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Gene: RNF180 |
Gene summary for RNF180 |
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Gene information | Species | Human | Gene symbol | RNF180 | Gene ID | 285671 |
Gene name | ring finger protein 180 | |
Gene Alias | RINES | |
Cytomap | 5q12.3 | |
Gene Type | protein-coding | GO ID | GO:0000209 | UniProtAcc | Q86T96 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
285671 | RNF180 | HTA11_3410_2000001011 | Human | Colorectum | AD | 2.32e-22 | 5.64e-01 | 0.0155 |
285671 | RNF180 | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.12e-23 | 8.14e-01 | -0.1808 |
285671 | RNF180 | HTA11_2951_2000001011 | Human | Colorectum | AD | 2.22e-10 | 6.19e-01 | 0.0216 |
285671 | RNF180 | HTA11_1938_2000001011 | Human | Colorectum | AD | 1.35e-40 | 1.77e+00 | -0.0811 |
285671 | RNF180 | HTA11_78_2000001011 | Human | Colorectum | AD | 2.12e-28 | 8.76e-01 | -0.1088 |
285671 | RNF180 | HTA11_347_2000001011 | Human | Colorectum | AD | 4.63e-29 | 7.25e-01 | -0.1954 |
285671 | RNF180 | HTA11_411_2000001011 | Human | Colorectum | SER | 2.64e-05 | 7.46e-01 | -0.2602 |
285671 | RNF180 | HTA11_2112_2000001011 | Human | Colorectum | SER | 5.97e-09 | 8.06e-01 | -0.2196 |
285671 | RNF180 | HTA11_3361_2000001011 | Human | Colorectum | AD | 4.64e-14 | 5.35e-01 | -0.1207 |
285671 | RNF180 | HTA11_83_2000001011 | Human | Colorectum | SER | 2.06e-12 | 6.89e-01 | -0.1526 |
285671 | RNF180 | HTA11_696_2000001011 | Human | Colorectum | AD | 8.73e-38 | 8.26e-01 | -0.1464 |
285671 | RNF180 | HTA11_866_2000001011 | Human | Colorectum | AD | 2.83e-21 | 5.62e-01 | -0.1001 |
285671 | RNF180 | HTA11_1391_2000001011 | Human | Colorectum | AD | 1.89e-21 | 6.65e-01 | -0.059 |
285671 | RNF180 | HTA11_2992_2000001011 | Human | Colorectum | SER | 8.71e-09 | 4.51e-01 | -0.1706 |
285671 | RNF180 | HTA11_546_2000001011 | Human | Colorectum | AD | 6.29e-04 | 3.34e-01 | -0.0842 |
285671 | RNF180 | HTA11_9341_2000001011 | Human | Colorectum | SER | 1.66e-04 | 8.24e-01 | -0.00410000000000005 |
285671 | RNF180 | HTA11_7862_2000001011 | Human | Colorectum | AD | 1.06e-21 | 8.58e-01 | -0.0179 |
285671 | RNF180 | HTA11_866_3004761011 | Human | Colorectum | AD | 3.43e-15 | 5.98e-01 | 0.096 |
285671 | RNF180 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 5.60e-105 | 2.06e+00 | 0.294 |
285671 | RNF180 | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 2.19e-19 | 1.62e+00 | 0.3487 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0045862113 | Thyroid | PTC | positive regulation of proteolysis | 198/5968 | 372/18723 | 6.68e-18 | 6.91e-16 | 198 |
GO:1901800112 | Thyroid | PTC | positive regulation of proteasomal protein catabolic process | 80/5968 | 114/18723 | 4.80e-17 | 4.27e-15 | 80 |
GO:1903052112 | Thyroid | PTC | positive regulation of proteolysis involved in cellular protein catabolic process | 88/5968 | 133/18723 | 4.30e-16 | 3.39e-14 | 88 |
GO:0032436113 | Thyroid | PTC | positive regulation of proteasomal ubiquitin-dependent protein catabolic process | 66/5968 | 90/18723 | 7.51e-16 | 5.64e-14 | 66 |
GO:2000060113 | Thyroid | PTC | positive regulation of ubiquitin-dependent protein catabolic process | 73/5968 | 107/18723 | 1.19e-14 | 7.75e-13 | 73 |
GO:000020920 | Thyroid | PTC | protein polyubiquitination | 128/5968 | 236/18723 | 7.81e-13 | 3.65e-11 | 128 |
GO:190332210 | Thyroid | PTC | positive regulation of protein modification by small protein conjugation or removal | 73/5968 | 138/18723 | 2.34e-07 | 4.11e-06 | 73 |
GO:00313989 | Thyroid | PTC | positive regulation of protein ubiquitination | 63/5968 | 119/18723 | 1.47e-06 | 2.08e-05 | 63 |
GO:001049832 | Thyroid | ATC | proteasomal protein catabolic process | 309/6293 | 490/18723 | 1.78e-41 | 1.13e-37 | 309 |
GO:0043161210 | Thyroid | ATC | proteasome-mediated ubiquitin-dependent protein catabolic process | 265/6293 | 412/18723 | 7.09e-38 | 1.49e-34 | 265 |
GO:0009896210 | Thyroid | ATC | positive regulation of catabolic process | 290/6293 | 492/18723 | 2.15e-31 | 1.94e-28 | 290 |
GO:0031331210 | Thyroid | ATC | positive regulation of cellular catabolic process | 258/6293 | 427/18723 | 2.09e-30 | 1.65e-27 | 258 |
GO:004217635 | Thyroid | ATC | regulation of protein catabolic process | 239/6293 | 391/18723 | 2.63e-29 | 1.85e-26 | 239 |
GO:190336235 | Thyroid | ATC | regulation of cellular protein catabolic process | 168/6293 | 255/18723 | 3.50e-26 | 1.58e-23 | 168 |
GO:190305035 | Thyroid | ATC | regulation of proteolysis involved in cellular protein catabolic process | 146/6293 | 221/18723 | 4.18e-23 | 1.20e-20 | 146 |
GO:006113633 | Thyroid | ATC | regulation of proteasomal protein catabolic process | 128/6293 | 187/18723 | 1.63e-22 | 4.30e-20 | 128 |
GO:2000058210 | Thyroid | ATC | regulation of ubiquitin-dependent protein catabolic process | 116/6293 | 164/18723 | 2.15e-22 | 5.43e-20 | 116 |
GO:0032434210 | Thyroid | ATC | regulation of proteasomal ubiquitin-dependent protein catabolic process | 100/6293 | 134/18723 | 2.41e-22 | 5.86e-20 | 100 |
GO:0045732210 | Thyroid | ATC | positive regulation of protein catabolic process | 148/6293 | 231/18723 | 1.93e-21 | 4.36e-19 | 148 |
GO:190336434 | Thyroid | ATC | positive regulation of cellular protein catabolic process | 109/6293 | 155/18723 | 8.26e-21 | 1.49e-18 | 109 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
RNF180 | SNV | Missense_Mutation | novel | c.1502N>C | p.Ile501Thr | p.I501T | Q86T96 | protein_coding | deleterious(0.04) | benign(0.007) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
RNF180 | SNV | Missense_Mutation | c.1037C>T | p.Ser346Leu | p.S346L | Q86T96 | protein_coding | tolerated(0.27) | benign(0.203) | TCGA-BH-A0DT-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | CR | |
RNF180 | SNV | Missense_Mutation | c.1378N>A | p.Leu460Met | p.L460M | Q86T96 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-BH-A18J-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | PD | |
RNF180 | SNV | Missense_Mutation | novel | c.1497N>C | p.Leu499Phe | p.L499F | Q86T96 | protein_coding | tolerated(0.05) | benign(0.246) | TCGA-PE-A5DE-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | CR |
RNF180 | insertion | Frame_Shift_Ins | novel | c.710_711insTTGCTATTACTTTCTCCTCCTTTTCCTTCCTCCTTCCTCCGTGTGG | p.Glu237AspfsTer26 | p.E237Dfs*26 | Q86T96 | protein_coding | TCGA-A8-A07G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | 5-fluorouracil | CR | ||
RNF180 | SNV | Missense_Mutation | novel | c.1223N>T | p.His408Leu | p.H408L | Q86T96 | protein_coding | tolerated(0.33) | benign(0.039) | TCGA-VS-A8EL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
RNF180 | SNV | Missense_Mutation | rs373363351 | c.186G>C | p.Met62Ile | p.M62I | Q86T96 | protein_coding | tolerated(0.06) | benign(0.292) | TCGA-VS-A953-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | PD |
RNF180 | SNV | Missense_Mutation | c.832N>A | p.Tyr278Asn | p.Y278N | Q86T96 | protein_coding | tolerated(0.44) | benign(0) | TCGA-AA-3693-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
RNF180 | SNV | Missense_Mutation | novel | c.1592A>G | p.His531Arg | p.H531R | Q86T96 | protein_coding | tolerated(1) | benign(0) | TCGA-AA-3815-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
RNF180 | SNV | Missense_Mutation | novel | c.443N>G | p.Asp148Gly | p.D148G | Q86T96 | protein_coding | tolerated(0.09) | benign(0.057) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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