | 1.12e-11 | -3.60e-01 | 0.2022 |
9528 | TMEM59 | GSM4909296 | Human | Breast | IDC | 3.64e-20 | -4.56e-01 | 0.1524 |
9528 | TMEM59 | GSM4909297 | Human | Breast | IDC | 1.24e-24 | -7.56e-02 | 0.1517 |
9528 | TMEM59 | GSM4909301 | Human | Breast | IDC | 2.23e-03 | -2.35e-01 | 0.1577 |
9528 | TMEM59 | GSM4909305 | Human | Breast | IDC | 1.13e-02 | 2.69e-01 | 0.0436 |
9528 | TMEM59 | GSM4909306 | Human | Breast | IDC | 1.71e-02 | 2.59e-01 | 0.1564 |
9528 | TMEM59 | GSM4909311 | Human | Breast | IDC | 5.58e-51 | -4.41e-01 | 0.1534 |
9528 | TMEM59 | GSM4909312 | Human | Breast | IDC | 6.00e-11 | 9.33e-02 | 0.1552 |
9528 | TMEM59 | GSM4909316 | Human | Breast | IDC | 1.76e-03 | -1.55e-01 | 0.21 |
9528 | TMEM59 | GSM4909319 | Human | Breast | IDC | 3.39e-61 | -5.19e-01 | 0.1563 |
9528 | TMEM59 | GSM4909320 | Human | Breast | IDC | 8.30e-12 | -5.78e-01 | 0.1575 |
9528 | TMEM59 | GSM4909321 | Human | Breast | IDC | 3.55e-22 | -2.61e-01 | 0.1559 |
9528 | TMEM59 | M2 | Human | Breast | IDC | 6.84e-07 | -5.59e-01 | 0.21 |
9528 | TMEM59 | NCCBC14 | Human | Breast | DCIS | 3.69e-21 | -2.14e-01 | 0.2021 |
9528 | TMEM59 | NCCBC2 | Human | Breast | DCIS | 3.32e-05 | -1.77e-01 | 0.1554 |
9528 | TMEM59 | NCCBC3 | Human | Breast | DCIS | 7.78e-03 | 3.68e-02 | 0.1198 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0031331111 | Esophagus | ESCC | positive regulation of cellular catabolic process | 292/8552 | 427/18723 | 8.67e-22 | 1.53e-19 | 292 |
GO:001050617 | Esophagus | ESCC | regulation of autophagy | 220/8552 | 317/18723 | 6.72e-18 | 6.36e-16 | 220 |
GO:0072659110 | Esophagus | ESCC | protein localization to plasma membrane | 193/8552 | 284/18723 | 1.95e-14 | 1.03e-12 | 193 |
GO:199077819 | Esophagus | ESCC | protein localization to cell periphery | 217/8552 | 333/18723 | 4.08e-13 | 1.88e-11 | 217 |
GO:005160418 | Esophagus | ESCC | protein maturation | 189/8552 | 294/18723 | 7.64e-11 | 2.39e-09 | 189 |
GO:190547519 | Esophagus | ESCC | regulation of protein localization to membrane | 117/8552 | 175/18723 | 1.14e-08 | 2.26e-07 | 117 |
GO:00091002 | Esophagus | ESCC | glycoprotein metabolic process | 226/8552 | 387/18723 | 2.64e-07 | 3.94e-06 | 226 |
GO:190437519 | Esophagus | ESCC | regulation of protein localization to cell periphery | 85/8552 | 125/18723 | 3.63e-07 | 5.06e-06 | 85 |
GO:1903076110 | Esophagus | ESCC | regulation of protein localization to plasma membrane | 72/8552 | 104/18723 | 9.74e-07 | 1.23e-05 | 72 |
GO:00700854 | Esophagus | ESCC | glycosylation | 144/8552 | 240/18723 | 5.12e-06 | 5.38e-05 | 144 |
GO:001050816 | Esophagus | ESCC | positive regulation of autophagy | 81/8552 | 124/18723 | 7.74e-06 | 7.65e-05 | 81 |
GO:00064865 | Esophagus | ESCC | protein glycosylation | 135/8552 | 226/18723 | 1.36e-05 | 1.24e-04 | 135 |
GO:00434135 | Esophagus | ESCC | macromolecule glycosylation | 135/8552 | 226/18723 | 1.36e-05 | 1.24e-04 | 135 |
GO:001648514 | Esophagus | ESCC | protein processing | 134/8552 | 225/18723 | 1.81e-05 | 1.60e-04 | 134 |
GO:19038289 | Esophagus | ESCC | negative regulation of cellular protein localization | 76/8552 | 117/18723 | 1.97e-05 | 1.72e-04 | 76 |
GO:00091012 | Esophagus | ESCC | glycoprotein biosynthetic process | 181/8552 | 317/18723 | 2.54e-05 | 2.15e-04 | 181 |
GO:0045861111 | Esophagus | ESCC | negative regulation of proteolysis | 195/8552 | 351/18723 | 1.13e-04 | 7.85e-04 | 195 |
GO:001095511 | Esophagus | ESCC | negative regulation of protein processing | 20/8552 | 29/18723 | 9.66e-03 | 3.34e-02 | 20 |
GO:190331811 | Esophagus | ESCC | negative regulation of protein maturation | 20/8552 | 29/18723 | 9.66e-03 | 3.34e-02 | 20 |
GO:19030778 | Esophagus | ESCC | negative regulation of protein localization to plasma membrane | 17/8552 | 24/18723 | 1.13e-02 | 3.81e-02 | 17 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TMEM59 | SNV | Missense_Mutation | c.545C>A | p.Ser182Tyr | p.S182Y | Q9BXS4 | protein_coding | deleterious(0) | possibly_damaging(0.832) | TCGA-BH-A18G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
TMEM59 | SNV | Missense_Mutation | c.910N>A | p.Glu304Lys | p.E304K | Q9BXS4 | protein_coding | tolerated(0.24) | benign(0.026) | TCGA-C5-A1BK-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
TMEM59 | SNV | Missense_Mutation | c.943A>C | p.Lys315Gln | p.K315Q | Q9BXS4 | protein_coding | deleterious(0) | probably_damaging(0.991) | TCGA-FU-A3HZ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
TMEM59 | SNV | Missense_Mutation | rs776175537 | c.272N>A | p.Arg91Gln | p.R91Q | Q9BXS4 | protein_coding | tolerated(0.57) | benign(0.011) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
TMEM59 | SNV | Missense_Mutation | c.874C>T | p.Pro292Ser | p.P292S | Q9BXS4 | protein_coding | tolerated(0.21) | possibly_damaging(0.863) | TCGA-CM-6674-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
TMEM59 | SNV | Missense_Mutation | rs776175537 | c.272N>A | p.Arg91Gln | p.R91Q | Q9BXS4 | protein_coding | tolerated(0.57) | benign(0.011) | TCGA-EI-6917-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5fluorouracil+oxaciplatina+l-folinian | SD |
TMEM59 | SNV | Missense_Mutation | novel | c.664C>A | p.Leu222Ile | p.L222I | Q9BXS4 | protein_coding | tolerated(0.32) | benign(0.003) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
TMEM59 | SNV | Missense_Mutation | rs776175537 | c.272G>A | p.Arg91Gln | p.R91Q | Q9BXS4 | protein_coding | tolerated(0.57) | benign(0.011) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
TMEM59 | SNV | Missense_Mutation | novel | c.477N>T | p.Gln159His | p.Q159H | Q9BXS4 | protein_coding | tolerated(0.39) | benign(0.005) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
TMEM59 | SNV | Missense_Mutation | c.655N>G | p.Arg219Gly | p.R219G | Q9BXS4 | protein_coding | tolerated(0.06) | benign(0.007) | TCGA-AP-A054-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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