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Gene: KIF14 |
Gene summary for KIF14 |
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Gene information | Species | Human | Gene symbol | KIF14 | Gene ID | 9928 |
Gene name | kinesin family member 14 | |
Gene Alias | MCPH20 | |
Cytomap | 1q32.1 | |
Gene Type | protein-coding | GO ID | GO:0000070 | UniProtAcc | Q15058 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9928 | KIF14 | LZE2T | Human | Esophagus | ESCC | 4.73e-03 | 4.63e-01 | 0.082 |
9928 | KIF14 | LZE7T | Human | Esophagus | ESCC | 1.02e-03 | 2.11e-01 | 0.0667 |
9928 | KIF14 | P1T-E | Human | Esophagus | ESCC | 7.11e-04 | 3.96e-01 | 0.0875 |
9928 | KIF14 | P2T-E | Human | Esophagus | ESCC | 9.35e-10 | 3.64e-01 | 0.1177 |
9928 | KIF14 | P4T-E | Human | Esophagus | ESCC | 1.78e-10 | 3.32e-01 | 0.1323 |
9928 | KIF14 | P5T-E | Human | Esophagus | ESCC | 5.79e-16 | 6.76e-01 | 0.1327 |
9928 | KIF14 | P9T-E | Human | Esophagus | ESCC | 1.88e-05 | 1.93e-01 | 0.1131 |
9928 | KIF14 | P10T-E | Human | Esophagus | ESCC | 2.02e-06 | 2.66e-01 | 0.116 |
9928 | KIF14 | P15T-E | Human | Esophagus | ESCC | 2.11e-03 | 1.50e-01 | 0.1149 |
9928 | KIF14 | P16T-E | Human | Esophagus | ESCC | 8.40e-04 | 1.53e-01 | 0.1153 |
9928 | KIF14 | P20T-E | Human | Esophagus | ESCC | 3.97e-02 | 1.63e-01 | 0.1124 |
9928 | KIF14 | P21T-E | Human | Esophagus | ESCC | 3.89e-12 | 3.90e-01 | 0.1617 |
9928 | KIF14 | P22T-E | Human | Esophagus | ESCC | 4.17e-05 | 2.55e-01 | 0.1236 |
9928 | KIF14 | P24T-E | Human | Esophagus | ESCC | 1.66e-02 | 1.60e-01 | 0.1287 |
9928 | KIF14 | P26T-E | Human | Esophagus | ESCC | 9.20e-06 | 2.34e-01 | 0.1276 |
9928 | KIF14 | P28T-E | Human | Esophagus | ESCC | 4.44e-08 | 2.97e-01 | 0.1149 |
9928 | KIF14 | P31T-E | Human | Esophagus | ESCC | 8.40e-04 | 1.96e-01 | 0.1251 |
9928 | KIF14 | P32T-E | Human | Esophagus | ESCC | 1.97e-10 | 2.73e-01 | 0.1666 |
9928 | KIF14 | P37T-E | Human | Esophagus | ESCC | 1.42e-10 | 3.14e-01 | 0.1371 |
9928 | KIF14 | P42T-E | Human | Esophagus | ESCC | 9.05e-04 | 2.08e-01 | 0.1175 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0051781 | Thyroid | ATC | positive regulation of cell division | 41/6293 | 89/18723 | 9.71e-03 | 3.56e-02 | 41 |
GO:0021761 | Thyroid | ATC | limbic system development | 48/6293 | 107/18723 | 9.97e-03 | 3.63e-02 | 48 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
KIF14 | SNV | Missense_Mutation | c.3016C>T | p.His1006Tyr | p.H1006Y | Q15058 | protein_coding | tolerated(0.44) | benign(0.177) | TCGA-A2-A0CX-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | |
KIF14 | SNV | Missense_Mutation | c.4912G>A | p.Glu1638Lys | p.E1638K | Q15058 | protein_coding | tolerated(0.65) | benign(0.006) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
KIF14 | SNV | Missense_Mutation | novel | c.964C>A | p.Leu322Ile | p.L322I | Q15058 | protein_coding | tolerated(0.28) | benign(0.003) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
KIF14 | SNV | Missense_Mutation | c.901N>G | p.Pro301Ala | p.P301A | Q15058 | protein_coding | tolerated(0.95) | benign(0) | TCGA-BH-A0DZ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | docetaxel | SD | |
KIF14 | SNV | Missense_Mutation | c.391N>A | p.Glu131Lys | p.E131K | Q15058 | protein_coding | deleterious(0.02) | benign(0.326) | TCGA-BH-A0HF-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD | |
KIF14 | SNV | Missense_Mutation | novel | c.4456N>A | p.Glu1486Lys | p.E1486K | Q15058 | protein_coding | tolerated(0.06) | benign(0.005) | TCGA-BH-A2L8-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | CR |
KIF14 | SNV | Missense_Mutation | c.2344N>G | p.Gln782Glu | p.Q782E | Q15058 | protein_coding | tolerated(1) | benign(0.003) | TCGA-BH-A2L8-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | CR | |
KIF14 | SNV | Missense_Mutation | c.1349G>T | p.Gly450Val | p.G450V | Q15058 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-D8-A1JE-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamicin | SD | |
KIF14 | SNV | Missense_Mutation | c.1139N>C | p.Val380Ala | p.V380A | Q15058 | protein_coding | tolerated(0.07) | benign(0.19) | TCGA-D8-A1XK-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicine+cyclophosphamide | SD | |
KIF14 | SNV | Missense_Mutation | novel | c.4456N>A | p.Glu1486Lys | p.E1486K | Q15058 | protein_coding | tolerated(0.06) | benign(0.005) | TCGA-D8-A73U-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | SD |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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