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Gene: NR2F2 |
Gene summary for NR2F2 |
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Gene information | Species | Human | Gene symbol | NR2F2 | Gene ID | 7026 |
Gene name | nuclear receptor subfamily 2 group F member 2 | |
Gene Alias | ARP-1 | |
Cytomap | 15q26.2 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | P24468 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
7026 | NR2F2 | GSM4909282 | Human | Breast | IDC | 1.05e-09 | 3.49e-01 | -0.0288 |
7026 | NR2F2 | GSM4909286 | Human | Breast | IDC | 2.83e-04 | 1.74e-01 | 0.1081 |
7026 | NR2F2 | GSM4909291 | Human | Breast | IDC | 3.11e-11 | 5.62e-01 | 0.1753 |
7026 | NR2F2 | GSM4909293 | Human | Breast | IDC | 1.73e-33 | 6.41e-01 | 0.1581 |
7026 | NR2F2 | GSM4909308 | Human | Breast | IDC | 8.63e-06 | 3.36e-01 | 0.158 |
7026 | NR2F2 | GSM4909311 | Human | Breast | IDC | 3.94e-03 | -3.93e-02 | 0.1534 |
7026 | NR2F2 | GSM4909317 | Human | Breast | IDC | 1.88e-03 | 3.23e-01 | 0.1355 |
7026 | NR2F2 | GSM4909319 | Human | Breast | IDC | 5.01e-06 | -1.55e-01 | 0.1563 |
7026 | NR2F2 | brca10 | Human | Breast | Precancer | 1.37e-02 | -9.38e-02 | -0.0029 |
7026 | NR2F2 | M2 | Human | Breast | IDC | 3.09e-02 | 1.40e-01 | 0.21 |
7026 | NR2F2 | M5 | Human | Breast | IDC | 3.92e-11 | 8.81e-01 | 0.1598 |
7026 | NR2F2 | NCCBC14 | Human | Breast | DCIS | 1.11e-04 | 2.92e-01 | 0.2021 |
7026 | NR2F2 | NCCBC5 | Human | Breast | DCIS | 2.29e-05 | 4.96e-02 | 0.2046 |
7026 | NR2F2 | P1 | Human | Breast | IDC | 2.59e-02 | -5.21e-02 | 0.1527 |
7026 | NR2F2 | P3 | Human | Breast | IDC | 5.07e-03 | 5.13e-01 | 0.1542 |
7026 | NR2F2 | DCIS2 | Human | Breast | DCIS | 3.44e-09 | 6.72e-02 | 0.0085 |
7026 | NR2F2 | HTA11_347_2000001011 | Human | Colorectum | AD | 1.15e-16 | 4.66e-01 | -0.1954 |
7026 | NR2F2 | HTA11_696_2000001011 | Human | Colorectum | AD | 2.14e-05 | 3.00e-01 | -0.1464 |
7026 | NR2F2 | HTA11_866_2000001011 | Human | Colorectum | AD | 2.60e-02 | 2.29e-01 | -0.1001 |
7026 | NR2F2 | HTA11_1391_2000001011 | Human | Colorectum | AD | 7.06e-03 | 2.37e-01 | -0.059 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00506731 | Colorectum | MSS | epithelial cell proliferation | 108/3467 | 437/18723 | 6.76e-04 | 7.30e-03 | 108 |
GO:00487362 | Colorectum | MSS | appendage development | 48/3467 | 172/18723 | 1.61e-03 | 1.46e-02 | 48 |
GO:00601732 | Colorectum | MSS | limb development | 48/3467 | 172/18723 | 1.61e-03 | 1.46e-02 | 48 |
GO:00435422 | Colorectum | MSS | endothelial cell migration | 70/3467 | 279/18723 | 3.69e-03 | 2.71e-02 | 70 |
GO:00031581 | Colorectum | MSS | endothelium development | 38/3467 | 136/18723 | 4.53e-03 | 3.19e-02 | 38 |
GO:00485681 | Colorectum | MSS | embryonic organ development | 100/3467 | 427/18723 | 6.00e-03 | 4.03e-02 | 100 |
GO:0050678 | Colorectum | MSS | regulation of epithelial cell proliferation | 90/3467 | 381/18723 | 6.92e-03 | 4.45e-02 | 90 |
GO:0001893 | Colorectum | MSS | maternal placenta development | 13/3467 | 35/18723 | 7.38e-03 | 4.68e-02 | 13 |
GO:00454461 | Colorectum | MSS | endothelial cell differentiation | 33/3467 | 118/18723 | 7.66e-03 | 4.81e-02 | 33 |
GO:00614589 | Endometrium | AEH | reproductive system development | 88/2100 | 427/18723 | 9.50e-09 | 6.41e-07 | 88 |
GO:00486089 | Endometrium | AEH | reproductive structure development | 87/2100 | 424/18723 | 1.43e-08 | 9.12e-07 | 87 |
GO:00605376 | Endometrium | AEH | muscle tissue development | 83/2100 | 403/18723 | 2.57e-08 | 1.50e-06 | 83 |
GO:003052210 | Endometrium | AEH | intracellular receptor signaling pathway | 60/2100 | 265/18723 | 7.16e-08 | 3.77e-06 | 60 |
GO:00018909 | Endometrium | AEH | placenta development | 39/2100 | 144/18723 | 1.07e-07 | 5.20e-06 | 39 |
GO:000166710 | Endometrium | AEH | ameboidal-type cell migration | 90/2100 | 475/18723 | 3.73e-07 | 1.57e-05 | 90 |
GO:00506738 | Endometrium | AEH | epithelial cell proliferation | 84/2100 | 437/18723 | 4.88e-07 | 1.94e-05 | 84 |
GO:009013014 | Endometrium | AEH | tissue migration | 73/2100 | 365/18723 | 5.79e-07 | 2.20e-05 | 73 |
GO:009013214 | Endometrium | AEH | epithelium migration | 72/2100 | 360/18723 | 6.90e-07 | 2.55e-05 | 72 |
GO:00017019 | Endometrium | AEH | in utero embryonic development | 73/2100 | 367/18723 | 7.18e-07 | 2.63e-05 | 73 |
GO:001063114 | Endometrium | AEH | epithelial cell migration | 71/2100 | 357/18723 | 1.02e-06 | 3.52e-05 | 71 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
NR2F2 | SNV | Missense_Mutation | novel | c.1064A>C | p.Asn355Thr | p.N355T | P24468 | protein_coding | tolerated(0.42) | possibly_damaging(0.543) | TCGA-A2-A25A-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | Cytoxan | SD |
NR2F2 | SNV | Missense_Mutation | c.1094N>C | p.Leu365Pro | p.L365P | P24468 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-D8-A1XK-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicine+cyclophosphamide | SD | |
NR2F2 | SNV | Missense_Mutation | c.653N>A | p.Arg218Lys | p.R218K | P24468 | protein_coding | tolerated(0.07) | probably_damaging(0.997) | TCGA-EA-A1QS-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
NR2F2 | SNV | Missense_Mutation | c.1102C>A | p.Pro368Thr | p.P368T | P24468 | protein_coding | deleterious(0.02) | probably_damaging(1) | TCGA-EA-A50E-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | PD | |
NR2F2 | SNV | Missense_Mutation | novel | c.814N>A | p.Ala272Thr | p.A272T | P24468 | protein_coding | deleterious(0.01) | benign(0.272) | TCGA-GH-A9DA-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
NR2F2 | SNV | Missense_Mutation | novel | c.823C>A | p.Leu275Met | p.L275M | P24468 | protein_coding | tolerated(0.12) | probably_damaging(0.97) | TCGA-MA-AA42-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD |
NR2F2 | SNV | Missense_Mutation | c.911N>T | p.Ala304Val | p.A304V | P24468 | protein_coding | tolerated(0.08) | benign(0.022) | TCGA-AA-3678-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | folinic | CR | |
NR2F2 | SNV | Missense_Mutation | c.1112N>A | p.Arg371His | p.R371H | P24468 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AA-3715-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
NR2F2 | SNV | Missense_Mutation | novel | c.517N>T | p.Asn173Tyr | p.N173Y | P24468 | protein_coding | deleterious(0.03) | benign(0.003) | TCGA-AA-3855-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
NR2F2 | SNV | Missense_Mutation | c.899N>G | p.Glu300Gly | p.E300G | P24468 | protein_coding | deleterious(0.03) | probably_damaging(1) | TCGA-AZ-4313-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
7026 | NR2F2 | NUCLEAR HORMONE RECEPTOR, TRANSCRIPTION FACTOR, DRUGGABLE GENOME | CYCLOHEXIMIDE | CYCLOHEXIMIDE | ||
7026 | NR2F2 | NUCLEAR HORMONE RECEPTOR, TRANSCRIPTION FACTOR, DRUGGABLE GENOME | GNF-PF-1678 | CHEMBL580340 | ||
7026 | NR2F2 | NUCLEAR HORMONE RECEPTOR, TRANSCRIPTION FACTOR, DRUGGABLE GENOME | TCMDC-125620 | CHEMBL530291 | ||
7026 | NR2F2 | NUCLEAR HORMONE RECEPTOR, TRANSCRIPTION FACTOR, DRUGGABLE GENOME | RESACTIN A | RESACTIN A | ||
7026 | NR2F2 | NUCLEAR HORMONE RECEPTOR, TRANSCRIPTION FACTOR, DRUGGABLE GENOME | PYRIDABEN | PYRIDABEN | ||
7026 | NR2F2 | NUCLEAR HORMONE RECEPTOR, TRANSCRIPTION FACTOR, DRUGGABLE GENOME | GNF-PF-4659 | CHEMBL584442 |
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