Tissue | Expression Dynamics | Abbreviation |
Cervix | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Cervix/RREB1_pca_on_diff_genes.png) | CC: Cervix cancer |
HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions |
N_HPV: HPV-infected normal cervix |
Colorectum (GSE201348) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Becker/RREB1_pca_on_diff_genes.png) | FAP: Familial adenomatous polyposis |
CRC: Colorectal cancer |
Colorectum (HTA11) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Chen/RREB1_pca_on_diff_genes.png) | AD: Adenomas |
SER: Sessile serrated lesions |
MSI-H: Microsatellite-high colorectal cancer |
MSS: Microsatellite stable colorectal cancer |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/RREB1_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/RREB1_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Skin | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Skin/RREB1_pca_on_diff_genes.png) | AK: Actinic keratosis |
cSCC: Cutaneous squamous cell carcinoma |
SCCIS:squamous cell carcinoma in situ |
Thyroid | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Thyroid/RREB1_pca_on_diff_genes.png) | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00226045 | Colorectum | CRC | regulation of cell morphogenesis | 74/2078 | 309/18723 | 9.25e-11 | 5.04e-08 | 74 |
GO:00108105 | Colorectum | CRC | regulation of cell-substrate adhesion | 57/2078 | 221/18723 | 6.94e-10 | 2.60e-07 | 57 |
GO:00315894 | Colorectum | CRC | cell-substrate adhesion | 78/2078 | 363/18723 | 6.22e-09 | 1.49e-06 | 78 |
GO:00108115 | Colorectum | CRC | positive regulation of cell-substrate adhesion | 37/2078 | 123/18723 | 8.34e-09 | 1.85e-06 | 37 |
GO:00487325 | Colorectum | CRC | gland development | 88/2078 | 436/18723 | 1.62e-08 | 2.79e-06 | 88 |
GO:00072653 | Colorectum | CRC | Ras protein signal transduction | 70/2078 | 337/18723 | 1.49e-07 | 1.66e-05 | 70 |
GO:00975815 | Colorectum | CRC | lamellipodium organization | 28/2078 | 90/18723 | 2.43e-07 | 2.27e-05 | 28 |
GO:19027435 | Colorectum | CRC | regulation of lamellipodium organization | 20/2078 | 54/18723 | 5.62e-07 | 4.00e-05 | 20 |
GO:19027455 | Colorectum | CRC | positive regulation of lamellipodium organization | 16/2078 | 37/18723 | 6.56e-07 | 4.50e-05 | 16 |
GO:00420605 | Colorectum | CRC | wound healing | 80/2078 | 422/18723 | 1.06e-06 | 6.54e-05 | 80 |
GO:00457855 | Colorectum | CRC | positive regulation of cell adhesion | 81/2078 | 437/18723 | 2.28e-06 | 1.10e-04 | 81 |
GO:00107204 | Colorectum | CRC | positive regulation of cell development | 60/2078 | 298/18723 | 3.27e-06 | 1.47e-04 | 60 |
GO:00313464 | Colorectum | CRC | positive regulation of cell projection organization | 67/2078 | 353/18723 | 7.45e-06 | 2.72e-04 | 67 |
GO:00016674 | Colorectum | CRC | ameboidal-type cell migration | 82/2078 | 475/18723 | 3.09e-05 | 8.01e-04 | 82 |
GO:00344465 | Colorectum | CRC | substrate adhesion-dependent cell spreading | 27/2078 | 108/18723 | 3.70e-05 | 9.18e-04 | 27 |
GO:00107695 | Colorectum | CRC | regulation of cell morphogenesis involved in differentiation | 24/2078 | 96/18723 | 9.80e-05 | 1.96e-03 | 24 |
GO:00106344 | Colorectum | CRC | positive regulation of epithelial cell migration | 36/2078 | 176/18723 | 2.04e-04 | 3.48e-03 | 36 |
GO:00106325 | Colorectum | CRC | regulation of epithelial cell migration | 53/2078 | 292/18723 | 2.11e-04 | 3.55e-03 | 53 |
GO:00107705 | Colorectum | CRC | positive regulation of cell morphogenesis involved in differentiation | 20/2078 | 79/18723 | 3.03e-04 | 4.77e-03 | 20 |
GO:19000245 | Colorectum | CRC | regulation of substrate adhesion-dependent cell spreading | 16/2078 | 57/18723 | 3.40e-04 | 5.17e-03 | 16 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
RREB1 | SNV | Missense_Mutation | novel | c.4799N>C | p.Cys1600Ser | p.C1600S | Q92766 | protein_coding | deleterious(0) | probably_damaging(0.98) | TCGA-5L-AAT0-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD |
RREB1 | SNV | Missense_Mutation | novel | c.953G>T | p.Cys318Phe | p.C318F | Q92766 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-5T-A9QA-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxol | SD |
RREB1 | SNV | Missense_Mutation | novel | c.4672G>A | p.Val1558Met | p.V1558M | Q92766 | protein_coding | tolerated(0.13) | benign(0.023) | TCGA-A2-A0CT-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | cytoxan | SD |
RREB1 | SNV | Missense_Mutation | novel | c.220N>G | p.Ile74Val | p.I74V | Q92766 | protein_coding | tolerated(0.42) | benign(0.001) | TCGA-A8-A06P-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unspecific | | SD |
RREB1 | SNV | Missense_Mutation | | c.4658N>G | p.Asp1553Gly | p.D1553G | Q92766 | protein_coding | tolerated(0.12) | benign(0.42) | TCGA-A8-A09Z-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
RREB1 | SNV | Missense_Mutation | | c.694G>A | p.Asp232Asn | p.D232N | Q92766 | protein_coding | tolerated(0.07) | possibly_damaging(0.892) | TCGA-AN-A0FY-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
RREB1 | SNV | Missense_Mutation | | c.1636C>T | p.Pro546Ser | p.P546S | Q92766 | protein_coding | tolerated(0.11) | benign(0.037) | TCGA-B6-A0RE-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
RREB1 | SNV | Missense_Mutation | | c.601N>A | p.Glu201Lys | p.E201K | Q92766 | protein_coding | tolerated(0.16) | benign(0.234) | TCGA-C8-A138-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
RREB1 | SNV | Missense_Mutation | | c.4854N>C | p.Gln1618His | p.Q1618H | Q92766 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-C8-A27B-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | 5-fluorouracil | CR |
RREB1 | SNV | Missense_Mutation | | c.2088N>C | p.Glu696Asp | p.E696D | Q92766 | protein_coding | deleterious(0) | probably_damaging(0.984) | TCGA-D8-A1XQ-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |