Tissue | Expression Dynamics | Abbreviation |
Cervix | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Cervix/SENP6_pca_on_diff_genes.png) | CC: Cervix cancer |
HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions |
N_HPV: HPV-infected normal cervix |
Colorectum (GSE201348) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Becker/SENP6_pca_on_diff_genes.png) | FAP: Familial adenomatous polyposis |
CRC: Colorectal cancer |
Colorectum (HTA11) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Chen/SENP6_pca_on_diff_genes.png) | AD: Adenomas |
SER: Sessile serrated lesions |
MSI-H: Microsatellite-high colorectal cancer |
MSS: Microsatellite stable colorectal cancer |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/SENP6_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/SENP6_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Lung | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Lung/SENP6_pca_on_diff_genes.png) | AAH: Atypical adenomatous hyperplasia |
AIS: Adenocarcinoma in situ |
IAC: Invasive lung adenocarcinoma |
MIA: Minimally invasive adenocarcinoma |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/SENP6_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Prostate | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Prostate/SENP6_pca_on_diff_genes.png) | BPH: Benign Prostatic Hyperplasia |
Skin | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Skin/SENP6_pca_on_diff_genes.png) | AK: Actinic keratosis |
cSCC: Cutaneous squamous cell carcinoma |
SCCIS:squamous cell carcinoma in situ |
Thyroid | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Thyroid/SENP6_pca_on_diff_genes.png) | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00513822 | Skin | cSCC | kinetochore assembly | 11/4864 | 18/18723 | 1.74e-03 | 1.06e-02 | 11 |
GO:003288612 | Skin | cSCC | regulation of microtubule-based process | 82/4864 | 240/18723 | 2.82e-03 | 1.58e-02 | 82 |
GO:00169255 | Skin | cSCC | protein sumoylation | 23/4864 | 53/18723 | 4.39e-03 | 2.29e-02 | 23 |
GO:00706464 | Skin | cSCC | protein modification by small protein removal | 55/4864 | 157/18723 | 7.29e-03 | 3.46e-02 | 55 |
GO:00901698 | Thyroid | HT | regulation of spindle assembly | 9/1272 | 25/18723 | 2.26e-05 | 5.09e-04 | 9 |
GO:004325430 | Thyroid | HT | regulation of protein-containing complex assembly | 50/1272 | 428/18723 | 1.24e-04 | 2.00e-03 | 50 |
GO:00902247 | Thyroid | HT | regulation of spindle organization | 10/1272 | 39/18723 | 2.09e-04 | 3.01e-03 | 10 |
GO:00512258 | Thyroid | HT | spindle assembly | 17/1272 | 117/18723 | 2.34e-03 | 2.00e-02 | 17 |
GO:19021158 | Thyroid | HT | regulation of organelle assembly | 23/1272 | 186/18723 | 3.89e-03 | 2.88e-02 | 23 |
GO:007050710 | Thyroid | HT | regulation of microtubule cytoskeleton organization | 19/1272 | 148/18723 | 5.50e-03 | 3.62e-02 | 19 |
GO:000705110 | Thyroid | HT | spindle organization | 22/1272 | 184/18723 | 6.95e-03 | 4.22e-02 | 22 |
GO:003304418 | Thyroid | HT | regulation of chromosome organization | 22/1272 | 187/18723 | 8.36e-03 | 4.79e-02 | 22 |
GO:0043254113 | Thyroid | PTC | regulation of protein-containing complex assembly | 215/5968 | 428/18723 | 1.23e-15 | 9.09e-14 | 215 |
GO:00182059 | Thyroid | PTC | peptidyl-lysine modification | 188/5968 | 376/18723 | 1.34e-13 | 7.09e-12 | 188 |
GO:003304419 | Thyroid | PTC | regulation of chromosome organization | 102/5968 | 187/18723 | 1.04e-10 | 3.58e-09 | 102 |
GO:007050717 | Thyroid | PTC | regulation of microtubule cytoskeleton organization | 80/5968 | 148/18723 | 1.79e-08 | 4.19e-07 | 80 |
GO:000705116 | Thyroid | PTC | spindle organization | 92/5968 | 184/18723 | 2.21e-07 | 3.92e-06 | 92 |
GO:190211516 | Thyroid | PTC | regulation of organelle assembly | 88/5968 | 186/18723 | 7.41e-06 | 8.65e-05 | 88 |
GO:00328866 | Thyroid | PTC | regulation of microtubule-based process | 105/5968 | 240/18723 | 6.91e-05 | 6.03e-04 | 105 |
GO:00169256 | Thyroid | PTC | protein sumoylation | 30/5968 | 53/18723 | 1.71e-04 | 1.31e-03 | 30 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SENP6 | SNV | Missense_Mutation | | c.1471C>G | p.Leu491Val | p.L491V | Q9GZR1 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-A2-A0YH-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | SD |
SENP6 | SNV | Missense_Mutation | rs550031341 | c.1316N>T | p.Ser439Phe | p.S439F | Q9GZR1 | protein_coding | deleterious(0.01) | possibly_damaging(0.45) | TCGA-AC-A2B8-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | chemo | PD |
SENP6 | SNV | Missense_Mutation | novel | c.3139C>T | p.Leu1047Phe | p.L1047F | Q9GZR1 | protein_coding | tolerated(0.13) | benign(0.051) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SENP6 | SNV | Missense_Mutation | novel | c.1543N>G | p.Gln515Glu | p.Q515E | Q9GZR1 | protein_coding | tolerated(0.3) | benign(0.003) | TCGA-BH-A0B6-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SENP6 | insertion | Frame_Shift_Ins | novel | c.2597_2598insAGCTGGAATGCTGTGGCACAATCTCGGCTCACTGCAACCTCTGCCTC | p.His866GlnfsTer50 | p.H866Qfs*50 | Q9GZR1 | protein_coding | | | TCGA-A8-A07R-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Ancillary | zoledronic | SD |
SENP6 | insertion | In_Frame_Ins | novel | c.2667_2668insTATGTTATT | p.Lys889_Ser890insTyrValIle | p.K889_S890insYVI | Q9GZR1 | protein_coding | | | TCGA-AR-A0U2-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Hormone Therapy | tamoxiphen | PD |
SENP6 | SNV | Missense_Mutation | | c.1126N>A | p.Glu376Lys | p.E376K | Q9GZR1 | protein_coding | tolerated(0.09) | possibly_damaging(0.544) | TCGA-C5-A901-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
SENP6 | SNV | Missense_Mutation | | c.1276N>G | p.Gln426Glu | p.Q426E | Q9GZR1 | protein_coding | tolerated(0.08) | benign(0.08) | TCGA-DS-A0VM-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PD |
SENP6 | SNV | Missense_Mutation | novel | c.1355N>G | p.Val452Gly | p.V452G | Q9GZR1 | protein_coding | deleterious(0) | possibly_damaging(0.791) | TCGA-MA-AA43-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unknown | Unknown | SD |
SENP6 | SNV | Missense_Mutation | novel | c.2254G>C | p.Glu752Gln | p.E752Q | Q9GZR1 | protein_coding | tolerated(0.91) | benign(0.241) | TCGA-VS-A9U6-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PD |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
26054 | SENP6 | ENZYME, PROTEASE, DRUGGABLE GENOME | | GNF-PF-1702 | CHEMBL600313 | |
26054 | SENP6 | ENZYME, PROTEASE, DRUGGABLE GENOME | | CID 4101591 | CHEMBL428789 | |
26054 | SENP6 | ENZYME, PROTEASE, DRUGGABLE GENOME | | DNDI1417156 | CHEMBL1504679 | |
26054 | SENP6 | ENZYME, PROTEASE, DRUGGABLE GENOME | | DIHYDROXANTHOHUMOL | DIHYDROXANTHOHUMOL | |
26054 | SENP6 | ENZYME, PROTEASE, DRUGGABLE GENOME | | IPRIFLAVONE | IPRIFLAVONE | |
26054 | SENP6 | ENZYME, PROTEASE, DRUGGABLE GENOME | | XANTHOANGELOL B | XANTHOANGELOL B | |
26054 | SENP6 | ENZYME, PROTEASE, DRUGGABLE GENOME | | 4-PHENYLAMINO-[1,2]NAPHTHOQUINONE | CHEMBL299853 | |
26054 | SENP6 | ENZYME, PROTEASE, DRUGGABLE GENOME | | 6,4'-DIHYDROXYFLAVONE | CHEMBL484663 | |
26054 | SENP6 | ENZYME, PROTEASE, DRUGGABLE GENOME | | 2-(4-NITROBENZYLSULFANYL)BENZOXAZOLE | CHEMBL412603 | |
26054 | SENP6 | ENZYME, PROTEASE, DRUGGABLE GENOME | | BAS-0338868 | CHEMBL378903 | |