Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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	Gene summary
	Malignant transformation analysis
	Malignant transformation related pathway analysis
	Cell-cell communication analysis
	Single-cell gene regulatory network inference analysis
	Somatic mutation of malignant transformation related genes
	Related drugs of malignant transformation related genes

Gene: KIT

Gene summary for KIT

Gene summary.

Gene information	Species	Human
	Gene symbol	KIT
	Gene ID	3815
	Gene name	KIT proto-oncogene, receptor tyrosine kinase
	Gene Alias	C-Kit
	Cytomap	4q12
	Gene Type	protein-coding
	GO ID	GO:0000003
	UniProtAcc	A0A024RDA0

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Malignant transformation analysis

Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells

Malignant transformation involving gene list.

Entrez ID	Symbol	Replicates	Species	Organ	Tissue	Adj P-value	Log2FC	Malignancy
3815	KIT	CA_HPV_1	Human	Cervix	CC	8.43e-19	-5.22e-01	0.0264
3815	KIT	HSIL_HPV_2	Human	Cervix	HSIL_HPV	2.69e-05	4.16e-03	0.0208
3815	KIT	N_HPV_2	Human	Cervix	N_HPV	1.74e-04	-4.11e-01	-0.0131
3815	KIT	CCI_1	Human	Cervix	CC	3.82e-02	-6.26e-01	0.528
3815	KIT	CCI_2	Human	Cervix	CC	1.64e-03	-6.47e-01	0.5249
3815	KIT	CCI_3	Human	Cervix	CC	6.60e-06	-6.47e-01	0.516
3815	KIT	CCII_1	Human	Cervix	CC	7.51e-09	-6.47e-01	0.3249
3815	KIT	Tumor	Human	Cervix	CC	2.56e-26	-6.47e-01	0.1241
3815	KIT	sample1	Human	Cervix	CC	4.04e-07	-6.47e-01	0.0959
3815	KIT	sample3	Human	Cervix	CC	2.05e-24	-6.47e-01	0.1387
3815	KIT	H2	Human	Cervix	HSIL_HPV	4.26e-21	-6.30e-01	0.0632
3815	KIT	L1	Human	Cervix	CC	7.11e-10	-6.47e-01	0.0802
3815	KIT	T1	Human	Cervix	CC	3.62e-15	-6.42e-01	0.0918
3815	KIT	T3	Human	Cervix	CC	1.16e-23	-6.47e-01	0.1389
3815	KIT	C46	Human	Oral cavity	OSCC	4.79e-03	5.01e-02	0.1673
3815	KIT	LN46	Human	Oral cavity	OSCC	2.27e-04	1.34e-01	0.1666
3815	KIT	EOLP-1	Human	Oral cavity	EOLP	1.56e-14	6.63e-01	-0.0202
3815	KIT	EOLP-2	Human	Oral cavity	EOLP	2.93e-21	8.39e-01	-0.0203
3815	KIT	NEOLP-1	Human	Oral cavity	NEOLP	6.26e-04	4.10e-01	-0.0194

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Transcriptomic changes along malignancy continuum.

Tissue	Expression Dynamics	Abbreviation
Cervix		CC: Cervix cancer
		HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions
		N_HPV: HPV-infected normal cervix
Oral Cavity		EOLP: Erosive Oral lichen planus
		LP: leukoplakia
		NEOLP: Non-erosive oral lichen planus
		OSCC: Oral squamous cell carcinoma

∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer

Figure of enriched GO biological processes.

Tissue	Disease Stage	Enriched GO biological Processes
Colorectum	AD
Colorectum	SER
Colorectum	MSS
Colorectum	MSI-H
Colorectum	FAP

∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).

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Enriched GO biological processes.

GO ID	Tissue	Disease Stage	Description	Gene Ratio	Bg Ratio	pvalue	p.adjust	Count
GO:0043299	Cervix	N_HPV	leukocyte degranulation	7/534	73/18723	4.74e-03	3.51e-02	7
GO:0002551	Cervix	N_HPV	mast cell chemotaxis	3/534	13/18723	5.33e-03	3.84e-02	3
GO:0030219	Cervix	N_HPV	megakaryocyte differentiation	6/534	57/18723	5.54e-03	3.94e-02	6
GO:009706611	Cervix	N_HPV	response to thyroid hormone	4/534	26/18723	5.94e-03	4.16e-02	4
GO:0097531	Cervix	N_HPV	mast cell migration	3/534	14/18723	6.64e-03	4.45e-02	3
GO:0002444	Cervix	N_HPV	myeloid leukocyte mediated immunity	8/534	99/18723	7.37e-03	4.80e-02	8
GO:0002440	Cervix	N_HPV	production of molecular mediator of immune response	17/534	308/18723	7.51e-03	4.88e-02	17
GO:00421131	Cervix	N_HPV	B cell activation	18/534	334/18723	7.67e-03	4.96e-02	18
GO:00466613	Cervix	N_HPV	male sex differentiation	11/534	165/18723	7.83e-03	4.97e-02	11
GO:0097191111	Esophagus	ESCC	extrinsic apoptotic signaling pathway	159/8552	219/18723	4.12e-16	2.94e-14	159
GO:007190016	Esophagus	ESCC	regulation of protein serine/threonine kinase activity	227/8552	359/18723	1.12e-11	4.10e-10	227
GO:0030099111	Esophagus	ESCC	myeloid cell differentiation	232/8552	381/18723	1.22e-09	2.90e-08	232
GO:000726510	Esophagus	ESCC	Ras protein signal transduction	201/8552	337/18723	1.44e-07	2.30e-06	201
GO:0002262111	Esophagus	ESCC	myeloid cell homeostasis	104/8552	157/18723	1.49e-07	2.36e-06	104
GO:0061458110	Esophagus	ESCC	reproductive system development	247/8552	427/18723	2.24e-07	3.42e-06	247
GO:004860818	Esophagus	ESCC	reproductive structure development	245/8552	424/18723	2.82e-07	4.14e-06	245
GO:0048872111	Esophagus	ESCC	homeostasis of number of cells	163/8552	272/18723	1.40e-06	1.69e-05	163
GO:00719029	Esophagus	ESCC	positive regulation of protein serine/threonine kinase activity	124/8552	200/18723	2.27e-06	2.61e-05	124
GO:000257317	Esophagus	ESCC	myeloid leukocyte differentiation	128/8552	208/18723	2.75e-06	3.15e-05	128
GO:00380347	Esophagus	ESCC	signal transduction in absence of ligand	48/8552	65/18723	3.63e-06	3.97e-05	48

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Enriched KEGG pathways.

Pathway ID	Tissue	Disease Stage	Description	Gene Ratio	Bg Ratio	pvalue	p.adjust	qvalue	Count
hsa0401512	Cervix	CC	Rap1 signaling pathway	56/1267	210/8465	6.23e-06	5.61e-05	3.32e-05	56
hsa040142	Cervix	CC	Ras signaling pathway	51/1267	236/8465	3.55e-03	1.34e-02	7.91e-03	51
hsa040109	Cervix	CC	MAPK signaling pathway	62/1267	302/8465	4.89e-03	1.67e-02	9.86e-03	62
hsa0523010	Cervix	CC	Central carbon metabolism in cancer	18/1267	70/8465	1.29e-02	3.87e-02	2.29e-02	18
hsa05224	Cervix	CC	Breast cancer	32/1267	147/8465	1.66e-02	4.88e-02	2.88e-02	32
hsa0401513	Cervix	CC	Rap1 signaling pathway	56/1267	210/8465	6.23e-06	5.61e-05	3.32e-05	56
hsa0401411	Cervix	CC	Ras signaling pathway	51/1267	236/8465	3.55e-03	1.34e-02	7.91e-03	51
hsa0401012	Cervix	CC	MAPK signaling pathway	62/1267	302/8465	4.89e-03	1.67e-02	9.86e-03	62
hsa0523013	Cervix	CC	Central carbon metabolism in cancer	18/1267	70/8465	1.29e-02	3.87e-02	2.29e-02	18
hsa052241	Cervix	CC	Breast cancer	32/1267	147/8465	1.66e-02	4.88e-02	2.88e-02	32
hsa04640	Cervix	HSIL_HPV	Hematopoietic cell lineage	18/459	99/8465	4.97e-06	8.10e-05	6.54e-05	18
hsa046401	Cervix	HSIL_HPV	Hematopoietic cell lineage	18/459	99/8465	4.97e-06	8.10e-05	6.54e-05	18
hsa041516	Oral cavity	OSCC	PI3K-Akt signaling pathway	185/3704	354/8465	6.26e-04	1.86e-03	9.49e-04	185
hsa0415113	Oral cavity	OSCC	PI3K-Akt signaling pathway	185/3704	354/8465	6.26e-04	1.86e-03	9.49e-04	185
hsa0401023	Oral cavity	EOLP	MAPK signaling pathway	68/1218	302/8465	7.48e-05	3.40e-04	2.01e-04	68
hsa0415123	Oral cavity	EOLP	PI3K-Akt signaling pathway	73/1218	354/8465	7.03e-04	2.69e-03	1.59e-03	73
hsa0522121	Oral cavity	EOLP	Acute myeloid leukemia	19/1218	67/8465	2.20e-03	7.32e-03	4.32e-03	19
hsa040722	Oral cavity	EOLP	Phospholipase D signaling pathway	31/1218	148/8465	1.82e-02	4.67e-02	2.76e-02	31
hsa0523041	Oral cavity	EOLP	Central carbon metabolism in cancer	17/1218	70/8465	1.87e-02	4.75e-02	2.80e-02	17
hsa0401033	Oral cavity	EOLP	MAPK signaling pathway	68/1218	302/8465	7.48e-05	3.40e-04	2.01e-04	68

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Cell-cell communication analysis

Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states

Ligand	Receptor	LRpair	Pathway	Tissue	Disease Stage
KITLG	KIT	KITL_KIT	KIT	Breast	Healthy
KITLG	KIT	KITL_KIT	KIT	Cervix	CC
KITLG	KIT	KITL_KIT	KIT	Cervix	Healthy
KITLG	KIT	KITL_KIT	KIT	Cervix	Precancer
KITLG	KIT	KITL_KIT	KIT	CRC	Healthy
KITLG	KIT	KITL_KIT	KIT	Endometrium	AEH
KITLG	KIT	KITL_KIT	KIT	Endometrium	EEC
KITLG	KIT	KITL_KIT	KIT	Esophagus	ESCC
KITLG	KIT	KITL_KIT	KIT	HNSCC	OSCC
KITLG	KIT	KITL_KIT	KIT	HNSCC	Precancer
KITLG	KIT	KITL_KIT	KIT	Lung	AAH
KITLG	KIT	KITL_KIT	KIT	Lung	AIS
KITLG	KIT	KITL_KIT	KIT	Lung	IAC
KITLG	KIT	KITL_KIT	KIT	Lung	MIAC
KITLG	KIT	KITL_KIT	KIT	Lung	Precancer
KITLG	KIT	KITL_KIT	KIT	Skin	ADJ
KITLG	KIT	KITL_KIT	KIT	Skin	AK
KITLG	KIT	KITL_KIT	KIT	Skin	cSCC

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Single-cell gene regulatory network inference analysis

Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states

Cell Type

Tissue

Disease Stage

Target Gene

RSS

Regulon Activity

∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.

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Somatic mutation of malignant transformation related genes

Annotation of somatic variants for genes involved in malignant transformation

Hugo Symbol

Variant Class

Variant Classification

dbSNP RS

HGVSc

HGVSp

HGVSp Short

SWISSPROT

BIOTYPE

SIFT

PolyPhen

Tumor Sample Barcode

Tissue

Histology

Sex

Age

Stage

Therapy Types

Drugs

Outcome

KIT

SNV

Missense_Mutation

c.656C>T

p.Ala219Val

p.A219V

P10721

protein_coding

tolerated(0.25)

benign(0.019)

TCGA-A8-A07G-01

Breast

breast invasive carcinoma

Female

>=65

I/II

Chemotherapy

5-fluorouracil

KIT

SNV

Missense_Mutation

c.117N>G

p.Ile39Met

p.I39M

P10721

protein_coding

deleterious(0)

probably_damaging(0.989)

TCGA-A8-A095-01

Breast

breast invasive carcinoma

Female

<65

I/II

Chemotherapy

5-fluorouracil

KIT

SNV

Missense_Mutation

c.1295G>A

p.Gly432Glu

p.G432E

P10721

protein_coding

deleterious(0)

probably_damaging(1)

TCGA-A8-A09A-01

Breast

breast invasive carcinoma

Female

<65

I/II

Hormone Therapy

tamoxiphen

KIT

SNV

Missense_Mutation

rs753318751

c.771G>T

p.Glu257Asp

p.E257D

P10721

protein_coding

tolerated(0.62)

benign(0.011)

TCGA-AN-A046-01

Breast

breast invasive carcinoma

Female

>=65

I/II

Unknown

KIT

SNV

Missense_Mutation

rs386833402

c.839N>T

p.Ala280Val

p.A280V

P10721

protein_coding

tolerated(1)

benign(0.001)

TCGA-AN-A04A-01

Breast

breast invasive carcinoma

Female

<65

III/IV

Unknown

KIT

SNV

Missense_Mutation

rs143772138

c.2057N>A

p.Arg686His

p.R686H

P10721

protein_coding

deleterious(0.01)

benign(0.096)

TCGA-AN-A0AK-01

Breast

breast invasive carcinoma

Female

>=65

I/II

Unknown

KIT

SNV

Missense_Mutation

novel

c.1391N>T

p.Ser464Leu

p.S464L

P10721

protein_coding

tolerated(0.35)

benign(0.172)

TCGA-BH-A0B6-01

Breast

breast invasive carcinoma

Female

<65

I/II

Unknown

KIT

SNV

Missense_Mutation

rs781633384

c.106C>A

p.Pro36Thr

p.P36T

P10721

protein_coding

tolerated(0.39)

benign(0.112)

TCGA-C8-A1HM-01

Breast

breast invasive carcinoma

Female

>=65

I/II

Chemotherapy

doxorubicin

KIT

insertion

Nonsense_Mutation

novel

c.2253_2254insCAAGGAGACCTCAGTAAATATTATTGATGG

p.Asp751_Val752insGlnGlyAspLeuSerLysTyrTyrTerTrp

p.D751_V752insQGDLSKYY*W

P10721

protein_coding

TCGA-AN-A049-01

Breast

breast invasive carcinoma

Female

<65

I/II

Unknown

KIT

SNV

Missense_Mutation

novel

c.2401A>G

p.Thr801Ala

p.T801A

P10721

protein_coding

deleterious(0)

probably_damaging(0.982)

TCGA-2W-A8YY-01

Cervix

cervical & endocervical cancer

Female

<65

I/II

Chemotherapy

cisplatin

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Related drugs of malignant transformation related genes

Identification of chemicals and drugs interact with genes involved in malignant transfromation

(DGIdb 4.0)

Entrez ID	Symbol	Category	Interaction Types	Drug Claim Name	Drug Name	PMIDs
3815	KIT	CLINICALLY ACTIONABLE, KINASE, TRANSCRIPTION FACTOR, DRUGGABLE GENOME, TYROSINE KINASE, DRUG RESISTANCE, EXTERNAL SIDE OF PLASMA MEMBRANE		Pazopanib HCl
3815	KIT	CLINICALLY ACTIONABLE, KINASE, TRANSCRIPTION FACTOR, DRUGGABLE GENOME, TYROSINE KINASE, DRUG RESISTANCE, EXTERNAL SIDE OF PLASMA MEMBRANE	inhibitor	178102337	SORAFENIB
3815	KIT	CLINICALLY ACTIONABLE, KINASE, TRANSCRIPTION FACTOR, DRUGGABLE GENOME, TYROSINE KINASE, DRUG RESISTANCE, EXTERNAL SIDE OF PLASMA MEMBRANE		G007-LK		28611108
3815	KIT	CLINICALLY ACTIONABLE, KINASE, TRANSCRIPTION FACTOR, DRUGGABLE GENOME, TYROSINE KINASE, DRUG RESISTANCE, EXTERNAL SIDE OF PLASMA MEMBRANE		Sorafenib	SORAFENIB
3815	KIT	CLINICALLY ACTIONABLE, KINASE, TRANSCRIPTION FACTOR, DRUGGABLE GENOME, TYROSINE KINASE, DRUG RESISTANCE, EXTERNAL SIDE OF PLASMA MEMBRANE	inhibitor	4'-N-BENZOYLSTAUROSPORINE
3815	KIT	CLINICALLY ACTIONABLE, KINASE, TRANSCRIPTION FACTOR, DRUGGABLE GENOME, TYROSINE KINASE, DRUG RESISTANCE, EXTERNAL SIDE OF PLASMA MEMBRANE	inhibitor	CHEMBL124660	TANDUTINIB
3815	KIT	CLINICALLY ACTIONABLE, KINASE, TRANSCRIPTION FACTOR, DRUGGABLE GENOME, TYROSINE KINASE, DRUG RESISTANCE, EXTERNAL SIDE OF PLASMA MEMBRANE	inhibitor	178102585	DOVITINIB
3815	KIT	CLINICALLY ACTIONABLE, KINASE, TRANSCRIPTION FACTOR, DRUGGABLE GENOME, TYROSINE KINASE, DRUG RESISTANCE, EXTERNAL SIDE OF PLASMA MEMBRANE	inhibitor	178102286	QUIZARTINIB
3815	KIT	CLINICALLY ACTIONABLE, KINASE, TRANSCRIPTION FACTOR, DRUGGABLE GENOME, TYROSINE KINASE, DRUG RESISTANCE, EXTERNAL SIDE OF PLASMA MEMBRANE	inhibitor	328083485	OSI-930
3815	KIT	CLINICALLY ACTIONABLE, KINASE, TRANSCRIPTION FACTOR, DRUGGABLE GENOME, TYROSINE KINASE, DRUG RESISTANCE, EXTERNAL SIDE OF PLASMA MEMBRANE		OSI-930	OSI-930

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