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Gene: NDUFB5 |
Gene summary for NDUFB5 |
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Gene information | Species | Human | Gene symbol | NDUFB5 | Gene ID | 4711 |
Gene name | NADH:ubiquinone oxidoreductase subunit B5 | |
Gene Alias | CISGDH | |
Cytomap | 3q26.33 | |
Gene Type | protein-coding | GO ID | GO:0006091 | UniProtAcc | O43674 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
4711 | NDUFB5 | GSM4909281 | Human | Breast | IDC | 9.51e-16 | 5.63e-01 | 0.21 |
4711 | NDUFB5 | GSM4909282 | Human | Breast | IDC | 7.14e-06 | 3.94e-01 | -0.0288 |
4711 | NDUFB5 | GSM4909285 | Human | Breast | IDC | 1.91e-60 | 9.66e-01 | 0.21 |
4711 | NDUFB5 | GSM4909293 | Human | Breast | IDC | 4.10e-03 | 3.18e-01 | 0.1581 |
4711 | NDUFB5 | GSM4909294 | Human | Breast | IDC | 4.74e-02 | -5.54e-02 | 0.2022 |
4711 | NDUFB5 | GSM4909296 | Human | Breast | IDC | 2.44e-07 | -8.42e-02 | 0.1524 |
4711 | NDUFB5 | GSM4909297 | Human | Breast | IDC | 8.94e-12 | -8.44e-02 | 0.1517 |
4711 | NDUFB5 | GSM4909301 | Human | Breast | IDC | 1.96e-09 | -2.46e-01 | 0.1577 |
4711 | NDUFB5 | GSM4909308 | Human | Breast | IDC | 3.61e-12 | 4.77e-01 | 0.158 |
4711 | NDUFB5 | GSM4909311 | Human | Breast | IDC | 8.06e-22 | -3.29e-01 | 0.1534 |
4711 | NDUFB5 | GSM4909312 | Human | Breast | IDC | 1.44e-07 | -1.27e-02 | 0.1552 |
4711 | NDUFB5 | GSM4909316 | Human | Breast | IDC | 5.07e-06 | 3.90e-01 | 0.21 |
4711 | NDUFB5 | GSM4909319 | Human | Breast | IDC | 1.14e-29 | -3.16e-01 | 0.1563 |
4711 | NDUFB5 | GSM4909320 | Human | Breast | IDC | 1.25e-04 | -2.88e-01 | 0.1575 |
4711 | NDUFB5 | GSM4909321 | Human | Breast | IDC | 2.86e-10 | 3.40e-02 | 0.1559 |
4711 | NDUFB5 | NCCBC14 | Human | Breast | DCIS | 1.72e-05 | 8.35e-02 | 0.2021 |
4711 | NDUFB5 | NCCBC5 | Human | Breast | DCIS | 1.31e-08 | 4.92e-02 | 0.2046 |
4711 | NDUFB5 | P1 | Human | Breast | IDC | 5.40e-12 | -2.23e-01 | 0.1527 |
4711 | NDUFB5 | P2 | Human | Breast | IDC | 3.47e-07 | 3.94e-01 | 0.21 |
4711 | NDUFB5 | DCIS2 | Human | Breast | DCIS | 2.77e-50 | 1.66e-01 | 0.0085 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:002290017 | Prostate | Tumor | electron transport chain | 76/3246 | 175/18723 | 5.59e-16 | 1.09e-13 | 76 |
GO:000612017 | Prostate | Tumor | mitochondrial electron transport, NADH to ubiquinone | 33/3246 | 51/18723 | 7.04e-14 | 8.26e-12 | 33 |
GO:003310817 | Prostate | Tumor | mitochondrial respiratory chain complex assembly | 47/3246 | 93/18723 | 2.28e-13 | 2.49e-11 | 47 |
GO:001025717 | Prostate | Tumor | NADH dehydrogenase complex assembly | 31/3246 | 57/18723 | 2.46e-10 | 1.39e-08 | 31 |
GO:003298117 | Prostate | Tumor | mitochondrial respiratory chain complex I assembly | 31/3246 | 57/18723 | 2.46e-10 | 1.39e-08 | 31 |
GO:0009060111 | Skin | cSCC | aerobic respiration | 118/4864 | 189/18723 | 3.71e-26 | 1.22e-23 | 118 |
GO:0045333111 | Skin | cSCC | cellular respiration | 131/4864 | 230/18723 | 1.57e-23 | 3.39e-21 | 131 |
GO:0006091111 | Skin | cSCC | generation of precursor metabolites and energy | 224/4864 | 490/18723 | 1.13e-21 | 2.21e-19 | 224 |
GO:002290026 | Skin | cSCC | electron transport chain | 104/4864 | 175/18723 | 7.28e-21 | 1.23e-18 | 104 |
GO:0006119112 | Skin | cSCC | oxidative phosphorylation | 89/4864 | 141/18723 | 1.56e-20 | 2.49e-18 | 89 |
GO:004277326 | Skin | cSCC | ATP synthesis coupled electron transport | 68/4864 | 95/18723 | 1.59e-20 | 2.49e-18 | 68 |
GO:004277526 | Skin | cSCC | mitochondrial ATP synthesis coupled electron transport | 68/4864 | 95/18723 | 1.59e-20 | 2.49e-18 | 68 |
GO:0046034112 | Skin | cSCC | ATP metabolic process | 142/4864 | 277/18723 | 1.38e-19 | 1.96e-17 | 142 |
GO:002290426 | Skin | cSCC | respiratory electron transport chain | 74/4864 | 114/18723 | 2.52e-18 | 3.29e-16 | 74 |
GO:001598026 | Skin | cSCC | energy derivation by oxidation of organic compounds | 154/4864 | 318/18723 | 4.19e-18 | 5.15e-16 | 154 |
GO:003310824 | Skin | cSCC | mitochondrial respiratory chain complex assembly | 64/4864 | 93/18723 | 5.48e-18 | 6.58e-16 | 64 |
GO:001964626 | Skin | cSCC | aerobic electron transport chain | 61/4864 | 87/18723 | 7.73e-18 | 8.97e-16 | 61 |
GO:000612026 | Skin | cSCC | mitochondrial electron transport, NADH to ubiquinone | 40/4864 | 51/18723 | 6.69e-15 | 5.06e-13 | 40 |
GO:001025724 | Skin | cSCC | NADH dehydrogenase complex assembly | 42/4864 | 57/18723 | 6.46e-14 | 4.09e-12 | 42 |
GO:003298124 | Skin | cSCC | mitochondrial respiratory chain complex I assembly | 42/4864 | 57/18723 | 6.46e-14 | 4.09e-12 | 42 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0501224 | Breast | IDC | Parkinson disease | 107/867 | 266/8465 | 2.57e-39 | 8.36e-37 | 6.26e-37 | 107 |
hsa0502023 | Breast | IDC | Prion disease | 102/867 | 273/8465 | 3.70e-34 | 4.01e-32 | 3.00e-32 | 102 |
hsa0501623 | Breast | IDC | Huntington disease | 103/867 | 306/8465 | 5.14e-30 | 4.17e-28 | 3.12e-28 | 103 |
hsa0019023 | Breast | IDC | Oxidative phosphorylation | 62/867 | 134/8465 | 4.78e-27 | 2.59e-25 | 1.94e-25 | 62 |
hsa0501023 | Breast | IDC | Alzheimer disease | 107/867 | 384/8465 | 1.70e-23 | 7.88e-22 | 5.90e-22 | 107 |
hsa0501423 | Breast | IDC | Amyotrophic lateral sclerosis | 102/867 | 364/8465 | 1.29e-22 | 5.22e-21 | 3.91e-21 | 102 |
hsa0471424 | Breast | IDC | Thermogenesis | 75/867 | 232/8465 | 8.41e-21 | 3.04e-19 | 2.27e-19 | 75 |
hsa0502223 | Breast | IDC | Pathways of neurodegeneration - multiple diseases | 116/867 | 476/8465 | 3.63e-20 | 1.18e-18 | 8.82e-19 | 116 |
hsa0520824 | Breast | IDC | Chemical carcinogenesis - reactive oxygen species | 71/867 | 223/8465 | 2.55e-19 | 7.53e-18 | 5.63e-18 | 71 |
hsa0541523 | Breast | IDC | Diabetic cardiomyopathy | 67/867 | 203/8465 | 3.17e-19 | 8.59e-18 | 6.43e-18 | 67 |
hsa0493223 | Breast | IDC | Non-alcoholic fatty liver disease | 50/867 | 155/8465 | 3.48e-14 | 8.08e-13 | 6.05e-13 | 50 |
hsa0472323 | Breast | IDC | Retrograde endocannabinoid signaling | 31/867 | 148/8465 | 7.62e-05 | 7.50e-04 | 5.61e-04 | 31 |
hsa0501234 | Breast | IDC | Parkinson disease | 107/867 | 266/8465 | 2.57e-39 | 8.36e-37 | 6.26e-37 | 107 |
hsa0502033 | Breast | IDC | Prion disease | 102/867 | 273/8465 | 3.70e-34 | 4.01e-32 | 3.00e-32 | 102 |
hsa0501633 | Breast | IDC | Huntington disease | 103/867 | 306/8465 | 5.14e-30 | 4.17e-28 | 3.12e-28 | 103 |
hsa0019033 | Breast | IDC | Oxidative phosphorylation | 62/867 | 134/8465 | 4.78e-27 | 2.59e-25 | 1.94e-25 | 62 |
hsa0501033 | Breast | IDC | Alzheimer disease | 107/867 | 384/8465 | 1.70e-23 | 7.88e-22 | 5.90e-22 | 107 |
hsa0501433 | Breast | IDC | Amyotrophic lateral sclerosis | 102/867 | 364/8465 | 1.29e-22 | 5.22e-21 | 3.91e-21 | 102 |
hsa0471434 | Breast | IDC | Thermogenesis | 75/867 | 232/8465 | 8.41e-21 | 3.04e-19 | 2.27e-19 | 75 |
hsa0502233 | Breast | IDC | Pathways of neurodegeneration - multiple diseases | 116/867 | 476/8465 | 3.63e-20 | 1.18e-18 | 8.82e-19 | 116 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
NDUFB5 | SNV | Missense_Mutation | rs373322203 | c.76N>T | p.Arg26Cys | p.R26C | O43674 | protein_coding | tolerated(0.12) | possibly_damaging(0.663) | TCGA-D8-A1XJ-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Hormone Therapy | tamoxiphen | SD |
NDUFB5 | SNV | Missense_Mutation | novel | c.20N>G | p.Leu7Trp | p.L7W | O43674 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-EW-A1OZ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Targeted Molecular therapy | trastuzumab | SD |
NDUFB5 | SNV | Missense_Mutation | c.289N>A | p.Glu97Lys | p.E97K | O43674 | protein_coding | tolerated(0.12) | possibly_damaging(0.836) | TCGA-A6-2679-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
NDUFB5 | SNV | Missense_Mutation | c.345N>G | p.His115Gln | p.H115Q | O43674 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-A6-6141-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | 5-fu | SD | |
NDUFB5 | SNV | Missense_Mutation | c.122C>A | p.Ala41Asp | p.A41D | O43674 | protein_coding | tolerated(0.64) | benign(0) | TCGA-G4-6320-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | oxaliplatin | SD | |
NDUFB5 | SNV | Missense_Mutation | novel | c.356N>T | p.Arg119Ile | p.R119I | O43674 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
NDUFB5 | SNV | Missense_Mutation | rs757736171 | c.197G>A | p.Arg66His | p.R66H | O43674 | protein_coding | deleterious(0.01) | probably_damaging(0.959) | TCGA-AX-A0J1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
NDUFB5 | SNV | Missense_Mutation | novel | c.533N>G | p.Leu178Arg | p.L178R | O43674 | protein_coding | deleterious(0) | probably_damaging(0.989) | TCGA-AX-A1CE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | SD |
NDUFB5 | SNV | Missense_Mutation | novel | c.186N>A | p.Phe62Leu | p.F62L | O43674 | protein_coding | deleterious(0.01) | possibly_damaging(0.755) | TCGA-B5-A1MR-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
NDUFB5 | SNV | Missense_Mutation | novel | c.125N>A | p.Ala42Asp | p.A42D | O43674 | protein_coding | tolerated(0.08) | possibly_damaging(0.698) | TCGA-DF-A2KU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
4711 | NDUFB5 | ENZYME | inhibitor | CHEMBL3545320 | ME-344 | |
4711 | NDUFB5 | ENZYME | inhibitor | CHEMBL3545135 | NV-128 | |
4711 | NDUFB5 | ENZYME | inhibitor | CHEMBL1703 | METFORMIN HYDROCHLORIDE |
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