Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: MID1

Gene summary for MID1

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

MID1

Gene ID

4281

Gene namemidline 1
Gene AliasBBBG1
CytomapXp22.2
Gene Typeprotein-coding
GO ID

GO:0000165

UniProtAcc

A0A024RBV4


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
4281MID1CA_HPV_3HumanCervixCC1.15e-037.83e-020.0414
4281MID1CCI_1HumanCervixCC1.21e-111.03e+000.528
4281MID1CCI_2HumanCervixCC5.49e-161.54e+000.5249
4281MID1CCII_1HumanCervixCC8.10e-032.34e-010.3249
4281MID1HTA11_1938_2000001011HumanColorectumAD8.38e-034.51e-01-0.0811
4281MID1HTA11_347_2000001011HumanColorectumAD3.67e-168.05e-01-0.1954
4281MID1HTA11_3361_2000001011HumanColorectumAD1.41e-04-5.64e-01-0.1207
4281MID1HTA11_5216_2000001011HumanColorectumSER6.28e-03-4.30e-01-0.1462
4281MID1HTA11_99999965104_69814HumanColorectumMSS1.51e-201.47e+000.281
4281MID1HTA11_99999974143_84620HumanColorectumMSS1.98e-12-5.14e-010.3005
4281MID1A015-C-203HumanColorectumFAP1.35e-30-4.70e-01-0.1294
4281MID1A015-C-204HumanColorectumFAP2.27e-03-1.78e-01-0.0228
4281MID1A014-C-040HumanColorectumFAP1.85e-04-3.22e-01-0.1184
4281MID1A002-C-201HumanColorectumFAP1.64e-10-3.16e-010.0324
4281MID1A002-C-203HumanColorectumFAP1.21e-02-1.45e-010.2786
4281MID1A001-C-119HumanColorectumFAP3.37e-06-3.94e-01-0.1557
4281MID1A001-C-108HumanColorectumFAP6.85e-18-4.35e-01-0.0272
4281MID1A002-C-205HumanColorectumFAP2.72e-25-4.95e-01-0.1236
4281MID1A001-C-104HumanColorectumFAP1.89e-02-3.32e-010.0184
4281MID1A015-C-006HumanColorectumFAP2.84e-24-8.23e-01-0.0994
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
CervixThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.CC: Cervix cancer
HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions
N_HPV: HPV-infected normal cervix
Colorectum (GSE201348)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.FAP: Familial adenomatous polyposis
CRC: Colorectal cancer
Colorectum (HTA11)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AD: Adenomas
SER: Sessile serrated lesions
MSI-H: Microsatellite-high colorectal cancer
MSS: Microsatellite stable colorectal cancer
EndometriumThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AEH: Atypical endometrial hyperplasia
EEC: Endometrioid Cancer
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
LiverThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.HCC: Hepatocellular carcinoma
NAFLD: Non-alcoholic fatty liver disease
LungThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AAH: Atypical adenomatous hyperplasia
AIS: Adenocarcinoma in situ
IAC: Invasive lung adenocarcinoma
MIA: Minimally invasive adenocarcinoma
Oral CavityThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.EOLP: Erosive Oral lichen planus
LP: leukoplakia
NEOLP: Non-erosive oral lichen planus
OSCC: Oral squamous cell carcinoma
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:004218011LiverCirrhoticcellular ketone metabolic process80/4634211/187231.40e-051.95e-0480
GO:004689011LiverCirrhoticregulation of lipid biosynthetic process67/4634171/187232.00e-052.65e-0467
GO:00329846LiverCirrhoticprotein-containing complex disassembly82/4634224/187234.78e-055.54e-0482
GO:19029046LiverCirrhoticnegative regulation of supramolecular fiber organization63/4634167/187231.29e-041.26e-0363
GO:001056511LiverCirrhoticregulation of cellular ketone metabolic process49/4634133/187231.25e-038.41e-0349
GO:0045923LiverCirrhoticpositive regulation of fatty acid metabolic process17/463439/187237.71e-033.63e-0217
GO:00705072LiverCirrhoticregulation of microtubule cytoskeleton organization50/4634148/187238.33e-033.87e-0250
GO:00423043LiverCirrhoticregulation of fatty acid biosynthetic process20/463449/187239.60e-034.35e-0220
GO:002241112LiverHCCcellular component disassembly282/7958443/187231.02e-191.38e-17282
GO:001605321LiverHCCorganic acid biosynthetic process200/7958316/187235.24e-143.22e-12200
GO:000663122LiverHCCfatty acid metabolic process238/7958390/187238.24e-144.84e-12238
GO:004639421LiverHCCcarboxylic acid biosynthetic process198/7958314/187231.19e-136.78e-12198
GO:005125822LiverHCCprotein polymerization182/7958297/187234.17e-111.58e-09182
GO:190290322LiverHCCregulation of supramolecular fiber organization224/7958383/187231.54e-105.33e-09224
GO:001063912LiverHCCnegative regulation of organelle organization204/7958348/187237.67e-102.37e-08204
GO:003298411LiverHCCprotein-containing complex disassembly138/7958224/187235.59e-091.46e-07138
GO:006201222LiverHCCregulation of small molecule metabolic process190/7958334/187236.77e-081.40e-06190
GO:007233021LiverHCCmonocarboxylic acid biosynthetic process129/7958214/187231.08e-072.09e-06129
GO:004218021LiverHCCcellular ketone metabolic process123/7958211/187232.52e-063.37e-05123
GO:00192162LiverHCCregulation of lipid metabolic process181/7958331/187234.58e-065.79e-05181
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
hsa0412014CervixCCUbiquitin mediated proteolysis49/1267142/84654.26e-097.68e-084.54e-0849
hsa0412015CervixCCUbiquitin mediated proteolysis49/1267142/84654.26e-097.68e-084.54e-0849
hsa04120ColorectumADUbiquitin mediated proteolysis58/2092142/84651.46e-051.53e-049.76e-0558
hsa041201ColorectumADUbiquitin mediated proteolysis58/2092142/84651.46e-051.53e-049.76e-0558
hsa041202ColorectumSERUbiquitin mediated proteolysis39/1580142/84656.18e-033.66e-022.66e-0239
hsa041203ColorectumSERUbiquitin mediated proteolysis39/1580142/84656.18e-033.66e-022.66e-0239
hsa041204ColorectumMSSUbiquitin mediated proteolysis55/1875142/84655.02e-066.00e-053.68e-0555
hsa041205ColorectumMSSUbiquitin mediated proteolysis55/1875142/84655.02e-066.00e-053.68e-0555
hsa041206ColorectumFAPUbiquitin mediated proteolysis51/1404142/84651.55e-085.84e-073.55e-0751
hsa041207ColorectumFAPUbiquitin mediated proteolysis51/1404142/84651.55e-085.84e-073.55e-0751
hsa041208ColorectumCRCUbiquitin mediated proteolysis42/1091142/84659.98e-086.67e-064.52e-0642
hsa041209ColorectumCRCUbiquitin mediated proteolysis42/1091142/84659.98e-086.67e-064.52e-0642
hsa0412016EndometriumAEHUbiquitin mediated proteolysis41/1197142/84653.42e-064.27e-053.13e-0541
hsa0412017EndometriumAEHUbiquitin mediated proteolysis41/1197142/84653.42e-064.27e-053.13e-0541
hsa0412023EndometriumEECUbiquitin mediated proteolysis41/1237142/84657.86e-069.58e-057.14e-0541
hsa0412033EndometriumEECUbiquitin mediated proteolysis41/1237142/84657.86e-069.58e-057.14e-0541
hsa0412026EsophagusHGINUbiquitin mediated proteolysis49/1383142/84657.78e-081.33e-061.06e-0649
hsa04120111EsophagusHGINUbiquitin mediated proteolysis49/1383142/84657.78e-081.33e-061.06e-0649
hsa0412027EsophagusESCCUbiquitin mediated proteolysis122/4205142/84656.53e-207.29e-183.74e-18122
hsa0412036EsophagusESCCUbiquitin mediated proteolysis122/4205142/84656.53e-207.29e-183.74e-18122
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
MID1SNVMissense_Mutationc.427N>Ap.Asp143Asnp.D143NO15344protein_codingtolerated(0.22)benign(0.025)TCGA-A2-A0CL-01Breastbreast invasive carcinomaFemale<65III/IVChemotherapycytoxanSD
MID1SNVMissense_Mutationc.265N>Ap.Ala89Thrp.A89TO15344protein_codingdeleterious(0.01)possibly_damaging(0.602)TCGA-A8-A07W-01Breastbreast invasive carcinomaFemale>=65III/IVHormone TherapyexemestaneSD
MID1SNVMissense_Mutationnovelc.1825N>Ap.Asp609Asnp.D609NO15344protein_codingdeleterious(0)probably_damaging(1)TCGA-A8-A08H-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
MID1SNVMissense_Mutationrs150291968c.1888G>Ap.Asp630Asnp.D630NO15344protein_codingtolerated(0.18)benign(0.009)TCGA-AN-A046-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
MID1SNVMissense_Mutationc.224N>Ap.Arg75Hisp.R75HO15344protein_codingdeleterious(0)probably_damaging(0.981)TCGA-B6-A40B-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
MID1SNVMissense_Mutationrs765748631c.203N>Ap.Arg68Glnp.R68QO15344protein_codingdeleterious(0.01)benign(0.06)TCGA-BH-A0B6-01Breastbreast invasive carcinomaFemale<65I/IIUnknownUnknownSD
MID1SNVMissense_Mutationc.616N>Ap.Asp206Asnp.D206NO15344protein_codingtolerated(0.3)benign(0.07)TCGA-BH-A0C1-01Breastbreast invasive carcinomaFemale<65III/IVChemotherapyadriamycinPD
MID1SNVMissense_Mutationc.1082C>Tp.Thr361Ilep.T361IO15344protein_codingtolerated(0.05)benign(0.093)TCGA-E9-A1N9-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapydoxorubicinSD
MID1SNVMissense_Mutationc.712N>Cp.Glu238Glnp.E238QO15344protein_codingtolerated(0.24)benign(0.146)TCGA-E9-A1RG-01Breastbreast invasive carcinomaFemale<65III/IVHormone TherapytamoxiphenSD
MID1SNVMissense_Mutationc.373N>Ap.Asp125Asnp.D125NO15344protein_codingdeleterious(0.03)benign(0.052)TCGA-GM-A2DN-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapytaxolCR
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
4281MID1ENZYME, B30_2 SPRY DOMAIN, DRUGGABLE GENOMESUN-N8075
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