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Gene: PLAA |
Gene summary for PLAA |
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Gene information | Species | Human | Gene symbol | PLAA | Gene ID | 9373 |
Gene name | phospholipase A2 activating protein | |
Gene Alias | DOA1 | |
Cytomap | 9p21.2 | |
Gene Type | protein-coding | GO ID | GO:0000209 | UniProtAcc | Q9Y263 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9373 | PLAA | LZE4T | Human | Esophagus | ESCC | 1.36e-12 | 3.26e-01 | 0.0811 |
9373 | PLAA | LZE7T | Human | Esophagus | ESCC | 1.71e-16 | 5.27e-01 | 0.0667 |
9373 | PLAA | LZE8T | Human | Esophagus | ESCC | 4.12e-05 | 1.69e-01 | 0.067 |
9373 | PLAA | LZE20T | Human | Esophagus | ESCC | 7.77e-06 | 9.11e-02 | 0.0662 |
9373 | PLAA | LZE24T | Human | Esophagus | ESCC | 7.87e-16 | 3.26e-01 | 0.0596 |
9373 | PLAA | LZE6T | Human | Esophagus | ESCC | 1.50e-02 | 4.94e-02 | 0.0845 |
9373 | PLAA | P1T-E | Human | Esophagus | ESCC | 2.57e-03 | 1.16e-01 | 0.0875 |
9373 | PLAA | P2T-E | Human | Esophagus | ESCC | 1.02e-42 | 7.54e-01 | 0.1177 |
9373 | PLAA | P4T-E | Human | Esophagus | ESCC | 2.16e-13 | 2.34e-01 | 0.1323 |
9373 | PLAA | P5T-E | Human | Esophagus | ESCC | 1.12e-32 | 5.31e-01 | 0.1327 |
9373 | PLAA | P8T-E | Human | Esophagus | ESCC | 3.75e-12 | 1.61e-01 | 0.0889 |
9373 | PLAA | P9T-E | Human | Esophagus | ESCC | 2.81e-18 | 4.15e-01 | 0.1131 |
9373 | PLAA | P10T-E | Human | Esophagus | ESCC | 5.29e-20 | 2.85e-01 | 0.116 |
9373 | PLAA | P11T-E | Human | Esophagus | ESCC | 1.22e-16 | 6.20e-01 | 0.1426 |
9373 | PLAA | P12T-E | Human | Esophagus | ESCC | 6.49e-15 | 2.44e-01 | 0.1122 |
9373 | PLAA | P15T-E | Human | Esophagus | ESCC | 4.91e-18 | 3.28e-01 | 0.1149 |
9373 | PLAA | P16T-E | Human | Esophagus | ESCC | 1.47e-15 | 2.52e-01 | 0.1153 |
9373 | PLAA | P17T-E | Human | Esophagus | ESCC | 2.19e-05 | 2.23e-01 | 0.1278 |
9373 | PLAA | P19T-E | Human | Esophagus | ESCC | 1.12e-11 | 5.42e-01 | 0.1662 |
9373 | PLAA | P20T-E | Human | Esophagus | ESCC | 3.26e-17 | 2.18e-01 | 0.1124 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00085443 | Stomach | GC | epidermis development | 33/1159 | 324/18723 | 3.43e-03 | 2.96e-02 | 33 |
GO:00099134 | Stomach | GC | epidermal cell differentiation | 23/1159 | 202/18723 | 3.50e-03 | 3.02e-02 | 23 |
GO:00224116 | Stomach | GC | cellular component disassembly | 42/1159 | 443/18723 | 3.99e-03 | 3.35e-02 | 42 |
GO:00464862 | Stomach | GC | glycerolipid metabolic process | 38/1159 | 392/18723 | 4.15e-03 | 3.47e-02 | 38 |
GO:0046470 | Stomach | GC | phosphatidylcholine metabolic process | 11/1159 | 74/18723 | 5.62e-03 | 4.34e-02 | 11 |
GO:000991311 | Stomach | CAG with IM | epidermal cell differentiation | 22/1050 | 202/18723 | 2.23e-03 | 2.25e-02 | 22 |
GO:000854411 | Stomach | CAG with IM | epidermis development | 31/1050 | 324/18723 | 2.66e-03 | 2.58e-02 | 31 |
GO:000854421 | Stomach | CSG | epidermis development | 30/1034 | 324/18723 | 3.99e-03 | 3.47e-02 | 30 |
GO:000991321 | Stomach | CSG | epidermal cell differentiation | 21/1034 | 202/18723 | 4.02e-03 | 3.48e-02 | 21 |
GO:002241111 | Stomach | CSG | cellular component disassembly | 38/1034 | 443/18723 | 4.84e-03 | 4.04e-02 | 38 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa04141211 | Esophagus | ESCC | Protein processing in endoplasmic reticulum | 147/4205 | 174/8465 | 3.29e-22 | 1.10e-19 | 5.64e-20 | 147 |
hsa04141310 | Esophagus | ESCC | Protein processing in endoplasmic reticulum | 147/4205 | 174/8465 | 3.29e-22 | 1.10e-19 | 5.64e-20 | 147 |
hsa0414122 | Liver | HCC | Protein processing in endoplasmic reticulum | 146/4020 | 174/8465 | 7.34e-24 | 2.46e-21 | 1.37e-21 | 146 |
hsa0414132 | Liver | HCC | Protein processing in endoplasmic reticulum | 146/4020 | 174/8465 | 7.34e-24 | 2.46e-21 | 1.37e-21 | 146 |
hsa0414130 | Oral cavity | OSCC | Protein processing in endoplasmic reticulum | 143/3704 | 174/8465 | 6.82e-26 | 2.28e-23 | 1.16e-23 | 143 |
hsa04141113 | Oral cavity | OSCC | Protein processing in endoplasmic reticulum | 143/3704 | 174/8465 | 6.82e-26 | 2.28e-23 | 1.16e-23 | 143 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PLAA | SNV | Missense_Mutation | c.2294N>G | p.Ser765Cys | p.S765C | Q9Y263 | protein_coding | deleterious(0) | probably_damaging(0.972) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
PLAA | SNV | Missense_Mutation | rs769694733 | c.1919N>T | p.Ser640Ile | p.S640I | Q9Y263 | protein_coding | tolerated(0.67) | benign(0.021) | TCGA-AR-A0TU-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | Doxorubicin | SD |
PLAA | SNV | Missense_Mutation | c.1475N>G | p.Asp492Gly | p.D492G | Q9Y263 | protein_coding | deleterious(0.01) | probably_damaging(0.989) | TCGA-D8-A1XK-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicine+cyclophosphamide | SD | |
PLAA | insertion | Nonsense_Mutation | novel | c.1905_1906insTGATACCCTGGTGGCCCCAATCCTCTACGCT | p.Gly636Ter | p.G636* | Q9Y263 | protein_coding | TCGA-A2-A0EO-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
PLAA | deletion | Frame_Shift_Del | novel | c.1917delN | p.Phe639LeufsTer9 | p.F639Lfs*9 | Q9Y263 | protein_coding | TCGA-AR-A0TU-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | Doxorubicin | SD | ||
PLAA | insertion | Frame_Shift_Ins | novel | c.1578_1579insTCAGATTTTGTGGAAA | p.Ala527SerfsTer8 | p.A527Sfs*8 | Q9Y263 | protein_coding | TCGA-B6-A0RE-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
PLAA | deletion | Frame_Shift_Del | c.1689delN | p.Glu564LysfsTer5 | p.E564Kfs*5 | Q9Y263 | protein_coding | TCGA-E2-A1II-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD | |||
PLAA | SNV | Missense_Mutation | rs760173766 | c.1087N>A | p.Glu363Lys | p.E363K | Q9Y263 | protein_coding | tolerated(0.09) | probably_damaging(0.986) | TCGA-C5-A2LV-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
PLAA | SNV | Missense_Mutation | novel | c.1255N>A | p.Pro419Thr | p.P419T | Q9Y263 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-DS-A1OB-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | carboplatin | PD |
PLAA | SNV | Missense_Mutation | novel | c.996C>G | p.Ile332Met | p.I332M | Q9Y263 | protein_coding | deleterious(0) | benign(0.418) | TCGA-VS-A9V4-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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