|
Gene: NDUFAB1 |
Gene summary for NDUFAB1 |
Gene summary. |
Gene information | Species | Human | Gene symbol | NDUFAB1 | Gene ID | 4706 |
Gene name | NADH:ubiquinone oxidoreductase subunit AB1 | |
Gene Alias | ACP | |
Cytomap | 16p12.2 | |
Gene Type | protein-coding | GO ID | GO:0006082 | UniProtAcc | O14561 |
Top |
Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
4706 | NDUFAB1 | GSM4909282 | Human | Breast | IDC | 3.17e-17 | 4.94e-01 | -0.0288 |
4706 | NDUFAB1 | GSM4909285 | Human | Breast | IDC | 1.06e-02 | 3.32e-01 | 0.21 |
4706 | NDUFAB1 | GSM4909290 | Human | Breast | IDC | 1.47e-05 | 3.34e-01 | 0.2096 |
4706 | NDUFAB1 | GSM4909291 | Human | Breast | IDC | 1.02e-02 | 2.29e-01 | 0.1753 |
4706 | NDUFAB1 | GSM4909293 | Human | Breast | IDC | 4.66e-05 | 3.12e-01 | 0.1581 |
4706 | NDUFAB1 | GSM4909294 | Human | Breast | IDC | 2.35e-08 | 2.88e-01 | 0.2022 |
4706 | NDUFAB1 | GSM4909296 | Human | Breast | IDC | 6.52e-13 | 1.77e-01 | 0.1524 |
4706 | NDUFAB1 | GSM4909297 | Human | Breast | IDC | 6.05e-11 | -1.08e-01 | 0.1517 |
4706 | NDUFAB1 | GSM4909298 | Human | Breast | IDC | 2.92e-03 | 3.03e-01 | 0.1551 |
4706 | NDUFAB1 | GSM4909301 | Human | Breast | IDC | 1.45e-03 | 2.27e-01 | 0.1577 |
4706 | NDUFAB1 | GSM4909304 | Human | Breast | IDC | 7.12e-04 | 3.82e-01 | 0.1636 |
4706 | NDUFAB1 | GSM4909306 | Human | Breast | IDC | 4.03e-29 | 6.71e-01 | 0.1564 |
4706 | NDUFAB1 | GSM4909307 | Human | Breast | IDC | 1.63e-04 | 3.02e-01 | 0.1569 |
4706 | NDUFAB1 | GSM4909308 | Human | Breast | IDC | 1.87e-15 | 4.27e-01 | 0.158 |
4706 | NDUFAB1 | GSM4909309 | Human | Breast | IDC | 2.35e-03 | 5.61e-02 | 0.0483 |
4706 | NDUFAB1 | GSM4909311 | Human | Breast | IDC | 5.04e-42 | -1.57e-01 | 0.1534 |
4706 | NDUFAB1 | GSM4909312 | Human | Breast | IDC | 1.46e-11 | 2.08e-02 | 0.1552 |
4706 | NDUFAB1 | GSM4909316 | Human | Breast | IDC | 3.55e-07 | 2.83e-01 | 0.21 |
4706 | NDUFAB1 | GSM4909318 | Human | Breast | IDC | 6.18e-05 | 3.47e-01 | 0.2031 |
4706 | NDUFAB1 | GSM4909319 | Human | Breast | IDC | 5.17e-49 | -1.40e-01 | 0.1563 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 |
Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00061203 | Colorectum | MSI-H | mitochondrial electron transport, NADH to ubiquinone | 22/1319 | 51/18723 | 8.17e-13 | 1.74e-10 | 22 |
GO:00463941 | Colorectum | MSI-H | carboxylic acid biosynthetic process | 36/1319 | 314/18723 | 2.68e-03 | 3.48e-02 | 36 |
GO:00160531 | Colorectum | MSI-H | organic acid biosynthetic process | 36/1319 | 316/18723 | 2.98e-03 | 3.78e-02 | 36 |
GO:00516043 | Colorectum | MSI-H | protein maturation | 34/1319 | 294/18723 | 3.02e-03 | 3.80e-02 | 34 |
GO:00460344 | Colorectum | FAP | ATP metabolic process | 87/2622 | 277/18723 | 6.50e-14 | 6.63e-11 | 87 |
GO:00060914 | Colorectum | FAP | generation of precursor metabolites and energy | 128/2622 | 490/18723 | 5.58e-13 | 4.28e-10 | 128 |
GO:00159804 | Colorectum | FAP | energy derivation by oxidation of organic compounds | 85/2622 | 318/18723 | 1.36e-09 | 2.77e-07 | 85 |
GO:00090604 | Colorectum | FAP | aerobic respiration | 57/2622 | 189/18723 | 7.02e-09 | 1.02e-06 | 57 |
GO:00453334 | Colorectum | FAP | cellular respiration | 65/2622 | 230/18723 | 1.13e-08 | 1.33e-06 | 65 |
GO:00229004 | Colorectum | FAP | electron transport chain | 51/2622 | 175/18723 | 1.44e-07 | 9.03e-06 | 51 |
GO:00061194 | Colorectum | FAP | oxidative phosphorylation | 43/2622 | 141/18723 | 3.39e-07 | 1.86e-05 | 43 |
GO:00229044 | Colorectum | FAP | respiratory electron transport chain | 35/2622 | 114/18723 | 3.43e-06 | 1.23e-04 | 35 |
GO:00427734 | Colorectum | FAP | ATP synthesis coupled electron transport | 28/2622 | 95/18723 | 7.10e-05 | 1.32e-03 | 28 |
GO:00427754 | Colorectum | FAP | mitochondrial ATP synthesis coupled electron transport | 28/2622 | 95/18723 | 7.10e-05 | 1.32e-03 | 28 |
GO:00066313 | Colorectum | FAP | fatty acid metabolic process | 81/2622 | 390/18723 | 1.43e-04 | 2.24e-03 | 81 |
GO:00196464 | Colorectum | FAP | aerobic electron transport chain | 25/2622 | 87/18723 | 2.63e-04 | 3.59e-03 | 25 |
GO:00061204 | Colorectum | FAP | mitochondrial electron transport, NADH to ubiquinone | 14/2622 | 51/18723 | 8.70e-03 | 4.98e-02 | 14 |
GO:004603416 | Endometrium | AEH | ATP metabolic process | 106/2100 | 277/18723 | 4.13e-32 | 1.24e-28 | 106 |
GO:000611915 | Endometrium | AEH | oxidative phosphorylation | 70/2100 | 141/18723 | 6.41e-30 | 1.28e-26 | 70 |
GO:000906010 | Endometrium | AEH | aerobic respiration | 75/2100 | 189/18723 | 3.22e-24 | 4.82e-21 | 75 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 |
Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0501218 | Breast | Precancer | Parkinson disease | 99/684 | 266/8465 | 3.58e-42 | 5.65e-40 | 4.33e-40 | 99 |
hsa0502016 | Breast | Precancer | Prion disease | 95/684 | 273/8465 | 1.39e-37 | 1.46e-35 | 1.12e-35 | 95 |
hsa0501616 | Breast | Precancer | Huntington disease | 98/684 | 306/8465 | 2.85e-35 | 2.25e-33 | 1.72e-33 | 98 |
hsa0019016 | Breast | Precancer | Oxidative phosphorylation | 59/684 | 134/8465 | 6.15e-30 | 3.24e-28 | 2.48e-28 | 59 |
hsa0501016 | Breast | Precancer | Alzheimer disease | 103/684 | 384/8465 | 1.03e-29 | 4.66e-28 | 3.57e-28 | 103 |
hsa0501416 | Breast | Precancer | Amyotrophic lateral sclerosis | 98/684 | 364/8465 | 2.13e-28 | 8.41e-27 | 6.44e-27 | 98 |
hsa0502216 | Breast | Precancer | Pathways of neurodegeneration - multiple diseases | 112/684 | 476/8465 | 6.96e-27 | 2.44e-25 | 1.87e-25 | 112 |
hsa0520818 | Breast | Precancer | Chemical carcinogenesis - reactive oxygen species | 68/684 | 223/8465 | 3.61e-23 | 1.14e-21 | 8.73e-22 | 68 |
hsa0471418 | Breast | Precancer | Thermogenesis | 68/684 | 232/8465 | 4.40e-22 | 1.26e-20 | 9.69e-21 | 68 |
hsa0541518 | Breast | Precancer | Diabetic cardiomyopathy | 63/684 | 203/8465 | 5.63e-22 | 1.48e-20 | 1.14e-20 | 63 |
hsa0493216 | Breast | Precancer | Non-alcoholic fatty liver disease | 48/684 | 155/8465 | 6.16e-17 | 1.50e-15 | 1.15e-15 | 48 |
hsa0472316 | Breast | Precancer | Retrograde endocannabinoid signaling | 25/684 | 148/8465 | 3.05e-04 | 2.47e-03 | 1.89e-03 | 25 |
hsa0501219 | Breast | Precancer | Parkinson disease | 99/684 | 266/8465 | 3.58e-42 | 5.65e-40 | 4.33e-40 | 99 |
hsa0502017 | Breast | Precancer | Prion disease | 95/684 | 273/8465 | 1.39e-37 | 1.46e-35 | 1.12e-35 | 95 |
hsa0501617 | Breast | Precancer | Huntington disease | 98/684 | 306/8465 | 2.85e-35 | 2.25e-33 | 1.72e-33 | 98 |
hsa0019017 | Breast | Precancer | Oxidative phosphorylation | 59/684 | 134/8465 | 6.15e-30 | 3.24e-28 | 2.48e-28 | 59 |
hsa0501017 | Breast | Precancer | Alzheimer disease | 103/684 | 384/8465 | 1.03e-29 | 4.66e-28 | 3.57e-28 | 103 |
hsa0501417 | Breast | Precancer | Amyotrophic lateral sclerosis | 98/684 | 364/8465 | 2.13e-28 | 8.41e-27 | 6.44e-27 | 98 |
hsa0502217 | Breast | Precancer | Pathways of neurodegeneration - multiple diseases | 112/684 | 476/8465 | 6.96e-27 | 2.44e-25 | 1.87e-25 | 112 |
hsa0520819 | Breast | Precancer | Chemical carcinogenesis - reactive oxygen species | 68/684 | 223/8465 | 3.61e-23 | 1.14e-21 | 8.73e-22 | 68 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 |
Top |
Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
NDUFAB1 | SNV | Missense_Mutation | c.286G>A | p.Glu96Lys | p.E96K | O14561 | protein_coding | tolerated(0.06) | benign(0.1) | TCGA-A8-A095-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | 5-fluorouracil | CR | |
NDUFAB1 | SNV | Missense_Mutation | novel | c.194N>A | p.Cys65Tyr | p.C65Y | O14561 | protein_coding | tolerated(0.15) | benign(0.009) | TCGA-AR-A0TS-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD |
NDUFAB1 | SNV | Missense_Mutation | c.231G>C | p.Glu77Asp | p.E77D | O14561 | protein_coding | tolerated(0.3) | benign(0.005) | TCGA-AR-A24H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | SD | |
NDUFAB1 | SNV | Missense_Mutation | novel | c.461T>C | p.Val154Ala | p.V154A | O14561 | protein_coding | deleterious(0.04) | probably_damaging(0.987) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
NDUFAB1 | SNV | Missense_Mutation | c.136G>A | p.Gly46Arg | p.G46R | O14561 | protein_coding | tolerated(0.26) | benign(0.001) | TCGA-CK-6746-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
NDUFAB1 | SNV | Missense_Mutation | rs776920868 | c.256N>A | p.Val86Ile | p.V86I | O14561 | protein_coding | tolerated(0.08) | possibly_damaging(0.647) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
NDUFAB1 | SNV | Missense_Mutation | rs75847980 | c.301N>G | p.Asn101Asp | p.N101D | O14561 | protein_coding | tolerated(0.38) | benign(0.001) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
NDUFAB1 | SNV | Missense_Mutation | novel | c.218N>A | p.Pro73His | p.P73H | O14561 | protein_coding | deleterious(0) | benign(0.336) | TCGA-AX-A06F-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD |
NDUFAB1 | SNV | Missense_Mutation | novel | c.212T>C | p.Met71Thr | p.M71T | O14561 | protein_coding | tolerated(0.48) | benign(0) | TCGA-AX-A3FT-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
NDUFAB1 | SNV | Missense_Mutation | c.322N>A | p.Leu108Met | p.L108M | O14561 | protein_coding | deleterious(0.02) | probably_damaging(0.996) | TCGA-B5-A11E-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
Page: 1 2 |
Top |
Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
4706 | NDUFAB1 | NA | inhibitor | CHEMBL3545320 | ME-344 | |
4706 | NDUFAB1 | NA | inhibitor | CHEMBL1703 | METFORMIN HYDROCHLORIDE | |
4706 | NDUFAB1 | NA | inhibitor | CHEMBL3545135 | NV-128 |
Page: 1 |