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Gene: LAMB2 |
Gene summary for LAMB2 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | LAMB2 | Gene ID | 3913 |
| Gene name | laminin subunit beta 2 | |
| Gene Alias | LAMS | |
| Cytomap | 3p21.31 | |
| Gene Type | protein-coding | GO ID | GO:0000902 | UniProtAcc | A0A024R319 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 3913 | LAMB2 | S43 | Human | Liver | Cirrhotic | 5.59e-05 | 3.31e-01 | -0.0187 |
| 3913 | LAMB2 | HCC1_Meng | Human | Liver | HCC | 2.18e-44 | 3.50e-02 | 0.0246 |
| 3913 | LAMB2 | HCC2_Meng | Human | Liver | HCC | 6.46e-14 | -1.60e-02 | 0.0107 |
| 3913 | LAMB2 | cirrhotic2 | Human | Liver | Cirrhotic | 1.74e-13 | 2.56e-01 | 0.0201 |
| 3913 | LAMB2 | cirrhotic3 | Human | Liver | Cirrhotic | 1.16e-09 | 2.49e-01 | 0.0215 |
| 3913 | LAMB2 | HCC1 | Human | Liver | HCC | 5.52e-04 | 3.75e+00 | 0.5336 |
| 3913 | LAMB2 | HCC2 | Human | Liver | HCC | 1.51e-08 | 3.52e+00 | 0.5341 |
| 3913 | LAMB2 | Pt13.b | Human | Liver | HCC | 4.34e-05 | 1.14e-01 | 0.0251 |
| 3913 | LAMB2 | Pt14.b | Human | Liver | HCC | 2.72e-03 | 2.76e-01 | 0.018 |
| 3913 | LAMB2 | S014 | Human | Liver | HCC | 1.47e-06 | 4.29e-01 | 0.2254 |
| 3913 | LAMB2 | S015 | Human | Liver | HCC | 2.63e-08 | 6.80e-01 | 0.2375 |
| 3913 | LAMB2 | S016 | Human | Liver | HCC | 1.58e-07 | 4.37e-01 | 0.2243 |
| 3913 | LAMB2 | S027 | Human | Liver | HCC | 2.99e-10 | 8.22e-01 | 0.2446 |
| 3913 | LAMB2 | S028 | Human | Liver | HCC | 2.00e-18 | 8.76e-01 | 0.2503 |
| 3913 | LAMB2 | S029 | Human | Liver | HCC | 7.15e-24 | 9.42e-01 | 0.2581 |
| 3913 | LAMB2 | C21 | Human | Oral cavity | OSCC | 2.79e-03 | 9.93e-02 | 0.2678 |
| 3913 | LAMB2 | C30 | Human | Oral cavity | OSCC | 3.19e-05 | 4.85e-01 | 0.3055 |
| 3913 | LAMB2 | C46 | Human | Oral cavity | OSCC | 1.74e-04 | 1.54e-01 | 0.1673 |
| 3913 | LAMB2 | C08 | Human | Oral cavity | OSCC | 1.75e-02 | 7.90e-02 | 0.1919 |
| 3913 | LAMB2 | C09 | Human | Oral cavity | OSCC | 1.32e-06 | 4.06e-01 | 0.1431 |
| Page: 1 2 3 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease | ||
| Oral Cavity |  | EOLP: Erosive Oral lichen planus |
| LP: leukoplakia | ||
| NEOLP: Non-erosive oral lichen planus | ||
| OSCC: Oral squamous cell carcinoma | ||
| Prostate |  | BPH: Benign Prostatic Hyperplasia |
| Thyroid |  | ATC: Anaplastic thyroid cancer |
| HT: Hashimoto's thyroiditis | ||
| PTC: Papillary thyroid cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:0034446111 | Thyroid | PTC | substrate adhesion-dependent cell spreading | 58/5968 | 108/18723 | 2.07e-06 | 2.82e-05 | 58 |
| GO:004867517 | Thyroid | PTC | axon extension | 63/5968 | 120/18723 | 2.14e-06 | 2.89e-05 | 63 |
| GO:000740918 | Thyroid | PTC | axonogenesis | 178/5968 | 418/18723 | 2.17e-06 | 2.91e-05 | 178 |
| GO:0002064112 | Thyroid | PTC | epithelial cell development | 101/5968 | 220/18723 | 8.53e-06 | 9.74e-05 | 101 |
| GO:004858819 | Thyroid | PTC | developmental cell growth | 106/5968 | 234/18723 | 1.07e-05 | 1.19e-04 | 106 |
| GO:006056018 | Thyroid | PTC | developmental growth involved in morphogenesis | 105/5968 | 234/18723 | 1.94e-05 | 1.98e-04 | 105 |
| GO:199013817 | Thyroid | PTC | neuron projection extension | 81/5968 | 172/18723 | 2.07e-05 | 2.08e-04 | 81 |
| GO:00301986 | Thyroid | PTC | extracellular matrix organization | 124/5968 | 301/18723 | 3.75e-04 | 2.53e-03 | 124 |
| GO:00430626 | Thyroid | PTC | extracellular structure organization | 124/5968 | 302/18723 | 4.38e-04 | 2.92e-03 | 124 |
| GO:00452296 | Thyroid | PTC | external encapsulating structure organization | 124/5968 | 304/18723 | 5.96e-04 | 3.79e-03 | 124 |
| GO:00717116 | Thyroid | PTC | basement membrane organization | 19/5968 | 31/18723 | 7.02e-04 | 4.39e-03 | 19 |
| GO:00328364 | Thyroid | PTC | glomerular basement membrane development | 9/5968 | 11/18723 | 9.49e-04 | 5.70e-03 | 9 |
| GO:004206315 | Thyroid | PTC | gliogenesis | 121/5968 | 301/18723 | 1.30e-03 | 7.41e-03 | 121 |
| GO:007207316 | Thyroid | PTC | kidney epithelium development | 60/5968 | 136/18723 | 1.78e-03 | 9.66e-03 | 60 |
| GO:0031099110 | Thyroid | PTC | regeneration | 82/5968 | 198/18723 | 2.83e-03 | 1.40e-02 | 82 |
| GO:00720067 | Thyroid | PTC | nephron development | 61/5968 | 142/18723 | 3.49e-03 | 1.69e-02 | 61 |
| GO:00508089 | Thyroid | PTC | synapse organization | 161/5968 | 426/18723 | 5.11e-03 | 2.36e-02 | 161 |
| GO:00850293 | Thyroid | PTC | extracellular matrix assembly | 23/5968 | 45/18723 | 5.62e-03 | 2.55e-02 | 23 |
| GO:00328356 | Thyroid | PTC | glomerulus development | 29/5968 | 62/18723 | 9.96e-03 | 4.07e-02 | 29 |
| GO:004867812 | Thyroid | PTC | response to axon injury | 37/5968 | 83/18723 | 1.02e-02 | 4.11e-02 | 37 |
| Page: 1 2 3 4 5 6 7 8 9 10 11 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| hsa0451021 | Liver | Cirrhotic | Focal adhesion | 93/2530 | 203/8465 | 9.27e-07 | 1.10e-05 | 6.80e-06 | 93 |
| hsa05165 | Liver | Cirrhotic | Human papillomavirus infection | 124/2530 | 331/8465 | 1.55e-03 | 7.83e-03 | 4.83e-03 | 124 |
| hsa0514512 | Liver | Cirrhotic | Toxoplasmosis | 47/2530 | 112/8465 | 4.16e-03 | 1.63e-02 | 1.00e-02 | 47 |
| hsa0451031 | Liver | Cirrhotic | Focal adhesion | 93/2530 | 203/8465 | 9.27e-07 | 1.10e-05 | 6.80e-06 | 93 |
| hsa051651 | Liver | Cirrhotic | Human papillomavirus infection | 124/2530 | 331/8465 | 1.55e-03 | 7.83e-03 | 4.83e-03 | 124 |
| hsa0514513 | Liver | Cirrhotic | Toxoplasmosis | 47/2530 | 112/8465 | 4.16e-03 | 1.63e-02 | 1.00e-02 | 47 |
| hsa0451041 | Liver | HCC | Focal adhesion | 125/4020 | 203/8465 | 3.12e-05 | 1.88e-04 | 1.04e-04 | 125 |
| hsa051652 | Liver | HCC | Human papillomavirus infection | 188/4020 | 331/8465 | 3.34e-04 | 1.49e-03 | 8.29e-04 | 188 |
| hsa0514521 | Liver | HCC | Toxoplasmosis | 70/4020 | 112/8465 | 9.25e-04 | 3.52e-03 | 1.96e-03 | 70 |
| hsa052224 | Liver | HCC | Small cell lung cancer | 57/4020 | 92/8465 | 3.54e-03 | 1.12e-02 | 6.22e-03 | 57 |
| hsa0451051 | Liver | HCC | Focal adhesion | 125/4020 | 203/8465 | 3.12e-05 | 1.88e-04 | 1.04e-04 | 125 |
| hsa051653 | Liver | HCC | Human papillomavirus infection | 188/4020 | 331/8465 | 3.34e-04 | 1.49e-03 | 8.29e-04 | 188 |
| hsa0514531 | Liver | HCC | Toxoplasmosis | 70/4020 | 112/8465 | 9.25e-04 | 3.52e-03 | 1.96e-03 | 70 |
| hsa0522211 | Liver | HCC | Small cell lung cancer | 57/4020 | 92/8465 | 3.54e-03 | 1.12e-02 | 6.22e-03 | 57 |
| hsa051659 | Oral cavity | OSCC | Human papillomavirus infection | 200/3704 | 331/8465 | 3.83e-10 | 4.93e-09 | 2.51e-09 | 200 |
| hsa0451019 | Oral cavity | OSCC | Focal adhesion | 128/3704 | 203/8465 | 1.71e-08 | 1.63e-07 | 8.31e-08 | 128 |
| hsa052228 | Oral cavity | OSCC | Small cell lung cancer | 66/3704 | 92/8465 | 4.43e-08 | 3.38e-07 | 1.72e-07 | 66 |
| hsa0514520 | Oral cavity | OSCC | Toxoplasmosis | 75/3704 | 112/8465 | 5.28e-07 | 3.16e-06 | 1.61e-06 | 75 |
| hsa041516 | Oral cavity | OSCC | PI3K-Akt signaling pathway | 185/3704 | 354/8465 | 6.26e-04 | 1.86e-03 | 9.49e-04 | 185 |
| hsa051468 | Oral cavity | OSCC | Amoebiasis | 59/3704 | 102/8465 | 2.78e-03 | 7.17e-03 | 3.65e-03 | 59 |
| Page: 1 2 3 4 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| LAMB2 | ITGA1_ITGB1 | LAMB2_ITGA1_ITGB1 | LAMININ | Breast | ADJ |
| LAMB2 | ITGA2_ITGB1 | LAMB2_ITGA2_ITGB1 | LAMININ | Breast | ADJ |
| LAMB2 | CD44 | LAMB2_CD44 | LAMININ | Breast | ADJ |
| LAMB2 | ITGA1_ITGB1 | LAMB2_ITGA1_ITGB1 | LAMININ | Breast | DCIS |
| LAMB2 | ITGA2_ITGB1 | LAMB2_ITGA2_ITGB1 | LAMININ | Breast | DCIS |
| LAMB2 | ITGA6_ITGB1 | LAMB2_ITGA6_ITGB1 | LAMININ | Breast | DCIS |
| LAMB2 | ITGA7_ITGB1 | LAMB2_ITGA7_ITGB1 | LAMININ | Breast | DCIS |
| LAMB2 | ITGA6_ITGB4 | LAMB2_ITGA6_ITGB4 | LAMININ | Breast | DCIS |
| LAMB2 | CD44 | LAMB2_CD44 | LAMININ | Breast | DCIS |
| LAMB2 | DAG1 | LAMB2_DAG1 | LAMININ | Breast | DCIS |
| LAMB2 | ITGA1_ITGB1 | LAMB2_ITGA1_ITGB1 | LAMININ | Breast | Healthy |
| LAMB2 | ITGA2_ITGB1 | LAMB2_ITGA2_ITGB1 | LAMININ | Breast | Healthy |
| LAMB2 | ITGA6_ITGB1 | LAMB2_ITGA6_ITGB1 | LAMININ | Breast | Healthy |
| LAMB2 | ITGA7_ITGB1 | LAMB2_ITGA7_ITGB1 | LAMININ | Breast | Healthy |
| LAMB2 | ITGAV_ITGB8 | LAMB2_ITGAV_ITGB8 | LAMININ | Breast | Healthy |
| LAMB2 | CD44 | LAMB2_CD44 | LAMININ | Breast | Healthy |
| LAMB2 | ITGA1_ITGB1 | LAMB2_ITGA1_ITGB1 | LAMININ | Breast | IDC |
| LAMB2 | ITGA6_ITGB1 | LAMB2_ITGA6_ITGB1 | LAMININ | Breast | IDC |
| LAMB2 | CD44 | LAMB2_CD44 | LAMININ | Breast | IDC |
| LAMB2 | ITGA1_ITGB1 | LAMB2_ITGA1_ITGB1 | LAMININ | Breast | Precancer |
| Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| LAMB2 | SNV | Missense_Mutation | c.5393N>T | p.Gln1798Leu | p.Q1798L | P55268 | protein_coding | deleterious(0) | probably_damaging(0.991) | TCGA-A8-A06P-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unspecific | SD | ||
| LAMB2 | SNV | Missense_Mutation | rs762984990 | c.3442N>T | p.Arg1148Cys | p.R1148C | P55268 | protein_coding | deleterious(0.01) | possibly_damaging(0.524) | TCGA-AC-A3W6-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
| LAMB2 | SNV | Missense_Mutation | c.1000C>T | p.Arg334Cys | p.R334C | P55268 | protein_coding | deleterious(0) | possibly_damaging(0.837) | TCGA-D8-A1X5-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Hormone Therapy | tamoxiphen | SD | |
| LAMB2 | SNV | Missense_Mutation | c.931N>G | p.Ile311Val | p.I311V | P55268 | protein_coding | tolerated(1) | benign(0) | TCGA-D8-A1XK-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicine+cyclophosphamide | SD | |
| LAMB2 | SNV | Missense_Mutation | rs777003946 | c.1264N>T | p.Arg422Cys | p.R422C | P55268 | protein_coding | deleterious(0.03) | possibly_damaging(0.576) | TCGA-E2-A14Q-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD |
| LAMB2 | SNV | Missense_Mutation | c.4868N>A | p.Gly1623Asp | p.G1623D | P55268 | protein_coding | tolerated(0.44) | possibly_damaging(0.738) | TCGA-E2-A14Y-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | SD | |
| LAMB2 | SNV | Missense_Mutation | c.2260N>A | p.Leu754Met | p.L754M | P55268 | protein_coding | tolerated(0.46) | benign(0.09) | TCGA-E9-A1R4-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | 5-fluorouracil | SD | |
| LAMB2 | SNV | Missense_Mutation | c.3107N>G | p.His1036Arg | p.H1036R | P55268 | protein_coding | tolerated(1) | benign(0) | TCGA-EW-A1IZ-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | taxotere | SD | |
| LAMB2 | SNV | Missense_Mutation | c.311N>G | p.His104Arg | p.H104R | P55268 | protein_coding | tolerated(0.37) | benign(0.02) | TCGA-GM-A2DD-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | fluorouracil | CR | |
| LAMB2 | insertion | Nonsense_Mutation | novel | c.5165_5166insGTAGTATGTTTGAATCTTCTGATATCTCCT | p.Gln1722_Gly1723insTer | p.Q1722_G1723ins* | P55268 | protein_coding | TCGA-A2-A0EY-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD |
| Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| 3913 | LAMB2 | DRUGGABLE GENOME | CHEMBL2095222 | OCRIPLASMIN | ||
| 3913 | LAMB2 | DRUGGABLE GENOME | CHEMBL2095222 | OCRIPLASMIN |
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