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Gene: TIMM17A |
Gene summary for TIMM17A |
Gene summary. |
Gene information | Species | Human | Gene symbol | TIMM17A | Gene ID | 10440 |
Gene name | translocase of inner mitochondrial membrane 17A | |
Gene Alias | TIM17 | |
Cytomap | 1q32.1 | |
Gene Type | protein-coding | GO ID | GO:0006508 | UniProtAcc | Q99595 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10440 | TIMM17A | LZE2T | Human | Esophagus | ESCC | 3.13e-04 | 1.17e+00 | 0.082 |
10440 | TIMM17A | LZE4T | Human | Esophagus | ESCC | 6.13e-17 | 5.45e-01 | 0.0811 |
10440 | TIMM17A | LZE5T | Human | Esophagus | ESCC | 8.79e-03 | 3.38e-01 | 0.0514 |
10440 | TIMM17A | LZE7T | Human | Esophagus | ESCC | 1.64e-07 | 9.13e-01 | 0.0667 |
10440 | TIMM17A | LZE8T | Human | Esophagus | ESCC | 2.27e-08 | 2.59e-01 | 0.067 |
10440 | TIMM17A | LZE20T | Human | Esophagus | ESCC | 2.38e-07 | 1.54e-01 | 0.0662 |
10440 | TIMM17A | LZE22D1 | Human | Esophagus | HGIN | 8.26e-05 | -3.58e-02 | 0.0595 |
10440 | TIMM17A | LZE24T | Human | Esophagus | ESCC | 8.04e-10 | 3.78e-01 | 0.0596 |
10440 | TIMM17A | LZE6T | Human | Esophagus | ESCC | 5.46e-04 | 1.46e-01 | 0.0845 |
10440 | TIMM17A | P2T-E | Human | Esophagus | ESCC | 6.92e-24 | 6.27e-01 | 0.1177 |
10440 | TIMM17A | P4T-E | Human | Esophagus | ESCC | 7.77e-52 | 1.40e+00 | 0.1323 |
10440 | TIMM17A | P5T-E | Human | Esophagus | ESCC | 3.60e-52 | 1.39e+00 | 0.1327 |
10440 | TIMM17A | P8T-E | Human | Esophagus | ESCC | 5.44e-23 | 4.57e-01 | 0.0889 |
10440 | TIMM17A | P9T-E | Human | Esophagus | ESCC | 3.23e-27 | 9.10e-01 | 0.1131 |
10440 | TIMM17A | P10T-E | Human | Esophagus | ESCC | 1.51e-57 | 1.13e+00 | 0.116 |
10440 | TIMM17A | P11T-E | Human | Esophagus | ESCC | 2.54e-13 | 8.71e-01 | 0.1426 |
10440 | TIMM17A | P12T-E | Human | Esophagus | ESCC | 1.06e-15 | 4.80e-01 | 0.1122 |
10440 | TIMM17A | P15T-E | Human | Esophagus | ESCC | 2.46e-27 | 7.62e-01 | 0.1149 |
10440 | TIMM17A | P16T-E | Human | Esophagus | ESCC | 9.20e-28 | 8.27e-01 | 0.1153 |
10440 | TIMM17A | P17T-E | Human | Esophagus | ESCC | 1.36e-08 | 4.12e-01 | 0.1278 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000683929 | Thyroid | ATC | mitochondrial transport | 151/6293 | 254/18723 | 2.07e-17 | 2.14e-15 | 151 |
GO:004586234 | Thyroid | ATC | positive regulation of proteolysis | 202/6293 | 372/18723 | 1.07e-16 | 9.42e-15 | 202 |
GO:007058533 | Thyroid | ATC | protein localization to mitochondrion | 83/6293 | 125/18723 | 6.24e-14 | 3.37e-12 | 83 |
GO:007265533 | Thyroid | ATC | establishment of protein localization to mitochondrion | 80/6293 | 120/18723 | 1.27e-13 | 6.46e-12 | 80 |
GO:000662626 | Thyroid | ATC | protein targeting to mitochondrion | 67/6293 | 100/18723 | 8.62e-12 | 3.21e-10 | 67 |
GO:001703822 | Thyroid | ATC | protein import | 110/6293 | 206/18723 | 3.49e-09 | 8.09e-08 | 110 |
GO:199054226 | Thyroid | ATC | mitochondrial transmembrane transport | 57/6293 | 102/18723 | 3.05e-06 | 3.49e-05 | 57 |
GO:0051604110 | Thyroid | ATC | protein maturation | 136/6293 | 294/18723 | 4.00e-06 | 4.42e-05 | 136 |
GO:001648515 | Thyroid | ATC | protein processing | 100/6293 | 225/18723 | 4.39e-04 | 2.62e-03 | 100 |
GO:007180631 | Thyroid | ATC | protein transmembrane transport | 32/6293 | 59/18723 | 8.74e-04 | 4.72e-03 | 32 |
GO:006500231 | Thyroid | ATC | intracellular protein transmembrane transport | 27/6293 | 51/18723 | 3.41e-03 | 1.52e-02 | 27 |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TIMM17A | SNV | Missense_Mutation | rs750416279 | c.253G>A | p.Gly85Arg | p.G85R | Q99595 | protein_coding | tolerated(0.36) | benign(0.113) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
TIMM17A | SNV | Missense_Mutation | c.17N>C | p.Arg6Pro | p.R6P | Q99595 | protein_coding | deleterious(0.01) | possibly_damaging(0.747) | TCGA-BH-A18K-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |
TIMM17A | SNV | Missense_Mutation | rs756338629 | c.112C>T | p.Arg38Cys | p.R38C | Q99595 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
TIMM17A | SNV | Missense_Mutation | c.119N>A | p.Ser40Tyr | p.S40Y | Q99595 | protein_coding | deleterious(0) | possibly_damaging(0.815) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
TIMM17A | SNV | Missense_Mutation | c.98N>T | p.Ala33Val | p.A33V | Q99595 | protein_coding | tolerated(0.48) | possibly_damaging(0.744) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD | |
TIMM17A | SNV | Missense_Mutation | rs202092277 | c.386N>T | p.Ala129Val | p.A129V | Q99595 | protein_coding | tolerated(1) | benign(0.017) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TIMM17A | SNV | Missense_Mutation | novel | c.140G>T | p.Arg47Ile | p.R47I | Q99595 | protein_coding | deleterious(0.01) | probably_damaging(0.987) | TCGA-AX-A2HC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | PD |
TIMM17A | SNV | Missense_Mutation | novel | c.209N>A | p.Gly70Glu | p.G70E | Q99595 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-B5-A0JU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TIMM17A | SNV | Missense_Mutation | rs756338629 | c.112N>T | p.Arg38Cys | p.R38C | Q99595 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-B5-A1MR-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
TIMM17A | SNV | Missense_Mutation | rs757756350 | c.88N>G | p.Ile30Val | p.I30V | Q99595 | protein_coding | tolerated(0.78) | benign(0.026) | TCGA-B5-A3FA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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