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Gene: SLC25A3 |
Gene summary for SLC25A3 |
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Gene information | Species | Human | Gene symbol | SLC25A3 | Gene ID | 5250 |
Gene name | solute carrier family 25 member 3 | |
Gene Alias | OK/SW-cl.48 | |
Cytomap | 12q23.1 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | A0A024RBE8 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
5250 | SLC25A3 | GSM4909281 | Human | Breast | IDC | 1.19e-06 | -3.02e-01 | 0.21 |
5250 | SLC25A3 | GSM4909282 | Human | Breast | IDC | 2.41e-12 | -4.59e-01 | -0.0288 |
5250 | SLC25A3 | GSM4909287 | Human | Breast | IDC | 4.19e-02 | -3.39e-01 | 0.2057 |
5250 | SLC25A3 | GSM4909288 | Human | Breast | IDC | 3.96e-03 | 5.27e-03 | 0.0988 |
5250 | SLC25A3 | GSM4909294 | Human | Breast | IDC | 5.05e-07 | -8.92e-02 | 0.2022 |
5250 | SLC25A3 | GSM4909296 | Human | Breast | IDC | 4.43e-11 | -2.96e-01 | 0.1524 |
5250 | SLC25A3 | GSM4909297 | Human | Breast | IDC | 8.03e-29 | -4.08e-01 | 0.1517 |
5250 | SLC25A3 | GSM4909301 | Human | Breast | IDC | 2.79e-26 | -7.03e-01 | 0.1577 |
5250 | SLC25A3 | GSM4909302 | Human | Breast | IDC | 1.50e-11 | -5.51e-01 | 0.1545 |
5250 | SLC25A3 | GSM4909307 | Human | Breast | IDC | 2.08e-08 | -4.16e-01 | 0.1569 |
5250 | SLC25A3 | GSM4909309 | Human | Breast | IDC | 5.38e-03 | -2.59e-01 | 0.0483 |
5250 | SLC25A3 | GSM4909311 | Human | Breast | IDC | 2.07e-59 | -7.57e-01 | 0.1534 |
5250 | SLC25A3 | GSM4909312 | Human | Breast | IDC | 4.15e-09 | -1.41e-01 | 0.1552 |
5250 | SLC25A3 | GSM4909313 | Human | Breast | IDC | 4.49e-03 | -1.90e-01 | 0.0391 |
5250 | SLC25A3 | GSM4909315 | Human | Breast | IDC | 8.42e-12 | 2.27e-01 | 0.21 |
5250 | SLC25A3 | GSM4909316 | Human | Breast | IDC | 3.12e-13 | 1.66e-01 | 0.21 |
5250 | SLC25A3 | GSM4909319 | Human | Breast | IDC | 1.70e-70 | -6.35e-01 | 0.1563 |
5250 | SLC25A3 | GSM4909320 | Human | Breast | IDC | 4.81e-14 | -8.00e-01 | 0.1575 |
5250 | SLC25A3 | GSM4909321 | Human | Breast | IDC | 3.13e-22 | -4.52e-01 | 0.1559 |
5250 | SLC25A3 | brca1 | Human | Breast | Precancer | 2.84e-13 | 3.97e-01 | -0.0338 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0033013 | Liver | Cirrhotic | tetrapyrrole metabolic process | 24/4634 | 59/18723 | 5.06e-03 | 2.62e-02 | 24 |
GO:0006778 | Liver | Cirrhotic | porphyrin-containing compound metabolic process | 20/4634 | 49/18723 | 9.60e-03 | 4.35e-02 | 20 |
GO:000609122 | Liver | HCC | generation of precursor metabolites and energy | 340/7958 | 490/18723 | 4.04e-34 | 2.85e-31 | 340 |
GO:000906012 | Liver | HCC | aerobic respiration | 147/7958 | 189/18723 | 3.13e-23 | 6.61e-21 | 147 |
GO:004533312 | Liver | HCC | cellular respiration | 171/7958 | 230/18723 | 6.35e-23 | 1.26e-20 | 171 |
GO:004603422 | Liver | HCC | ATP metabolic process | 198/7958 | 277/18723 | 8.30e-23 | 1.55e-20 | 198 |
GO:001598022 | Liver | HCC | energy derivation by oxidation of organic compounds | 221/7958 | 318/18723 | 1.02e-22 | 1.86e-20 | 221 |
GO:000683912 | Liver | HCC | mitochondrial transport | 184/7958 | 254/18723 | 2.30e-22 | 3.83e-20 | 184 |
GO:003310812 | Liver | HCC | mitochondrial respiratory chain complex assembly | 80/7958 | 93/18723 | 3.47e-18 | 4.15e-16 | 80 |
GO:000611912 | Liver | HCC | oxidative phosphorylation | 110/7958 | 141/18723 | 6.58e-18 | 7.45e-16 | 110 |
GO:001593111 | Liver | HCC | nucleobase-containing compound transport | 150/7958 | 222/18723 | 3.17e-14 | 2.03e-12 | 150 |
GO:003286821 | Liver | HCC | response to insulin | 172/7958 | 264/18723 | 7.14e-14 | 4.23e-12 | 172 |
GO:003286921 | Liver | HCC | cellular response to insulin stimulus | 137/7958 | 203/18723 | 4.69e-13 | 2.44e-11 | 137 |
GO:004343422 | Liver | HCC | response to peptide hormone | 247/7958 | 414/18723 | 9.55e-13 | 4.77e-11 | 247 |
GO:01400531 | Liver | HCC | mitochondrial gene expression | 82/7958 | 108/18723 | 1.49e-12 | 7.20e-11 | 82 |
GO:199054212 | Liver | HCC | mitochondrial transmembrane transport | 78/7958 | 102/18723 | 2.73e-12 | 1.26e-10 | 78 |
GO:007137521 | Liver | HCC | cellular response to peptide hormone stimulus | 179/7958 | 290/18723 | 2.54e-11 | 9.88e-10 | 179 |
GO:190165321 | Liver | HCC | cellular response to peptide | 211/7958 | 359/18723 | 2.86e-10 | 9.63e-09 | 211 |
GO:004346722 | Liver | HCC | regulation of generation of precursor metabolites and energy | 89/7958 | 130/18723 | 1.84e-09 | 5.35e-08 | 89 |
GO:001604921 | Liver | HCC | cell growth | 269/7958 | 482/18723 | 1.84e-09 | 5.35e-08 | 269 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SLC25A3 | insertion | Nonsense_Mutation | novel | c.832_833insTTTTTTTTTTTTCCCTAGAGTAAGGAC | p.Ala278delinsValPhePhePheSerLeuGluTerGlyPro | p.A278delinsVFFFSLE*GP | Q00325 | protein_coding | TCGA-A8-A07R-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Ancillary | zoledronic | SD | ||
SLC25A3 | SNV | Missense_Mutation | novel | c.1031N>A | p.Arg344His | p.R344H | Q00325 | protein_coding | deleterious(0) | benign(0.007) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
SLC25A3 | SNV | Missense_Mutation | c.607G>A | p.Ala203Thr | p.A203T | Q00325 | protein_coding | tolerated(0.07) | possibly_damaging(0.845) | TCGA-A6-3809-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
SLC25A3 | SNV | Missense_Mutation | novel | c.566N>A | p.Arg189Gln | p.R189Q | Q00325 | protein_coding | deleterious(0.01) | probably_damaging(0.962) | TCGA-AA-3818-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
SLC25A3 | SNV | Missense_Mutation | c.914N>T | p.Arg305Ile | p.R305I | Q00325 | protein_coding | deleterious(0.01) | benign(0.14) | TCGA-AA-3977-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
SLC25A3 | SNV | Missense_Mutation | c.883N>C | p.Lys295Gln | p.K295Q | Q00325 | protein_coding | deleterious(0.02) | benign(0.152) | TCGA-CA-6718-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD | |
SLC25A3 | SNV | Missense_Mutation | c.32C>T | p.Ala11Val | p.A11V | Q00325 | protein_coding | tolerated_low_confidence(0.51) | benign(0.03) | TCGA-D5-6930-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
SLC25A3 | SNV | Missense_Mutation | c.963N>T | p.Met321Ile | p.M321I | Q00325 | protein_coding | deleterious(0) | probably_damaging(0.948) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
SLC25A3 | SNV | Missense_Mutation | c.880N>A | p.Glu294Lys | p.E294K | Q00325 | protein_coding | tolerated(0.21) | benign(0.174) | TCGA-A5-A2K5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
SLC25A3 | SNV | Missense_Mutation | novel | c.206N>T | p.Gly69Val | p.G69V | Q00325 | protein_coding | deleterious(0.02) | probably_damaging(0.964) | TCGA-AP-A051-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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