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Gene: RPL27 |
Gene summary for RPL27 |
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Gene information | Species | Human | Gene symbol | RPL27 | Gene ID | 6155 |
Gene name | ribosomal protein L27 | |
Gene Alias | DBA16 | |
Cytomap | 17q21.31 | |
Gene Type | protein-coding | GO ID | GO:0002181 | UniProtAcc | A0A024R1V4 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
6155 | RPL27 | GSM4909282 | Human | Breast | IDC | 4.51e-02 | -1.04e-01 | -0.0288 |
6155 | RPL27 | GSM4909285 | Human | Breast | IDC | 5.79e-38 | 2.89e-01 | 0.21 |
6155 | RPL27 | GSM4909286 | Human | Breast | IDC | 1.43e-103 | 4.28e-01 | 0.1081 |
6155 | RPL27 | GSM4909287 | Human | Breast | IDC | 1.63e-40 | -6.44e-01 | 0.2057 |
6155 | RPL27 | GSM4909293 | Human | Breast | IDC | 7.76e-30 | -2.39e-01 | 0.1581 |
6155 | RPL27 | GSM4909294 | Human | Breast | IDC | 1.26e-11 | -3.37e-01 | 0.2022 |
6155 | RPL27 | GSM4909296 | Human | Breast | IDC | 1.36e-02 | -1.21e-01 | 0.1524 |
6155 | RPL27 | GSM4909297 | Human | Breast | IDC | 2.13e-11 | -1.90e-02 | 0.1517 |
6155 | RPL27 | GSM4909302 | Human | Breast | IDC | 1.32e-02 | -1.55e-02 | 0.1545 |
6155 | RPL27 | GSM4909304 | Human | Breast | IDC | 1.13e-15 | -1.82e-01 | 0.1636 |
6155 | RPL27 | GSM4909307 | Human | Breast | IDC | 2.70e-09 | 1.72e-01 | 0.1569 |
6155 | RPL27 | GSM4909311 | Human | Breast | IDC | 1.17e-29 | -3.03e-02 | 0.1534 |
6155 | RPL27 | GSM4909315 | Human | Breast | IDC | 1.19e-26 | -4.57e-01 | 0.21 |
6155 | RPL27 | GSM4909316 | Human | Breast | IDC | 4.13e-09 | -5.70e-01 | 0.21 |
6155 | RPL27 | GSM4909317 | Human | Breast | IDC | 1.61e-34 | -4.17e-01 | 0.1355 |
6155 | RPL27 | GSM4909319 | Human | Breast | IDC | 1.39e-42 | -3.95e-01 | 0.1563 |
6155 | RPL27 | GSM4909320 | Human | Breast | IDC | 9.76e-03 | -1.70e-02 | 0.1575 |
6155 | RPL27 | GSM4909321 | Human | Breast | IDC | 6.94e-04 | -1.23e-01 | 0.1559 |
6155 | RPL27 | brca2 | Human | Breast | Precancer | 1.84e-05 | -2.92e-02 | -0.024 |
6155 | RPL27 | M1 | Human | Breast | IDC | 2.61e-04 | -1.43e-01 | 0.1577 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:003196021 | Liver | HCC | response to corticosteroid | 98/7958 | 167/18723 | 1.73e-05 | 1.87e-04 | 98 |
GO:009730522 | Liver | HCC | response to alcohol | 138/7958 | 253/18723 | 6.91e-05 | 6.26e-04 | 138 |
GO:000218132 | Liver | Cyst | cytoplasmic translation | 70/496 | 148/18723 | 9.01e-71 | 3.85e-67 | 70 |
GO:00021818 | Lung | IAC | cytoplasmic translation | 85/2061 | 148/18723 | 3.11e-43 | 1.85e-39 | 85 |
GO:00485458 | Lung | IAC | response to steroid hormone | 69/2061 | 339/18723 | 2.99e-07 | 2.34e-05 | 69 |
GO:19016548 | Lung | IAC | response to ketone | 39/2061 | 194/18723 | 1.40e-04 | 2.60e-03 | 39 |
GO:00319607 | Lung | IAC | response to corticosteroid | 31/2061 | 167/18723 | 2.47e-03 | 2.33e-02 | 31 |
GO:000218113 | Lung | AIS | cytoplasmic translation | 85/1849 | 148/18723 | 5.48e-47 | 3.19e-43 | 85 |
GO:004854513 | Lung | AIS | response to steroid hormone | 59/1849 | 339/18723 | 1.15e-05 | 4.65e-04 | 59 |
GO:190165413 | Lung | AIS | response to ketone | 34/1849 | 194/18723 | 6.76e-04 | 1.01e-02 | 34 |
GO:00226138 | Lung | AIS | ribonucleoprotein complex biogenesis | 63/1849 | 463/18723 | 5.49e-03 | 4.68e-02 | 63 |
GO:00973057 | Lung | AIS | response to alcohol | 38/1849 | 253/18723 | 5.88e-03 | 4.89e-02 | 38 |
GO:000218123 | Lung | AAH | cytoplasmic translation | 64/613 | 148/18723 | 1.74e-55 | 7.99e-52 | 64 |
GO:00422548 | Lung | AAH | ribosome biogenesis | 30/613 | 299/18723 | 5.70e-08 | 5.22e-05 | 30 |
GO:002261313 | Lung | AAH | ribonucleoprotein complex biogenesis | 33/613 | 463/18723 | 2.61e-05 | 3.42e-03 | 33 |
GO:00063645 | Lung | AAH | rRNA processing | 20/613 | 225/18723 | 5.37e-05 | 5.35e-03 | 20 |
GO:00160725 | Lung | AAH | rRNA metabolic process | 20/613 | 236/18723 | 1.04e-04 | 7.23e-03 | 20 |
GO:009730513 | Lung | AAH | response to alcohol | 19/613 | 253/18723 | 7.02e-04 | 2.55e-02 | 19 |
GO:000218133 | Lung | MIAC | cytoplasmic translation | 73/967 | 148/18723 | 4.84e-54 | 2.48e-50 | 73 |
GO:004225413 | Lung | MIAC | ribosome biogenesis | 33/967 | 299/18723 | 3.37e-05 | 1.92e-03 | 33 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0301018 | Breast | Precancer | Ribosome | 80/684 | 167/8465 | 7.33e-44 | 2.32e-41 | 1.77e-41 | 80 |
hsa0517118 | Breast | Precancer | Coronavirus disease - COVID-19 | 81/684 | 232/8465 | 3.74e-32 | 2.36e-30 | 1.81e-30 | 81 |
hsa0301019 | Breast | Precancer | Ribosome | 80/684 | 167/8465 | 7.33e-44 | 2.32e-41 | 1.77e-41 | 80 |
hsa0517119 | Breast | Precancer | Coronavirus disease - COVID-19 | 81/684 | 232/8465 | 3.74e-32 | 2.36e-30 | 1.81e-30 | 81 |
hsa0301024 | Breast | IDC | Ribosome | 83/867 | 167/8465 | 6.07e-39 | 9.87e-37 | 7.38e-37 | 83 |
hsa0517124 | Breast | IDC | Coronavirus disease - COVID-19 | 86/867 | 232/8465 | 1.50e-28 | 9.72e-27 | 7.27e-27 | 86 |
hsa0301034 | Breast | IDC | Ribosome | 83/867 | 167/8465 | 6.07e-39 | 9.87e-37 | 7.38e-37 | 83 |
hsa0517134 | Breast | IDC | Coronavirus disease - COVID-19 | 86/867 | 232/8465 | 1.50e-28 | 9.72e-27 | 7.27e-27 | 86 |
hsa0301044 | Breast | DCIS | Ribosome | 82/846 | 167/8465 | 8.69e-39 | 1.40e-36 | 1.03e-36 | 82 |
hsa0517144 | Breast | DCIS | Coronavirus disease - COVID-19 | 86/846 | 232/8465 | 2.42e-29 | 1.56e-27 | 1.15e-27 | 86 |
hsa0301054 | Breast | DCIS | Ribosome | 82/846 | 167/8465 | 8.69e-39 | 1.40e-36 | 1.03e-36 | 82 |
hsa0517154 | Breast | DCIS | Coronavirus disease - COVID-19 | 86/846 | 232/8465 | 2.42e-29 | 1.56e-27 | 1.15e-27 | 86 |
hsa0517120 | Cervix | CC | Coronavirus disease - COVID-19 | 111/1267 | 232/8465 | 1.82e-33 | 5.90e-31 | 3.49e-31 | 111 |
hsa0301020 | Cervix | CC | Ribosome | 85/1267 | 167/8465 | 3.17e-28 | 5.14e-26 | 3.04e-26 | 85 |
hsa05171110 | Cervix | CC | Coronavirus disease - COVID-19 | 111/1267 | 232/8465 | 1.82e-33 | 5.90e-31 | 3.49e-31 | 111 |
hsa03010110 | Cervix | CC | Ribosome | 85/1267 | 167/8465 | 3.17e-28 | 5.14e-26 | 3.04e-26 | 85 |
hsa0301025 | Cervix | HSIL_HPV | Ribosome | 80/459 | 167/8465 | 9.61e-58 | 2.82e-55 | 2.28e-55 | 80 |
hsa0517125 | Cervix | HSIL_HPV | Coronavirus disease - COVID-19 | 91/459 | 232/8465 | 2.14e-56 | 3.13e-54 | 2.53e-54 | 91 |
hsa0301035 | Cervix | HSIL_HPV | Ribosome | 80/459 | 167/8465 | 9.61e-58 | 2.82e-55 | 2.28e-55 | 80 |
hsa0517135 | Cervix | HSIL_HPV | Coronavirus disease - COVID-19 | 91/459 | 232/8465 | 2.14e-56 | 3.13e-54 | 2.53e-54 | 91 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
RPL27 | SNV | Missense_Mutation | rs143145441 | c.41T>A | p.Leu14Gln | p.L14Q | P61353 | protein_coding | deleterious(0.01) | probably_damaging(0.954) | TCGA-BH-A0DI-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | CR |
RPL27 | SNV | Missense_Mutation | c.350N>C | p.Lys117Thr | p.K117T | P61353 | protein_coding | tolerated(0.21) | benign(0.063) | TCGA-D8-A147-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicine | SD | |
RPL27 | SNV | Missense_Mutation | c.360N>C | p.Glu120Asp | p.E120D | P61353 | protein_coding | tolerated(0.11) | benign(0.143) | TCGA-DR-A0ZM-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unspecific | Cisplatin | SD | |
RPL27 | SNV | Missense_Mutation | rs760389648 | c.404G>A | p.Arg135Gln | p.R135Q | P61353 | protein_coding | tolerated(0.09) | benign(0.215) | TCGA-A6-5661-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
RPL27 | SNV | Missense_Mutation | c.170T>C | p.Met57Thr | p.M57T | P61353 | protein_coding | tolerated(0.07) | benign(0.305) | TCGA-A6-6780-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
RPL27 | SNV | Missense_Mutation | c.329N>A | p.Ala110Asp | p.A110D | P61353 | protein_coding | deleterious(0) | probably_damaging(0.954) | TCGA-AG-3883-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
RPL27 | SNV | Missense_Mutation | rs776186138 | c.107G>A | p.Arg36His | p.R36H | P61353 | protein_coding | tolerated(0.31) | benign(0.063) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
RPL27 | SNV | Missense_Mutation | rs754021880 | c.143G>A | p.Arg48His | p.R48H | P61353 | protein_coding | tolerated(0.15) | benign(0.007) | TCGA-B5-A3FA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
RPL27 | SNV | Missense_Mutation | novel | c.192N>T | p.Lys64Asn | p.K64N | P61353 | protein_coding | deleterious(0.01) | probably_damaging(0.921) | TCGA-FI-A2D5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD |
RPL27 | SNV | Missense_Mutation | c.62N>A | p.Arg21His | p.R21H | P61353 | protein_coding | tolerated(0.28) | benign(0.025) | TCGA-CC-A7IH-01 | Liver | liver hepatocellular carcinoma | Male | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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